The degradation, swelling and erosion properties of biodegradable implants prepared by extrusion or compression moulding of poly(lactide-co-glycolide) and ABA triblock copolymers

Biomaterials

Volumn 21, Issue 9, 2000, Pages 931-938

  Witt, Christian ^a   Mäder, Karsten ^b   Kissel, Thomas ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

ABA triblock copolymers; EPR spectroscopy; Extrusion; Poly(lactide co glycolide); Poly(oxyethylene); Polymer degradation; Swelling

Indexed keywords

BIODEGRADATION; BLOCK COPOLYMERS; COMPRESSION MOLDING; CONTROLLED DRUG DELIVERY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PARAMAGNETIC RESONANCE; PH; POLYETHYLENE GLYCOLS; SWELLING; TEMPERATURE;

INCUBATION; MOLECULAR WEIGHT LOSS; POLYMER EROSION;

BIOMATERIALS;

COPOLYMER; POLYGLACTIN; POLYOXYETHYLENE;

ARTICLE; BIODEGRADABLE IMPLANT; DRUG MANUFACTURE; EROSION; IN VITRO STUDY; MATERIALS; MOLECULAR WEIGHT; PH; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; TECHNIQUE; TEMPERATURE;

BIODEGRADATION, ENVIRONMENTAL; DRUG IMPLANTS; MAGNETIC RESONANCE SPECTROSCOPY; MATERIALS TESTING; MICROSCOPY, ELECTRON, SCANNING; POLYETHYLENE GLYCOLS; POLYGLACTIN 910;

EID: 0342514752     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0142-9612(99)00262-8     Document Type: Article

References (30)

