The molecular basis of rheumatoid arthritis

Journal of Molecular Medicine

Volumn 75, Issue 11-12, 1997, Pages 772-785

  Weyand, Cornelia M ^{a,b,d,e,f,g,h}   Goronzy, Jörg J ^{a,c,d,e,f,g,h}  

^a MAYO CLINIC   (United States)

^b UNIVERSITY OF BONN   (Germany)

^c RWTH AACHEN UNIVERSITY   (Germany)

^d GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^e HANNOVER MEDICAL SCHOOL   (Germany)

^f STANFORD UNIVERSITY   (United States)

^g MAYO CLINIC COLLEGE OF MEDICINE   (United States)

^h MAYO GRADUATE SCHOOL   (United States)

Author keywords

Genetic susceptibility; HLA; Pathogenesis; Rheumatoid arthritis; T cells

Indexed keywords

AUTOIMMUNITY; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; HLA SYSTEM; HUMAN; INFLAMMATORY DISEASE; LYMPHOCYTE PROLIFERATION; PATHOGENESIS; REVIEW; RHEUMATOID ARTHRITIS; SYNOVIUM; T LYMPHOCYTE;

EID: 0030825959     PISSN: 09462716     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001090050167     Document Type: Review

References (87)

1. Nocton JJ, Steere AC (1995) Lyme disease. Adv Intern Med 40:69-117
2. Burmester GR, Daser A, Kamradt T, Krause A, Mitchison NA, Sieper J, Wolf N (1995) Immunology of reactive arthritides. Annu Rev Immunol 13:229-250
3. Nishioka K, Sumida T, Hasunuma T (1996) Human T lymphotropic virus type I in arthropathy and autoimmune disorders. Arthritis Rheum 39:1410-1418
4. Nakajima T, Aono H, Hasunuma T, Yamamoto K, Maruyama I, Nosaka T, Hatanaka M, Nishioka K (1993) Overgrowth of human synovial cells driven by the human T cell leukemia virus type I tax gene. J Clin Invest 92:186-193
5. Stransky G, Vernon J, Aicher WK, Moreland LW, Gay RE, Gay S (1993) Virus-like particles in synovial fluids from patients with rheumatoid arthritis. Br J Rheumat 32:1044-1048
6. Ashton-Rickardt PG, Tonegawa S (1994) A differential-avidity model for T cell selection. Immunol Today 15:362-366
7. Von Boehmer H (1994) Positive selection of lymphocytes. Cell 76:219-228
8. Germain RN (1994) major histocompatibility complex-dependent antigen processing and peptide presentation: providing ligands for T lymphocyte activation. Cell 76:287-299
9. Cremer MA, Ye XJ, Terato K, Owens SW, Seyer JM, Kang AH (1994) Type XI collagen-induced arthritis in the Lewis rat. Characterization of cellular and humoral immune responses to native types XI, V, and II collagen and constituent alpha-chains. J Immunol 153:824-832
10. Nabozny GH, Baisch JM, Cheng S, Cosgrove D, Griffiths MM, Luthra HS, David CS (1996) HLA-DQ8 transgenic mice are highly susceptible to collagen-induced arthritis: a novel model for human polyarthritis. J Exp Med 183:27-37
11. Erlandsson H, Mussener A, Klareskog L, Gold DP (1994) Restricted T cell receptor usage in DA rats during early collagen-induced arthritis. Eur J Immunol 24:1929-1932
12. Goodacre JA, Middleton S, Lynn S, Ross DA, Pearson J (1993) Human cartilage aggrecan CS1 region contains cryptic T-cell recognition sites. Immunol 78:586-591
13. Buzas EI, Brennan FR, Mikecz K, Garzo M, Negroiu G, Hollo K, Cs-Szabo G, Pintye E, Giant TT (1995) A proteoglycan (aggrecan)-specific T cell hybridoma induces arthritis in BALB/c mice. J Immunol 155:2679-2687
14. Stastny P (1978) Association of the B-cell alloantigen DRw4 with rheumatoid arthritis. New Engl J Med 298:869-871
15. Gregersen PK, Silver J, Winchester RJ (1987) The shared epitope hypothesis. Arthritis Rheum 30:1205-1213
