Glucocorticoids and the prevention of hypoxic-ischemic brain damage

Neuroscience and Biobehavioral Reviews

Volumn 21, Issue 2, 1997, Pages 175-179

  Tuor, Ursula I ^a  

^a NATIONAL RESEARCH COUNCIL CANADA   (Canada)

Author keywords

ATP; Cerebral hypoxia ischemia; Corticosterone; Dexamethasone; Glucocorticoid; Glucose; Methylprednisolo ne; Neonatal; Rat

Indexed keywords

CORTICOSTERONE; CYCLOHEXIMIDE; DACTINOMYCIN; DEXAMETHASONE; GLUCOCORTICOID; GLUCOCORTICOID ANTAGONIST; GLUCOCORTICOID RECEPTOR; GLUCOSE; METHYLPREDNISOLONE; MIFEPRISTONE; PROTEIN SYNTHESIS INHIBITOR;

ANIMAL MODEL; ARTICLE; BRAIN BLOOD FLOW; BRAIN HYPOXIA; BRAIN ISCHEMIA; BRAIN METABOLISM; BRAIN PROTECTION; CEREBROVASCULAR DISEASE; CONTROLLED STUDY; CORTICOSTEROID THERAPY; DRUG MECHANISM; GLUCOSE BRAIN LEVEL; INTRAPERITONEAL DRUG ADMINISTRATION; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ANOXIA; BRAIN DAMAGE, CHRONIC; BRAIN ISCHEMIA; GLUCOCORTICOIDS; RATS;

EID: 0031052113     PISSN: 01497634     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0149-7634(96)00007-3     Document Type: Article

References (33)

