Gene expression induced by interleukin-17 in fibroblast-like synoviocytes of patients with rheumatoid arthritis: upregulation of hyaluronan-binding protein TSG-6

Arthritis Research and Therapy

Volumn 5, Issue 4, 2003, Pages

  Kehlen, Astrid ^a   Pachnio, A ^a   Thiele, K ^a   Langner, J ^a  

^a MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

Author keywords

fibroblast like synoviocytes; interleukin 17; rheumatoid arthritis; TSG 6

Indexed keywords

CELL ADHESION MOLECULE; HYALURONIC ACID; INTERLEUKIN 1; INTERLEUKIN 17; INTERLEUKIN 6; INTERLEUKIN 8; TNFAIP6 PROTEIN, HUMAN; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AGED; ARTICLE; BIOSYNTHESIS; CELL CULTURE; CYTOLOGY; DRUG EFFECT; DRUG POTENTIATION; FIBROBLAST; GENETICS; HUMAN; METABOLISM; MIDDLE AGED; RHEUMATOID ARTHRITIS; SYNOVIUM; TRANSACTIVATION; UPREGULATION;

ADULT; AGED; ARTHRITIS, RHEUMATOID; CELL ADHESION MOLECULES; CELLS, CULTURED; DRUG SYNERGISM; FIBROBLASTS; HUMANS; HYALURONIC ACID; INTERLEUKIN-1; INTERLEUKIN-17; INTERLEUKIN-6; INTERLEUKIN-8; MIDDLE AGED; SYNOVIAL MEMBRANE; TRANS-ACTIVATION (GENETICS); TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EID: 0242304091     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/ar762     Document Type: Article

References (43)

