Effects of intravenous Injections Paederiae and Stauntonia on spontaneous pain, hyperalgesia and inflammation induced by cutaneous chemical tissue injury in the rat

Acta Physiologica Sinica

Volumn 55, Issue 5, 2003, Pages 516-524

  Peng, Xiao Li ^a,b   Gao, Xi Ling ^a   Chen, Jun ^a   Huang, Xi ^b   Chen, Hui Sheng ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Anti inflammation; Anti nociception; Bee venom test; Formalin test; Hyperalgesia; Injection paederiae; Injection stauntonia; Persistent spontaneous pain

Indexed keywords

BEE VENOM; CHINESE DRUG; NALOXONE; PAEDERIAE EXTRACT; STAUNTONIA EXTRACT; UNCLASSIFIED DRUG; ZZ 5982;

ANIMAL EXPERIMENT; ANTINOCICEPTION; ARTICLE; CHEMICAL INJURY; CHINESE HERB; CONTROLLED STUDY; HYPERALGESIA; INFLAMMATION; MALE; MECHANICAL STIMULATION; NEUROMODULATION; NOCICEPTION; NONHUMAN; PAEDERIAE; PATHOPHYSIOLOGY; RAT; SKIN INJURY; STAUNTONIA;

ANALGESICS; ANIMALS; BEE VENOMS; DRUGS, CHINESE HERBAL; FEMALE; FORMALDEHYDE; HYPERALGESIA; INFLAMMATION; INJECTIONS, INTRAVENOUS; MALE; NOCICEPTORS; PAIN; PAIN THRESHOLD; PYRANS; RATS; RATS, SPRAGUE-DAWLEY; SAPONINS; STEROIDS;

EID: 0242459561     PISSN: 03710874     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Chen J, Luo C, Li HL. Primary hyperalgesia to mechanical and heat stimuli following subcutaneous bee venom injection into the plantar surface of hindpaw in the conscious rat: A comparative study with the formalin test. Pain 1999;83:67-76.
2. Chen HS, Chen J. Secondary heat, but not mechanical hyperalgesia induced by subcutaneous injection of bee venom in the conscious rat: effect of systemic MK-801, a non-competitive NMDA receptor antagonist. Eur J Pain 2000;4:389-401.
3. Chen J, Chen HS. Pivotal role of capsaicin-sensitive primary afferents in development of both heat and mechanical hyperalgesia induced by intraplantar bee venom injection. Pain 2001;91:367-376.
4. Lariviere WR, Melzack R. The bee venom test: a new tonic-pain test. Pain 1996;66:271-277.
5. Chen J, Luo C, Li HL. The contribution of spinal neuronal changes to development of prolonged, tonic nociceptive responses of the cat induced by subcutaneous bee venom injection. Eur J Pain 1998;2:359-376.
6. Chen J, Li HL, Luo C, Li Z, Zheng JH. Involvement of peripheral NMDA and non-NMDA receptors in development of persistent firing of spinal wide-dynamic-range neurons induced by subcutaneous bee venom injection in the cat. Brain Res 1999;844:98-105.
7. You HJ, Chen J. Differential effects of subcutaneous injection of formalin and bee venom on response of wide-dynamic-range neurons in spinal dorsal horn of the rat. Eur J Pain 1999;3:177-180.
8. You HJ, Chen J, Morch C, Arendt-Nielsen L. Differential effect of peripheral glutamate (NMDA, non-NMDA) receptor antagonists on bee venom-induced spontaneous nociception and sensitization. Brain Res Bull 2002;58: 561-567.
9. Luo C, Chen J, Li HL, Li JS. Spatial and temporal expression of c-Fos protein in the spinal cord of anesthetized rat induced by subcutaneous bee venom injection. Brain Res 1998;806:175-185.
10. Chen HS, Chen J, Sun YY. Contralateral heat hyperalgesia induced by unilaterally intra-plantar bee venom injection is produced by central changes: a behavioral study in the conscious rat. Neurosci Lett 2000;284:45-48.
11. Li KC, Zheng JH, Chen J. Involvement of spinal protein kinase C in the induction and maintenance of subcutaneous bee venom injection induced persistent flinching reflex in the conscious rat. Neurosci Lett 2000;285:103-106.
12. Zheng JH, Chen J. Modulatory roles of the ATP P2x-purinoceptor in generation of the persistent nociception induced by subcutaneous bee venom injection in the conscious rat. Neurosci Lett 2000;278:41-44.
13. Zheng JH, Chen J. Differential roles of spinal neurokinin 1/2 receptors in development of the persistent spontaneous nociception and hyperalgesia induced by subcutaneous bee venom injection in the conscious rat. Neuropeptides 2001;1:32-44.
14. Chen J. Diversity of pathological pain: new evidence from the bee venom model. Chin J Neuroanat 2001;17(Suppl):28-34.
15. Lariviere WR, Wilson SG, Laughlin TM, Kokayeff A, West EE, Adhikari SM, Wan Y, Mogil JS. Heritability of nociception. III. Genetic relationships among commonly used assays of nociception and hypersensitivity. Pain 2002;97:75-86.
16. Chen J. Spinal transmission of pain sensation. In: Jiang CC, Zhao ZQ, Jiang H ed. Basics and Clinics of Pain. Shanghai: Fudan University Press 2001;4:30-81 (Chinese).
17. Zhang XY, Tan LZ, Zhao SY. Experimental study on analgesia and anti-inflammation of Caulis Stauntoniae Cbinensis Tablet. Acad J Guangdong Coll Pharm 1999;3:195-196 (Chinese, English abstract).
18. Zimmerman M. Ethical guidelines for investigations of experimental pain in conscious animals. Pain 1983; 16: 109-110.
19. Ye WB, Liou Q, Ye Q, Lu BL. The effects of Injection Stauntoniae on the conduction of the saphenous nerve of rat. Chin Trad Herb Drugs 1995;1:20-21.
20. Ye WB, Xue SP, Li J. The effects of Injection Stauntoniae on the conduction of the sciatic nerve in bullfrog. J Shanghai Teachers Univ (Natural Sciences) 1997;4:49-53 (Chinese, English abstract).
21. Ye WB, Dai SM, Jiang F. The effect of Injection Stauntoniae on axon membrane and myelin sheath of the saphenous nerve of rat. Chin J of Neuroanat 1999;4:390-392 (Chinese, English abstract).