Stem cells and immune reconstitution in AIDS

Blood Reviews

Volumn 17, Issue 4, 2003, Pages 227-231

  Scadden, David T ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Acquired immunodeficiency syndrome; Hematopoiesis; Human immunodeficiency virus; Immune reconstitution; Stem cells

Indexed keywords

ANTIRETROVIRUS AGENT; CD4 ANTIGEN; CD45 ANTIGEN; CD8 ANTIGEN; PADGEM PROTEIN; T LYMPHOCYTE RECEPTOR;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; CELL FUNCTION; HEMATOPOIETIC SYSTEM; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE RESPONSE; IMMUNITY; IMMUNOPHENOTYPING; MEMORY CELL; PRIORITY JOURNAL; REVIEW; STEM CELL; T LYMPHOCYTE; THYMUS; VIRUS CELL INTERACTION;

EID: 0242354770     PISSN: 0268960X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0268-960X(03)00021-3     Document Type: Review

References (35)

1. Rosenberg ES, Billingsley JM, Caliendo AM, Boswell SL, Sax PE, Kalams SA, Walker BD. Vigorous HIV-I-specific CD4+ T cell responses associated with control of viremia [see comments]. Science 1997; 278: 1447-1450.
2. Douek DC, Brenchley JM, Betts MR, Ambrozak DR, Hill BJ, Okamoto Y, Casazza JP, Kuruppu J, Kunstman K, Wolinsky S, Grossman Z, Dybul M, Oxenius A, Price DA, Connors M, Koup RA. HIV preferentially infects HIV-specific CD4+ T cells. Nature 2002; 417: 95-98.
3. Rosenberg ES, Altfeld M, Poon SH, Phillips MN, Wilkes BM, Eldridge RL, Robbins GK, D'Aquila RT, Goulder PJ, Walker BD. Immune control of HIV-I after early treatment of acute infection. Nature 2000; 407: 523-526.
4. Hellerstein M, Hanley MB, Cesar D, Siler S, Papageorgopoulos C, Wieder E, Schmidt D, Hoh R, Neese R, Macallan D, Deeks S, McCune JM. Directly measured kinetics of circulating T lymphocytes in normal and HIV-I-infected humans [see comments]. Nat Med 1999; 5: 83-89.
5. Mohri H, Perelson AS, Tung K, Ribeiro RM, Ramratnam B, Markowitz M, Kost R, Hurley A, Weinberger L, Cesar D, Hellerstein MK, Ho DD. Increased turnover of T lymphocytes in HIV-I infection and its reduction by antiretroviral therapy. J Exp Med 2001; 194: 1277-1287.
6. Pakker NG, Notermans DW, de Boer RJ, Roos MT, de Wolf F, Hill A, Leonard JM, Danner SA, Miedema F, Schellekens PT. Biphasic kinetics of peripheral blood T cells after triple combination therapy in HIV-I infection: a composite of redistribution and proliferation. Nat Med 1998; 4: 208-214.
7. Bucy RP, Hockett RD, Derdeyn CA, Saag MS, Squires K, Sillers M, Mitsuyasu RT, Kilby JM. Initial increase in blood CD4 (+) lymphocytes after HIV antiretroviral therapy reflects redistribution from lymphoid tissues. J Clin Invest 1999; 103: 1391-1398.
8. Autran BG, Carcelain TS, Li C, Blanc D, Mathez R, Tubiana C, Katlama P, Debre J, Leibowitch T. Positive effects of combined antiretroviral therapy on CD4+ T cell homeostasis and function in advanced HIV disease. Science 1997; 277: 112-116.
9. Douek DC, McFarland RD, Keiser PH, Gage EA, Massey JM, Haynes BF, Polis MA, Haase AT, Feinberg MB, Sullivan JL, Jamieson BD, Zack JA, Picker LJ, Koup RA. Changes in thymic function with age and during the treatment of HIV infection [see comments]. Nature 1998; 396: 690-695.
