Arginine on its metabolic and physiological context;La arginina en su contexto metabólico y fisiológico

Acta Bioquimica Clinica Latinoamericana

Volumn 37, Issue 2, 2003, Pages 165-179

  Teixeira De Almeida, Deusdelia ^a,c   Santaolaria Ayora, Ma Luisa ^b   Alonso Iglesias, Eulalia ^b  

^a FEDERAL UNIVERSITY OF BAHIA   (Brazil)

^b UNIVERSITY OF VALENCIA   (Spain)

^c Depto de Bioquim y Biol Molec ^*  (Brazil)

Author keywords

Ammonia detoxification; Arginine; Creatine; Nitric oxide; Polyamines

Indexed keywords

ARGININE; ARGININOSUCCINATE SYNTHASE; CARBAMOYL PHOSPHATE SYNTHASE; CREATINE; GLUTAMATE ACETYLTRANSFERASE; GLUTAMINASE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; ORNITHINE CARBAMOYLTRANSFERASE; ORNITHINE DECARBOXYLASE; ORNITHINE OXOACID AMINOTRANSFERASE; POLYAMINE; PROLINE DEHYDROGENASE; PYRROLINE 5 CARBOXYLATE REDUCTASE; TETRAHYDROBIOPTERIN; UREA;

AMINO ACID ANALYSIS; AMINO ACID COMPOSITION; AMINO ACID METABOLISM; AMINO ACID SYNTHESIS; DETOXIFICATION; DIET SUPPLEMENTATION; ENZYME REGULATION; ENZYME SYNTHESIS; ENZYMOLOGY; HUMAN; IMMUNE RESPONSE; NEUROTRANSMISSION; NONHUMAN; PROTEIN FUNCTION; REVIEW; UREA CYCLE; VASODILATATION;

MAMMALIA;

EID: 0242352477     PISSN: 03252957     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (136)

