Intracerebroventricular Administration of Insulin and Glucose Inhibits the Anorectic Action of Leptin in Rats

Experimental Biology and Medicine

Volumn 228, Issue 10, 2003, Pages 1156-1161

  Fujita, Naruhiro ^a   Sakamaki, Hiroyuki ^a   Uotani, Shigeo ^a   Takahashi, Ryoko ^a   Kuwahara, Hironaga ^a   Kita, Atsushi ^a   Oshima, Katsuya ^a   Yamasaki, Hironori ^a   Yamaguchi, Yoshihiko ^a   Eguchi, Katsumi ^a  

^a NAGASAKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Glucose; Hyperphagia; Insulin; Leptin

Indexed keywords

GLUCOSE; INSULIN; LEPTIN; STAT3 PROTEIN;

ANIMAL EXPERIMENT; CONFERENCE PAPER; CONTROLLED STUDY; FOOD INTAKE; HORMONAL REGULATION; HYPERPHAGIA; MALE; NEUROENDOCRINOLOGY; NEUROMODULATION; NONHUMAN; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 0242694049     PISSN: 15353702     EISSN: None     Source Type: Journal    
DOI: 10.1177/153537020322801009     Document Type: Conference Paper

References (27)

1. Dagogo-Jack S, Fanelli C, Paramore D, Brothers J, Landt M. Plasma leptin and insulin relationships in obese and nonobese humans. Diabetes 45:695-698, 1996.
2. Collier GR, Walder K, Lewandowski P, Sanigorski A, Zimmet P. Leptin and the development of obesity and diabetes in Psammomys obesus. Obes Res 5:455-458, 1997.
3. Bodkin NL, Nicolson M, Ortmeyer HK, Hansen BC. Hyperleptinemia: relationship to adiposity and insulin resistance in the spontaneously obese rhesus monkey. Horm Metab Res 28:674-678, 1996.
4. Baskin DG, Lattemann DF, Seeley RJ, Woods SC, Porte D Jr, Schwartz MW. Insulin and leptin: dual adiposity signals to the brain for the regulation of food intake and body weight. Brain Res 848:114-123, 1999.
5. Müller C, Voirol MJ, Stefanoni N, Surmely JF, Jequier E, Gaillard RC, Tappy L. Effect of chronic intracerebroventricular infusion of insulin on brown adipose tissue activity in fed and fasted rats. Int J Obes 21:562-566, 1997.
6. Sipols AJ, Baskin DG, Schwartz MW. Effect of intracerebroventricular insulin infusion on diabetic hyperphagia and hypothalamic neuropeptide gene expression. Diabetes 44:147-151, 1994.
7. Bruning JC, Gautam D, Burks DJ, Gillette J, Schubert M, Orban PC, Klein R, Krone W, Muller-Wieland D, Kahn CR. Role of brain insulin receptor in control of body weight and reproduction. Science 22:2122-2125, 2000.
8. Robinzon B, Snapir N. Intraventricular glucose administration inhibits feeding in satiated but not in 24 hours food deprived cocks. Pharmacol Biochem Behav 19:929-932, 1982.
9. Bergen HT, Monkman N, Mobbs CV. Injection with gold thioglucose impairs sensitivity to glucose: Evidence that glucose-responsive neurons are important for long-term regulation of body weight. Brain Res 734:332-336, 1996.
10. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature 372:425-432, 1994.
11. Friedman JM, Halaas JL. Leptin and the regulation of body weight in mammals. Nature 395:763-770, 1998.
12. Dunbar JC, Lu H. Chronic intracerebroventricular insulin attenuates the leptin-mediated but not alpha melanocyte stimulating hormone increase in sympathetic and cardiovascular responses. Brain Res Bull 52:123-126, 2000.
13. McCowen KC, Chow JC, Smith RJ. Leptin signaling in the hypothalamus of normal rats in vivo. Endocrinology 139:4442-4447, 1998.
14. Hakansson ML, Meister B. Transcription factor STAT3 in leptin target neurons of the rat hypothalamus. Neuroendocrinology 68:420-427, 1998.
15. Kellerer M, Lammers R, Fritsche A, Strack V, Machicao F, Borboni P, Ullrich A, Haring HU. Insulin inhibits leptin receptor signalling in HEK293 cells at the level of janus kinase-2: A potential mechanism for hyperinsulinemia-associated leptin resistance. Diabetologia 44:1125-1132, 2001.
16. Wang J, Obici S, Morgan K, Barzilai N, Feng Z, Rossetti L. Over-feeding rapidly induced leptin and insulin resistance. Diabetes 50:2786-2791, 2001.
17. Lowry OH, Rosebrough NJ, Farr AL. Protein measurement with the Folin Phenol reagent. J Biol Chem 193:265-275, 1951.
18. Fujita N, Sakamaki H, Uotani S, Takahashi R, Kuwahara H, Kita A, Oshima K, Yamasaki H, Yoshihiko Y, Eguchi K. Acute effects of ethanol on feeding behavior and leptin-induced STAT3 phosphorylation in rat hypothalamus. Int J Obes 27:55-59, 2003.
19. Kopelman PG. Obesity as a medical problem. Nature 404:635-643, 2000.
20. Odeleye OE, de Courten M, Pettitt DJ, Ravussin E. Fasting hyperinsulinemia is a predictor of increased body weight gain and obesity in Pima Indian children. Diabetes 46:1341-1345, 1997.
21. Ono T, Steffens AB, Sasaki K. Influence of peripheral and intracerebroventricular glucose and insulin infusions on peripheral and cerebrospinal fluid glucose and insulin levels. Physiol Behav 30:301-306, 1983.
22. Schwartz MW, Sipols A, Kahn SE, Lattemann DF, Taborsky GJ Jr, Bergman RN, Woods SC, Porte D Jr. Kinetic and specificity of insulin uptake from plasma into cerebrospinal fluid. Am J Physiol 259:E378-E383, 1990.
23. Peraldi P, Filloux C, Emanuelli B, Hilton DJ, Van Obberghen E. Insulin induces suppressor of cytokine signaling-3 tyrosine phosphorylation through janus-activated kinase. J Biol Chem 276:24614-24620, 2001.
24. Bjorbaek C, Elmquist JK, Frantz JD, Shoelson SE, Flier JS. Identification of SOCS-3 as a potential mediator of central leptin resistance. Mol Cell 1:619-625, 1998.
25. Carvalheira JBC, Siloto RMP, Ignacchitti I, Brenelli SL, Carvalho CRO, Leite A, Velloso LA, Gontijo JAR, Saad MJA. Insulin modulates leptin-induced STAT3 activation in rat hypothalamus. FEBS Lett 500:119-124, 2001.
26. Yang XJ, Kow LM, Funabashi T, Mobbs CV. Hypothalamic glucose sensor, similarities to and differences from pancreatic β-cell mechanism. Diabetes 48:1763-1772, 1999.
27. Mercer JG, Hoggard N, Williams LM, Lawrence CB, Hannah LT, Trayhurn P. Localization of leptin receptor mRNA and the long form splice variant (Ob-Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization. FEBS Lett 387:113-116, 1996.