Reduced Transcription of the RB2/p130 Gene in Human Lung Cancer

Molecular Carcinogenesis

Volumn 38, Issue 3, 2003, Pages 124-129

  Jun, Hu Xue ^a   Gemma, Akihiko ^a   Hosoya, Yoko ^a   Matsuda, Kuniko ^a   Nara, Michiya ^a   Hosomi, Yukio ^a   Okano, Tetsuya ^a   Kurimoto, Futoshi ^a   Seike, Masahiro ^a   Takenaka, Kiyoshi ^a   Yoshimura, Akinobu ^a   Toyota, Minoru ^b   Kudoh, Shoji ^a  

^a NIPPON MEDICAL SCHOOL   (Japan)

^b SAPPORO MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Lung cancer; Rb2 p130; Reduced expression; Transcription

Indexed keywords

PROTEIN P130;

ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DEACETYLATION; DNA SEQUENCE; GENE INACTIVATION; GENE MUTATION; GENETIC STABILITY; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; LUNG CANCER; METHYLATION; PRIORITY JOURNAL; RESTRICTION MAPPING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SINGLE STRAND CONFORMATION POLYMORPHISM; TRANSCRIPTION REGULATION; TUMOR SUPPRESSOR GENE;

ADENOCARCINOMA; CARCINOMA, NON-SMALL-CELL LUNG; CARCINOMA, SMALL CELL; CARCINOMA, SQUAMOUS CELL; CASE-CONTROL STUDIES; DNA METHYLATION; DNA MUTATIONAL ANALYSIS; DNA, NEOPLASM; EXONS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LUNG; LUNG NEOPLASMS; MUTATION; PHOSPHOPROTEINS; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; PROTEINS; RETINOBLASTOMA PROTEIN; RETINOBLASTOMA-LIKE PROTEIN P130; TRANSCRIPTION, GENETIC;

EID: 0242406700     PISSN: 08991987     EISSN: None     Source Type: Journal    
DOI: 10.1002/mc.10152     Document Type: Article

References (37)