1. Firestein GS: Invasive fibroblast-like synoviocytes in rheumatoid arthritis. Passive responders or transformed aggressors?. Arthritis Rheum. 1996, 39: 1781-1790. DOI: 10.1002/art.1780391103
2. Weyand CM, Goronzy JJ: The molecular basis of rheumatoid arthritis. J Mol Med. 1997, 75: 772-785. 10.1007/s001090050167. DOI: 10.1007/s001090050167
3. Breedveld FC: New insights in the pathogenesis of rheumatoid arthritis. J Rheumatol. 1998, 53 (suppl): S3-S7.
4. Feldmann M, Brennan FM, Maini RN: Role of cytokines in rheumatoid arthritis. Annu Rev Immunol. 1996, 14: 397-440. 10.1146/annurev.immunol.14.1.397. DOI: 10.1146/annurev.immunol.14.1.397
5. Feldmann M, Brennan FM, Maini RN: Rheumatoid arthritis. Cell. 1996, 85: 307-310. 10.1016/S0092-8674(00)81109-5. DOI: 10.1016/S0092-8674(00)81109-5
6. Koch AE, Kunkel SL, Strieter RM: Cytokines in rheumatoid arthritis. J Invest Med. 1995, 43: 28-38.
7. Chabaud M, Durand JM, Buchs N, Fossiez F, Page G, Frappart L, Miossec P: Human interleukin-17: a T cell-derived proinflammatory cytokine produced by the rheumatoid synovium. Arthritis Rheum. 1999, 42: 963-970. 10.1002/1529-0131(199905)42:5<963::AID-ANR15>3.0.CO;2-E. DOI: 10.1002/1529-0131(199905)42:5<963::AID-ANR15>3.0.CO;2-E
8. Ziolkowska M, Koc A, Luszczykiewicz G, Ksiezopolska-Pietrzak K, Klimczak E, Chwalinska-Sadowska H, Maslinski W: High levels of IL-17 in rheumatoid arthritis patients: IL-15 triggers in vitro IL-17 production via cyclosporin A-sensitive mechanism. J Immunol. 2000, 164: 2832-2838. DOI: 10.4049/jimmunol.164.5.2832
9. Fossiez F, Djossou O, Chomarat P, Flores-Romo L, Ait-Yahia S, Maat C, Pin JJ, Garrone P, Garcia E, Saeland S, Blanchard D, Gaillard C, Das MB, Rouvier E, Golstein P, Banchereau J, Lebecque S: T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines. J Exp Med. 1996, 183: 2593-2603. 10.1084/jem.183.6.2593. DOI: 10.1084/jem.183.6.2593
10. Yao Z, Painter SL, Fanslow WC, Ulrich D, Macduff BM, Spriggs MK, Armitage RJ: Human IL-17: a novel cytokine derived from T cells. J Immunol. 1995, 155: 5483-5486.
11. Chabaud M, Fossiez F, Taupin JL, Miossec P: Enhancing effect of IL-17 on IL-1-induced IL-6 and leukemia inhibitory factor production by rheumatoid arthritis synoviocytes and its regulation by Th2 cytokines. J Immunol. 1998, 161: 409-414.
12. Chabaud M, Garnero P, Dayer JM, Guerne PA, Fossiez F, Miossec P: Contribution of interleukin 17 to synovium matrix destruction in rheumatoid arthritis. Cytokine. 2000, 12: 1092-1099. 10.1006/cyto.2000.0681. DOI: 10.1006/cyto.2000.0681
13. Dudler J, Renggli-Zulliger N, Busso N, Lotz M, So A: Effect of interleukin 17 on proteoglycan degradation in murine knee joints. Ann Rheum Dis. 2000, 59: 529-532. 10.1136/ard.59.7.529. DOI: 10.1136/ard.59.7.529
14. Jovanovic DV, Martel-Pelletier J, Di Battista JA, Mineau F, Jolicoeur FC, Benderdour M, Pelletier JP: Stimulation of 92-kd gelatinase (matrix metalloproteinase 9) production by interleukin-17 in human monocyte/macrophages: a possible role in rheumatoid arthritis. Arthritis Rheum. 2000, 43: 1134-1144. 10.1002/1529-0131(200005)43:5<1134::AID-ANR24>3.0.CO;2-#. DOI: 10.1002/1529-0131(200005)43:5<1134::AID-ANR24>3.0.CO;2-#
15. Kehlen A, Thiele K, Riemann D, Langner J: Expression, modulation and signalling of IL-17 receptor in fibroblast- like synoviocytes of patients with rheumatoid arthritis. Clin Exp Immunol. 2002, 127: 539-546. 10.1046/j.1365-2249.2002.01782.x. DOI: 10.1046/j.1365-2249.2002.01782.x
16. Bush KA, Farmer KM, Walker JS, Kirkham BW: Reduction of joint inflammation and bone erosion in rat adjuvant arthritis by treatment with interleukin-17 receptor IgG1 Fc fusion protein. Arthritis Rheum. 2002, 46: 802-805. 10.1002/art.10173. DOI: 10.1002/art.10173