1. Alonso E. Arginina y Diabetes. SEMERGEN 1996; 22 (3): 175-81.
2. Beaumier L, Castillo L, YuY-M, Ajami AM, Young VR. Arginine: new and exciting development for an "old" amino acid [review]. Biomed Environ Sci 1996; 9 (2-3): 296-315.
3. Cynober L, Le Boucher J, Vasson MP. Arginine metabolism in mammals [review]. J Nutr Biochem 1995; 6: 402-3.
4. Reyes AA, Karl IE, Klahr S. Role of arginine in renal disease. [review]. Am J Physiol 1994; 267 (3 PT 2): F331-46.
5. Visek WJ. Arginine, physiological state and usual diets. A reevaluation [review]. J Nutr 1986; 116 (1): 36-46.
6. Moncada S, Palmer RMJ, Higgs EA. Nitric oxide: physiology, pathophysiology, and pharmacology [review]. Pharmacol Rev 1991; 43 (2): 109-42.
7. Singh S, Evans TW. Nitric oxide, the biological mediator of the decade: fact or fiction? [review]. Eur Respir J 1997; 10 (3): 699-707.
8. Flora FR, Zilberstein B. Nitric oxide: the simple messenger passing through complexity. Metabolism, synthesis and functions [review]. Rev Assoc Med Bras 2000; 46 (3): 265-71.
9. Wu G, Morris SM. Arginine metabolism: nitric oxide and beyond [review]. Biochem J 1998; 15: 336 (Pt 1): 1-17.
10. Lubec B, Hayn M, Kitzmüller H. L-arginine reduces lipid peroxidation in patients with diabetes mellitus. Free Rad Biol Med 1997; 22 (1-2): 355-7.
11. Wu G, Meininger CJ. Arginine nutrition and cardiovascular function [review]. J Nutr 2000; 130 (11): 2626-9.
12. Tentolouris C, Tousoulis D, Goumas G, Stefanadis C, Davies G, Toutouzas P. L-arginine in coronary atherosclerosis. Int J Cardiol 2000; 75 (2-3): 123-8.
13. Meneu V. Metabolismo de la arginina en la patología diabética: Estudio en humanos [dissertation]. Valencia (Spain). Valencia Univ; 2000.
14. Cooke JP, Tsao PS. Arginine: A new therapy for atherosclerosis? Circulation 1997; 95 (2): 311-2.
15. Chowienczyk P, Ritter J. Arginine: NO more than a simple aminoacid? Lancet 1997; 350 (9082): 901-2.
16. Wascher T, Posch K, Wallner S, Hermetter A. Kostner GM, Graier WF. Vascular effects of L-arginine: anything beyond a substrate for the NO-synthase? Biochem Biophys Res Commun 1997; 234 (1): 35-8.
17. Tenenbaum A, Fisman EZ, Motro M. L-Arginine: rediscovery in progress. Cardiology 1998; 90 (3): 153-9.
18. Jones ME. Convertion of glutamate to ornithine and proline: pyrroline-5-carboxylate, a posible modulator of arginine requirements. J Nutr 1985; 115 (4): 509-15.
19. Wakabayashi Y, Iwashima A, Yamada E, Yamada RH. Enzymological evidence for the indispensability of small intestine in the synthesis of arginine from glutamate. Arch Biochem Biophys 1991; 291 (1): 9-14.
20. Hoogenraad N, Totino N, Elmer H, Wraight C, Alewood P, Johns RB. Inhibition of intestinal citrulline synthesis causes severe growth retardation in rats. Am J Physiol 1985; 249 (6 Pt 1): G792-9.
21. Hurwitz R, Kretchmer N. Development of arginine-synthesizing enzymes in mouse intestine. Am J Physiol 1986; 251 (1 Pt 1): G103-10.
22. Alonso E. Aspectos experimentales del ciclo de la ornitina. [dissertation]. Valencia (Spain). Valencia Univ., 1986.
23. Levillain O, Hus-Citharel A, Morel F, Bankir L. Localization of arginine synthesis along rat nephron. Am J Physiol 1990; 259 (6 Pt 2): F916-23.
24. Morel F, Citharel-Hus A, Levillain L. Biochemical heterogeneity of arginine metabolism along kidney proximal tubules. Kidney Int 1996; 49 (6): 1608-10.
25. Aiello S, Noris M, Remizzi G. Nitric oxide synthesis and L-arginine in uremia. Miner Electrolyte Metab 1997; 23 (3-6): 151-6.
