Cell motility: Proline-rich proteins promote protrusions

Trends in Cell Biology

Volumn 11, Issue 1, 2001, Pages 38-46

  Holt, M R ^a   Koffer, A ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; EZRIN; PROFILACTIN; PROFILIN; PROLINE; PROLINE RICH PROTEIN; PROTEIN FYB; PROTEIN PRM1; PROTEIN WIP; UNCLASSIFIED DRUG; VINCULIN; WISKOTT ALDRICH SYNDROME PROTEIN; ZYXIN;

ACTIN POLYMERIZATION; ARTICLE; CELL MOTILITY; CONSENSUS SEQUENCE; GEOMETRY; INTRACELLULAR TRANSPORT; MEMBRANE BINDING; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

EID: 0035185978     PISSN: 09628924     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0962-8924(00)01876-6     Document Type: Review

References (54)

1. Putting a new twist on actin: ADF/cofilins modulate actin dynamics
2. Signaling to actin dynamics
3. How WASP-family proteins and the Arp2/3 complex convert intracellular signals into cytoskeletal structures
4. Actin machinery: Pushing the envelope
5. In vivo functions of actin-binding proteins
6. Profilin as a potential mediator of membrane-cytoskeleton communication
7. Specific interaction between phosphatidylinositol 4,5-bisphosphate and profilactin
8. The essential role of profilin in the assembly of actin for microspike formation
9. ABM-1 and ABM-2 homology sequences: Consensus docking sites for actin-based motility defined by oligoproline regions in Listeria ActA surface protein and human VASP
10. p140mDia, a mammalian homolog of Drosophila diaphanous, is a target protein for Rho small GTPase and is a ligand for profilin
11. Mena, a relative of VASP and Drosophila Enabled, is implicated in the control of microfilament dynamics
12. The proline-rich focal adhesion and microfilament protein VASP is a ligand for profilins
13. Waltzing with WASP
14. The pleckstrin homology domain of the Wiskott-Aldrich syndrome protein is involved in the organization of actin cytoskeleton
15. EVH1/WH1 domains of VASP and WASP proteins belong to a large family including Ran-binding domains of the RanBP1 family
16. Structural basis of the membrane-targeting and unmasking mechanism of the radixin FERM domain
17. The PH superfold: A structural scaffold for multiple functions
18. The tandem repeat domain in the Listeria monocytogenes ActA protein controls the rate of actin-based motility, the percentage of moving bacteria, and the localization of vasodilator-stimulated phosphoprotein and profilin
19. The EVH2 domain of the vasodilator-stimulated phosphoprotein mediates tetramerization F-actin binding, and actin bundle formation
20. N-WASP, a novel actin-depolymerizing protein, regulates the cortical cytoskeletal rearrangement in a PIP2-dependent manner downstream of tyrosine kinases
21. Two activities of cofilin, severing and accelerating directional depolymerization of actin filaments, are affected differentially by mutations around the actin-binding helix
22. GRB2 links signaling to actin assembly by enhancing interaction of neural Wiskott-Aldrich syndrome protein (N-WASp) with actin-related protein (ARP2/3) complex
23. Mechanism of N-WASP activation by CDC42 and phosphatidylinositol 4,5-bisphosphate
24. Identification of two human WAVE/SCAR homologues as general actin regulatory molecules which associate with the Arp2/3 complex
25. Arp2/3 complex-independent actin regulatory function of WAVE
26. FH proteins as cytoskeletal organizers
27. Analysis of RhoA-binding proteins reveals an interaction domain conserved in heterotrimeric G protein beta subunits and the yeast response regulator protein Skn7
28. Nonsyndromic deafness DFNA1 associated with mutation of a human homolog of the Drosophila gene Diaphanous
29. Actin filament organisation in activated mast cells is regulated by heterotrimeric and small GTP-binding proteins
30. Cooperation between mDia1 and ROCK in Rho-induced actin reorganization
31. Distinct actions and cooperative roles of ROCK and mDia in Rho small G protein-induced reorganization of the actin cytoskeleton in Madin-Darby canine kidney cells
32. ERM proteins in cell adhesion and membrane dynamics
33. Regulation of cortical structure by the ezrin-radixin-moesin protein family
34. Cortical actin organization: Lessons from ERM (Ezrin/Radixin/Moesin) proteins
35. Interactions of drebrin and gephyrin with profilin
36. Drebrin is a widespread actin-associating protein enriched at junctional plaques, defining a specific microfilament anchorage system in polar epithelial cells
37. Dual epitope recognition by the VASP EVH1 domain modulates polyproline ligand specificity and binding affinity
38. Structure of EVH1, a novel proline-rich ligand-binding module involved in cytoskeletal dynamics and neural function
39. Cell motility: Complex dynamics at the leading edge
40. Arrest of Listeria movement in host cells by a bacterial ActA analogue: Implications for actin-based motility
41. Profilin interacts with the Gly-Pro-Pro-Pro-Pro-Pro sequences of vasodilator-stimulated phosphoprotein (VASP): Implications for actin-based Listeria motility
42. Zyxin: Zinc fingers at sites of cell adhesion
43. An alpha-actinin binding site of zyxin is essential for subcellular zyxin localization and alpha-actinin recruitment
44. The focal adhesion phospho-protein, VASP
45. The interaction of the cell-contact proteins VASP and vinculin is regulated by phosphatidylinositol-4,5-bisphosphate
46. Focal adhesions - The cytoskeletal connection
47. Neural Wiskott-Aldrich syndrome protein is implicated in the actin-based motility of Shigella flexneri
48. Shigella actin-based motility in the absence of vinculin
49. Shigella actin-based motility in the presence of truncated vinculin
50. Fyn-binding protein (Fyb)/SLP-76-associated protein (SLAP), Ena/vasodilator-stimulated phosphoprotein (VASP) proteins and the Arp2/3 complex link T cell receptor (TCR) signaling to the actin cytoskeleton
51. Cutting edge: WIP, a binding partner for Wiskott-Aldrich syndrome protein, cooperates with Vav in the regulation of T cell activation
52. A novel proline-rich motif present in ActA of Listeria monocytogenes and cytoskeletal proteins is the ligand for the EVH1 domain, a protein module present in the Ena/VASP family
53. Mutations that cause the Wiskott-Aldrich syndrome impair the interaction of Wiskott-Aldrich syndrome protein (WASP) with WASP interacting protein
54. Surfing pathogens and the lessons learned for actin polymerization