Metabolic characterization of tumor cell-specific protoporphyrin IX accumulation after exposure to 5-aminolevulinic acid in human colonic cells

Photochemistry and Photobiology

Volumn 76, Issue 5, 2002, Pages 518-525

  Krieg, René C ^a   Messmann, Helmut ^b   Rauch, Joachim ^b   Seeger, Stefan ^c   Knuechel, Ruth ^b  

^a NATIONAL CANCER INSTITUTE   (United States)

^b UNIVERSITY OF REGENSBURG   (Germany)

^c UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOLEVULINIC ACID; CARBON 14; FERROCHELATASE; IRON; PORPHOBILINOGEN DEAMINASE; PROTOPORPHYRIN; TRANSFERRIN RECEPTOR;

ARTICLE; CANCER CELL CULTURE; CELL STRAIN CACO 2; CELL STRAIN HT29; COLON ADENOCARCINOMA; CONTROLLED STUDY; DRUG EXPOSURE; DRUG METABOLISM; DRUG SELECTIVITY; DRUG UPTAKE; ENDOSCOPY; FIBROBLAST; FLUORESCENCE; GASTROINTESTINAL CARCINOMA; HUMAN; HUMAN CELL; KINETICS; MITOCHONDRION; MUCOSA; PORPHYRIN METABOLISM; STROMA CELL; TUMOR CELL;

ADENOCARCINOMA; AMINOLEVULINIC ACID; CELL LINE, TUMOR; COLONIC NEOPLASMS; DOSE-RESPONSE RELATIONSHIP, DRUG; FIBROBLASTS; HUMANS; IRON; LIGHT; MITOCHONDRIA; PHOTOCHEMOTHERAPY; PHOTOSENSITIZING AGENTS; PROTOPORPHYRINS; RECEPTORS, TRANSFERRIN; SPECTROMETRY, FLUORESCENCE;

EID: 0036877640     PISSN: 00318655     EISSN: None     Source Type: Journal    
DOI: 10.1562/0031-8655(2002)076<0518:MCOTCS>2.0.CO;2     Document Type: Article

References (46)

