The Drosophila homolog of Onecut homeodomain proteins is a neural- specific transcriptional activator with a potential role in regulating neural differentiation

Mechanisms of Development

Volumn 97, Issue 1-2, 2000, Pages 57-72

  Nguyen, Duc N T ^a   Rohrbaugh, Margaret ^a   Lai, Zhi Chun ^a  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

Cut domain; DNA binding; Drosophila; Homeodomain; Nervous system; Onecut; Transcriptional regulation

Indexed keywords

HOMEODOMAIN PROTEIN; NUCLEAR PROTEIN;

ARTICLE; CELL DIFFERENTIATION; CELL FATE; DNA BINDING; DNA SEQUENCE; DROSOPHILA; EYE DEVELOPMENT; GENE EXPRESSION; HOMEOBOX; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PHOTORECEPTOR; PRIORITY JOURNAL; PROTEIN DOMAIN;

AMINO ACID SEQUENCE; ANIMAL; BASE SEQUENCE; BINDING SITES; CELL DIFFERENTIATION; DNA; DNA, COMPLEMENTARY; DNA-BINDING PROTEINS; DROSOPHILA; ENHANCER ELEMENTS (GENETICS); EYE; GENE EXPRESSION REGULATION; GENES, INSECT; GENES, REPORTER; HOMEODOMAIN PROTEINS; HUMAN; INSECT PROTEINS; LUCIFERASE; MICE; MOLECULAR SEQUENCE DATA; NEURONS; NUCLEAR PROTEINS; PHOTORECEPTORS, INVERTEBRATE; RECOMBINANT FUSION PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SUPPORT, U.S. GOV'T, P.H.S.; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; ZINC FINGERS;

DROSOPHILA;

EID: 0342409278     PISSN: 09254773     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0925-4773(00)00431-7     Document Type: Article

References (65)