26. Rogers QR, Freedland RA, Symmons RA. In vivo synthesis and utilization of arginine in the rat. Am J Physiol 1972; 223: 236-40.
27. Hartman WJ, Prior RL. Dietary arginine deficiency alters flux of glutamine and urea cycle intermediates across the portal-drained viscera and liver of rats. J Nutr 1992; 122 (7): 1472-82.
28. Fleming GA. Steel G, Valle D. The aqueous humor of rabbit contains high concentrations of pyrroline-5-carboxylate. Metabolism 1986; 35 (10): 933-7.
29. Mixson AJ, Phang JM. The uptake of pyrroline-5-carboxylate. J Biol Chem 1988; 263 (22): 10720-4.
30. Fleming GA, Granger A, Rogers QR, Prosser M, Ford B, Phang JM. Fluctuations in plasma pyrroline-5-carboxylate concentrations during feeding and fasting. J Clin Endocrinol Metab 1989; 69 (2): 448-52.
31. Morris SM. Regulation of enzymes of urea and arginine. Annu Rev Nutr 1992; 12: 81-101.
32. 1-pyrroline-5- carboxylic acid in human fibroblast. Biochem Biophys Res Commun 1979; 87 (2): 363-70.
33. Yamada E, Wakabayashi Y. Development of pyrroline-5-carboxylate synthase and N-acetylglutamate synthase and their changes in lactation and aging. Arch Biochem Biophys 1991; 291 (1): 15-23.
34. Wu G, Meininger CJ, Kelly K, Watford M, Morris SM. A cortisol surge mediates the enhanced expression of pig intestinal pyrroline-5-carboxylate synthase during weaning. J Nutr 2000; 130 (8): 1914-9.
35. Alonso E, Rubio V. Participation of ornithine amino-transferase in the synthesis and catabolism of ornithine in mice. Biochem J 1989; 259 (1): 131-8.
36. Hu CA. Lin WW, Obie C, Valle D. Molecular enzymology of mammalian Delta1-pyrroline-5-carboxylate synthase. Alternative splice donor utilization generates isoforms with different sensitivity to ornithine inhibition. J Biol Chem 1999; 274 (10): 6754-62.
37. Flodström M, Niemann A, Bedoya FJ, Morris SM, Eizink DL. Expression of the citrulline-nitric oxide cycle in rodent and human pancreatic β-cells: Induction of argininosuccinate synthetase by cytokines. Endocrinology 1995; 136 (8): 3200-6.
38. Wu G, Meininger CJ. Impaired arginine metabolism and NO synthesis in coronary endothelial cells of the spontaneously diabetic BB rat. Am J Physiol 1995; 269 (4 Pt 2): H1312-8.
39. Oyadomari S, Gotoh T, Aoyagi K, Araki E, Shichiri M, Mori M. Coinduction of endothelial nitric oxide synthase and arginine recycling enzymes in aorta of diabetic rats. Nitric Oxide 2001; 5 (3): 252-60.
40. Wu G. An important role for pentose cycle in the synthesis of citrulline and proline from glutamine in porcine enterocytes. Arch Biochem Biophys 1996; 336 (2): 224-30.
41. Phang JM. The regulatory function of proline and pyrroline-5-carboxylic acid [review]. Curr Top Cell Regul 1985; 25: 91-132.
42. Mendes Ribeiro AC, Brunini TM, Ellory JC, Mann GE. Abnormalities in L-arginine transport and nitric oxide biosynthesis in chronic renal and heart failure [review]. Cardiovasc Res 2001; 49 (4): 697-712.
43. Devés R, Boyd CAR. Transporters for cationic amino acids in animal cells: discovery, structure, and function [review]. Physiol Rev 1998; 78 (2): 487-545.
44. Mori M, Gotoh T. Regulation of nitric oxide production by arginine metabolic enzymes [review]. Biochem Biophys Res Commun 2000; 275 (3): 715-9.
45. Durante W, Liao L, Reyna SV, Peyton KJ, Schafer AI. Ransforminxg growth factor-beta (1) stimulates L-arginine transport and metabolism in vascular smooth muscle cells: role in polyamine and collagen synthesis. Circulation 2001; 103 (8): 1121-7.