16. Nepom GT, Nepom BS (1992) Prediction of susceptibility to rheumatoid arthritis by human leukocyte antigen genotyping. Rheum Dis Clin North Am 18:785-792
17. Winchester R (1994) The molecular basis of susceptibility to rheumatoid arthritis. Adv Immunol 56:389-466
18. Stamenkovic I, Stegagno M, Wright KA, Krane SM, Amento EP, Colvin RB, Duquesnoy RJ, Kurnick JT (1988) Clonal dominance among T-lymphocyte infiltrates in arthritis. Proc Natl Acad Sci USA 85:1179-1183
19. Duby AD, Sinclair AK, Osborne-Lawrence SL, Zeldes W, Kan L, Fox DA (1989) Clonal heterogeneity of synovial fluid T lymphocytes from patients with rheumatoid arthritis. Proc Natl Acad Sci USA 86:6206-6210
20. Keystone EC, Minden M, Klock R, Poplonski L, Zalcberg J, Takadera T, Mak TW (1988) Structure of T cell antigen receptor β chain in synovial fluid cells from patients with rheumatoid arthritis. Arthritis Rheum 31:1555-1557
21. Paliard X, West SG, Lafferty JA, Clements JR, Kappler JW, Marrack P, Kotzin BL (1991) Evidence for the effects of a superantigen in rheumatoid arthritis. Science 253:325-329
22. Howell MD, Diveley JP, Lundeen KA, Esty A, Winters ST, Carlo DJ, Brostoff SW (1991) Limited T cell receptor β-chain heterogeneity among IL-2 receptor-positive synovial T cells suggests a role for superantigen in rheumatoid arthritis. Proc Natl Acad Sci USA 88:10921-10925
23. Uematsu Y, Wege H, Straus A, Ott M, Bannwarth W, Lanchbury J, Panayi G, Steinmetz M (1991) The T-cell-receptor repertoire in the synovial fluid of a patient with rheumatoid arthritis is polyclonal. Proc Natl Acad Sci USA 88:8534-8538
24. Williams WV, Fang Q, Demarco D, VonFeldt J, Zurier RB, Weiner DB (1992) Restricted heterogeneity of T cell receptor transcripts in rheumatoid synovium. J Clin Invest 90:326-33
25. Jenkins RN, Nikaein A, Zimmermann A, Meek K, Lipsky PE (1993) T cell receptor Vβ gene bias in rheumatoid arthritis. J Clin Invest 92:2688-2701
26. Goronzy JJ, Weyand CM (1993) Interplay of T lymphocytes and HLA-DR molecules in rheumatoid arthritis. Curr Opin Rheumatol 5:169-177
27. Struyk L, Hawes GE, Chatila MK, Breedveld FC, Kurnick JT, van den Elsen PJ (1995) T cell receptors in rheumatoid arthritis. Arthritis Rheum 38:577-589
28. - expression undergo clonal expansion and express shared T cell receptor sequences in rheumatoid arthritis. J Mol Med 2:608-618
29. Meyer JM, Han J, Singh R, Moxley G (1996) Sex influences on the penetrance of HLA shared-epitope genotypes for rheumatoid arthritis. Am J Hum Genet 58:371-383
30. Lynn AH, Kwoh CK, Venglish CM, Aston CE, Chakravarti A (1995) Genetic epidemiology of rheumatoid arthritis. Am J Hum Genet 57:150-159
31. Schmidt D, Goronzy JJ, Weyand CM (1995) A male and a female pattern in rheumatoid arthritis. Arthritis Rheum 38:S289 (816)
32. Weyand CM, Schönberger J, Oppitz U, Hunder NNH, Hicok KC, Goronzy JJ (1994) Distinct vascular lesions in giant cell arteritis share identical T cell clonotypes. J Exp Med 179:951-960
33. Martinez-Taboada V, Hunder NNH, Hunder GG, Weyand CM, Goronzy JJ (1996) Recognition of tissue residing antigen by T cells in vasculitic lesions of giant cell arteritis. J Mol Med 74:695-703
34. Wagner AD, Björnsson J, Bartley GB, Goronzy JJ, Weyand CM (1996) Interferon gamma producing T cells in giant cell vasculitis represent a minority of tissue infiltrating cells and are located distant from the site of pathology. Am J Pathol 148:1925-1933