1. Altman D.I., Young R.S.K., Yagel S.K. Effects of dexamethazone in hypoxic ischemic brain injury in the neonatal rat. Biol. Neonate. 46:1984;149-156.
2. Avery G.B., Fletcher A.B., Kaplan M., Brudno D.S. Controlled trial of dexamethasone in respirator-dependent infants with bronchopulmonary dysplasia. Pediatrics. 75:1985;106-111.
3. Barks J.D.E., Post M., Tuor U.I. Dexamethasone prevents hypoxic-ischemic brain damage in the neonatal rat. Pediatr. Res. 29:1991;558-563.
4. Barondes S.H., Jarvik M.E. The influence of actinomycin-D on brain RNA synthesis and on memory. J. Neurochem. 11:1964;187-195.
5. Behrmann D.L., Bresnahan J.C., Beattie M.S. Modeling of acute spinal cord injury in the rat: Neuroprotection and enhanced recovery with methylprednisolone, U-74006F and YM-14673. Exp. Neurol. 126:1994;61-75.
6. Bohn M.C., Dean D., Hussain S., Giuliano R. Development of mRNAs for glucocorticoid and mineralocorticoid receptors in rat hippocampus. Dev. Brain Res. 77:1994;157-162.
7. Chumas P.D., Del Bigio M.R., Drake J.M., Tuor U.I. A comparison of the protective effect of dexamethasone to other potential prophylactic agents in a neonatal rat model of cerebral hypoxia-ischemia. J. Neurosurg. 79:1993;414-420.
8. Cintra A., Solfrini V., Bunnemann B., Okret S., Bortolotti F., Gustafsson J.-Å., Fuxe K. Prenatal development of gluco-corticoid receptor gene expression and immunoreactivity in the rat brain and pituitary gland: A combined in situ hybridization and immunocytochemical analysis. Neuroendocrinology. 57:1993;1133-1147.
9. Cummings J.J., D'Eugenio D.B., Gross S.J. A controlled trial of dexamethasone in preterm infants at high risk for bronchopulmonary dysplasia. New Engl. J. Med. 320:1989;1505-1510.
10. De Courten-Myers G.M., Kleinholz M., Wagner K.R., Xi G., Myers R.E. Efficacious experimental stroke treatment with high-dose methylprednisolone. Stroke. 25:1994;487-493.
11. Domer F.R., Mori K., Dinarello C.A., Sokoloff L. Effects of leukocytic pyrogen (interleukin-1) on local cerebral glucose utilization in rats with and without premedication with indomethacin or dexamethasone. J. Cereb. Blood Flow Metab. 8:1988;173-178.
12. Goldstein M., Barnett H.J.M., Orgogozo J.M., Sartorius N., Symon L., Vereschagin N.V. Recommendations on stroke prevention, diagnosis and therapy: report of the WHO task force on stroke and other cerebrovascular disorders. Stroke. 20:1989;1407-1431.
13. Goodman Gilman, A.; Rall, T.W.; Nies, A.S., Taylor, P. In: Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th edn, Toronto: McGraw-Hill; 1993:1241.
14. Goto K., Ishige A., Sekiguchi K., Iizuka S., Sugimoto A., Yuzurihara M., Aburada M., Hosoya E., Kogure K. Effects of cycloheximide on delayed neuronal death in rat hippocampus. Brain Res. 534:1990;299-302.
15. Hall E.D. The neuroprotective pharmacology of methylprednisolone. J. Neurosurg. 76:1992;13-22.
16. Jastremski M., Sutton-Tyrell K., Vaagenes P., Abramson N., Heiselman D., Safar P. The brain resuscitation clinical trial I study group) Glucocorticoid treatment does not improve neurologic recovery following cardiac arrest. J. Am. Med. A. 262:1989;3427-3430.
17. Joëls M., De Kloet E.R. Control of neuronal excitability by corticosteroid hormones. Trends Neurosci. 15:1992;25-30.
18. Kadekaro M., Ito M., Gross P.M. Local Cerebral Glucose Utilization is Increased in Acutely Adrenalectomized Rats. Neuroendocrinology. 47:1988;329-334.
19. Koide T., Wieloch T.W., Siesjo B.K. Chronic dexamethasone pretreatment aggravates ischemic neuronal necrosis. J. Cereb. Blood Flow Metab. 6:1986;395-404.
20. McEwen B.S., De Kloet E.R., Rostene W. Adrenal steroid receptors and actions in the nervous system. Physiol. Rev. 66:1986;1121-1143.
21. Meaney M.J., Sapolsky R.M., McEwen B.S. The development of glucocorticoid receptor system in the rat limbic brain. I. Ontogeny and autoregulation. Dev. Brain Res. 18:1985;159-164.
22. Mima T., Halaby I., Levy D., Pulsinelli W. Cycloheximide attenuates ischemic damage to CA1 hippocampal neurons in rats. Soc. Neurosci. Abst. 17:1991;185.
23. Norris J.W., Hacinski V.C. High dose steroid therapy in cerebral infarction. Br. Med. J. 292:1986;21-23.
24. Phillips P.C., Berger C.A., Rottenberg D.A. High-dose dexamethasone decreases-regional cerebral glucose metabolism in the rat. Neurol. 37:((Supp. 1)):1987;248.
25. Sapolsky R.M., Meaney M.J. The maturation of the adrenocortical response in the rat. Brain Res. Rev. 11:1986;65-76.
26. Sapolsky R.M., Pulsinelli W.A. Glucocorticoids potentiate ischemic injury to neurons: therapeutic implications. Science. 229:1985;1397-1400.
27. Tortosa A., Rivera R., Ferrer I. Dose-related effects of cycloheximide on delayed neuronal death in the gerbil hippocampus after bilateral transitory forebrain ischemia. J. Neurol. Sci. 121:1994;10-17.
28. Tuor, U.I. Dexamethasone and the prevention of neonatal hypoxic-ischemic brain damage. In: Trembly, B.; Slikker, W. eds. Proceedings of the International Conference on Neuroprotective Agents, New York: New York Academy of Sciences; 1995: 179-195.
29. Tuor U.I., Chumas P.D., Del Bigio M.R. Prevention of hypoxic-ischemic damage with dexamethasone is dependent on age and not influenced by fasting. Exp. Neurol. 132:1995;116-122.
30. Tuor U.I., Del Bigio M.R. Protection against hypoxic-ischemic damage with corticosterone and dexamethasone: Inhibition by a glucocorticoid antagonist. J. Cereb. Blood Flow Metab. 15:((Suppl.1)):1995;S279.
31. Tuor U.I., Simone C.S., Arellano R., Tanswell K., Post M. Glucocorticoid prevention of neonatal hypoxic-ischemic damage: Role of hyperglycemia and antioxidant enzymes. Brain Res. 604:1993;165-172.
32. Tuor U.I., Simone C.S., Barks J.D.E., Post M. Dexamethasone prevents cerebral infarction without affecting cerebral blood flow in neonatal rats. Stroke. 24:1993;452-457.
33. Vannucci R.C., Christensen M.A., Stein D.T. Regional cerebral glucose utilization in the immature rat: Effect of hypoxia-ischemia. Pediatr. Res. 26:1989;208-214.