1. Ades S.E., Sauer R.T. Differential DNA-binding specificity of the Engrailed homeodomain: the role of residue 50. Biochemistry. 33:1994;9187-9194.
2. Andres V., nadal-Ginard B., Madhdavi V. Clox, a mammalian homeobox gene related to Drosophila cut, encodes DNA binding regulatory proteins differentially expressed during development. Development. 116:1992;321-334.
3. Andres V., Chiara M.D., Mahdavi V. A new bipartite DNA-binding domain: cooperative interaction between the cut repeat and homeo domain of the cut homeo proteins. Genes Dev. 8:1994;245-257.
4. Aufiero B., Neufeld E.J., Orkin S.H. Sequence-specific DNA binding of individual cut repeats of the human CCAAT displacement/cut homeodomain protein. Proc. Natl. Acad. Sci. USA. 91:1994;7757-7761.
5. Ballinger D.G., Xue N., Harshman K.D. A Drosophila photoreceptor cell-specific protein. Calphotin, binds calcium and contains a leucine zipper. Proc. Natl. Acad. Sci. USA. 90:1993;1536-1540.
6. Blochlinger K., Jan L.Y., Jan Y.N. Transformation of sensory organ identity by ectopic expression of Cut in Drosophila. Genes Dev. 5:1991;1124-1135.
7. Blochlinger K., Bodmer R., Jack J., Jan L.Y., Jan Y.N. Primary structure and expression of a product from cut, a locus involved in specifying sensory organ identity in Drosophila. Nature. 333:1988;629-635.
8. Bodmer R., Barbel S., Sheperd S., Jack J.W., Jan L.Y., Jan Y.N. Transformation of sensory organs by mutations of the cut locus of D. melanogaster. Cell. 51:1987;293-307.
9. Brand A., Perrimon N. Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development. 118:1993;401-415.
10. Cassata G., Kagoshima H., Pretot R.F., Aspock G., Niklaus G., Burglin T.R. Rapid expression screening of Caenorhabditis elegans homeobox open reading frames using a two-step polymerase chain reaction promoter-gfp reporter construction technique. Gene. 212:1998;127-135.
11. Catt D., Luo W., Skalnik D.G. DNA-binding properties of CCAAT displacement protein cut repeats. Cell. Mol. Biol. 45:1999;1149-1160.
12. Coqueret O., Berube G., Nepveu A. DNA binding by Cut homeodomain proteins is down-modulated by protein kinase C. J. Biol. Chem. 271:1996;24862-24868.
13. Coqueret O., Berube G., Nepveu A. The mammalian Cut homeodomain protein functions as a cell-cycle-dependent transcriptional repressor which downmodulates p21WAF1/CIP1/SDL1 in S phase. EMBO J. 17:1998;4680-4694.
14. Coqueret O., Martin N., Berube G., Rabbat M., Litchfield D.W., Nepveu A. DNA binding by Cut homeodomain proteins is down-modulated by casein kinase II. J. Biol. Chem. 273:1998;2561-2566.
15. Desplan C., Theis J., O'Farrell P.H. The sequence specificity of homeodomain-DNA interaction. Cell. 54:1988;1081-1090.
16. Dickinson L.A., Dickinson C.D., Kohwi-Shigematsu T. An atypical homeodomain in SATB1 promotes specific recognition of the key structural element in a matrix attachment region. J. Biol. Chem. 272:1997;11463-11470.
17. Dufort D., Nepveu A. The human Cut homeodomain protein represses transcription from the c-myc promoter. Mol. Cell. Biol. 14:1994;4251-4257.
18. Ellis M.C., O'Neill E.M., Rubin G.M. Expression of Drosophila glass protein and evidence for negative regulation of its activity in non-neuronal cells by another DNA-binding protein. Development. 119:1993;855-865.
19. Fortini M.E., Rubin G.M. Analysis of cis-acting requirements of the Rh3 and Rh4 genes reveals a bipartite organization to rhodopsin promoters in Drosophila melanogaster. Genes Dev. 4:1990;444-463.
20. Fortini M.E., Lai Z.-C., Rubin G.M. The Drosophila zfh-1 and zfh-2 genes encode novel proteins containing both zinc-finger and homeodomain motifs. Mech. Dev. 34:1991;113-122.
21. Furukawa T., Morrow E.M., Cepko C.L. Crx, a novel otx-like homeobox gene, shows photoreceptor-specific expression and regulates photoreceptor differentiation. Cell. 91:1997;531-541.
22. Gehring W.J., Affolter M., Burglin T. Homeodomain proteins. Annu. Rev. Biochem. 63:1994;487-526.
23. Gruss P., Walther C. Pax in development. Cell. 69:1992;719-722.