35. Gonzalez-Quintial R, Baccala R, Pope RM, Theofilopoulos AN (1996) Identification of clonally expanded T cells in rheumatoid arthritis using a sequence enrichment nuclease assay. J Clin Invest 97:1335-1343
36. Ikeda Y, Masuko K, Nakai Y, Kato T, Hasanuma T, Yoshino SI, Mizushima Y, Nishioka K, Yamamoto K (1996) High frequencies of identical T cell clonotypes in synovial tissues of rheumatoid arthritis patients suggest the occurrence of common antigen-driven immune responses. Arthritis Rheum 39: 446-453
37. Rittner HL, Zettl A, Klimiuk P, Jendro JC, Bartz-Bazzanella P, Goronzy JJ, Weyand CM, (1997) Multiple mechanisms support oligoclonal T cell expansion in rheumatoid synovitis. Mol Med (in press)
38. Geiler T, Kriegsmann J, Keyszer GM, Gay RE, Gay S (1994) A new model for rheumatoid arthritis generated by engraftment of rheumatoid synovial tissue and normal human cartilage into SCID mice. Arthritis Rheum 37:1664-1671
39. Simon AK, Seipelt E, Sieper J (1994) Divergent T-cell cytokine patterns in inflammatory arthritis. Proc Natl Acad Sci USA 91:8562-8566
40. Dolhain RJ, ter Haar NT, Hoefakker S, Tak PP, de Ley M, Claassen E, Breedveld FC, Millenburg AM (1996) Increased expression of interferon (IFN)-gamma together with IFN-gamma receptor in the rheumatoid synovial membrane compared with synovium of patients with osteoarthritis. Br J Rheumatol 35:24-32
41. Isomaki P, Luukkainen R, Saario R, Toivanen P, Punnonen J (1996) Interleukin-10 functions as an antiinflammatory cytokine in rheumatoid synovium. Arthritis Rheum 39:386-395
42. van Roon JA, van Roy JL, Gmelig-Meyling FH, Lafeber FP, Bijlsma JW (1996) Prevention and reversal of cartilage degradation in rheumatoid arthritis by interleukin-10 and interleukin-4. Arthritis Rheum 39:829-835
43. McInnes IB, al-Mughales J, Field M, Leung BP, Huang FP, Dixon R, Sturrock RD, Wilkinson PC, Liew FY (1996) The role of interleukin-15 in T-cell migration and activation in rheumatoid arthritis. Nature Med 2:175-182
44. Deleuran BW, Chu CQ, Field M, Brennan FM, Mitchell T, Feldmann M, Maini RN (1992) Localization of tumor necrosis factor receptors in the synovial tissue and cartilage-pannus junction in patients with rheumatoid arthritis. Implications for local actions of tumor necrosis factor alpha. Arthritis Rheum 35:1170-1178
45. Maini RN, Elliolt MJ, Brennan FM, Williams RO, Chu CQ, Paleolog E, Charles PJ, Taylor PC, Feldmann M (1995) Monoclonal anti-TNF alpha antibody as a probe of pathogenesis and therapy of rheumatoid disease. Immunol Rev 144:195-223
46. Elliott MJ, Maini RN, Feldmann M, Kalden JR, Antoni C, Smolen JS, Leeb B, Breedveld FC, Macfarlane JD, Bijl H et al (1994) Randomised double-blind comparison of chimeric monoclonal antibody to tumour necrosis factor alpha (cA2) versus placebo in rheumatoid arthritis. Lancet 344:1105-1110
47. Baumgartner S, Moreland LW, Schiff MH, Tindall F, Fleischmann RM, Weaver A, Ettlinger RE, Gruber BL, Katz RS, Skosey JL. Lies RB, Robison A, Blosch CM (1996) Double-blind, placebo-controlled trial of tumor necrosis factor receptor (p80) fusion protein (TNFR-Fc) in active rheumatoid arthritis. Arthritis Rheum 39:S74(283)
48. Carson DA, Chen PP, Fox RI et al (1987) Rheumatoid factors and immune networks. Ann Rev Immunol 5:109-126
49. Randen I, Thompson KM, Pascual V et al (1992) Rheumatoid factor V genes from patients with rheumatoid arthritis are diverse and show evidence of an antigen-driven response. Immunol Rev 128:49-71
