Immunohistochemical Demonstration of Dihydropyrimidine Dehydrogenase in Normal and Cancerous Tissues

Acta Histochemica et Cytochemica

Volumn 36, Issue 5, 2003, Pages 471-479

  Kamoshida, Shingo ^a   Shiogama, Kazuya ^a   Matsuoka, Hiroshi ^a   Matsuyama, Atsuji ^a   Shimomura, Ryoichi ^a   Inada, Ken Ichi ^a   Maruta, Morito ^a   Tsutsumi, Yutaka ^a  

^a FUJITA HEALTH UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

5 fluorouracil; Antigen retrieval; Chemoresistance; Dihydropyrimidine dehydrogenase; Immunohistochemistry

Indexed keywords

ANTIGEN; DIHYDROPYRIMIDINE DEHYDROGENASE; EDETIC ACID; FLUOROURACIL; FORMALDEHYDE; MONOCLONAL ANTIBODY; PARAFFIN; POLYCLONAL ANTIBODY;

ANTIGEN RETRIEVAL; ANTIGENICITY; ARTICLE; BLADDER CARCINOMA; BREAST CARCINOMA; CANCER TISSUE; CLARA CELL; COLORECTAL CARCINOMA; CONTROLLED STUDY; ENDOTHELIUM CELL; EPIDERMIS; EPITHELIUM CELL; FIBROBLAST; GALLBLADDER CARCINOMA; HUMAN; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LIVER CELL; LIVER CELL CARCINOMA; LUNG ADENOCARCINOMA; MACROPHAGE; MYOEPITHELIUM CELL; PANCREAS ADENOCARCINOMA; PH; PLASMA CELL; PRESSURE; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REPRODUCIBILITY; SKIN APPENDAGE; SQUAMOUS CELL CARCINOMA; SQUAMOUS EPITHELIUM; STOMACH CARCINOMA; TISSUE TYPES; TUMOR RESISTANCE;

EID: 0242492335     PISSN: 00445991     EISSN: None     Source Type: Journal    
DOI: 10.1267/ahc.36.471     Document Type: Article

References (35)

