Nicotinic Acetylcholine Receptor Distribution in Relation to Spinal Neurotransmission Pathways

Journal of Comparative Neurology

Volumn 467, Issue 1, 2003, Pages 44-59

  Khan, Imran ^a   Osaka, Hitoshi ^a   Stanislaus, Shanaka ^a   Calvo, Rosa M ^a   Deerinck, Tom ^a   Yaksh, Tony L ^a,b   Taylor, Palmer ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b University of California at San Diego   (United States)

Author keywords

Cholinergic neurons; Immunohistochemistry; Neuronal nicotinic receptor subunits; Presynaptic receptors; Primary afferent terminals; Receptor autoradiography; Spinal nicotinic receptor

Indexed keywords

EPIBATIDINE; NICOTINIC RECEPTOR; SYNAPTOPHYSIN;

ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BINDING SITE; CHEMICAL LABELING; IMMUNOHISTOCHEMISTRY; MALE; MOLECULAR WEIGHT; NERVE ENDING; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RABBIT; RAT; RECEPTOR DENSITY; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SENSORY STIMULATION; SPINAL CORD; SPINAL CORD DORSAL HORN; SPINAL CORD VENTRAL HORN; SPINAL GANGLION; TISSUE DISTRIBUTION;

ANIMALS; AUTONOMIC PATHWAYS; AUTORADIOGRAPHY; BICYCLO COMPOUNDS, HETEROCYCLIC; BLOTTING, WESTERN; GANGLIA, SPINAL; IMMUNOHISTOCHEMISTRY; MALE; MOTOR NEURONS; NEURAL PATHWAYS; NEUROGLIA; NICOTINIC AGONISTS; POSTERIOR HORN CELLS; PYRIDINES; RABBITS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, NICOTINIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SPINAL CORD;

EID: 0242300269     PISSN: 00219967     EISSN: None     Source Type: Journal    
DOI: 10.1002/cne.10913     Document Type: Article

References (55)

