Intracellular Localization is a Cofactor for the Phototoxicity of Protoporphyrin IX in the Gastrointestinal Tract: In Vitro Study

Photochemistry and Photobiology

Volumn 78, Issue 4, 2003, Pages 393-399

  Krieg, René C ^a   Messmann, Helmut ^b   Schlottmann, Klaus ^c   Endlicher, Esther ^c   Seeger, Stephan ^d   Schölmerich, Jürgen ^c   Knuechel, Ruth ^c,e  

^a NATIONAL CANCER INSTITUTE   (United States)

^b KLINIKUM AUGSBURG   (Germany)

^c UNIVERSITY OF REGENSBURG   (Germany)

^d UNIVERSITY OF ZURICH   (Switzerland)

^e UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOLEVULINIC ACID; DNA FRAGMENT; PHOTOSENSITIZING AGENT; PROTOPORPHYRIN;

APOPTOSIS; BIOLOGICAL MODEL; CANCER CELL CULTURE; CELL DAMAGE; CELL DEATH; CELL DIFFERENTIATION; CELL GROWTH; CELL LEVEL; CELL SPECIFICITY; CELL STRUCTURE; CELLULAR DISTRIBUTION; COLON CARCINOMA; CONFERENCE PAPER; CONTROLLED STUDY; CYTOPATHOGENIC EFFECT; DRUG ACCUMULATION; DRUG DISTRIBUTION; DRUG SELECTIVITY; FIBROBLAST CULTURE; GASTROINTESTINAL TRACT; GASTROINTESTINAL TUMOR; GROWTH INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; MEMBRANE POTENTIAL; MEMBRANE STRUCTURE; MITOCHONDRIAL MEMBRANE; OUTCOMES RESEARCH; PARAMETER; PHOTODYNAMIC THERAPY; PHOTOTOXICITY; PROTEIN INDUCTION; RADIATION DOSE; TUMOR DIFFERENTIATION;

ADENOCARCINOMA; COLONIC NEOPLASMS; DIGESTIVE SYSTEM; HUMANS; PHOTOCHEMOTHERAPY; PHOTOSENSITIZING AGENTS; PROTOPORPHYRINS; TUMOR CELLS, CULTURED;

EID: 0242331751     PISSN: 00318655     EISSN: None     Source Type: Journal    
DOI: 10.1562/0031-8655(2003)078<0393:ILIACF>2.0.CO;2     Document Type: Conference Paper

References (33)