1. Peng, Q., T. Warloe, K. Berg, J. Moan, M. Kongshaug, K. E. Giercksky and J. M. Nesland (1997) 5-Aminolevulinic acid-based photodynamic therapy: clinical research and future challenges. Cancer 79, 2282-2308.
2. Waidelich, R., A. Hofstetter, H. Stepp, R. Baumgartner, E. Weninger and M. Kriegmair (1998) Early clinical experience with 5-amino-levulinic acid for the photodynamic therapy of upper tract urothelial tumors. J. Urol. 159, 401-404.
3. Gossner, L., M. Stolte, R. Sroka, K. Rick, A. May, E. G. Hahn and C. Ell (1998) Photodynamic ablation of high-grade dysplasia and early cancer in Barrett's esophagus by means of 5-aminolevulinic acid. Gastroenterology 114, 448-455.
4. Peng, Q., K. Berg, J. Moan, M. Kongshaug and J. M. Nesland (1997) 5-aminolevulinic acid-based photodynamic therapy: principles and experimental research. Photochem. Photobiol. 65, 235-251.
5. Marti, A., N. Lange, H. van den Bergh, D. Sedmera, P. Jichlinski and P. Kucera (1999) Optimisation of the formation and distribution of protoporphyrin IX in the urothelium: an in vitro approach. J. Urol. 162, 546-552.
6. Zaak, D., M. Kriegmair, H. Stepp, H. Stepp, R. Baumgartner, R. Oberneder, P. Schneede, S. Corvin, D. Frimberger, R. Knuchel and A. Hofstetter (2001) Endoscopic detection of transitional cell carcinoma with 5-aminolevulinic acid: results of 1012 fluorescence endoscopies. Urology 57, 690-694.
7. Baumgartner, R., R. M. Huber, H. Schulz, H. Stepp, K. Rick, F. Gamarra, A. Leberig and C. Roth (1996) Inhalation of 5-aminolevulinic acid: a new technique for fluorescence detection of early stage lung cancer. J. Photochem. Photobiol. B: Biol. 36, 169-174.
8. Messmann, H. (2000) 5-Aminolevulinic acid-induced protoporphyrin IX for the detection of gastrointestinal dysplasia. Gastrointest. Endosc. Clin. N. Am. 10, 497-512.
9. Endlicher, E., R. Knuechel, T. Hauser, R. M. Szeimis, J. Schölmerich and H. Messmann (2001) Endoscopic fluorescence detection of low and high grade dysplasia in Barrett's esophagus using systemic or local 5-aminolevulinic acid sensitisation. Gut 48, 314-319.
10. Endlicher, E., P. Rümmele, F. Hausmann, R. Krieg, R. Knüchel, H. C. Rath, J. Schölmerich and H. Messmann (2001) Protoporphyrin IX distribution following local application of 5-aminolevulinic acid and its esterified derivatives in the tissue layers of the normal rat colon. Br. J. Cancer 85, 1572-1576.
11. Gederaas, O. A., K. Berg and I. Romslo (2000) A comparative study of normal and reverse phase high pressure liquid chromatography for analysis of porphyrins accumulated after 5-aminolevulinic acid treatment of colon adenocarcinoma cells. Cancer Lett. 150, 205-213.
12. Hinnen, P., F. W. M. de Rooij, E. M. Terlouw, A. Edixhoven, H. van Dekken, R. van Hillegersberg, H. W. Tilanus, J. H. P. Wilson and P. D. Siersema (2000) Porphyrin biosynthesis in human Barrett's oesophagus and adenocarcinoma after ingestion of 5-aminolevulinic acid. Br. J. Cancer 83, 539-543.
13. Krieg, R. C., S. Fickweiler, O. S. Wolfbeis and R. Knüchel (2000) Cell-type specific protoporphyrin LX metabolism in human bladder cancer in vitro. Photochem. Photobiol. 72, 226-233.
14. Rud, E., O. Gederaas, A. Høgset and K. Berg (2000) 5-aminolevulinic acid, but not 5-aminolevulinic acid esters, is transported into adenocarcinoma cells by system BETA transporters. Photochem. Photobiol. 71, 640-647.
15. Gibson, S. L., N. L. Nguyen, J. J. Havens, A. Barbarin and R. Hilf (1999) Relationship of δ-aminolevulinic acid-induced protoporphyrin IX levels to mitochondrial content in neoplastic cells in vitro. Biochem. Biophys. Res. Commun. 265, 315-321.
16. Hill, R., J. J. Havens and S. L. Gibson (1999) Effect of δ-amino-levulinic acid on protoporphyrinn IX accumulation in tumor cells transfected with plasmids containing porphobilinogen deaminase DNA. Photochem. Photobiol. 70, 334-340.
17. Hinnen, P., F. W. M. de Rooij, M. L. F. van Velthuysen, A. Edixhofen, R. van Hillegersberg, H. W. Tilanus, J. H. P. Wilson and P. D. Siersema (1998) Biochemical basis of 5-aminolevulinic acid-induced protoporphyrin IX accumulation: a study in patients with (pre)malignant lesions of the oesophagus. Br. J. Cancer 78, 679-682.
18. Steinbach, P., M. Kriegmair, R. Baumgartner, F. Hofstädter and R. Knüchel (1994) Intravesical instillation of 5-aminolevulinic acid: the fluorescence is limited to urothelial cells. Urology 44, 676-681.
19. Alcaraz, A., M. A. Barranco, M. J. Corral, M. J. Ribal, A. Carrio, C. Mallofre, J. Llopis, A. Cetina and R. Alvarez-Vijande (2001) High-grade prostate intraepithelial neoplasia shares cytogenetic alterations with invasive prostate cancer. Prostate 47, 29-35.
20. Waldmann, F. M., S. DeVries, K. L. Chew, D. H. Moore, K. Kerlikowske and B. M. Ljung (2000) Chromosomal alterations in ductal carcinomas in situ and their in situ recurrences. J. Natl. Cancer Inst. 92, 313-320.
21. Métivier, D., B. Dallaporta, N. Zamzami, N. Larochette, S. A. Susin and G. Kroemer (1998) Cytofluorometric detection of mitochondrial alterations in early CD95/Fas/APO-1-triggered apoptosis of Jurkat T lymphoma cells. Comparison of seven mitochondrion-specific fluorochromes. Immunol. Lett. 61, 157-163.