46. Nelin L, Nash HE, Chicoine L. Cytokine treatment increases arginine metabolism and uptake in bovine pulmonary arterial endothelial cells. Am J Physiol Lung Cell Mol Physiol 2001; 281 (5): L1232-9.
47. Castillo L, Sanchez M, Chapman TE, Äjami A, Burke JF, Young VR. The plasma flux and oxidation rate of ornithine adaptively decline with restricted arginine intake. Proc Natl Acad Sci USA 1994; 91 (14): 6393-7.
48. Castillo L, Chapman TE, Sanchez M, Yu Y-M, Burke JF, Äjami AM, Vogt J, et al. Plasma arginine and citrulline kinetics in adults given adequate and arginine-free diets. Proc Natl Acad Sci USA 1993; 90 (16): 7749-53.
49. Castillo L, Sanchez M, Vogt J, Chapman TE, DeRojas Walker TC, Tannenbaum SR, et al. Plasma arginine, citrulline, and ornithine kinetics in adults, with observations on nitric oxide synthesis. Am J Physiol 1995; 268 (2 Pt 1): E360-7.
50. Wakabayashi Y, Yamada E, Yoshida T, Takahashi N. Effect of intestinal resection and arginine-free diet on rat physiology. Am J Physiol 1995; 269 (2 Pt 1): G313-18.
51. Bankir L, Bouby N, Thinh-Trang-Tan M-M, Ahloulay M. Direct and indirect cost of urea excretion. Kidney Int 1996; 49 (6): 1598-607.
52. Takiguchi M, Mori M. Transcriptional regulation of genes for ornithine cycle enzymes [review]. Biochem J 1995; 312 (Pt 3): 649-59.
53. Voet D, Voet JG. Amino acid metabolism. In: Biochemistry. New York: John Wiley & Sons, INC., 1995.
54. Beliveau Carey G, Cheung CW, Cohen NS, Brusilow S, Raijman L. Regulation of urea and citrulline synthesis under physiological conditions. Biochem J 1993; 292 (Pt 1): 241-7.
55. Morimoto BH, Brady IF, Atkinson DE. Effect of level of dietary protein on arginine-stimulated citrulline synthesis. Biochem J 1990; 272 (3): 671-5.
56. Hayase K, Yonekawa G, Yoshida A. Changes in liver concentration of N-acetylglutamate and ornithine are involved in regulating urea synthesis in rats treated with thyroid hormone. J Nutr 1992; 122 (5): 1143-8.
57. Cynober L. Can arginine and ornithine support gut functions? Gut 1994; 35 Supl 1: S42-45.
58. Milner JA, Prior RL, Visek WJ. Arginine deficiency and orotic aciduria in mammals. Proc Soc Exp Biol Med 1975; 150 (2): 282-8.
59. Milner JA, Wakeling AE, Visek WJ. Effect of arginine deficiency on growth and intermediary metabolism in rats. J Nutr 1974; 104 (12): 1681-9.
60. Alonso E, Rubio V. Orotic aciduria due to arginine deprivation: changes in the levels of carbamoyl phosphate and of other urea Cycle intermediates in mouse liver. J Nutr 1989; 119 (8): 1188-95.
61. Carey GP, Kime Z, Rogers QR, Morris JG, Hargrove. An Arginine-deficient diet in humans does not evoke hyperammonemia or Orotic Aciduria. J Nutr 1987; 117 (10): 1734-9.
62. Milner JA, Visek WJ. Orotic aciduria and arginine deficiency. Nature (London) 1973; 245 (5422): 211-3.
63. Gross KI, Hartman WJ, Ronnenberg A. Prior RL Arginine-deficient diets alter plasma and tissue amino acids in young and aged rats. J Nutr 1991; 121 (10): 1591-9.
64. Morris JG. Nutritional and metabolic responses to arginine deficiency in carnivores. J Nutr 1985; 115 (4): 524-31.
65. Burns RA, Milner JA, Corbin JE. Arginine: An indispensable amino acid for mature dogs. J Nutr 1981; 111 (6): 1020-4.
66. Stuart-Smith K. Demystified. Nitric oxide [review] 2002; 55 (6): 360-6
67. Snyder SH, Bredt DS. Funciones biológicas del óxido nítrico. Investigación y Ciencia 1992; 12-20.
68. Wink DA, Mitchell JB. Chemical biology of nitric oxide: Insights into regulatory, cytotoxic, and cytoprotective mechanisms of nitric oxide [review]. Free Rad Biol Med 1998; 25 (4-5): 434-56.
