Adverse Effects of Dietary Glycotoxins on Wound Healing in Genetically Diabetic Mice

Diabetes

Volumn 52, Issue 11, 2003, Pages 2805-2813

  Peppa, Melpomeni ^a   Brem, Harold ^a   Ehrlich, Paul ^b   Zhang, Jian Gang ^a   Cai, Weijing ^a   Li, Zhu ^a   Croitoru, Anca ^a   Thung, Swan ^a   Vlassara, Helen ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b PENN STATE MILTON S HERSHEY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 N CARBOXYMETHYLLYSINE; ADVANCED GLYCATION END PRODUCT; COLLAGEN; GLUCOSE; METHYLGLYOXAL;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DIABETES MELLITUS; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITHELIZATION; FEMALE; FOOD INTAKE; GLUCOSE BLOOD LEVEL; GRANULATION TISSUE; HISTOPATHOLOGY; INFLAMMATION; MOUSE; MOUSE STRAIN; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; WOUND HEALING IMPAIRMENT;

ADMINISTRATION, ORAL; ANIMALS; BLOOD GLUCOSE; DIABETES MELLITUS; DIET; GLYCOSYLATION END PRODUCTS, ADVANCED; MICE; MICE, MUTANT STRAINS; SKIN; WOUND HEALING;

EID: 0242332119     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.52.11.2805     Document Type: Article

References (49)