24. Harada R., Dufort D., Denis-Larose C., Nepveu A. Conserved cut repeats in the human cut homeodomain protein function as DNA binding domains. J. Biol. Chem. 269:1994;2062-2067.
25. Harada R., Berube G., Tamplin O.J., Denis-Larose C., Nepveu A. DNA-binding specificity of the cut repeats from the human cut-like protein. Mol. Cell. Biol. 15:1996;129-140.
26. Hay B.A., Wolff T., Rubin G.M. Expression of baculovirus P35 prevents cell death in Drosophila. Development. 120:1994;2121-2129.
27. Hayashi S., Scott M.P. What determines the specificity of action of Drosophila homeodomain proteins? Cell. 63:1990;883-894.
28. Hoey T., Levine M. Divergent homeo box proteins recognize similar DNA sequences in Drosophila. Nature. 332:1988;858-861.
29. Hoey T., Warrior R., Manak J., Levine M. DNA-binding activities of the Drosophila melanogaster even-skipped protein are mediated by its homeo domain and influenced by protein context. Mol. Cell. Biol. 8:1988;4598-4607.
30. Ingraham H.A., Flynn S.E., Voss J.W., Albert V.R., Kapiloff M.S., Wilson L., Rosenfeld M.G. The POU-specific domain of Pit-1 is essential for sequence-specific, high affinity DNA binding and DNA-dependent Pit-1-Pit-1 interactions. Cell. 61:1990;1021-1033.
31. Jacquemin P., Lannoy V.J., Rousseau G.G., Lemaigre F.P. OC-2, a novel mammalian member of the Onecut class of homeodomain transcription factors whose function in liver partially overlaps with that of hepatocyte nuclear factor-6. J. Biol. Chem. 274:1999;2665-2671.
32. Jun S., Desplan C. Cooperative interactions between paired domain and homeodomain. Development. 122:1996;2639-2650.
33. Kikuchi T., Raju K., Breitman M.L., Shinohara T. The proximal promoter of the mouse arrestin gene directs gene expression in photoreceptor cells and contains an evolutionarily conserved retinal factor-binding site. Mol. Cell. Biol. 13:1993;4400-4408.
34. Kruglyak S., Tang H. Regulation of adjacent yeast genes. Trends Genet. 16:2000;109-111.
35. Landry C., Clotman F., Hioki T., Oda H., Picard J.J., Lemaigre F.P., Rousseau G.G. HNF-6 is expressed in endoderm derivatives and nervous system of the mouse embryo and participates to the cross-regulatory network of liver-enriched transcription factors. Dev. Biol. 192:1997;247-257.
36. Lannoy V.J., Burglin T.R., Rousseau G.G., Lemaigre F.P. Isoforms of hepatocyte nuclear factor-6 differ in DNA-binding properties, contain a bifunctional homeodomain, and define the new ONECUT class of homeodomain proteins. J. Biol. Chem. 273:1998;13552-13562.
37. Lannoy V.J., Rodolosse A., Pierreux C.E., Rousseau G.G., Lemaigre F.P. Transcriptional stimulation by HNF-6: Target-specific recruitment of either CBP or p/CAF. J. Biol. Chem. 275:2000;22098-22103.
38. Lemaigre F.P., Durviaux S.M., Truong O., Lannoy V.J., Hsuan J.J., Rousseau G.G. Hepatocyte nuclear factor 6, a transcription factor that contains a novel type of homeodomain and a single cut domain. Proc. Natl. Acad. Sci. USA. 93:1996;9460-9464.
39. Lievens P.M.-J., Donady J.J., Tufarelli C., Neufeld E.J. Repressor activity of CCAAT displacement protein in HL-60 myeloid leukemia cells. J. Biol. Chem. 270:1995;12745-12750.
40. Mlodzik M., Hiromi Y., Weber U., Goodman C.S., Rubin G.M. The Drosophila seven-up gene, a member of the steroid receptor gene superfamily, controls photoreceptor cell fates. Cell. 60:1990;211-224.
41. Moses K., Rubin G.M. Glass encodes a site-specific DNA-binding protein that is regulated in response to positional signals in the developing Drosophila eye. Genes Dev. 5:1991;583-593.
42. Moses K., Ellis M.C., Rubin G.M. The glass gene encodes a zinc-finger protein required by Drosophila photoreceptor cells. Nature. 340:1989;531-536.
43. Neufeld E.J., Skalnik D.G., Lievens P.M.-J., Orkin S.H. Human CCAAT displacement protein is homologous to the Drosophila homeodomain protein. Cut. Nat. Genet. 1:1992;50-55.
44. Patel N.H., Martin-Blanco E., Coleman K.G., Poole S.J., Ellis M.C., Kornberg T.B., Goodman C.S. Expression of engrailed proteins in arthropods, annelids, and chordates. Cell. 58:1989;955-968.