1. Sundaresan V, Ganly P, hasleton P, et al. p53 and chromosome 3 abnormalities, characteristic of malignant lung tumours, are detectable in preinvasive lesions of the bronchus. Oncogene 1992;7:1989-1997.
2. Gazdar AF, Bader S, Hung J, et al. Molecular genetic changes found in human lung cancer and its precursor lesions. Cold Spring Harb Symp Quant Biol 1994;59:565-572.
3. Wistuba II, Lam S, Behrens C, et al. Molecular damage in the bronchial epithelium of current and former smokers. J Natl Cancer Inst 1997;89:1366-1373.
4. Harbour JW, Lai SL, Whang-Peng J, Gazdar AF, Minna JD, Kaye FJ. Abnormalities in structure and expression of the human retinoblastoma gene in SCLC. Science 1988;241:353-357.
5. Yokota J, Akiyama T, Fung YK, et al. Altered expression of the retinoblastoma (RB) gene in small-cell carcinoma of the lung. Oncogene 1988;3:471-475.
6. Reissmann PT, Koga H, Takahashi R, et al. Inactivation of the retinoblastoma susceptibility gene in non-small-cell lung cancer. The Lung Cancer Study Group. Oncogene 1993;8:1913-1919.
7. Takahashi T, Nau MM, Chiba I, et al. p53: A frequent target for genetic abnormalities in lung cancer. Science 1989;246:491-494.
8. Hollstein M, Sidransky D, Vogelstein B, Harris CC. p53 mutations in human cancers. Science 1991;253:49-53.
9. Greenblatt MS, Bennett WP, Hollstein M, Harris CC. Mutations in the p53 tumor suppressor gene: Clues to cancer etiology and molecular pathogenesis. Cancer Res 1994;54:4855-4878.
10. Whang-Peng J, Kao-Shan CS, Lee EC, et al. Specific chromosome defect associated with human small-cell lung cancer; deletion 3p(14-23). Science 1982;215:181-182.
11. Kok K, Osinga J, Carritt B, et al. Deletion of a DNA sequence at the chromosomal region 3p21 in all major types of lung cancer. Nature 1987;330:578-581.
12. Naylor SL, Johnson BE, Minna JD, Sakaguchi AY. Loss of heterozygosity of chromosome 3p markers in small-cell lung cancer. Nature 1987;329:451-454.
13. Brauch H, Johnson B, Hovis J, et al. Molecular analysis of the short arm of chromosome 3 in small-cell and non-small-cell carcinoma of the lung. N Engl J Med 1987;317:1109-1113.
14. Kratzke RA, Otterson GA, Hogg A, Coxon AB. Partial inactivation of the RB product in a family with incomplete penetrance of familial retinoblastoma and benign retinal tumors. Oncogene 1994;9:1321-1326.
15. Shimizu E, Coxon A, Otterson GA, et al. RB protein status and clinical correlation from 171 cell lines representing lung cancer, extrapulmonary small cell carcinoma, and mesothelioma. Oncogene 1994;9:2441-2448.
16. Lee MH, Williams BO, Mulligan G, et al. Targeted disruption of p107: Functional overlap between p107 and Rb. Genes Dev 1996;10:1621-1632.
17. Dyson N. The regulation of E2F by pRB-family proteins. Genes Dev 1998;12:2245-2262.
18. Zhu L, van den Heuvel S, Helin K, et al. Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein. Genes Dev 1993;7:1111-1125.
19. Vairo G, Livingston DM, Ginsberg D. Functional interaction between E2F-4 and p130: Evidence for distinct mechanisms underlying growth suppression by different retinoblastoma protein family members. Genes Dev 1995;9:869-881.
20. Helin K, Holm K, Niebuhr A, et al. Loss of the retinoblastoma protein-related p130 protein in small cell lung carcinoma. Proc Natl Acad Sci USA 1997;94:6933-6938.
21. Baldi A, Esposito V, De Luca A, et al. Differential expression of the retinoblastoma gene family members pRb/p105, p107, and pRb2/p130 in lung cancer. Clin Cancer Res 1996;2:1239-1245.
22. Baldi A, Esposito V, De Luca A, et al. Differential expression of Rb2/p130 and p107 in normal human tissues and in primary lung cancer. Clin Cancer Res 1997;3:1691-1697.
23. Claudio PP, Howard CM, Pacilio C, et al. Mutations in the retinoblastoma-related gene RB2/p130 in lung tumors and suppression of tumor growth in vivo by retrovirus-mediated gene transfer. Cancer Res 2000;60:372-382.
24. Modi S, Kubo A, Oie H, Coxon AB, Rehmatulla A, Kaye FJ. Protein expression of the RB-related gene family and SV40 large T antigen in mesothelioma and lung cancer. Oncogene 2000;19:4632-4639.
25. Gemma A, Takenoshita S, Hagiwara K, et al. Molecular analysis of the cyclin-dependent kinase inhibitor genes p15INK4b/MTS2, p16INK4/MTS1, p18, and p19 in human cancer cell lines. Int J Cancer 1996;68:605-611.
26. Gemma A, Seike M, Seike Y, et al. Somatic mutation of the hBUB1 mitotic checkpoint gene in primary lung cancer. Genes Chromosomes Cancer 2000;29:213-218.
27. Gemma A, Takenaka K, Hosoya Y, et al. Altered expression of several genes in highly metastatic subpopulations of a human pulmonary adenocarcinoma cell line. Eur J Cancer 2001;37:1554-1561.
28. Gibson UE, Heid CA, Williams PM. A novel method for real time quantitative RT-PCR. Genome Res 1996;6(10):995-1001.
29. Gemma A, Hagiwara K, Ke Y, et al. FHIT mutations in human primary gastric cancer. Cancer Res 1997;57:1435-1437.
30. Xiong Z, Laird PW. COBRA: A sensitive and quantitative DNA methylation assay. Nucleic Acids Res 1997;25:2532-2534.
31. Okamoto A, Hussain SP, Hagiwara K, et al. Mutations in the p16INK4/MTS1/CDKN2, p15INK4B/MTS2, and p18 genes in primary and metastatic lung cancer. Cancer Res 1995;55:1448-1451.
32. Baldi A, Boccia V, Claudio PP, De Luca A, Giordano A. Genomic structure of the human retinoblastoma-related Rb2/ p130 gene. Proc Natl Acad Sci USA 1996;93:4629-4632.
33. Fajas L, Le Cam L, Polanowska J, et al. A CDE/CHR-like element mediates repression of transcription of the mouse RB2 (p130) gene. FEBS Lett 2000;471:29-33.
34. Paggi MG, Bonetto F, Severino A, et al. The retinoblastoma-related Rb2/p130 gene is an effector downstream of AP-2 during neural differentiation. Oncogene 2001;20:2570-2578.
35. Christensen JB, Imperiale MJ. Inactivation of the retinoblastoma susceptibility protein is not sufficient for the transforming function of the conserved region 2-like domain of simian virus 40 large T antigen. J Virol 1995;69:3945-3948.
36. Zalvide J, Stubdal H, DeCaprio JA. The J domain of simian virus 40 large T antigen is required to functionally inactivate RB family proteins. Mol Cell Biol 1998;18:1408-1415.
37. Gardiner-Garden M, Frommer M. CpG islands in vertebrate genomes. J Mol Biol 1987;196:261-282.