1. Bodmer D., Kissel T., Traechslin E. Factors influencing the release of peptides and proteins from biodegradable parenteral depot systems. J Control Rel. 21:1992;129-137.
2. Cohen S., Yoshioka T., Lucarelli M., Hwang L.H., Langer R. Controlled delivery systems for proteins based on poly(lactic/glycolic acid) microspheres. Pharm Res. 8(6):1991;713-720.
3. Jones D.H., Corries S., McDonald S., Clegg J.C.S., Farrar G.H. Poly(DL-lactide-co-glycolide) encapsulated plasmid DNA elicits systemic and mucosal antibody responses to encoded protein after oral administration. Vaccuum. 15:1997;814-817.
4. Athanasiou K.A., Niederauer G.G., Agrawal C.M. Sterilization, toxicity, biocompatibility and clinical applications of polylactic acid/polyglycolic acid copolymers. Biomaterials. 17:1996;93-102.
5. Tamada J.A., Langer R. Erosion kinetics of hydrolytically degradable polymers. Proc Natl Acad Sci USA. 90:1993;552-556.
6. Mäder K., Gallez B., Liu K.J., Swartz H.M. Noninvasive in vivo characterization of release processes in biodegradable polymers by low frequency electron paramagnetic resonance spectroscopy. Biomaterials. 17:1996;459-463.
7. Pitt C.G., Gratzl M.M., Kimmel G.L., Surles J., Schindler A. Aliphatic polyesters. II. The degradation of poly(DL-lactide), poly (. ε -caprolactone), and their copolymers in vivo Biomaterials. 2:1981;215-220.
8. Mäder K., Bittner B., Li Y., Wohlauf W., Kissel T. Monitoring microviscosity and microacidity of the albumin microenvironment inside degrading microparticles from poly(lactide-co-glycolide) (PLG) or ABA-triblock polymers containing hydrophobic poly(lactide-co-glycolide) A-blocks and poly(oxyethylene) B-blocks. Pharm Res. 15:1998;787-793.
9. M. Vert, G. Schwach, R. Engel, J. Coudane, Something new in the field of PLA/GA bioresorbable polymers? J Control Rel 1998;53:85-92.
10. Batycky R.P., Hanest J., Langer R., Edwards D.A. A Theoretical Model of Erosion and Macromolecular Drug Release from Biodegrading Microspheres. J Pharm Sci. 86:1997;1464-1477.
11. Göpferich A. Polymer bulk erosion. Macromolecules. 30:1997;2598-2604.
12. Li Y., Kissel T. Synthesis, characteristics and in vitro degradation of star-block copolymers consisting of L-lactide, glycolide and branched multi-arm poly(ethylene oxide). Polymer. 18:1998;4421-4427.
13. Ronneberger B., Kissel T., Anderson J.M. Biocompatibility of ABA triblock copolymer microparticles consisting of poly(L-lactic-co-glycolic-acid) A-blocks attached to central poly(oxyethylene) B-blocks in rats after intramuscular injection. Eur J Pharm Biopharm. 43:1997;19-28.
14. Bittner B., Witt C., Mäder K., Kissel T. Degradation and protein release properties of microspheres prepared from biodegradable poly(lactide-co-glycolide) and ABA triblock copolymers: influence of buffer media on polymer erosion and bovine serum albumin release. J Contol Rel. 60:1999;297-309.
15. Kissel T., Li Y.X., Volland C., Görich S., Koneberg R. Parenteral protein delivery systems using biodegradable ABA-block copolymers. J Control Rel. 39:1996;315-326.
16. Li Y.X., Volland C., Kissel T. In-vitro degradation, bovine serum albumin release of the ABA triblock copolymers consisting of poly(L(+)-lactic acid), or poly(L(+)-lactic acid-co-glycolic acid) A-blocks attached to central polyoxyethylene B-blocks. J Control Rel. 32:1994;121-128.
17. Bailey FE, Koleske JV, Polyoxyalkylenes in Ullmann's Encyclopedia of industrial chemistry, vol. A21. VCH Publishers Inc., 1992.
18. Kaetsu I.et al. Biodegradable implant composites for local therapy. J Control Rel. 6:1987;249-263.
19. Rosato DV. Extruding plastics, A practical processing handbook. London, UK: Chapman and Hall, 1998 [chapters 3 and 20].
20. Li Y.X., Kissel T. Synthesis and properties of biodegradable ABA triblock copolymers consisting of poly(L-lactic acid) or poly(L-lactic-co-glycolic acid) A-block attached to central poly(oxyethylene) B-blocks. J Contol Rel. 27:1993;247-257.
21. Khramtsov V., Weiner L.M. Proton exchange in stable nitroxide radicals. pH-sensitive spin probes Volodarsky L.B. Imidazoline nitroxides. vol. 2:1988;37-80 CRC Press, Boca Raton, FL.
22. Siemann U. Densiometric determination of the solubility parameters of biodegradable polyesters. Proc Int Symp Control Rel Bioact Mater. 12:1985;53-54.
23. Rothen-Weinhold A., Besseghir K., Gurny R. Analysis of the influence of polymer characteristics and core loading on the in vivo release of a somatostatin analogue. Eur J Pharm Sci. 5:1997;303-313.
24. Bhardwaj R., Blanchard J. In vitro evaluation of poly(D,L-lactide-co-glycolide) polymer-based implants containing the. α -melanocyte stimulating hormone analog, Melanotan-I J Control Rel. 45:1997;49-55.
25. Witt C, Traechslin E, Kissel T. Protein release from biodegradable poly(lactide-co-glycolide) matrices: does the swelling of implants influence the in-vitro release kinetic? STP Pharma Sci 1999;9:487-95.
26. Schmitt E.A., Flanagan D.R., Linhardt R.J. Degradation and release properties fabricated from three commercial poly(D,L-lactide-co-glycolide) biodegradable polymers. J Pharm Sci. 82:1993;326-329.
27. Göpferich A. Polymer degradation and erosion. mechanisms and applications Eur J Pharm Biopharm. 42:1996;1-11.
28. 1H-NMR spectroscopy Biomaterials. 18:1997;27-30.
29. Kenley R.A., Ott Lee M., Mahoney R., Sanders L.M. Poly(lactide-co-glycolide) decomposition kinetics in vivo and in vitro. Macromolecules. 20:1987;2398-2403.
30. Jeong B., Bae Y.H., Lee D.S., Kim S.W. Biodegradable block copolymers as injectable drug-delivery systems. Nature. 388:1997;860-862.