TSG-6 expression in human articular chondrocytes: Possible implications in joint inflammation and cartilage degradation

Arthritis and Rheumatism

Volumn 39, Issue 4, 1996, Pages 552-559

  Maier, Rainer ^a   Wisniewski, Hans Georg ^b   Vilcek, Jan ^b   Lotz, Martin ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIPLASMIN; DEXAMETHASONE; HYALURONIC ACID BINDING PROTEIN; INTERLEUKIN 1BETA; PLATELET DERIVED GROWTH FACTOR AA; PROTEIN KINASE C; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR STIMULATED GENE 6; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ARTHRITIS; ARTICLE; BONE REMODELING; CARTILAGE CELL; CONTROLLED STUDY; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; HUMAN TISSUE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

CARTILAGE, ARTICULAR; CELL ADHESION MOLECULES; CELLS, CULTURED; CYTOKINES; GROWTH SUBSTANCES; HUMANS; RNA, MESSENGER; SIGNAL TRANSDUCTION; TIME FACTORS; UP-REGULATION;

EID: 0029936595     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/art.1780390403     Document Type: Article

References (42)

1. Verbruggen G, Veys EM: Biological Regulation of the Chondrocytes: Regulation of Chondrocytes in Rheumatoid Arthritis. Edited by M Adolphe. Boca Raton, FL, CRC Press, Inc., 1992
2. Malemud CJ, Hering TM: Biological Regulation of the Chondrocytes: Regulation of Chondrocytes in Osteoarthrosis. Edited by M Adolphe. Boca Raton, FL, CRC Press, Inc., 1992
3. Neame PJ, Barry FP: The link proteins. Experientia 49:393-402, 1993
4. Lee GM, Johnstone B, Jacobson K, Caterson B: The dynamic structure of the pericellular matrix on living cells. J Cell Biol 123:1899-1907, 1993
5. Handley CJ, Ng CK: Biological Regulation of the Chondrocytes: Proteoglycan, Hyaluronan, and Noncollagenous Matrix Protein Metabolism by Chondrocytes. Edited by M Adolphe. Boca Raton, FL, CRC Press, Inc., 1992
6. Madsen K, Moskalewski S, von der Mark K, Friberg U: Synthesis of proteoglycans, collagen and elastin by cultures of rabbit articular chondrocytes - relation to age of the donor. Dev Biol 96:63-73, 1983
7. Thonar EJ, Buckwalter JA, Kuettner KE: Maturation related differences in the structure and composition of proteoglycans synthesized by chondrocytes from bovine articular cartilage. J Biol Chem 261:2467-2474, 1986
8. Plaas A, Sandy JD: Age-related decrease in the link-stability of proteoglycan aggregates formed by articular chondrocytes. Biochem J 220:337-340, 1984
9. Sandy JD, Barrach HJ, Flannery CR, Plaas A: The biosynthetic response of mature chondrocytes in early osteoarthritis. J Rheumatol 14:16-19, 1987
10. Santer V, White RJ, Roughley PJ: Proteoglycans from normal and degenerate cartilage of the adult human tibial plateau. Arthritis Rheum 24:691-700, 1981
11. Hardingham T, Bayliss M: Proteoglycans of articular cartilage: changes in aging and joint disease. Semin Arthritis Rheum 20:12-33, 1990
12. Roughley PJ, White RJ: Age-related changes in the structure of the proteoglycan subunits from human articular cartilage. J Biol Chem 255:217-224, 1980
13. Mort JS, Poole AR, Roughley PJ: Age-related changes in the structure of proteoglycan link proteins present in normal human articular cartilage. Biochem J 214:269-272, 1983
14. Lee TH, Wisniewski HG, Vilcek J: A novel secretory tumor necrosis factor-inducible protein (TSG-6) is a member of the family of hyaluronate binding proteins, closely related to the adhesion receptor CD44. J Cell Biol 116:545-550, 1992
15. Wisniewski HG, Maier R, Lotz M, Lee S, Klampfer L, Lee TH, Vilcek J: TSG-6: a TNF-, IL-1-, and LPS-inducible secreted glycoprotein associated with arthritis. J Immunol 151:6593-6601, 1993
16. Wisniewski H-G, Burgess WH, Oppenheim JD, Vilcek J: TSG-6, an arthritis-associated hyaluronan binding protein, forms a stable complex with the serum protein inter-α-inhibitor. Biochemistry 33:7432-7439, 1994
17. Wisniewski HG, Hua JC, Poppers DM, Naime D, Vilcek J, Cronstein BN: TNF/IL-1-inducible protein TSG-6 potentiates plasmin inhibition by inter-α-inhibitor and exerts a strong antiinflammatory effect in vivo. J Immunol 156:1609-1617, 1996
18. Blanco F, Geng Y, Lotz M: Differentiation-dependent effects of IL-1 and TGFβ on human articular chondrocyte proliferation are related to iNOS expression. J Immunol 154:4018-4026, 1995
19. Chomczynski P, Sacchi N: Single step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156-159, 1987