1. Pass, H. I. (1993) Photodynamic therapy in oncology: mechanisms and clinical use. J. Natl. Cancer Inst. 85, 443-456.
2. Fisher, A. M. R., A. L. Murphree and C. J. Gomer (1995) Clinical and preclinical photodynamic therapy. Lasers Surg. Med. 17, 2-31.
3. Kennedy, J. C. and R. H. Pottier (1992) Endogenous protoporphyrin IX, a clinical useful photosensitizer for potodynamic therapy. J. Photochem. Photobiol. B: Biol. 14, 275-292.
4. Kenneth, K. W. (1999) Current status of photodynamic therapy of Barrett's esophagus. Gastrointest. Endosc. 49, 20-23.
5. Krieg, R. C., H. Messmann, J. Rauch, S. Seeger and R. Knuechel (2002) Metabolic characterization of tumor cell specific protoporhyrin IX accumulation after exposure to 5-aminolevulinic acid in human colonic cells. Photochem. Photobiol. 76, 518-525.
6. Krieg, R. C., S. Fickweiler, O. S. Wolfbeis and R. Knuechel (2000) Cell-type specific protoporphyrin IX metabolism in human bladder cancer in vitro. Photochem. Photobiol. 72, 226-233.
7. Endlicher, E., R. Knuechel, T. Hauser, R. M. Szeimis, J. Schölmerich and H. Messmann (2001) Endoscopic fluorescence detection of low and high grade dysplasia in Barrett's esophagus using systemic or local 5-aminolevulinic acid sensitisation. Gut 48, 314-319.
8. Messmann, H., R. Knüchel, W. Bäumler, A. Holstege and J. Schölmerich (1999) Endoscopic fluorescence detection of dysplasia in patients with Barrett's esophagus, ulcerative colitis, or adenomatous polyps after 5-aminolevulinic acid-induced protoporphyrin IX sensitization. Gastrointest. Endosc. 49, 97-101.
9. Messmann, H. and R. M. Szeimies (1996) Photodynamische Therapie bei Tumorerkrankungen-Möglichkeiten und Grenzen. Klin. Gegenwart XII 7, 1-17.
10. Leibovitz, A., J. C. Stinson, W. B. McCombs, C. E. McCoy, K. C. Mazur and N. D. Mabry (1976) Classification of human colorectal adenocarcinoma cell lines. Cancer Res. 36, 4562-4569.
11. Thomas, D. R., G. W. Philpott and B. M. Jaffe (1974) Prostaglandin E (PGE) control of cell proliferation in vitro: characteristics of HT-29. J. Surg. Res. 16, 463-465.
12. Fogh, J., J. M. Fogh and T. Orfeo (1977) One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice. J. Natl. Cancer Res. 59, 221-226.
13. He, D., S. Sassa and H. W. Lim (1993) Effect of UVA and blue light on porphyrin biosynthesis on epidermal cells. Photochem. Photobiol. 57, 825-829.
14. Wyld, L., J. L. Burn, M. W. R. Reed and N. J. Brown (1997) Factors affecting aminolaevulinic acid-induced generation of protoporphyrin IX. Br. J. Cancer 76, 705-712.
15. Schlottmann, K. E., E. Gulbins, S. M. Lau and K. M. Coggeshall (1996) Activation of Src-family tyrosine kinases during Fas-induced apoptosis. J. Leukoc. Biol. 60, 546-554.
16. Schlottmann, K., F. P. Wachs, R. C. Krieg, F. Kullmann, J. Scholmerich and G. Rogler (2000) Characterization of bile salt-induced apoptosis in colon cancer cell lines. Cancer Res. 60, 4270-4276.
17. Romeis, B. (1989) Mikroskopische Technik. Urban & Schwarzenberg, Munich.
18. 6(3) or rhodamine 123, is a reliable fluorescent probe to assess Δψ changes in intact cells: implications for studies on mitochondrial functionality during apoptosis. FEBS Lett. 411, 77-82.
19. Rogler, G., R. Daig, E. Aschenbrenner, D. Vogl, K. Schlottmann, W. Falk, V. Gross, J. Scholmefich and T. Andus (1998) Establishment of long-term primary cultures of human small and large intestinal epithelial cells. Lab. Investig. 78, 889-890.
20. Henderson, B. W. and T. J. Dougherty (1992) How does photodynamic therapy work? Photochem. Photobiol. 55, 145-157.
21. Riccheli, F., G. Jori, G. Moreno, F. Vinzens and C. Salet (1990) Factors influencing the distribution pattern of porphyrins in cell membranes. J. Photochem. Photobiol. B: Biol. 6, 69-77.
22. Borst, P., R. Evers, M. Kool and J. Wijnholds (2000) A family of drug transporters: the multidrug resistance-associated proteins. J. Natl. Cancer Inst. 92, 1295-1302.
23. Miyashita, T. and J. C. Reed (1993) Bcl-2 oncoprotein blocks chemotherapy-induced apoptosis in a human leukemia cell line. Blood 81, 151-157.
24. Moan, J. and K. Berg (1991) The photodegradation of porphyrins can be used to estimate the lifetime of singlet oxygen. Photochem. Photobiol. 53, 49-53.
25. Wilson, B. C., M. Olivo and G. Singh (1997) Subcellular localization of Photofrin® and aminolevulinic acid and photodynamic cross-resistance in vitro in radiation-induced fibrosarcoma cells sensitive or resistant to Photofrin-mediated photodynamic therapy. Photochem. Photobiol. 65, 166-176.
26. Willingham, M. C. (1999) Cytochemical methods for the detection of apoptosis. J. Histochem. Cytochem. 47, 1101-1109.
27. Darzynkiewicz, Z., G. Juan, X. Li, W. Gorczyca, T. Murakami and F. Traganos (1997) Cytometry in cell necrobiology: analysis of apoptosis and accidental cell death (necrosis). Cytometry 27, 1-20.
28. Walker, R. P., L. Kokileva, J. LeBlanc and M. Sikorska (1993) Detection of the initial stages of DNA fragmentation in apoptosis. Biotechniques 15, 1032-1036.
29. Duvall, E. and A. H. Willey (1986) Death and the cell. Immunol. Today 7, 115-119.
30. Margaron, P., R. Sorrenti and J. G. Levy (1997) Photodynamic therapy inhibits cell adhesion without altering integrin expression. Biochim. Biophys. Acta 1359, 200-210.
31. Runnels, J. M., N. Chen, B. Ortel, D. Kato and T. Hasan (1999) BPD-MA-mediated photosensitization in vitro and in vivo: cellular adhesion and beta1 integrin expression in ovarian cancer cells. Br. J. Cancer 80, 946-953.
32. Luna, M. C., A. Ferrario, S. Wong, A. M. Fisher and C. J. Gomer (2000) Photodynamic therapy-mediated oxidative stress as a molecular switch for the temporal expression of genes ligated to the human heat shock promoter. Cancer Res. 60, 1637-1644.
33. Verwanger, T., G. Schnitzhofer and B. Krammer (1998) Expression kinetics of the (proto)oncogenes c-myc and bcl-2 following photodynamic treatment of normal and transformed human fibroblasts with 5-aminolaevulinic acid-stimulated endogenous protoporphyrin IX. J. Photochem. Photobiol. B: Biol. 45, 131-135.