Binge drinking disturbs hepatic microcirculation after transplantation: Prevention with free radical scavengers

Journal of Pharmacology and Experimental Therapeutics

Volumn 290, Issue 2, 1999, Pages 611-620

  Zhong, Zhi ^a   Arteel, Gavin E ^a,b   Connor, Henry D ^a   Schemmer, Peter ^a   Chou, Shu Chuan ^a   Raleigh, James A ^a,b   Mason, Ronald P ^c   Lemasters, John J ^b   Thurman, Ronald G ^a,b  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

^c NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 [3 TERT BUTYLTHIO 1 (4 CHLOROBENZYL) 5 ISOPROPYL 2 INDOLYL] 2,2 DIMETHYLPROPIONIC ACID; ALCOHOL; ASPARTATE AMINOTRANSFERASE; CAROLINA RINSE; CATECHIN; FREE RADICAL; GADOLINIUM CHLORIDE; PIMONIDAZOLE; PRESERVATION SOLUTION; SCAVENGER; UNCLASSIFIED DRUG; UNIVERSITY OF WISCONSIN SOLUTION;

ALCOHOL CONSUMPTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; FEMALE; GRAFT SURVIVAL; HISTOPATHOLOGY; HYPOXIA; INTRAVENOUS DRUG ADMINISTRATION; LIVER CIRCULATION; LIVER INJURY; LIVER PROTECTION; LIVER TOXICITY; LIVER TRANSPLANTATION; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ANOXIA; ASPARTATE AMINOTRANSFERASES; BILE; BLOOD PRESSURE; CATECHIN; ETHANOL; FEMALE; FREE RADICAL SCAVENGERS; FREE RADICALS; GADOLINIUM; GRAFT SURVIVAL; LIVER; LIVER CIRCULATION; LIVER FUNCTION TESTS; LIVER TRANSPLANTATION; MICROCIRCULATION; RATS; RATS, INBRED LEW; TRIGLYCERIDES;