17. Schwachula A, Riemann D, Kehlen A, Langner J: Characterization of the immunophenotype and functional properties of fibroblast-like synoviocytes in comparison to skin fibroblasts and umbilical vein endothelial cells. Immunobiology. 1994, 190: 67-92. DOI: 10.1016/S0171-2985(11)80284-6
18. Chomczynski P, Sacchi N: Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem. 1987, 162: 156-159. 10.1006/abio.1987.9999. DOI: 10.1016/0003-2697(87)90021-2
19. Bajorath J: Molecular organization, structural features, and ligand binding characteristics of CD44, a highly variable cell surface glycoprotein with multiple functions. Proteins. 2000, 39: 103-111. 10.1002/(SICI)1097-0134(20000501)39:2<103::AID-PROT1>3.3.CO;2-7. DOI: 10.1002/(SICI)1097-0134(20000501)39:2<103::AID-PROT1>3.0.CO;2-G
20. Lee TH, Wisniewski HG, Vilcek J: A novel secretory tumor necrosis factor-inducible protein (TSG-6) is a member of the family of hyaluronate binding proteins, closely related to the adhesion receptor CD44. J Cell Biol. 1992, 116: 545-557. 10.1083/jcb.116.2.545. DOI: 10.1083/jcb.116.2.545
21. Wisniewski HG, Hua JC, Poppers DM, Naime D, Vilcek J, Cronstein BN: TNF/IL-1-inducible protein TSG-6 potentiates plasmin inhibition by inter-alpha-inhibitor and exerts a strong anti-inflammatory effect in vivo. J Immunol. 1996, 156: 1609-1615.
22. Maier R, Wisniewski HG, Vilcek J, Lotz M: TSG-6 expression in human articular chondrocytes. Possible implications in joint inflammation and cartilage degradation. Arthritis Rheum. 1996, 39: 552-559. DOI: 10.1002/art.1780390403
23. Wisniewski HG, Vilcek J: TSG-6: an IL-1/TNF-inducible protein with anti-inflammatory activity. Cytokine Growth Factor Rev. 1997, 8: 143-156. 10.1016/S1359-6101(97)00008-7. DOI: 10.1016/S1359-6101(97)00008-7
24. Wisniewski HG, Burgess WH, Oppenheim JD, Vilcek J: TSG-6, an arthritis-associated hyaluronan binding protein, forms a stable complex with the serum protein inter-alpha-inhibitor. Biochemistry. 1994, 33: 7423-7429. 10.1021/bi00189a049. DOI: 10.1021/bi00189a049
25. Glant TT, Kamath RV, Bardos T, Gal I, Szanto S, Murad YM, Sandy JD, Mort JS, Roughley PJ, Mikecz K: Cartilage-specific constitutive expression of TSG-6 protein (product of tumor necrosis factor alpha-stimulated gene 6) provides a chondroprotective, but not antiinflammatory, effect in antigen-induced arthritis. Arthritis Rheum. 2002, 46: 2207-2218. 10.1002/art.10555. DOI: 10.1002/art.10555
26. Mindrescu C, Dias AA, Olszewski RJ, Klein MJ, Reis LF, Wisniewski HG: Reduced susceptibility to collagen-induced arthritis in DBA/1J mice expressing the TSG-6 transgene. Arthritis Rheum. 2002, 46: 2453-2464. 10.1002/art.10503. DOI: 10.1002/art.10503
27. Hirth A, Skapenko A, Kinne RW, Emmrich F, Schulze-Koops H, Sack U: Cytokine mRNA and protein expression in primary-culture and repeated-passage synovial fibroblasts from patients with rheumatoid arthritis. Arthritis Res. 2002, 4: 117-125. 10.1186/ar391. DOI: 10.1186/ar391
28. Firestein GS, Alvaro-Gracia JM, Maki R, Alvaro-Garcia JM: Quantitative analysis of cytokine gene expression in rheumatoid arthritis. J Immunol. 1990, 144: 3347-3353.
29. Szekanecz Z, Strieter RM, Kunkel SL, Koch AE: Chemokines in rheumatoid arthritis. Springer Semin Immunopathol. 1998, 20: 115-132. 10.1007/BF00832002. DOI: 10.1007/BF00832002
30. Heller RA, Schena M, Chai A, Shalon D, Bedilion T, Gilmore J, Woolley DE, Davis RW: Discovery and analysis of inflammatory disease-related genes using cDNA microarrays. Proc Natl Acad Sci USA. 1997, 94: 2150-2155. 10.1073/pnas.94.6.2150. DOI: 10.1073/pnas.94.6.2150
