The nicotinic acetylcholine receptor: From molecular model to single-channel conductance

European Biophysics Journal

Volumn 29, Issue 1, 2000, Pages 29-37

  Adcock, C ^a   Smith, G R ^a   Sansom, M S P ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Diffusion; Electrostatics; Ion channel; Molecular dynamics; Simulation; Water

Indexed keywords

ION CHANNEL; NICOTINIC RECEPTOR; WATER;

AMINO ACID SEQUENCE; ARTICLE; CHANNEL GATING; CHEMICAL STRUCTURE; CONDUCTANCE; DIFFUSION; ELECTRICITY; MATHEMATICAL ANALYSIS; MEMBRANE POTENTIAL; MOLECULAR DYNAMICS; MOLECULAR MODEL;

EID: 0033796251     PISSN: 01757571     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002490050248     Document Type: Article

References (61)

1. Electrostatics and the selectivity of ligand-gated ion channels
2. Receptor classes and the transmitter-gated ion channels
3. Stratification of the channel domain in neurotransmitter receptors
4. Molecular dynamics simulations of water within models of transbilayer pores
5. CHARMM: A program for macromolecular energy, minimisation, and dynamics calculations
6. Crystal structure and functional analysis of the HERG potassium channel N-terminus: A eukaryotic PAS domain
7. Structure of the MscL homolog from Mycobacterium tuberculosis: A gated mechanosensitive ion channel
8. The functional architecture of the acetylcholine nicotinic receptor explored by affinity labelling and site-directed mutagenesis
9. Charges, currents, and potentials in ionic channel of one conformation
10. Flux, coupling, and selectivity in ionic channels of one conformation
11. Permeation through an open channel: Poisson-Nernst-Planck theory of a synthetic ionic channel
12. Time-correlation analysis of simulated water motion in flexible and rigid gramicidin channels
13. The nature of ion and water barrier crossings in a simulated ion channel
14. Study of ionic currents across a model membrane channel using Brownian dynamics
15. Permeation of ions across the potassium channel: Brownian dynamics studies
16. The theory of ion transport through membrane channels
17. Molecular basis of the charge selectivity of nicotinic acetylcholine receptor and related ligand-gated ion channels
18. Electrostatics and diffusion of molecules in solution: Simulations with the University of Houston Brownian dynamics program
19. Exploration of the structural features defining the conduction properties of a synthetic ion channel
20. + conduction and selectivity
21. Crystal structure and functional characterization of OmpK36, the osmoporin of Klebsiella pneumoniae
22. Neurotransmitter-gated ion channels as unconventional allosteric proteins
23. Ion channels formed by HIV-1 Vpu: A modelling and simulation study
24. + channel beta subunit
25. The emerging three-dimensional structure of a receptor: The nicotinic acetylcholine receptor
26. Parallel helix bundles and ion channels: Molecular modelling via simulated annealing and restrained molecular dynamics
27. A helical-dipole model describes the single-channel current rectification of an uncharged peptide ion channel
28. Electrostatics of a simple membrane model using Greens-function formalism
29. MOLSCRIPT: A program to produce both detailed and schematic plots of protein structures
30. Crystal structure of the tetramerization domain of the Shaker potassium channel
31. Improved secondary structure predictions for a nicotinic receptor subunit: Incorporation of solvent accessibility and experimental data into a two-dimensional representation
32. Electrostatic effects on ion selectivity and rectification in designed ion channel peptides
33. The permeation pathway of neurotransmitter-gated ion channels
34. Raster3D: Photorealistic molecular graphics
35. Nicotinic acetylcholine receptor at 4.6 angstrom resolution: Transverse tunnels in the channel wall
36. Evolutionary history of the ligand gated ion channel superfamily of receptors
37. Molecular modelling of the nicotinic acetylcholine receptor transmembrane region in the open state
38. Mutations in the channel domain alter desensitization of a neuronal nicotinic receptor
39. Theory of transport in ion channels: From molecular dynamics simulations to experiments
40. Molecular dynamics simulations of ion channels: How far have we gone and where are we heading?
41. Molecular dynamics simulations of the gramicidin channel
42. + channel: Electrostatic stabilization of monovalent cations
43. The pore domain of the nicotinic acetylcholine receptor: Molecular modelling and electrostatics
44. Modelling membrane proteins using structural restraints
45. Modelling and simulation of ion channels: Applications to the nicotinic acetylcholine receptor
46. Microscopic dielectric properties of cytochrome c from molecular dynamics simulations in aqueous solution
47. Structure-based prediction of the conductance properties of ion channels
48. + ions in models of the pore region of the nicotinic acetylcholine receptor
49. + ions in models of ion channels: A molecular dynamics study
50. - ions in ion channel models
51. Integral weak diffusion and diffusion approximations applied to ion transport through biological ion channels
52. The drift approximation solves the Poisson, Nernst-Planck, and continuum equations in the limit of large external voltages
53. (In) validity of the constant field and constant currents assumptions in theories of ion transport
54. Kinked-helices model of the nicotinic acetylcholine receptor ion channel and its complexes with blockers: Simulation by the Monte Carlo minimization method
55. Ion channel of acetylcholine receptor reconstructed from images of postsynaptic membranes
56. Electrostatic models for computing protonation and redox equilibria in proteins
57. Nicotinic acetylcholine receptor at 9 Å resolution
58. Acetylcholine receptor channel imaged in the open state
59. Intrinsic rectification of ion flux in alamethicin channels: Studies with an alamethicin dimer