69. Torreilles J, Guérin CM. Does nitric oxide stress exist? [Review]. C R Séances Soc Biol Fil 1995; 189 (3): 389-400.
70. Butler AR, Rhodes P. Chemistry, analysis, and biological roles of S-nitrosothiols [review]. Anal Biochem 1997; 249 (1): 1-9.
71. Moncada S, Higgs A. The L-arginine-nitric oxide pathway. N Engl J Med 1993; 329 (27): 2002-12.
72. Knowles R. Nitric oxide synthases in mammals [review]. Biochemist J 1994; 298 (Pt 2): 249-58.
73. Nathan C, Xie Q-W. Regulation of biosynthesis of nitric oxide [review]. J Biol Chem 1994; 269 (19): 13725-8.
74. Southan GJ, Szabó C. Selective pharmacological inhibition of distinct nitric oxide synthase isoforms [review]. Biochem Pharmacol 1996; 51 (4): 383-94.
75. Stuehr DJ. Mammalian nitric oxide synthases [review]. Biochim Biophys Acta 1999; 1411 (2-3): 217-30.
76. Rodeberg DA, Chaet MS, Bass RC, Arkovitz MS, Garcia VF. Nitric oxide: An overview [review]. Am J Surg 1995; 170 (3): 292-303.
77. Klatt P, Schmidt K, Uray G, Mayer B. Multiple catalytic functions of brain nitric oxide synthase. Biochemical characterization, cofactor-requirement, and the role of N omega-hydroxy-L-arginine as an intermediate [review]. J Biol Chem 1993; 268 (20): 14781-7.
78. Fukuto JM, Chaudhuri G. Inhibition of constitutive and inducible nitric oxide synthase: potencial selective inhibition. Annu Rev Pharmacol Toxico 1995; (35): 165-94.
79. De Berrazueta JR. El óxido nítrico: un gas intercelular con acciones fisiológicas y tóxicas. Nuevas perspectivas. Rev Esp Cardiol 1994; 47: 199-208.
80. Cooke JP, Dzau VJ. Nitric oxide synthase: Role in the genesis of vascular disease. Annu Rev Med 1997; 48: 489-509.
81. Schafer AI. Antiplatelet therapy. Am J Med 1996; 101 (2): 199-209.
82. Lowenstein CJ, Dinerman JL, Snyder SH. A Nitric oxide: physiologic messenger [review]. Ann Intern Med 1994; 120 (3): 227-37.
83. Wu G, Brosnant JT. Macrophages can convert citrulline into arginine. Biochem J 1992; 281 (Pt 1): 45-8.
84. Bogle RG, Baydoún AR, Pearson JD, Moncada S, Mann GE. L-arginine transport is increased in macrophages generating nitric oxide. Biochem J 1992; 284 (Pt 1): 15-8.
85. Ortega MA, Amaya AA. Nitric oxide reactivity and mechanisms involved in its biological effects. Pharmacol Res 2000; 42: 421-7.
86. Colasanti M, Suzuki H. The dual personality of NO [review]. Trends Pharmacol Sci 2000; 21 (7): 249-52.
87. Bauer PM, Buga MG, Fukuto JM, Pegg AE, Ignarro LJ. Nitric oxide inhibits ornithine decarboxylase via s-nitrosylation of cysteine 360 in the active site of the enzyme. J Biol Chem 2001; 276 (37): 34458-64.
88. Billiar TR. Nitric oxide, novel biology with clinical relevance. Ann Surg 1995; 221 (4), 339-49.
89. Katusic ZS. Superoxide anion and endothelial regulation of arterial tone [review]. Free Rad Biol Med 1996; 20 (3), 443-8.
90. Beckman J, Chen X, Crow JP, Ye YZ. Reactions of nitric oxide, superoxide and peroxynitrite with superoxide dismutase in neurodegeneration. Prog Brain Res 1994; (103) 371-80.
91. De la Pena NC, Sosa-Melgarejo JA, Román RR, Méndez JD. inhibition of platelet aggregation by putrescine, spermidine, and spermine in hypercholesterolemic rabbits. Arch Med Res 2000; 31 (6): 546-50.
92. Gaugas JM editores. Polyaminesin biomedical research. New York: John Wiley & Sons; 1980.
93. Davies PJ. Plant hormones. Physiology, biochemistry and molecular biology. En: Galston, AW, Kaur-Sawhney, R, editors. Polyamines as endogenous growth regulators. Boston: Kluwer Academic; 1995; p. 1158-78.
