Structural basis for a disfavored elimination reaction in catalytic antibody 1D4

Journal of Molecular Biology

Volumn 314, Issue 1, 2001, Pages 93-102

  Larsen, Nicholas A ^a   Heine, Andreas ^a   Crane, Laura ^a   Cravatt, Benjamin F ^a   Lerner, Richard A ^a   A Wilson, Ian ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Catalytic antibody; Crystal structure; Disfavored chemistry; Syn elimination reaction

Indexed keywords

CATALYTIC ANTIBODY; CATALYTIC ANTIBODY 1D4; UNCLASSIFIED DRUG;

ANTIBODY STRUCTURE; ARTICLE; CATALYSIS; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; HYDROGEN BOND; LIGAND BINDING; OPTICAL RESOLUTION; PRIORITY JOURNAL; PROTEIN CONFORMATION; REACTION ANALYSIS; STEREOCHEMISTRY;

MURINAE;

EID: 0035900554     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.2001.5112     Document Type: Article

References (49)

1. Catalytic antibodies
2. Selective chemical catalysis by an antibody
3. Binding energy specificity and enzymic catalysis: The circe effect
4. A catalytic antibody against cocaine prevents cocaine's reinforcing and toxic effects in rats
5. Toward antibody-directed "abzyme" prodrug therapy, ADAPT: Carbamate prodrug activation by a catalytic antibody and its in vitro application to human tumor cell killing
6. Immune versus natural selection: Antibody aldolases with enzymic rates but broader scope
7. Anti-metallocene antibodies: A new approach to enantioselective catalysis of the Diels-Alder reaction
8. A new strategy for the generation of catalytic antibodies
9. Antibody catalyzed cationic cyclization
10. Control of the exo and endo pathways of the Diels-Alder reaction by antibody catalysis
11. Bait and switch strategy for obtaining catalytic antibodies with acyl-transfer capabilities
12. Stereospecific Claisen rearrangement catalyzed by an antibody
13. Antibody catalysis of a disfavored chemical transformation
14. Crossing extreme mechanistic barriers by antibody catalysis: Syn elimination to a cis olefin
15. Kabat Database and its applications: Future directions
16. Standard conformations for the canonical structures of immunoglobulins
17. Conformations of the third hypervariable region in the VH domain of immunoglobulins
18. Analytical molecular surface calculation
19. Structure of myohemerythrin in the azidomet state at 1.7/1.3 Å resolution
20. Cation-π interactions in chemistry and biology: A new view of benzene, Phe, Tyr, and Trp
21. Cation-π interactions in structural biology
22. Convergence of catalytic antibody and terpene cyclase mechanisms: Polyene cyclization directed by carbocation-π interactions
23. Crystal structure of a cocaine-binding antibody
24. Major antigen-induced domain rearrangements in an antibody
25. Understanding enzyme-catalyzed proton abstraction from carbon acids: Details of stepwise mechanisms for β-elimination reactions
26. A functionally diverse enzyme superfamily that abstracts the a protons of carboxylic acids
27. The enolase superfamily: A general strategy for enzyme-catalyzed abstraction of the α-protons of carboxylic acids
28. Electrostatic stabilization can explain the unexpected acidity of carbon acids in enzyme-catalyzed reactions
29. The lesser "burden borne" by o-succinylbenzoate synthase: An "easy" reaction involving a carboxylate carbon acid
30. Aromatic biosynthesis in higher plants. Preparation and properties of dehydroquinase
31. The two types of 3-dehydroquinase have distinct structures but catalyze the same overall reaction
32. Mechanism of dehydroquinase catalyzed dehydration. I. Formation of a Schiff base intermediate
33. Evidence from kinetic isotope studies for an enolate intermediate in the mechanism of type II dehydroquinases
34. Catalytic mechanism of scytalone dehydratase: Site-directed mutagenesis, kinetic isotope effects, and alternate substrates
35. Stereochemistry of the enolization of scytalone by scytalone dehydratase
36. Mechanistic studies of an antibody-catalyzed elimination reaction
37. Mechanistic studies of an antibody-catalyzed elimination reaction
38. Large rate accelerations in antibody catalysis by strategic use of haptenic charge
39. The streak seeding technique in protein crystallization
40. Processing of X-ray diffraction data collected in oscilliation mode
41. MERLOT, an integrated package of computer programs for the determination of crystal structures by molecular replacement
42. AMoRe: An automated package for molecular replacement
43. Molecular basis of crossreactivity and the limits of antibody-antigen complementarity
44. Crystallography & NMR system: A new software suite for molecular structure determination
45. Further additions to MOLSCRIPT version 1. 4, including reading and contouring of electron density maps
46. Raster3D version 2.0. A program for photorealistic molecular graphics
47. Protein folding and association: Insights from the interfacial and thermodynamic properties of hydrocarbons