45. Quaggin S.E., Heuvel G.B.V., Golden K., Bodmer R., Igarashi P. Primary structure, neural-specific expression, and chromosomal localization of Cux-2, a second murine homeobox gene related to Drosophila cut. J. Biol. Chem. 271:1996;22624-22634.
46. Rausa F., Samadani U., Ye H., Lim L., Fletcher C.F., Jenkins N.A., Copeland N.G., Costa R.H. The cut-homeodomain transcriptional activator HNF-6 is coexpressed with its target gene HNF-3β in the developing murine liver and pancreas. Dev. Biol. 192:1997;228-246.
47. Rosenfeld M.G. POU-domain transcription factors: pou-er-ful developmental regulators. Genes Dev. 5:1991;897-907.
48. Samadani U., Costa R.H. The transcriptional activator hepatocyte nuclear factor 6 regulates liver gene expression. Mol. Cell. Biol. 16:1996;6273-6284.
49. Scully A.L., McKeown M., Thomas J.B. Isolation and characterization of Dek, a Drosophila Eph receptor protein tyrosine kinase. Mol. Cell. Neurosci. 13:1999;337-347.
50. Sheng G., Thouvenot E., Schmucker D., Wilson D.S., Desplan C. Direct regulation of rhodopsin1 by Pax-6/eyeless in Drosophila: evidence for a conserved function in photoreceptors. Genes Dev. 11:1997;1122-1131.
51. Skalnik D.G., Strauss E.C., Orkin S.H. CCAAT displacement protein as a repressor of the myelomonocytic-specific gp91-phox gene promoter. J. Biol. Chem. 266:1991;16736-16744.
52. Smith D.B., Johnson K.S. Single-step purification of polypeptides expressed I Escherichia coli as fusions with glutathione S-transferase. Gene. 67:1988;31-40.
53. Spek C.A., Lannoy V.J., Lemaigre F.P., Rousseau G.G., Bertina R.M., Reitsma P.H. Type I protein C deficiency caused by disruption of a hepatocyte nuclear factor (HNF)-6/HNF-1 binding site in the human protein C gene promoter. J. Biol. Chem. 273:1998;10168-10173.
54. Sturm R.A., Herr W. The POU domain is a bipartite DNA-binding structure. Nature. 336:1988;601-604.
55. Tolkunova E.N., Fujioka M., Kobayashi M., Deka D., Jaynes J.B. Two distinct types of repression domain in Engrailed: one interacts with the Groucho corepressor and is preferentially active on integrated target genes. Mol. Cell. Biol. 18:1998;2804-2814.
56. Treisman J., Gonczy P., Vashishtha M., Harris E., Desplan C. A single amino acid can determine the DNA binding specificity of homeodomain proteins. Cell. 59:1989;553-562.
57. Treisman J.E., Rubin G.M. Targets of glass regulation in the Drosophila eye disc. Mech. Dev. 56:1996;17-24.
58. Tufarelli C., Fujiwara Y., Zappulla D.C., Neufeld E.J. Hair defects and pup loss in mice with targeted deletion of the first cut repeat domain of the Cux/CDP homeoprotein gene. Dev. Biol. 200:1998;69-81.
59. Valarche I., Tissier-Seta J.-P., Hirsch M.-R., Martinez S., Coridis C., Brunet J.-F. The mouse homeodomain protein Phox2 regulates NCAM promoter activity in concert with Cux/CDP and is a putative determinant of neurotransmitter phenotype. Development. 119:1993;881-896.
60. Vandendries E.R., Johnson D., Reinke R. orthodenticle is required for photoreceptor cell development in the Drosophila eye. Dev. Biol. 173:1996;243-255.
61. van Wijnen A.J., van Gurp M.F., de Ridder M.C., Tufarelli C., Last T.J., Birnbaum M., Vaughn P.S., Giordano A., Krek W., Neufeld E.J., Stein J.L., Stein G.S. CDP/cut is the DNA binding subunit of transcription factor HiNF-D (cyclin A. CDC-2, RB-related complex): a non-E2F mechanism for histone gene regulation at the G1/S phase cell cycle transition point. Proc. Natl. Acad. Sci. USA. 93:1996;11516-11521.
62. Verrijzer C.P., Alkema M.J., van Weperen W.W., Van Leeuwen H.C., Strating M.J.J., van der Vliet P.C. The DNA binding specificity of the bipartite POU domain and its subdomains. EMBO J. 11:1992;4993-5003.
63. Wilson D.S., Sheng G., Lecuit T., Dostani N., Desplan C. Cooperative dimerization of Paired class homeo domains on DNA. Genes Dev. 7:1993;2120-2134.
64. Yu X., Leconte L., Martinez J.A., Barnstable C.J. Ret-1, a cis-acting element of the rat opsin promoter, can direct gene expression in rod photoreceptors. J. Neurochem. 67:1996;2494-2504.
65. Zhang X., Smith T.F. Yeast 'operons'. Microb. Comp. Genomics. 3:1998;133-140.