20. Maniatis T, Fritsch EF, Sambrook J: Molecular Cloning: A Laboratory Manual. Cold Spring Harbor, NY, Cold Spring Harbor Laboratory Press, 1982
21. Danielson PE, Forss-Petter S, Brow MA, Calavetta L, Douglass J, Milner RJ, Sutcliffe JG: p1B 15: a CDNA clone of the rat mRNA encoding cyclophilin. DNA 7:261-267, 1988
22. Maier R, Ganu V, Lotz M: Interleukin-11, an inducible cytokine in human articular chondrocytes and synoviocytes, stimulates the production of the tissue inhibitor of metalloproteinases. J Biol Chem 268:21527-21532, 1993
23. Laemmli UK: Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-685, 1970
24. Wilbrink B, Nietfeld JJ, den Otter W, van Roy JL, Bijlsma JW, Huber-Bruning O: Role of TNF alpha, in relation to IL-1 and IL-6 in the proteoglycan turnover of human articular cartilage. Br J Rheumatol 30:265-271, 1991
25. Hardingham TE, Bayliss MT, Rayan V, Noble DP: Effects of growth factors and cytokines on proteoglycan turnover in articular cartilage. Br J Rheumatol 1:1-6, 1992
26. Shinmei M, Masuda K, Kikuchi T, Shimomura Y, Okada Y: Production of cytokines by chondrocytes and its role in proteoglycan degradation. J Rheumatol [Suppl 27]:89-91, 1991
27. Lee TH, Lee GW, Ziff EB, Vilcek J: Isolation and characterization of eight tumor necrosis factor-induced gene sequences from human fibroblasts. Mol Cell Biol 10:1982-1988, 1990
28. Pelletier JP, DiBattista JA, Roughley P, McCollum R, Martel-Pelletier J: Cytokines and inflammation in cartilage degradation. Rheum Dis Clin North Am 19:545-568, 1993
29. Chu CQ, Field M, Allard S, Abney E, Feldmann M, Maini RN: Detection of cytokines at the cartilage/pannus junction in patients with rheumatoid arthritis: implications for the role of cytokines in cartilage destruction and repair. Br J Rheumatol 31:653-661, 1992
30. Guerne PA, Carson DA, Lotz M: Interleukin-6 (IL-6) production by human articular chondrocytes: modulation of its synthesis by cytokines, growth factors and hormones in vitro. J Immunol 144:499-505, 1990
31. Harvey AK, Stack ST, Chandrasekhar S: Differential modulation of degradative and repair responses of interleukin-1-treated chondrocytes by platelet-derived growth factor. Biochem J 292:129-136, 1993
32. Schafer SJ, Luyten FP, Yanagishita M, Reddi AH: Proteoglycan metabolism is age related and modulated by isoforms of platelet-derived growth factor in bovine articular cartilage explant cultures. Arch Biochem Biophys 302:431-438, 1993
33. Lotz M, Moats T, Villiger PM: Leukemia inhibitory factor is expressed in cartilage and synovium and can contribute to the pathogenesis of arthritis. J Clin Invest 90:888-896, 1992
34. Feng P, Liau G: Identification of a novel serum and growth factor-inducible gene in vascular smooth muscle cells. J Biol Chem 268:9387-9392, 1993
35. Van Beuningen HM, van der Kraan PM, Arntz OJ, van den Berg WB: Protection from interleukin 1 induced destruction of articular cartilage by transforming growth factor beta: studies in anatomically intact cartilage in vitro and in vivo. Ann Rheum Dis 52:185-191, 1993
36. Rédini F, Mauviel A, Pronost S, Loyau G, Pujol J-P: Transforming growth factor β exerts opposite effects from interleukin-1β on cultured rabbit articular chondrocytes through reduction of interleukin-1 receptor expression. Arthritis Rheum 36:44-50, 1993
37. Chandrasekhar S, Harvey AK, Stack ST: Degradative and repair responses of cartilage to cytokines and growth factors occur via distinct pathways. Agents Actions Suppl 39:121-125, 1993
38. Harvey AK, Hrubey PS, Chandrasekhar S: Transforming growth factor-beta inhibition of interleukin-1 activity involves down-regulation of interleukin-1 receptors on chondrocytes. Exp Cell Res 195:376-385, 1991
39. Pujol JP, Galera P, Redini F, Mauviel A, Loyau G: Role of cytokines in osteoarthritis: comparative effects of interleukin 1 and transforming growth factor-beta on cultured rabbit articular chondrocyies. J Rheumatol [Suppl 27]:76-79, 1991
40. Seid JM, Rahman S, Graveley R, Bunning RAD, Nordmann R, Wishart W, Russell RG: The effect of interleukin-1 on cytokine gene expression in cultured human articular chondrocytes analyzed by messenger RNA phenotyping. Arthritis Rheum 36:35-43, 1993
41. Becker A, Sandson J: The source of the inter-alpha trypsin inhibitor in pathologic hyaluronateprotein. Arthritis Rheum 14:764-766, 1971
42. Poole AR: Cartilage in health and disease. In, Arthritis and Allied Conditions. Edited by DJ McCarty and WJ Koopman. Philadelphia, Lea & Febiger, 1993