94. Tabor CW, Tabor H. Polyamines [review]. Annu Rev Biochem 1984; (53): 747-90.
95. Pegg AE. Recent advances in the biochemistry of polyamines in eukaryotes. J Biochem 1986; 234 (2): 249-62.
96. Seiler N. Polyamine metabolism [review]. Digestion 1990; 46 (Suppl 2): 319-30.
97. Igarashi K, Kashiwagi K. Polyamines: Mysterious Modulators of Cellular functions [review]. Biochem Biophys Res Commun 2000; 271 (3): 559-64.
98. Løvaas E. Hypothesis: Spermine may be an important epidermal antioxidant [review]. Med Hypotheses 1995; 45 (1): 59-67.
99. Løvaas E, Carlin G. Spermine an anti-oxidant and anti-inflammatory agent. Free Rad Biol Med 1991; 11 (5): 455-61.
100. Jeevanandam M, Ali MR, Young DH, Schiller WR. Polyamine levels as biomarkers of injury response in polytrauma victims. Metabolism 1989; 38 (7): 625-30.
101. 12-diacetylspermidine in urine as novel markers of malignancy. J Cancer Res Clin Oncol 1997; 123 (10): 539-45.
102. Zhang M, Wang H, Tracey KJ. Regulation of macrophage activation and inflammation by spermine: A new chapter in an old story [review]. Crit Care Med 2000; 28 (4 suppl): N60-6.
103. Fernandez C, Sharrard RM, Talbot M, Reed BD, Monks N. Evaluation of the significance of polyamines and their oxidases in the aetiology of human cervical carcinoma. Br J Cancer 1995; 72 (5): 1194-9.
104. Bardózc S, Duguid TJ, Brown DS, Grant G, Pusztei A, White, et al. The importance of dietary polyamines in cell regeneration and growth. Br J Nutr 1995; 71 (6): 819-28.
105. Löser CHV, Torff L, Folsch UR. Uptake of extracellular, dietary putrescine is an important regulatory mechanism of intracellular polyamine metabolism during camostate-induced pancreatic growth in rats. Digest Dis Sci 1997; 42 (3): 503-13.
106. Pegg AE, McCann PP. Polyamine metabolism and function. Am J Physiol 1982; 243 (5): C212-21.
107. Hu R-H, Pegg AE. Rapid induction of apoptosis by deregulated uptake of polyamine analogues. Biochem J 1997; 328 (Pt 1): 307-16.
108. Flamigni F, Marmiroli S, Capanni C, Stefanelli, Guarnieri C, Caldarera CM. Phosphatidylinositol 3-Kinase is required for the induction of ornithine decarboxylase in leukemia cells stimulated to growth. Biochem Biophys Res Commun 1997; 239 (3): 729-33.
109. Li H, Meininger CJ, Hawker JR, Haynes TE, Kepka-Lenhart D, Mistry SK, et al. Regulatory role of arginase I and II in nitric oxide, polyamine, and proline synthese in endothelial cells. Am J Physiol Endocrinol Metab 2001; 280 (1): E75-82.
110. Kepka-Lenhart D, Mistry SK, Wu G, Morris SM. Arginase I: a limiting factor for nitric oxide and polyamine synthesis by activated macrophages? Am J Physiol Regul Integr Comp 2000; 279 (6): R2237-42.
111. De Jonge WJ, Marescau B, D'Hooge R, De Deyn PP, Hallemeesch MM, Deutz NE, et al. Overexpression of arginase alters circulating and tissue amino acids and guanidino compounds and affects neuromotor behavior in mice. J Nutr 2001; 131 (10): 2732-40.
112. Han X, Kazarinoff MN, Seiler N, Stanley BA. Rat colon ornithine and arginine metabolism: coordinated effects after proliferative stimuli. Am J Physiol 2001; 280 (3): G389-99.
113. Zhang C, Hein TW, Wang W, Chang CI, Kuo L. Constitutive expression of arginase in microvascular endothelial cells counteracts nitric oxide-mediated vasodilatory function. Faseb J 2001; 15 (7): 1264-6.
114. Jeevanandam M, Holaday NJ, Begay CK, Petersen SR. Amelioration of the protein metabolic response in spermidine-supplemented trauma rats. Metabolism 1998; 47 (2): 223-9.