1. Beck, A., Etienne, M. C., Chéradame, S., Fischel, J. L., Formento, P., Renée, N. and Milano, G. (1994) A role for dihydropyrimidine dehydrogenase and thymidylate synthase in tumour sensitivity to fluorouracil. Eur. J. Cancer 30A; 1517-1522.
2. Bussolati, G., Gugliotta, P., Volante, M., Pace, M. and Papotti, M. (1997) Retrieved endogenous biotin: A novel marker and a potential pitfall in diagnostic immunohistochemistry, Histopathology 31; 400-407.
3. Etienne, M. C., Chéradame, S., Fischel, J. L., Formento, P., Dassonville, O., Renée, N., Schneider, M., Thyss, A., Demard, F. and Milano, G. (1995) Response to fluorouracil therapy in cancer patients: The rule of tumoral dihydropyrimidine dehydrogenase activity. J. Clin. Oncol. 13; 1663-1670.
4. Fujii, R., Seshimo, A. and Kameoka, S. (2003) Relationships between the expression of thymidylate synthase, dihydropyrimidine dehydrogenase, and orotate phosphoribosyltransferase and cell proliferative activity and 5-fluorouracil sensitivity in colorectal carcinoma. Int. J. Clin. Oncol. 8; 72-78.
5. Gown, A. M. and Willingham, M. C. (2002) Improved detection of apoptotic cells in archival paraffin sections: Immunohistochemistry using antibodies to cleaved caspase 3. J. Histochem. Cytochem. 50; 449-454.
6. Harris, B. E., Carpenter, J. T. and Diasio, R. B. (1991) Severe 5-fluorouracil toxicity secondary to dihydropyrimidine dehydrogenase deficiency. A potentially more common pharmacogenetic syndrome. Cancer 68; 499-501.
7. Higashiyama, M., Kodama, K., Yokouchi, H., Takami, K., Fukushima, M., Minamigawa, K., Takano, T. and Kobayashi, H. (2001) Thymidylate synthase and dihydropyrimidine dehydrogenase activities in non-small cell lung cancer tissues: Relationship with in vitro sensitivity to 5-fluorouracil. Lung Cancer 34; 407-416.
8. Hirano, Y., Kageyama, S., Ushiyama, T., Suzuki, K. and Fujita, K. (2003) Clinical significance of thymidine phosphorylase and dihydropyrimidine dehydrogenase expression in transitional cell cancer. Cancer Chemother. Pharmacol. 51; 29-35.
9. Horiguchi, J., Takei, H., Koibuchi, Y., Iijima, K., Ninomiya, J., Uchida, K., Ochiai, R., Yoshida, M., Yokoe, T., Iino, Y. and Morishita, Y. (2002) Prognostic significance of dihydropyrimidine dehydrogenase expression in breast cancer. Br. J. Cancer 86; 222-225.
10. Huang, C-L., Yokomise, H., Kobayashi, S., Fukushima, M., Hitomi, S. and Wada, H. (2000) Intratumoral expression of thymidylate synthase and dihydropyrimidine dehydrogenase in non-small cell lung cancer patients treated with 5-FU-based chemotherapy. Int. J. Oncol. 17; 47-54.
11. Ikeguchi, M., Hirooka, Y., Makino, M. and Kaibara, N. (2001) Dihydropyrimidine dehydrogenase activity of cancerous and noncancerous tissues in liver and large intestine. Oncol. Rep. 8; 621-625.
12. Ishikawa, Y., Kubota, T., Otani, Y., Watanabe, M., Teramoto, T., Kumai, K., Takechi, T., Okabe, H., Fukushima, M. and Kitajima, M. (2000) Dihydropyrimidine dehydrogenase and messenger RNA levels in gastric cancer: Possible predictor for sensitivity to 5-fluorouracil. Jpn. J. Cancer Res. 91; 105-112.
13. Jiang, W., Lu, Z., He, Y. and Diasio, R. B. (1997) Dihydropyrimidine dehydrogenase activity in hepatocellular carcinoma: Implication in 5-fluorouracil-based chemotherapy. Clin. Cancer Res. 3; 395-399.
14. Kamoshida, S., Matsuoka, H., Matsuyama, A., Shimomura, R., Maruta, M. and Tsutsumi, Y. (2003) Reproducible and reliable immunohistochemical demonstration of thymidylate synthase in formalin-fixed, paraffin-embedded sections: Application of antigen retrieval in EDTA solution. Acta Histochem. Cytochem. 36; 115-118.
15. Kawasaki, G., Yoshitomi, I., Yanamoto, S. and Mizuno, A. (2002) Thymidylate synthase and dihydropyrimidine dehydrogenase expression in oral squamous cell carcinoma: An immunohistochemical and clinicopathologic study. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 94; 717-723.
16. Kirihara, Y., Yamamoto, W., Toge, T. and Nishiyama, M. (1999) Dihydropyrimidine dehydrogenase, multidrug resistance-associated protein, and thymidylate synthase gene expression levels can predict 5-fluorouracil resistance in human gastrointestinal cancer cells. Int. J. Oncol. 14; 551-556.
17. Kommann, M., Link, K. H., Galuba, I., Ott, K., Schwabe, W., Hausler, P., Scholz, P., Sträter, J., Polat, S., Leibl, B., Kettner, E., Schlichting, C., Baumann, W., Schramm, H., Hecker, U., Ridwelski, K., Vogt, J. H., Zerbian, K. U., Schütze F., Kreuser, E. D., Behnke, D. and Beger, H. G. (2002) Association of time to recurrence with thymidylate synthase and dihydropyrimidine dehydrogenase mRNA expression in stage II and III colorectal cancer, J. Gastrointest. Surg. 6; 331-337.