50. Lanzavecchia A (1990) Receptor-mediated antigen uptake and its effect on antigen presentation to class II-restricted T lymphocytes. Annu Rev Immunol 8:773-793
51. Carson DA, Chen PP, Kipps TJ (1991) New roles for rheumatoid factor. J Clin Invest 87:379-383
52. Tighe H, Chen PP, Tucker R et al (1993) Function of B cells expressing a human immunoglobulin M rheumatoid factor autoantibody in transgenic mice. J Exp Med 177:109-118
53. He X, Goronzy JJ, Weyand CM (1992) Selective induction of rheumatoid factors by superantigens and human helper T cells. J Clin Invest 89:673-680
54. + rheumatoid factor producing B cells by the staphylococcal enterotoxin D. Inlernatl Immunol 7:425-434
55. He X, Goronzy JJ, Zhong W, Xie C, Weyand CM (1995) VH3-21 B cells escape from a slate of tolerance in rheumatoid arthritis and secrete rheumatoid factor. Mol Med 1:768-780
56. Goronzy JJ, Weyand CM (1995) T cells in rheumatoid arthritis - paradigms and facts. Rheum Dis Clin North Am 21:655-674
57. Albani S, Keystone EC, Nelson JL, Oilier WE, La Cava A, Montemayor AC, Weher DA, Montecucco C, Martini A, Carson DA (1995) Positive selection in autoimmunity: abnormal immune responses to a bacterial dnaJ antigenic determinant in patients with early rheumatoid arthritis. Nat Med 1:448-452
58. Walser-Kuntz DR, Weyand CM, Weaver AJ, O'Fallon WM, Goronzy JJ (1995) Mechanisms underlying the formation of the T cell receptor repertoire in rheumatoid arthritis. Immunity 2:597-605
59. Firestein GS, Nguyen K, Aupperle K, Lwin A, Yeo M, Zvaifler NJ (1996) p53 overexpression in rheumatoid arthritis (RA) synovial tissue (ST). Arthritis Rheum 39:S118(547)
60. Krammer PH, Dhein J, Walczak H, Behrmann I, Mariani S, Matiba B, Fath M, Daniel PT, Knipping E, Westendorp MO et al (1994) The role of APO-1-mediated apoptosis in the immune system. Immunol Rev 142:175-191
61. Watanabe-Fukunaga R, Brunnan CI, Copeland NG, Jenkins NA, Nagata S (1992) Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature 356:314-317
62. Lynch DH, Watson ML, Alderson MR, Baum PR, Miller RE, Tough T, Gibson M, Davis-Smith T, Smith CA, Hunter K, Bhat D, Din W, Goodwill RG, Seldin MF (1994) The mouse Fas-ligand gene is mutated in gld mice and is part of a TNF family gene cluster. Immunity 1:131-136
63. + T cells in rheumatoid arthritis. J Clin Invest 94:2068-2076
64. + T cell expansions in the peripheral blood of rheumatoid arthritis patients. J Exp Med 177:1623-1631
65. + T cell expansions in normal individuals and patients with rheumatoid arthritis. J Immunol 154:3538-3547
66. Porcelli S, Yockey CE, Brenner MB, Balk SP (1993) Analysis of T cell antigen receptor (TCR) expression by human peripheral blood CD4 8 α/β T cells demonstrates preferential use of several Vβ genes and invariant TCR α chain. J Exp Med 178:1-16
67. Posneu DN, Sinha R, Kabak S, Russo C (1994) Clonal populations of T cells in normal elderly humans: the T cell equivalent to "benign monoclonal siammapathy" J Fxp Med 179: 609-618
68. Waase I, Kayser C, Carlson PJ, Goronzy JJ, Weyand CM (1996) Oligoclonal T cell proliferation in patients with rheumatoid arthritis and their unaffected siblings. Arthritis Rheum 39:904-913
69. + CD7 CD28 T cells are expanded in rheumatoid arthritis and are characterized by autoreactivity. J Clin Invest 97:2027-2037