EID: 0032788730     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Adachi Y, Moore LE, Bradford BU, Gao W and Thurman RG (1995) Antibiotics prevent liver injury in rats following long-term exposure to ethanol. Gastroenterology 108:218-224.
2. Anggard E (1985) Overview, in Recent Developments in Alcoholism (Galanter M ed) pp 85-100, Plenum Press, New York.
3. Anonymous (1994) Update: Alcohol-related traffic fatalities - United States, 1982-1993. Morb Mortal Wkly Rep 43:861-867.
4. Arteel GE, Thurman RG, Yates JA and Raleigh JA (1995) Evidence that hypoxia markers detect oxygen gradients in liver: Pimonidazole and retrograde perfusion of rat liver. Br J Cancer 72:889-895.
5. Bode CH, Kugler V and Bode JCH (1987) Endotoxemia in patients with alcoholic and non-alcoholic cirrhosis and in subjects with no evidence of chronic liver disease following acute alcohol excess. J Hepatol 4:8-14.
6. Bremer C, Bradford BU, Hunt KJ, Knecht KT, Connor HD, Mason RP and Thurman RG (1994) Role of Kupffer cells in the pathogenesis of hepatic reperfusion injury. Am J Physiol 267:G630-G636.
7. Brodie BB, Butler WM, Horning MG, Maickel RP and Maling HM (1961) Alcohol-induced triglyceride deposition in liver through derangement of fat transport. Am J Clin Nutr 9:432-435.
8. Bucolo G and David H (1973) Quantitative determination of serum triglycerides by the use of enzymes. Clin Chem 19:476-482.
9. Chamulitrat W, Jordan SJ and Mason RP (1992) Fatty acid radical formation in rats administered oxidized fatty acids: In vivo spin trapping investigation. Arch Biochem Biophys 299:361-367.
10. Clavien PA, Harvey PR, Sanabria JR, Cywes R, Levy GA and Strasberg SM (1993) Lymphocyte adherence in the reperfused rat liver: Mechanisms and effects. Hepatology 17:131-142.
11. Decker K (1990) Biologically active products of stimulated liver macrophages (Kupffer cells). Eur J Biochem 192:245-261.
12. Duling DR (1994) Simulation on multiple isotropic spin-trap EPR spectra. J Magn Reson 104:105-110.
13. Durand RE and Raleigh JA (1998) Identification of nonproliferating but viable hypoxic tumor cells in vivo. Cancer Res 58:3547-3550.
14. Enomoto N, Ikejima K, Bradford BU, Rivera CA, Kono H, Brenner DA and Thurman RG (1998) Alcohol causes both tolerance and sensitization of rat Kupffer cells via mechanisms dependent on endotoxin. Gastroenterology 115:443-451.
15. Gao W, Connor HD, Lemasters JJ, Mason RP and Thurman RG (1995) Primary nonfunction of fatty livers produced by alcohol is associated with a new, antioxidant-insensitive free radical species. Transplantation 59:674-679.
16. Gao W, Takei Y, Marzi I, Lindert KA, Caldwell-Kenkel JC, Currin RT, Tanaka Y, Lemasters JJ and Thurman RG (1991) Carolina Rinse solution: A new strategy to increase survival time after orthotopic liver transplantation in the rat. Transplantation 52:417-424.
17. Gillard J, Ford-Hutchinson AW, Chan C, Charleson S, Denis D, Foster A, Fortin R, Leger S, McFarlane CS, Morton H, Piechuta H, Riendeau D, Rouzer CA, Bach T, Eiermann G, Hopple S, Humes J, Hupe L, Luell S, Metzger J, Meurer R, Miller DK, Opas E and Pacholok S (1989) L-663,536 (MK-886) (3-[1-(4-chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2,22- dimethylpropanoic acid), a novel, orally active leukotriene biosynthesis inhibitor. Can J Physiol Pharmacol 67:456-464.
18. Goldman R, Ferber E and Zor U (1997) Involvement of reactive oxygen species in phospholipase A2 activation: Inhibition of protein tyrosine phosphatases and activation of protein kinases. Adv Exp Med Biol 400A:25-30.
19. Hardonk MJ, Dijkhuis FWJ, Hulstaert CE and Koudstaal J (1992) Heterogeneity of rat liver and spleen macrophages in gadolinium chloride-induced elimination and repopulation. J Leukocyte Biol 52:296-302.
20. Hassanein TI, Gavaler JS, Fishkin D, Gordon R, Starzl TE and Van Thiel DH (1991) Does the presence of a measurable blood alcohol level in a potential organ donor affect the outcome of liver transplantation? Alcohol Clin Exp Res 15:300-303.
21. Hijioka T, Sato N, Matsumura T, Yoshihara H, Takei Y, Fukui H, Oshita M, Kawano S and Kamada T (1991) Ethanol-induced disturbance of hepatic microcirculation and hepatic hypoxia. Biochem Pharmacol 11:1551-1557.
22. Ikai I, Chance E and Kumar C (1994) Reactive oxygen inducing vasoconstriction in the isolated perfused rat liver. Free Radical Biol Med 16:539-545.
23. 2-isoprostanes in vivo by acute Cr(VI) poisoning. Chem Res Toxicol 11:1516-1520.
24. Labarca C and Paigen K (1980) A simple, rapid, and sensitive DNA assay procedure. Anal Biochem 102:344-352.
25. Lin M, Pham TV and Tsukamoto T (1995) In vivo suppression of Kupffer cell NF-kB activation and cytokine gene expression by iron chelator. Hepatology 22:365A-365A.
26. Luna L (1968) Manual of Histologic Staining Method of the Armed Forces Institute of Pathology, McGraw-Hill Book Co., New York.
27. Marzi I, Takei Y, Knee J, Menger M, Gores GJ, Bühren V, Trentz O, Lemasters JJ and Thurman RG (1990) Assessment of reperfusion injury by intravital fluorescence microscopy following liver transplantation in the rat. Transplant Proc 22: 2004-2005.
28. Marzi I, Zhong Z, Lemasters JJ and Thurman RG (1989) Evidence that graft survival is not related to parenchymal cell viability in rat liver transplantation. Transplantation 48:463-468.
29. 2 analogue. Transplantation 55:1261-1265.
30. Raleigh JA and Koch CJ (1990) Importance of thiols in the reductive binding of 2-nitroimidazoles to macromolecules. Biochem Pharmacol 40:2457-2464.
31. Slater TF (1981) Free radical scavengers, in (+)-Cyanidanol-3 in Diseases of the Liver, International Workshop (Conn HO ed) pp 11-15, Academic Press Inc., New York.
32. Takei Y, Gao W, Hijioka T, Savier E, Lindert KA, Lemasters JJ and Thurman RG (1991a) Increase in survival of liver grafts after rinsing with warm Ringer's solution due to improvement of hepatic microcirculation. Transplantation 52:225-230.
33. Takei Y, Marzi I, Gao W, Gores GJ, Lemasters JJ and Thurman RG (1991b) Leukocyte adhesion and cell death following orthotopic liver transplantation in the rat. Transplantation 51:959-965.
34. Todo S, Demetris AJ, Makowa L, Teperman L, Podesta L, Shaver T, Tzakis A and Starzl TE (1989) Primary nonfunction of hepatic allografts with preexisting fatty infiltration. Transplantation 47:903-905.
35. Wendell GD and Thurman RG (1979) Effect of ethanol concentration on rates of ethanol elimination in normal and alcohol-treated rats in vivo. Biochem Pharmacol 28:273-279.
36. Ylikahri RH, Kähönen MT and Hassinen I (1972) Modification of metabolic effects of ethanol by fructose. Acta Med Scand 30:141-150.
37. Zhong Z, Connor HD, Mason RP, Lemasters JJ and Thurman RG (1998) Ethanol, not fat accumulation per se, increases free radical production in a low-flow, reflow liver perfusion model. Transplantation 66:1431-1438.
38. Zhong Z, Connor MD, Mason RP, Qu W, Stachlewitz RF, Gao W, Lemasters JJ and Thurman RG (1996) Destruction of Kupffer cells increases survival and reduces graft injury after transplantation of fatty livers from ethanol-treated rats. Liver Transplant Surg 2:383-387.
39. Zimmermann FA, Butcher GW, Davies HS, Brons G, Kamada N and Türel O (1979) Techniques of orthotopic liver transplantation in the rat and some studies of the immunologic response to fully allogenic liver grafts. Transplant Proc 1:571-577.