115. Morris DR, Marton LJ. editores. Polyamines in biology and medicine. New York: Marcel Dekker; 1981
116. Satriano J, Kelly CJ, Blantz RC. An emerging role for agmatine. Kidney Int 1999; 56 (4): 1252-3.
117. Blantz RC, Satriano J, Gabbai F, Kelly C. Biological effects of arginine metabolites. Acta Physiol Scand 2000; 168 (1): 21-5.
118. Lortie MJ, Novotny WF, Peterson OW, Vallon V, Malvey K, Mendonca M, et al. Agmatine, a bioactive metabolite of arginine. J Clin Invest 1996; 97 (2): 413-20.
119. Schwartz D, Peterson OW, Mendonca M, Satriano I, Lortie M, Blantz RC. Agmatine affects glomerular filtration via a nitric oxide synthase-dependent mechanism. Am J Physiol 1997; 272 (5 Pt 2): F597-601.
120. Wyss M, Kaddurah-Daouk R. Creatine and creatinine metabolism [review] Physiol Rev 2000; 80 (3): 1107-13.
121. Teixeira D. Repercusiones metabólicas y fisiológicas de la manipulación de arginina en el ratón. [dissertation]. Valencia (Spain). Valencia Univ.; 1999.
122. Torre PM, Ronnenberg AG, Hartman WJ. Prior RL. Oral arginine supplementation does not affect lymphocyte proliferation during endotoxin-induced inflammation in rats. J Nutr 1993; 123 (3): 481-8.
123. Mulloy AL, Kari FW, Visek WJ. Dietary arginine, insulin secretion, glucose tolerance and liver lipids during repletion of protein-depleted rats. Horm Metabol Res 1982; 14 (9): 471-5.
124. Larsson H, Ahrén B. Effects of arginine on the secretion of insulin and islet amyloid polypeptide in humans. Pancreas 1995; 11 (2): 201-5.
125. Egan JM, Henderson TE, Bernier M. Arginine enhances glycogen synthesis in response to insulin in 3T3 L1 adipocytes. Am J Physio 1995; 269 (1 Pt 1): E61-6.
126. Field CJ, Johnson I, Pratt VC. Glutamine and arginine: immunonutrients for improved health [review]. Med Sci Sports Exerc 2000; 32 (7 Suppl): S377-88.
127. Evoy D, Lieberman MD, Fahey III TJ, Daly JM. Immunonutrition: The role of arginine. Nutrition 1998; 14 (7-8): 611-7.
128. Lewis B, Langkamp-Henken B. Arginine enhances in vivo immune responses in young adult and aged mice. J Nutr 2000; 130 (7): 1827-30.
129. O'Donnell C, Liew E. Immunological aspects of nitric oxide. The Biochemist 1994; 19-22.
130. Drexler H, Zeiher AM, Meinzer K, Just H. Correction of endothelial dysfunction in coronary microcirculation of hypercholesterolaemic patiens by L-arginine. Lancet 1991; 338 (8782): 1546-50.
131. Schäffer MR, Tantry U, Van Wesep RA, Barbul A. Nitric oxide metabolism in wounds. J Surg Res 1997; 71 (15): 25-31.
132. Joshi M. The importance of L-arginine metabolism in melanoma: an hypothesis for the role of nitric oxide and polyamines in tumor angiogenesis [review]. Free Rad Biol Med 1997; 22 (3): 573-8.
133. De Nicola L, Minutolo R, Bellizi V, Andreucci M, La Verde A, Cianciaruso B. Enhancement of nitric oxide synthesis by L-arginine supplementation in renal disease: Is good or bad? Miner Electrolyte Metab 1997; 23 (3-6): 144-50.
134. Reyes AA, Karl IE, Kissane J, Klahr S. L-Arginine administration prevents glomerular hyperfiltration and decreases proteinuria in diabetic rats. J Am Soc Nephrol 1993; 4 (4): 1039-45.
135. He Z, Ibayashi S, Nagao T, Fujii K, Sadoshimo S, Fujishima M. L-Arginine ameliorates cerebral blood flow and metabolism and decreases infarct volume in rats with cerebral ischemia. Brain Res 1995; 699 (2): 208-13.
136. Waddington SN, Cattell V. Effects of dietetic supplementation with L-arginine in cancer patients. A review of literature. Arch Latinoam Nutr 1999; 49: 301-8.