31. Endo H, Akahoshi T, Takagishi K, Kashiwazaki S, Matsushima K: Elevation of interleukin-8 (IL-8) levels in joint fluids of patients with rheumatoid arthritis and the induction by IL-8 of leukocyte infiltration and synovitis in rabbit joints. Lymphokine Cytokine Res. 1991, 10: 245-252.
32. Unemori EN, Amento EP, Bauer EA, Horuk R: Melanoma growth-stimulatory activity/GRO decreases collagen expression by human fibroblasts. Regulation by C-X-C but not C-C cytokines. J Biol Chem. 1993, 268: 1338-1342.
33. Sekiya I, Colter DC, Prockop DJ: BMP-6 enhances chondrogen-esis in a subpopulation of human marrow stromal cells. Biochem Biophys Res Commun. 2001, 284: 411-418. 10.1006/bbrc.2001.4898. DOI: 10.1006/bbrc.2001.4898
34. Yamamoto N, Furuya K, Hanada K: Progressive development of the osteoblast phenotype during differentiation of osteoprogenitor cells derived from fetal rat calvaria: model for in vitro bone formation. Biol Pharm Bull. 2002, 25: 509-515. 10.1248/bpb.25.509. DOI: 10.1248/bpb.25.509
35. Plant A, Tobias JH: Increased bone morphogenetic protein-6 expression in mouse long bones after estrogen administration. J Bone Miner Res. 2002, 17: 782-790. DOI: 10.1359/jbmr.2002.17.5.782
36. Roivainen A, Pirila L, Yli-Jama T, Laaksonen H, Toivanen P: Expression of the myc-family proto-oncogenes and related genes max and mad in synovial tissue. Scand J Rheumatol. 1999, 28: 314-318. 10.1080/03009749950155517. DOI: 10.1080/03009749950155517
37. Hashiramoto A, Sano H, Maekawa T, Kawahito Y, Kimura S, Kusaka Y, Wilder RL, Kato H, Kondo M, Nakajima H: C-myc antisense oligodeoxynucleotides can induce apoptosis and down-regulate Fas expression in rheumatoid synoviocytes. Arthritis Rheum. 1999, 42: 954-962. 10.1002/1529-0131(199905)42:5<954::AID-ANR14>3.0.CO;2-J. DOI: 10.1002/1529-0131(199905)42:5<954::AID-ANR14>3.0.CO;2-J
38. Kehlen A, Thiele K, Riemann D, Rainov N, Langner J: Interleukin-17 stimulates the expression of IκB α mRNA and the secretion of IL-6 and IL-8 in glioblastoma cell lines. J Neuroimmunol. 1999, 101: 1-6. 10.1016/S0165-5728(99)00111-3. DOI: 10.1016/S0165-5728(99)00111-3
39. Chabaud M, Page G, Miossec P: Enhancing effect of IL-1, IL-17, and TNF-α on macrophage inflammatory protein-3α production in rheumatoid arthritis: regulation by soluble receptors and Th2 cytokines. J Immunol. 2001, 167: 6015-6020. DOI: 10.4049/jimmunol.167.10.6015
40. Lubberts E, Joosten LA, Oppers B, van Den BL, Coenen-De Roo CJ, Kolls JK, Schwarzenberger P, van De Loo FA, van Den Berg WB: IL-1-independent role of IL-17 in synovial inflammation and joint destruction during collagen-induced arthritis. J Immunol. 2001, 167: 1004-1013. DOI: 10.4049/jimmunol.167.2.1004
41. Attur MG, Patel RN, Abramson SB, Amin AR: Interleukin-17 upregulation of nitric oxide production in human osteoarthritis cartilage. Arthritis Rheum. 1997, 40: 1050-1053. DOI: 10.1002/art.1780400609
42. Martel-Pelletier J, Mineau F, Jovanovic D, Di Battista JA, Pelletier JP: Mitogen-activated protein kinase and nuclear factor κB together regulate interleukin-17-induced nitric oxide production in human osteoarthritic chondrocytes: possible role of transactivating factor mitogen-activated protein kinase-activated protein kinase (MAPKAPK). Arthritis Rheum. 1999, 42: 2399-2409. 10.1002/1529-0131(199911)42:11<2399::AID-ANR19>3.0.CO;2-Y. DOI: 10.1002/1529-0131(199911)42:11<2399::AID-ANR19>3.0.CO;2-Y
43. Shalom-Barak T, Quach J, Lotz M: Interleukin-17-induced gene expression in articular chondrocytes is associated with activation of mitogen-activated protein kinases and NF-κB. J Biol Chem. 1998, 273: 27467-27473. 10.1074/jbc.273.42.27467. DOI: 10.1074/jbc.273.42.27467