10. Prevot S, Audouin J, Andre-Bougaran J, Griffais R, Le Tourneau A, Fournier JG, Diebold J. Thymic pseudotumorous enlargement due to follicular hyperplasia in a human immunodeficiency virus sero-positive patient. Immunohistochemical and molecular biological study of viral infected cells. Am J Clin Pathol 1992; 97: 420-425.
11. Haynes BF, Markert ML, Sempowski GD, Patel DD, Hale LJ. The role of the thymus in immune reconstitution in aging, bone marrow transplantation, and HIV-I infection. Ann Rev Immunol 2000; 18: 529-560.
12. Stanley SK, McCune JM, Kaneshima H, Justement JS, Sullivan M, Boone E, Baseler M, Adelsberger J, Bonyhadi M, Orenstein J et al. Human immunodeficiency virus infection of the human thymus and disruption of the thymic microenvironment in the SCID-hu mouse. J Exp Med 1993; 178: 1151-1163.
13. McCune JM, Loftus R, Schmidt DK, Carroll P, Webster D, Swor-Yim LB, Francis IR, Gross BH, Grant RM. High prevalence of thymic tissue in adults with human immunodeficiency virus-I infection [see comments]. J Clin Invest 1998; 101: 2301-2308.
14. Amado RG, Jamieson BD, Cortado R, Cole SW, Zack JA. Reconstitution of human thymic implants is limited by human immunodeficiency virus breakthrough during antiretroviral therapy. J Virol 1999; 73: 6361-6369.
15. Zhang ZQ, Notermans DW, Sedgewick G, Cavert W, Wietgrefe S, Zupancic M, Gebhard K, Henry K, Boies L, Chen Z, Jenkins M, Mills R, McDade H, Goodwin C, Schuwirth CM, Danner SA, Haase AT. Kinetics of CD4+ T cell repopulation of lymphoid tissues after treatment of HIV-I infection. Proc Natl Acad Sci USA 1998; 95: 1154-1159.
16. Schuitemaker H, Kootstra NA, Koppelman MH, Bruisten SM, Huisman HG, Tersmette M, Miedema F. Proliferation-dependent HIV-I infection of monocytes occurs during differentiation into macrophages. J Clin Invest 1992; 89: 1154-1160.
17. Louache F, Bettaieb A, Henri A, Oksenhendler E, Farcet JP, Bierling P, Seligmann M, Vainchenker W. Infection of megakaryocytes by human immunodeficiency virus in seropositive patients with immune thrombocytopenic purpura. Blood 1991; 78: 1697-1705.
18. Shen H, Cheng T, Preffer FI, Dombkowski D, Tomasson MH, Golan DE, Yang O, Hofmann W, Sodroski JG, Luster AD, Scadden DT. Intrinsic human immunodeficiency virus type I resistance of hematopoietic stem cells despite coreceptor expression. J Virol 1999; 73: 728-737.
19. Koka PS, Jamieson BD, Brooks DG, Zack JA. Human immunodeficiency virus type I-induced hematopoietic inhibition is independent of productive infection of progenitor cells in vivo. J Virol 1999; 73: 9089-9097.
20. Bahner I, Kearns K, Coutinho S, Leonard EH, Kohn DB. Infection of human marrow immunodeficiency virus-I (HIV-I) is both required and sufficient for HIV-I-inducted hematopoletic suppression in vitro: demonstration by gene modification of primary human stroma. Blood 1997; 90: 1787.
21. Scadden DT, Ziera M, Woon A. HIV infection of human bone marrow stromal fibroblasts. Blood 1990; 76: 317-322.
22. Moses AV, Williams S, Heneveld ML, Strussenberg J, Rarick M, Loveless M, Bagby G, Nelson JA. Human immunodeficiency virus infection of bone marrow endothelium reduces induction of stromal hematopoietic growth factors. Blood 1996; 87: 919-925.