70. Linsley PS, Ledbetter JA (1993) The role of the CD28 receptor during T cell responses to antigen. Annu Rev Immunol 11:191-212
71. Boise EH, Minn AJ, Noel PJ, June CH, Accavitti MA, Lindsten T, Thompson CB (1995) CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-XL. Immunity 3:87-98
72. Park W, Weyand CM, Schmidt D, Goronzy JJ (1997) Costimulatory pathways controlling activation and peripheral tolerance of human CD4+CD28 T cells. Eur J Immunol 27:1082-1098
73. Behar SM, Roy C, Brenner MB (1994) Autoreactive Vα12 CD8 T cells are clonally expanded in rheumatoid arthritis. Arthritis Rheum 37:S313(911)
74. Jendro MC, Ganten T, Matteson EL, Weyand CM, Goronzy JJ (1995) Emergence of oligoclonal T cell populations following therapeutic T cell depletion in rheumatoid arthritis. Arthritis Rheum. 38:1242-1251
75. Kouskoff V, Korganow A-S, Duchatelle V, Degott C, Benoist C, Mathis D (1996) Organ-specific disease provoked by systemic autoimmunity. Cell 87:811-822
76. + T cells in severe rheumatoid arthritis. Arthritis Rheum (in press)
77. Weyand CM, Goronzy JJ (1997) Pathogenesis of rheumatoid arthritis. Med Clin North Am 81:29-55
78. Weyand CM, Xie C, Goronzy JJ (1992) Homozygosity for the HLA-DRB1 allele selects for extra-articular manifestations in rheumatoid arthritis. J Clin Invest 89:2033-2039
79. Weyand CM, Hicok KC, Conn DL, Goronzy JJ (1992) The influence of HLA-DRB1 genes on disease severity in rheumatoid arthritis. Ann Intern Med 117:801-806
80. Weyand CM, McCarthy TG, Goronzy JJ (1995) Correlation between disease phenotype and genetic heterogeneity in rheumatoid arthritis. J Clin Invest 95:2120-2126
81. Weyand CM, Goronzy JJ (1994) HLA molecules in rheumatoid arthritis - time for a paradigm shift. Rev Rhum 61:337-342
82. Cornélis F, Fauré S, Martinez M, Fritz P, Dib C, Prud'homme JF, Tran TH, Delaye A, Prince N, Lefevre C, Thomas G, Poirier M, Soubigou S, Alibert O, Lasbleiz S, Fouix S, Lioté F, Loste MN, Lepage V, Charron D, Gyapay G, Kuntz D, Bardin T, Weissenbach J for the European Rheumatoid Arthritis Family Study (1996) Systematic screening of the entire genome in rheumatoid arthritis families reveals 3 major susceptibility loci. Arthritis Rheum 39:S73(280)
83. Bali D, Gourley IS, Kostyu D, Bruce I, Bell A, Goel N, Zhu D, Amos C, Seldin MF (1996) Genetic analysis of multiplex rheumatoid arthritis families. Arthritis Rheum 39:573(279)
84. McDermott M, Kastner DL, Holloman JD, Schmidt-Wolf G, Lundberg AS, Sinha AA, Hsu C, Cashin P, Molloy MG, Mulcahy B, O'Gara F, McConnell FI, Adams C, Khan MA, Wolfe F, Rubin LA, Clegg DO, Husebye D, Amos CI, Ward RH, McDevitt HO (1995) The role of T cell receptor beta chain genes in susceptibility to rheumatoid arthritis. Arthritis Rheum 38:91-95
85. Mu H, Charmley P, King MC, Criswell LA (1996) Synergy between T cell receptor beta gene polymorphism and HLA-DR4 in susceptibility to rheumatoid arthritis. Arthritis Rheum 39:931-937
86. Mulcahy B, Waldron-Lynch F, McDermott MF, Adams C, Amos CI, Zhu DK, Ward RH, Clegg DO, Shanahan F, Molloy MG, O'Gara F (1996) Genetic variability in the tumor necrosis factor-lymphotoxin region influences susceptibility to rheumatoid arthritis. Am J Human Genet 59:676-683
87. Hajeer AH, Worthington J, Silman AJ, Ollier WE (1996) Association of tumor necrosis factor microsatellite polymorphisms with HLA-DRB1*04-bearing haplotypes in rheumatoid arthritis patients. Arthritis Rheum 39:1109-1114