22. Wilson, B. C., M. Olivo and G. Singh (1997) Subcellular localization of photofrin® and aminolevulinic acid and photodynamic cross-resistance in vitro in radiation-induced fibrosarcoma cells sensitive or resistant to photofrin-mediated photodynamic therapy. Photochem. Photobiol. 65, 166-176.
23. Leibovitz, A., J. C. Stinson, W. B. McCombs, C. E. McCoy, K. C. Mazur and N. D. Mabry (1976) Classification of human colorectal adenocarcinoma cell lines. Cancer Res. 36, 4562-4569.
24. Thomas, D. R., G. W. Philpott and B. M. Jaffe (1974) Prostaglandin E (PGE) control of cell proliferation in vitro: characteristics of HT-29. J. Surg. Res. 16, 463-465.
25. Fogh, J., J. M. Fogh and T. Orfeo (1977) One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice. J. Natl. Cancer Res. 59, 221-226.
26. Iinuma, S., S. S. Farshi, B. Ortel and T. Hasan (1994) A mechanistic study of cellular photodestruction with 5-aminolevulinic acid-induced porphyrin. Br. J. Cancer 70, 21-28.
27. Gaullier, J. M., K. Berg, Q. Peng, H. Anholt, P. K. Selbo and J. Moan (1997) The use of 5-aminolevulinic acid esters to improve photodynamic therapy on cells in culture. Cancer Res. 57, 1481-1486.
28. He, D., S. Sassa and H. W. Lim (1993) Effect of UVA and blue light on porphyrin biosynthesis on epidermal cells. Photochem. Photobiol. 57, 825-829.
29. Wyld, L., J. L. Burn, M. W. R. Reed and N. J. Brown (1997) Factors affecting aminolaevulinic acid-induced generation of protoporphyrin IX. Br. J. Cancer 76, 705-712.
30. Messmann, H., M. Geisler, U. Gross, C. Abels, R. M. Szeimies, P. Steinbach, R. Knuchel, M. Doss, J. Scholmerich and A. Holstege (1997) Influence of a haematoporphyrin derivative on the protoporphyrin IX synthesis and photodynamic effect after 5-aminolaevulinic acid sensitization in human colon carcinoma cells. Br. J. Cancer 76, 878-883.
31. Ortel, B., N. Chen, G. P. Dotto, E. Maytin and T. Hasan (1998) Differentiation-specific increase in ALA-induced protoporphyrin IX accumulation in primary mouse keratinocytes. Br. J. Cancer 77, 1744-1751.
32. Rud, E. and K. Berg (1998) Characterisation of the cellular uptake of 5-aminolevulinic acid. Proc. SPIE 3563, 28-37.
33. 2+ release sites in oligodendrocyte processes. J. Biol. Chem. 272, 22654-22661.
34. Groß, U., K. Jacob, M. Frank and M. O. Doss (1997) Haem precursors and PBG in erythrocytes and lymphocytes of patients with acute intermittent porphyria. Cell. Mol. Biol. 43, 29-35.
35. Berg, K., H. Anholt, O. Bech and J. Moan (1996) The influence of iron chelators on the accumulation of protoporphyrin IX in 5-aminolevulinic acid-treated cells. Br. J. Cancer 74, 688-697.
36. Lauber, K. (1980) Bestimmung von eisen im serum: methodenvergleich teepol/dithionit/bathophenanthrolin gegen guanidin/ascorbinsäure/ferrozin, J. Clin. Chem. Clin. Biochem. 18, 147-148.
37. Carter, P. (1971) Spectrophotometric determination of serum iron at the submicrogram level with a new reagent (ferrozine). Anal. Biochem. 40, 450-458.
38. Brockhoff, G., F. Hofstädter and R. Knüchel (1994) Flow cytometric detection and quantitation of the epidermal growth factor receptor in comparison to scatchard analysis in human bladder carcinoma cell lines. Cytometry 17, 75-83.
39. Rogler, G., R. Daig, E. Aschenbrenner, D. Vogl, K. Schlottmann, W. Falk, V. Gross, J. Scholmerich and T. Andus (1998) Establishment of long-term primary cultures of human small and large intestinal epithelial cells. Lab. Investig. 78, 889-890.
40. Knuechel, R., A. Siebert-Wellnhofer, O. Traub and R. Dermietzel (1996) Connexin expression and intercellular communication in two-and three-dimensional in vitro cultures of human bladder carcinoma. Am. J. Pathol. 149, 1321-1332.
41. Steinbach, P., H. Weingandt, R. Baumgartner, M. Kriegmair, F. Hofstädter and R. Knüchel (1995) Cellular fluorescence of the endogenous photosensitizer protoporphyrin IX following exposure to 5-aminolevulinic acid. Photochem. Photobiol. 62, 887-895.
42. Gibson, S. L., J. J. Havens, T. Foster and R. Hilf (1997) Time-dependent intracellular accumulation of δ-aminolevulinic acid, induction of porphyrin synthesis and subsequent phototoxicity. Photochem. Photobiol. 65, 416-421.
43. Gederaas, O. A., A. Holroyd, S. B. Brown, D. Vernon, J. Moan and K. Berg (2001) 5-aminolevulinic acid methyl ester transport on amino acid carriers in a human colon adenocarcinoma cell line. Photochem. Photobiol. 73, 164-169.
44. Brunner, H., F. Hausmann, R. C. Krieg, E. Endlicher, R. Knuechel and H. Messmann (2001) The effects of 5-aminolevulinic acid esters on protoporphyrin IX production in human adenocarcinoma cell lines. Photochem. Photobiol. 74, 721-725.
45. Thorstensen, K. and I. Romslo (1990) The role of transferrin in the mechanism of cellular iron uptake. Biochem. J. 271, 1-9.
46. Bottomley, S. S. and U. Muller-Eberhard (1988) Pathophysiology of heme synthesis. Semin. Hematol. 25, 282-202.