23. Moses A, Nelson J, Bagby Jr GC. The influence of human immunodeficiency virus-I on hematopoiesis. Blood 1998; 91: 1479-1495.
24. Gradstein S, Hahn T, Barak Y, Malach L, Revel M, Bentwich Z, Handzel ZT. In vitro effects of recombinant TNF-alpha binding protein (rTBP-I) on hematopoiesis of HIV-infected patients. J Acquir Immune Deficiency Syndr 2001; 26: 111-117.
25. Schooley RT, Mladenovic J, Sevin A, Chiu S, Miles SA, Pomerantz RJ, Campbell TB, Bell D, Ambruso D, Wong R, Landay A, Coombs RW, Fox L, Kamoun M, Jacovini J. Reduced Mobilization of CD34+ Stem Cells in Advanced Human Immunodeficiency Virus Type I Disease. J Infect Dis 2000; 181: 148-157.
26. Huang SS, Barbour JD, Deeks SG, Huang JS, Grant RM, Ng VL, McCune JM. Reversal of human immunodeficiency virus type I-associated hematosuppression by effective antiretroviral therapy. Clin Infect Dis 2000; 30: 504-510.
27. Isgro A, Mezzaroma I, Aiuti A, De Vita L, Franchi F, Pandolfi F, Alario C, Ficara F, Riva E, Antonelli G, Aiuti F. Recovery of hematopoietic activity in bone marrow from human immunodeficiency virus type I-infected patients during highly active antiretroviral therapy. AIDS Res Hum Retroviruses 2000; 16: 1471-1479.
28. Sloand EM, Maciejewski J, Kumar P, Kim S, Chaudhuri A, Young N. Protease inhibitors stimulate hematopoiesis and decrease apoptosis and ICE expression in CD34 (+) cells. Blood 2000; 96: 2735-2739.
29. Ranga U, Woffendin C, Verma S, Xu L, June CH, Bishop DK, Nabel GJ. Enhanced T cell engraftment after retroviral delivery of an antiviral gene in HIV-infected individuals. Proc Natl Acad Sci USA 1998; 95: 1201-1206.
30. Krishnan A, Molina A, Zaia J, Nademanee A, Kogut N, Rosenthal J, Woo D, Forman SJ. Autologous stem cell transplantation for HIV-associated lymphoma. Blood 2001; 98: 3857-3859.
31. Kohn DB, Bauer G, Rice CR, Rothschild JC, Carbonaro DA, Valdez P, Hao Q, Zhou C, Bahner I, Kearns K, Brody K, Fox S, Haden E, Wilson K, Salata C, Dolan C, Wetter C, Aguilar-Cordova E, Church J. A clinical trial of retroviral-mediated transfer of a rev-responsive element decoy gene into CD34 (+) cells from the bone marrow of human immunodeficiency virus-I-infected children. Blood 1999; 94: 368-371.
32. Robert NJ, Schneiderman H. Hodgkin's disease and the acquired immunodeficiency syndrome. Ann Intern Med 1984; 101: 142-143.
33. Yang OO, Tran AC, Kalams SA, Johnson RP, Roberts MR, Walker BD. Lysis of HIV-I-infected cells and inhibition of viral replication by universal receptor T cells. Proc Natl Acad Sci USA 1997; 94: 11478-11483.
34. Mitsuyasu RT, Anton PA, Deeks SG, Scadden DT, Connick E, Downs MT, Bakker A, Roberts MR, June CH, Jalali S, Lin AA, Pennathur-Das R, Hege KM. Prolonged survival and tissue trafficking following adoptive transfer of CD4ζ gene-modified autologous CD4 (+) and CD8 (+) T cells in human immunodeficiency virus-infected subjects. Blood 2000; 96: 785-793.
35. Deeks SG, Wagner B, Anton PA, Mitsuyasu RT, Scadden DT, Huang C, Macken C, Richman DD, Christopherson C, June CH, Lazar R, Broad DF, Jalali S, Hege KM. A Phase II Randomized Study of HIV-Specific T-Cell Gene Therapy in Subjects with Undetectable Plasma Viremia on Combination Antiretroviral Therapy. Mol Ther 2002; 5: 788-797.