18. Langer, C. J. (1999) The role of tegaful/uracil in pulmonary malignancy. Drugs 58 (Suppl 3); 71-75.
19. Mizutani, Y., Wada, H., Fukushima, M., Yoshida, O., Ukimura, O., Kawauchi, A. and Miki, T. (2001) The significance of dihydropyrimidine dehydrogenase (DPD) activity in bladder cancer. Eur. J. Cancer 37; 569-575.
20. Mori, K., Hasegawa, M., Nishida, M., Toma, H., Fukuda, M., Kubota, T., Nagasue, N., Yamana, H., Hirakawa, K-Chung, Y. S., Ikeda, T., Takasaki, K., Oka, M., Kameyama, M., Toi, M., Fujii, H., Kitamura, M., Murai, M., Sasaki, H., Ozono, S., Makuuchi, H., Shimada, Y., Onishi, Y., Aoyagi, S., Mizutani, K., Ogawa, M., Nakao, A., Kinoshita, H., Tono, T., Iwamoto, M., Nakashima, Y. and Manabe, T. (2000) Expression levels of thymidine phosphorylase and dihydropyrimidine dehydrogenase in various human tumor tissues. Int. J. Oncol. 17; 33-38.
21. Naguib, F. N. M., el Kouni, M. H. and Cha, S. (1985) Enzymes of uracil catabolism in normal and neoplastic human tissues. Cancer Res. 45; 5405-5412.
22. Nakagawa, T., Tanaka, F., Takata, T., Matsuoka, K., Miyahara, R., Otake, Y., Yanagihara, K., Fukushima, M. and Wada, H. (2002) Predictive value of dihydropyrimidine dehydrogenase expression in tumor tissue, regarding the efficacy of postoperatively administered UFT (tegafur+uracil) in patients with p-stage I nonsmall-cell lung cancer, J. Surg. Oncol. 81; 87-92.
23. Nozawa, H., Tsukui, H., Nishida, K., Yakumaru, K., Nagawa, H. and Sekikawa, T. (2002) Dihydropyrimidine dehydrogenase expression in preoperative biopsy and surgically resected specimens of gastric carcinoma. Cancer Chemother. Pharmacol. 49; 267-273.
24. Okabe, H., Arakawa, K., Takechi, T. and Fukushima, M. (2000) Expression of recombinant human dihydropyrimidine dehydrogenase and its application to the preparation of anti-DPD antibodies for immunochemical detection. Gan to Kagaku Ryoho 27; 891-898. (in Japanese with English abstract)
25. Pileri, S. A., Roncador, G., Ceccarelli, C., Piccioli, M., Briskomatis, A., Sabattini, E., Ascani, S., Santini, D., Piccaluga, P. P., Leone, O., Damiani, S., Ercolessi, C., Sandri, F., Pieri, F., Leoncini, L. and Falini, B. (1997) Antigen retrieval techniques in immunohistochemistry: Comparison of different methods. J. Pathol. 183; 116-123.
26. Salonga, D., Danenberg, K. D., Johnson, M., Metzger, R., Groshen, S., Tsao-Wei, D. D., Lenz, H-J., Leichman, C. G., Leichman, L., Diasio, R. B. and Danenberg, P. V. (2000) Colorectal tumors responding to 5-fluorouracil have low gene expression levels of dihydropyrimidine dehydrogenase, thymidylate synthase, and thymidine phosphorylase. Clin. Cancer Res. 6; 1322-1327.
27. Stephan, F., Etienne, M. C., Wallays, C., Milano, G. and Clergue, F. (1995) Depressed hepatic dihydropyrimidine dehydrogenase activity and fluorouracil-related toxicities. Am. J. Med. 99; 685-688.
28. Takabayashi, A., Iwata, S., Kawai, Y., Kanai, M., Taki, Y., Takechi, T. and Fukushima, M. (2000) Dihydropyrimidine dehydrogenase activity and mRNA expression in advanced gastric cancer analyzed in relation to effectiveness of preoperative 5-fluorouracil-based chemotherapy. Int. J. Oncol. 17; 889-895.
29. Takenoue, T., Kitayama, J., Takei, Y., Umetani, N., Matsuda, K., Nita, M. E., Hatano, K., Tsuruo, T. and Nagawa, H. (2000) Characterization of dihydropyrimidine dehydrogenase on immunohistochemistry in colon carcinoma, and correlation between immunohistochemical score and protein level or messenger RNA expression. Ann. Oncol. 11; 273-279.
30. Torti, F. M. and Harker, W. G. (1983) Chemotherapy of advanced transitional cell carcinoma of the uroepithelium. Cancer Chemother. Pharmacol. 11 (Suppl); S1-S4.
31. Uchida, K., Hayashi, K., Kuramochi, H. and Takasaki, K. (2001) Changes in intratumoral thymidylate synthase (TS) and dihydropyrimidine dehydrogenase (DPD) mRNA expression in colorectal and gastric cancer during continuous tegafur infusion. Int. J. Oncol. 19; 341-346.
32. van Groeningen, C. J. (1999) Intravenous and intra-arterial chemotherapeutic possibilities in biliopancreatic cancer. Ann. Oncol. 10 (Suppl 4); 305-307.
33. Van Kuilenburg, A. B. P., Van Lenthe, H., Wanders, R. J. A. and Van Gennip, A. H. (1997) Subcellular localization of dihydropyrimidine dehydrogenase. Biol. Chem. 378; 1047-1053.
34. Wanebo, H. J., Falkson, G. and Order, S. E. (1989) Cancer of hepatobiliary system. In "Cancer: Principles and Practice of Oncology", ed. by V. T. Devita, S. Hellman and S. A. Rosenberg, J. B. Lippincott, Philadelphia, pp. 836-874.
35. Weber, G., Queener, S. F. and Ferdinandus, J. A. (1970) Control of gene expression in carbohydrate, pyrimidine and DNA metabolism. Adv. Enzyme Regul. 9; 63-95.