Protease inhibitors stimulate hematopoiesis and decrease apoptosis and ICE expression in CD34+ cells

Blood

Volumn 96, Issue 8, 2000, Pages 2735-2739

  Sloand, E M ^a   Maciejewski, J ^a   Kumar, P ^a   Kim, S ^a   Chaudhud, A ^a   Young, N ^a  

^a NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLTYROSYLVALYLALANYLASPARTIC ACID DERIVATIVE; ANTIRETROVIRUS AGENT; CASPASE INHIBITOR; CD34 ANTIGEN; INTERLEUKIN 1BETA CONVERTING ENZYME; RITONAVIR; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BLOOD TOXICITY; CLINICAL ARTICLE; COLONY FORMATION; CONCENTRATION RESPONSE; DRUG MECHANISM; ENZYME MECHANISM; HEMATOPOIESIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; INHIBITION KINETICS; PRIORITY JOURNAL; PROTEINASE INHIBITION;

EID: 0034667552     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v96.8.2735.h8002735_2735_2739     Document Type: Article

References (24)

1. Infection and replication of HIV-1 in pudfied progenitor cells of normal buman bone marrow
2. CD34+ bone marrow cells are infected with HIV in a subset of seropositive individuals
3. CD34+ progenitor cells from asymptomatic patients are hot a major reservoir for human immunodeficiency virus- 1
4. Secondary colony formation after long-term bone marrow culture using peripheral blood and bone marrow of HIV-infected patients
5. Neither human immunodeficiency virus-1 (HIV-1) nor HIV-2 infects most-primitive human hematopoietic stem cells as assessed in long-term bone marrow cultures
6. HIV-1-related mechanisms of suppression of CD34+ hematopoietic progenitors
7. The roles of perforin and Fas-dependent cytotoxicity in protection against cytopathic and noncytopathic viruses
8. Fas antigen expression on CD34+ human marrow cells is induced by interferon gamma and tumot necrosis factor alpha and potentiates cytokine-mediated hematopoietic suppression in vitro
9. Functional expression of Fas antigen (CD95) on hematopoietic progenitor cells
10. Role of Fas ligand and receptor in the mechanism of T-cell depletion in acquired immunodeficiency syndrome: Effect on CD4+ lymphocyte depletion and human immuno-deficiency virus replication
11. Cytokine patterns in adults with AIDS
12. Increased expression of Fas antigen on bone marrow CD34+ cells of patients with aplastic anaemia
13. Caspase 1-independent IL-1beta release and inflammation induced by the apoptosis inducer Fas ligand
14. Caspase inhibition reduces apoptsois and increases survival of nigral transplants
15. Neuroprotection by a caspase inhbitor in acute bacterial meningitis
16. Sequential activation of ICE-like and CPP32-like proteases during as-mediated apoptosis
17. Inhibition of interleukin-1 β-converting enzyme in human hematopoietic progenitor cells results in blockade of cytokine-mediated apoptosis and expansion of their proliferative potential
18. Human immunodeficiency virus type 1 protease inhibitor modulates activation of peripheral blood CD4+ T cells and decreases their susceptibility to apoptosis in vitro and in vivo
19. Assessment of cytokines by immunofiuorescence and the paraformaldehyde-saponin procedure
20. Substrate and inhibitor specificity of intedeukin-1 β-converting enzyme and related caspases
21. The cytotoxic cell protease granzyme B initiates apoptosis in a cell-free system by proteolytic processing and activation of the ICE/CED-3 family protease, CPP32, via a novel two-step mechanism
22. Immunologic markers of progression to acquired immunodeficiency syndrome are time-dependent and illness-specific
23. Inhibitory cytokines in patients with anemia of chronic disorders
24. Inhibition of apoptotic trasduction pathway in human hematopoietic cells using synthetic caspase inhibitor Y-VAD