Antiinflammatory properties of mycophenolate mofetil in murine endotoxemia: inhibition of TNF-α and upregulation of IL-10 release

International Journal of Immunopharmacology

Volumn 21, Issue 9, 1999, Pages 581-587

  Durez, Patrick ^a   Appelboom, Thierry ^a   Pira, Chantal ^a   Stordeur, Patrick ^a   Vray, Bernard ^a   Goldman, Michel ^a  

^a ERASME HOSPITAL   (Belgium)

Author keywords

IL 10; LPS; Mycophenolate mofetil; NO; TNF

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; IMMUNOSUPPRESSIVE AGENT; INTERLEUKIN 10; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; NITRIC OXIDE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; ENDOTOXEMIA; INTRAPERITONEAL DRUG ADMINISTRATION; LETHALITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; SEPTIC SHOCK;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ENDOTOXEMIA; IMMUNOSUPPRESSIVE AGENTS; INTERLEUKIN-10; LIPOPOLYSACCHARIDES; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MYCOPHENOLIC ACID; NITRIC OXIDE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0032838201     PISSN: 01920561     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0192-0561(99)00037-5     Document Type: Article

References (23)

1. Sollinger H.W. US renal transplant mycophenolate mofetil study group: mycophenolate mofetil for the prevention of acute rejection in primary cadaveric renal allograft recipients. Transplantation. 60:1995;225-232.
2. Allison A.C., Eugui E.M. Immunosuppressive and other effects of mycophenolic acid and an ester prodrug, mycophenolate mofetil. Immunol. Rev. 136:1993;5-28.
3. Sintchak M.D., Fleming M.A., Futer O., Raybuck S.A., Chambers S.P., Caron P.R., Murko M.A., Wilson K.P. Structure and mechanism of inosine monophosphate dehydrogenase in complex with the immunosuppressant mycophenolic acid. Cell. 85:1996;921-930.
4. Schiff M. Emerging treatments for rheumatoid arthritis. Am. J. Med. 102:(1A):1997;11S-15S.
5. Green K., Wagner D., Glogowski J., Skipper P., Wishnock J., Tannenbaum S. Analysis of nitrate, nitrite and (15N) nitrate in biological fluids. Annal. Biochem. 126:1982;131-138.
6. Aono K., Isobe K., Kiuchi K., Fan Z., Ito M., Takeuchi A., Miyachi M., Nakashima I., Nimura Y. In vitro and in vivo expression of inducible nitric oxide synthase during experimental endotoxemia: involvement of other cytokines. J. Cell. Biochem. 65:1997;349-358.
7. Durez P., Abramowicz D., Gerard C., Van Mechelen M., Amraoui Z., Dubois C., Leo O., Velu T., Goldman M. In vivo induction of interleukin 10 by anti-CD3 monoclonal antibody or bacterial lipopolysaccharide: differential modulation by cyclosporin A. J. Exp. Med. 177:1993;551-555.
8. Gerard C., Bruyns C., Marchant A., Abramowicz D., Vandenabeele P., Delvaux A., Fiers W., Goldman M., Velu T. Interleukin 10 reduces the release of tumor necrosis factor and prevents lethality in experimental endotoxemia. J. Exp. Med. 177:1993;547-550.
9. Fiorentino D.F., Zlotnick T., Mosmann T., Howard M., O'Garra A. IL-10 inhibits cytokine production by activated macrophages. J. Immunol. 147:1991;3815-3822.
10. Beutler B., Milsark I.W., Cerami A.C. Passive immunization against cachectin/tumor necrosis factor protects mice from lethal effect of endotoxin. Science. 229:1985;869-871.
11. Standiford T.J., Strieter R.M., Lukacs N.W., Kunkel S.L. Neutralization of IL-10 increases lethality in endotoxemia. Cooperative effects of macrophage inflammatory protein-2 and tumor necrosis factor. J. Immunol. 155:1995;2222-2229.
12. Marchant A., Bruyns C., Vandenabeele P., Ducarme M., Gerard C., Delvaux A., De Groote D., Abramowicz D., Velu T., Goldman M. Interleukin-10 controls interferon-gamma and tumor necrosis factor production during experimental endotoxemia. Eur. J. Immunol. 24:1994;1167-1171.
13. Szabo C., Hasko G., Nemeth Z.H., Vizi E.S. Calcium entry blockers increase interleukin-10 production in endotoxemia. Shock. 7:1997;304-307.
14. Hasko G., Szabo C., Nemeth Z.H., Lendvai B., Vizi E.S. Modulation by dantrolene of endotoxin-induced interleukin-10, tumour necrosis factor-alpha and nitric oxide production in vivo and in vitro. Br. J. Pharmacol. 124:1998;1099-1106.
15. Nemeth Z.H., Hasko G., Vizi E.S. Pyrrolidine dithiocarbamate augments IL-10, inhibits TNF-alpha, MIP-1 alpha, IL-12, and nitric oxide production and protects from the lethal effect of endotoxin. Shock. 10:1998;49-53.
16. Marchant A., Amraoui Z., Gueydan C., Bruyns C., Lemoine O., Vandenabeele P., Fiers W., Buurman W.A., Goldman M. Methylprednisolone differentially regulates IL-10 and tumour necrosis factor (TNF) production during murine endotoxaemia. Clin. Exp. Immunol. 106:1996;91-96.
17. Mengozzi M., Fantuzzi G., Faggioni R., Marchant A., Goldman M., Orencole S., Clark B.D., Sironi M., Benigni F., Ghezzi P. Chlorpromazine specifically inhibits peripheral and brain TNF production, and up-regulates IL-10 production, in mice. Immunology. 82:1994;207-210.
18. Bourrie B., Bouaboula M., Benoit J.M., Derocq J.M., Esclangon M., Lefur G., Casellas P. Enhancement of endotoxin-induced interleukin-10 production by SR 31747A, a sigma ligand. Eur. J. Immunol. 25:1995;2882-2887.
19. Vanderpoll T., Coyle S.M., Barbosa K., Braxton C.C., Lowry S.F. Epinephrine inhibits tumor necrosis factor-alpha and potentiates interleukin 10 production during human endotoxemia. J. Clin. Invest. 97:1996;713-719.
20. Eigler A., Siegmund B., Emmerich U., Baumann K.H., Hartmann G., Endres S. Anti-inflammatory activities of cAMP-elevating agents: enhancement of IL-10 synthesis and concurrent suppression of TNF production. J. Leukocyte Biol. 63:1998;101-107.
21. Harbrecht B.G., Di Silvio M., Demetris A.J., Simmons R.L., Billiar T.R. Tumor necrosis factor-alpha regulates in vivo nitric oxide synthesis and induces liver injury during endotoxemia. Hepatology. 20:1994;1055-1060.
22. Jacobs F., Chaussabel D., Truyens C., Leclercq V., Carlier Y., Goldman M., Vray B. Interleukin-10 upregulates nitric oxide synthesis by lipopolysaccharide-activated macrophages: improved control of Trypanosoma cruzi infection. Clin. Exp. Immunol. 113:1998;59-64.
23. Romani L., Puccetti P., Mencacci A., Cenci E., Spaccapelo R., Tonnetti L., Grohmann U., Bistoni F. Neutralization of IL-10 up-regulates nitric oxide protection and protects susceptible mice from challenge with Candida albicans. J. Immunol. 152:1994;3514-3521.