1. Singer A, Clark R: Cutaneous wound healing. N Engl J Med 341:738-746, 1999
2. Moss SE, Klein R, Klein BE: Long-term incidence of lower-extremity amputations in a diabetic population. Arch Fam Med 5:391-398, 1996
3. Nwomeh BC, Yager DR, Cohen IK: Physiology of the chronic wound. Clin Plast Surg 25:341-356, 1998
4. Brem H, Balledux J, Bloom T, Kerstein M, Hollier L: Healing of diabetic ulcers and pressure ulcers with human skin equivalent: a new paradigm in wound healing. Arch Surg 135:627-634, 2000
5. Goova MT, Li J, Kislinger T, Qu W, Lu Y, Bucciarelli LG, Nowygrod S, Wolf BM, Caliste X, Yan SF, Stern DM, Schmidt AM: Blockade of receptor for advanced glycation end-products restores effective wound healing in diabetic mice. Am J Pathol 159:513-525, 2001
6. Vlassara H, Palace MR: Diabetes and advanced glycation endproducts. J Intern Med 251:87-101, 2002
7. Raj DSC, Choudhury D, Welbourne TC, Levi M: Advanced glycation end products: a nephrologist's perspective. Am J Kidney Dis 35:365-380, 2000
8. Dyer DG, Dunn JA, Thorpe SR, Lyons TJ, McCance DR, Baynes JW: Accumulation of Maillard reaction products in skin collagen in diabetes and aging. Ann N Y Acad Sci 663:421-422, 1992
9. Koschinsky T, He CJ, Mitsuhashi T, Bucala R, Liu C, Buenting C, Heitmann K, Vlassara H: Orally absorbed reactive advanced glycation end products (glycotoxins): an environmental risk factor in diabetic nephropathy. Proc Natl Acad Sci U S A 94:6474-6479, 1997
10. He C, Sabol J, Mitsuhashi T, Vlassara H: Dietary glycotoxins: inhibition of reactive products by aminoguanidine facilitates renal clearance and reduces tissue sequestration. Diabetes 48:1308-1315, 1999
11. Cai W, Cao Q, Zhu L, Peppa M, He C, Vlassara H: Oxidative stress-inducing carbonyl compounds from common foods: novel mediators of cellular dysfunction. Mol Med 8:337-346, 2002
12. Zheng F, He C, Cai W, Hattori M, Steffes M, Vlassara H: Prevention of diabetic nephropathy in mice by a diet low in glycoxidation products. Diabetes Metab Res Rev 18:224-237, 2002
13. Peppa M, He CJ, Hattori M, McEvoy R, Feng Z, Vlassara H: Fetal or neonatal low-glycotoxin environment prevents autoimmune diabetes in NOD mice. Diabetes 52:1441-1448, 2003
14. Lin RY, Reis ED, Dore AT, Lu M, Ghodsi N, Fallon JT, Fisher EA, Vlassara H: Lowering of dietary advanced glycation endproducts (AGE) reduces neointimal formation after arterial injury in genetically hypercholesterolemic mice. Atherosclerosis 163:303-311, 2002
15. Lin RY, Choudhury RP, Cai W, Lu M, Fallon JT, Fisher EA, Vlassara H: Dietary glycotoxins promote diabetic atherosclerosis in apolipoprotein E-deficient mice. Atherosclerosis 168:213-220, 2003
16. Hofmann SM, Dong HJ, Cai WJ, Altomonte J, Thung SN, Zeng F, Fisher EA, Vlassara H: Improved insulin sensitivity is associated with restricted intake of dietary glycoxidation products in the db/db mouse. Diabetes 51:2082-2089, 2002
17. Vlassara H, Cai W, Crandall J, Goldberg T, Oberstein R, Dardaine V, Peppa M, Rayfield E: Inflammatory mediators are induced by dietary glycotoxins, a major risk factor for diabetic angiopathy. Proc Natl Acad Sci USA 99:15596-15601, 2002
18. Uribarri J, Peppa M, Cai W, Goldberg T, Lu M, He C, Vlassara H: Restriction of dietary glycotoxins markedly reduces AGE toxins in renal failure patients. J Am Soc Nephrol 14:728-731, 2003
19. Uribarri J, Peppa M, Cai W, Goldberg T, Baliga S, Lu M, Vassalotti JA, Vlassara H: Dietary glycotoxins correlate with circulating advanced glycation end product levels in renal failure patients. J Am Kidney Dis 42:532-538, 2003
20. 1c as markers of diabetic complications. Diabetes 48:870-880, 1999
21. Schleicher ED, Wagner E, Nerlich AG: Increased accumulation of the glycoxidation product N (epsilon)-(carboxymethyl)lysine in human tissues in diabetes and aging. J Clin Invest 99:457-468, 1997
22. Beisswenger PJ, Makita Z, Curphey TJ, Moore LL, Jean S, Brinck-Johnsen T, Bucala R, Vlassara H: Formation of immunochemical advanced glycosylation end products precedes and correlates with early manifestations of renal and retinal disease in diabetes. Diabetes 44:824-829, 1995
23. Brennan M: Changes in solubility, non-enzymatic glycation, and fluorescence of collagen in tail tendons from diabetic rats. J Biol Chem 264: 20947-20952, 1989
24. Watala C, Golanski J, Witas H, Gurbiel R, Gwozdzinski K, Trojanowski Z: The effects of in vivo and in vitro non-enzymatic glycosylation and glycoxidation on physico-chemical properties of haemoglobin in control and diabetic patients. Int J Biochem Cell Biol 28:1393-1403, 1996
25. Duraisamy Y, Slevin M, Smith N, Bailey J, Zweit J, Smith C, Ahmed N, Gaffney J: Effect of glycation on basic fibroblast growth factor induced angiogenesis and activation of associated signal transduction pathways in vascular endothelial cells: possible relevance to wound healing in diabetes. Angiogenesis 4:277-288, 2001
26. Ido Y, Chang KC, Lejeune WS, Bjercke RJ, Reiser KM, Williamson JR, Tilton RG: Vascular dysfunction induced by AGE is mediated by VEGF via mechanisms involving reactive oxygen species, guanylate cyclase, and protein kinase C. Microcirculation 8:251-263, 2001
27. Portero-Otin M, Pamplona R, Bellmunt MJ, Ruiz MC, Prat J, Salvayre R, Negre-Salvayre A: Advanced glycation end product precursors impair epidermal growth factor receptor signaling. Diabetes 51:1535-1542, 2002
28. Twigg SM, Joly AH, Chen MM, Tsubaki J, Kim HS, Hwa V, Oh Y, Rosenfeld RG: Connective tissue growth factor/IGF-binding protein-related protein-2 is a mediator in the induction of fibronectin by advanced glycosylation end-products in human dermal fibroblasts. Endocrinology 143:1260-1269, 2002
29. Imani F, Horii Y, Suthanthiran M, Skolnik EY, Makita Z, Sharma V, Sehajpal P, Vlassara H: Advanced glycosylation endproduct-specific receptors on human and rat T-lymphocytes mediate synthesis of interferon gamma: role in tissue remodeling. J Exp Med 178:2165-2172, 1993
30. Collison KS, Parhar RS, Saleh SS, Meyer BF, Kwaasi AA, Hammami MM, Schmidt AM, Stern DM, Al-Mohanna FA: RAGE-mediated neutrophil dysfunction is evoked by advanced glycation end products (AGEs). J Leukoc Biol 71:433-444, 2002
31. Bernheim J, Rashid G, Gavrieli R, Korzets Z, Wolach B: In vitro effect of advanced glycation end-products on human polymorphonuclear superoxide production. Eur J Clin Invest 31:1064, 2001
32. Abordo EA, Westwood ME, Thornalley PJ: Synthesis and secretion of macrophage colony stimulating factor by mature human monocytes and human monocytic THP-1 cells induced by human serum albumin derivatives modified with methylglyoxal and glucose-derived advanced glycation endproducts. Immunol Lett 53:7-13, 1996
33. Daoud S, Schinzel R, Neumann A, Loske C, Fraccarollo D, Diez C, Simm A: Advanced glycation endproducts: activators of cardiac remodeling in primary fibroblasts from adult rat hearts. Mol Med 7:543-551, 2001
34. Kochakian M, Manjula BN, Egan JJ: Chronic dosing with aminoguanidine and novel advanced glycosylation end product-formation inhibitors ameliorates cross-linking of tail tendon collagen in STZ-induced diabetic rats. Diabetes 45:1694-1700, 1996
35. Teixeira AS, Caliari MV, Rocha OA, Machado RD, Andrade SP: Aminoguanidine prevents impaired healing and deficient angiogenesis in diabetic rats. Inflammation 23:569-581, 1999
36. Teixeira AS, Andrade SP: Glucose-induced inhibition of angiogenesis in the rat sponge granuloma is prevented by aminoguanidine. Life Sci 64:655-662, 1999
37. Yavuz D, Tugteppe H, Kaya H, Celikel S, Deyneli O, Uyar S, Akalin S: Effects of aminoguanidine on wound healing in a diabetic rat model (Abstract). Diabetes 51 (Suppl. 2):A256, 2002
38. Davidson JM: Animal models in wound repair. Arch Dermatol Res 290 (Suppl.):S1-S1137, 1998
39. Nutrient Requirements of Laboratory Animals. Washington, DC, The National Academy of Sciences, National Academy Press, 1995
40. Mellinghoff AJ, Wuerth JP, Founds HW, Landgraf R, Hepp KD: Formation of plasma advanced glycosylation end products (AGEs) has no influence on plasma viscosity. Diabet Med 14:832-836, 1997
41. Draper B, Komurasaki T, Davidson M, Nanney L: Topical epiregulin enhances repair of murine excisional wounds. Wound Repair Regen 11: 188, 2003
42. Yu W, Naim JO, Lanzafame RJ: Effects of photostimulation on wound healing in diabetic mice. Lasers Surg Med 20:56-63, 1997
43. Ehrlich HP, Desmouliere A, Diegelmann RF, Cohen IK, Compton CC, Garner WL, Kapanci Y, Gabbiani G: Morphological and immunochemical differences between keloid and hypertrophic scar. Am J Pathol 145:105-113, 1994
44. Vlassara H, Fuh H, Donnelly T, Cybulsky M: Advanced glycation endproducts promote adhesion molecule (VCAM-1, ICAM-1) expression and atheroma formation in normal rabbits. Mol Med 1:447-456, 1995
45. Stitt AW, Li YM, Gardiner TA, Archer DB, Vlassara H: Advanced glycation end products (AGEs) co-localize with AGE receptors in the retinal vasculature of diabetic and of AGE-infused rats. Am J Pathol 150:523-531, 1996
46. Nakamura Y, Horii Y, Nishino T, Shiiki H, Sakaguchi Y, Kagoshima T, Dohl K, Makita Z, Vlassara H, Bucala R: Immunohistochemical localization of advanced glycosylation endproducts (AGEs) in coronary atheroma and cardiac tissue in diabetes mellitus. Am J Pathol 143:1649-1656, 1993
47. O'Brien J, Morrissey PA: Nutritional and toxicological aspects of the Maillard browning reaction in foods. Crit Rev Food Sci Nutr 28:211-248, 1989
48. Pellegrino L, Cattaneo S: Occurrence of galactosyl isomaltol and galactosyl beta-pyranone in commercial drinking milk. Nahrung 45:195-200, 2001
49. Henle T: A food chemist's view of advanced glycation end-products. Perit Dial Int 21 (Suppl. 3):S125-S30, 2001