1. Alkondon M, Pereira EF, Eisenberg HM, Albuquerque EX. 1999. Choline and selective antagonists identify two subtypes of nicotinic acetylcholine receptors that modulate GABA release from CA1 interneurons in rat hippocampal slices. J Neurosci 19:2693-2705.
2. Arroyo-Jimenez MM, Bourgeois J-P, Marubio LM, Le Sourd AM, Ottersen OP, Rinvik E, Fairen A, Changeux J-P. 1999. Ultrastructural localization of the α4-subunit of the neuronal acetylcholine nicotinic receptor in the rat substantia nigra. J Neurosci 19:6475-6487.
3. Azam L, Winzer-Serhan UH, Chen Y, Leslie FM. 2002. Expression of neuronal nicotinic acetylcholine receptor subunit mRNAs within mid-brain dopamine neurons. J Comp Neurol 444:260-274.
4. Bertrand LS. 2001. Neuronal nicotinic receptors: from structure to function. Nicotine Tob Res 3:203-223.
5. Bertrand D, Ballivet M, Rungger D. 1990. Activation and blocking of neuronal nicotinic acetylcholine receptor reconstituted in Xenopus oocytes. Proc Natl Acad Sci U S A 87:1993-1997.
6. Boulter J, Connolly J, Denneris E, Goldman D, Heinemann S, Patrick J. 1987. Functional expression of two neuronal nicotinic acetylcholine receptors from cDNA clones identifies a gene family. Proc Natl Acad Sci U S A 84:7763-7767.
7. Boulter J, O'Shea-Greenfield A, Duvoisin RM, Connolly JG, Wada E, Jensen A, Gardner PD, Ballivet M, Deneris ES, McKinnon D. 1990. α3, α5, and β4: Three members of the rat neuronal nicotinic acetylcholine receptor-related gene family form a gene cluster. J Biol Chem 265:4472-4482.
8. Boyd RT, Jacob MH, McEachern AE, Caron S, Berg DK. 1991. Nicotinic acetylcholine receptor mRNA in dorsal root ganglion neurons. J Neurobiol 22:1-14.
9. Dun SL, Ng YK, Brailoiu GC, Ling EA, Dun NJ. 2002. Cocaine- and amphetamine-regulated transcript peptide-immunoreactivity in adrenergic C1 neurons projecting to the intermediolateral cell column of the rat. J Chem Neuroanat 23:123-132.
10. Elliot KJ, Ellis SB, Berckhan KJ, Urrutia A, Chavez-Noriega LE, Johnson ED, Velicelebli G, Harpold, MM. 1996. Comparative structure of human neuronal α2-α7 and β2-β4 nicotinic acetylcholine receptor subunits and functional expression of the α2, α3, α4, α7, β2 and β4 subunits. J Mol Neurosci 7:217-228.
11. Galzi J-L, Revah F, Bessis A, Changeux J-P. 1991. Functional architecture of the nicotinic acetylcholine receptor: from electric organ to brain. Annu Rev Pharmacol 31:37-72.
12. Genzen JR, Van Cleve W, McGehee DS. 2001. Dorsal root ganglion neurons express multiple nicotinic acetylcholine receptor subtypes. J Neurophysiol 86:773-782.
13. Gotti C, Moretti M, Maggi R, Longhi R, Hanke W, Klinke N, Clementi F. 1997. α7 and α8 nicotinic receptor subtypes immunopurified from chick retina have different immunological, pharmacological and functional properties. Eur J Neurosci 9:1201-1211.
14. Guan Z-Z, Zhang X, Ravid R, Nordberg A. 2000. Decreased protein levels of nicotinic receptor subunits in the hippocampus and temporal cortex of patients with Alzheimer's disease. J Neurochem 74:237-243.
15. Guan Z-Z, Zhang X, Mousavi M, Tian J-Y, Unger C, Nordberg A. 2001. Reduced expression of neuronal nicotinic acetylcholine receptors during the early stages of damage by oxidative stress in PC12 cells. J Neurosci Res 66:551-558.
16. 3 purinoceptor and IB4 binding sites. Eur J Neurosci 11:946-958.
17. Hellstrom J, Arvidsson U, Elde R, Cullheim S, Meister B. 1999. Differential expression of nerve terminal protein isoforms in VAChT-containing varicosities of the spinal cord ventral horn. J Comp Neurol 411:578-590.
18. Keiger CJH, Alker JC. 2000. Individual variation in the expression profiles of nicotinic receptors in the olfactory bulb and trigeminal ganglion and identification of α2, α6, α9, and β3 transcripts. Biochem Pharmacol 59:233-240.
19. Khan IM, Taylor P, Yaksh TL. 1994a. Stimulatory pathways and sites of actions of intrathecally administered nicotinic agonists. J Pharmacol Exp Ther 271:1550-1557.
20. Khan IM, Taylor P, Yaksh TL. 1994b. Cardiovascular and behavioral responses to nicotinic agonists administered intrathecally. J Pharmacol Exp Ther 270:150-158.
21. Khan IM, Yaksh TL, Taylor P. 1994c. Ligand specificity of nicotinic acetylcholine receptors in rat spinal cord: studies with nicotine and cytisine. J Pharmacol Exp Ther 270:159-166.
22. Khan IM, Marsala M, Printz MP, Taylor P, Yaksh TL. 1996a. Intrathecal nicotinic agonist-elicited release of excitatory amino acids as measured by in vivo spinal microdialysis in rats. J Pharmacol Exp Ther 278:97-106.
23. Khan IM, Youngblood KL, Yaksh TL, Printz MP, Taylor P. 1996b. Spinal nicotinic receptor expression in spontaneously hypertensive rats. Hypertension 28:1093-1098.
24. Khan IM, Yaksh TL, Taylor P. 1997. Epibatidine binding sites and activity in the spinal cord. Brain Res 753:269-282.
25. Khan IM, Buerkle H, Taylor P, Yaksh TL. 1998. Nociceptive and antinociceptive responses to intrathecally administered nicotinic agonists. Neuropharmacology 37:1515-1525.
26. Khan IM, Stanislaus S, Zhang L, Taylor P, Yaksh TL. 2001. A-85380 and epibatidine each interact with disparate spinal nicotinic receptor subtypes to achieve analgesia and nociception. J Pharmacol Exp Ther 297:230-239.
27. Khan IM, Singletary E, Alemayehu A, Stanislaus S, Printz MP, Yaksh TL, Taylor P. 2002. Nicotinic receptor gene cluster on rat chromosome 8 in nociceptive and blood pressure hyperresponsiveness. Physiol Genom 11:65-72.
28. Kiyosawa A, Katsurabayashi S, Akaike N, Pang ZP, Akaike N. 2001. Nicotine facilitates glycine release in the rat spinal dorsal horn. J Physiol 536:101-110.
29. Klink R, de Kerchove d'Exaerde A, Zoli M, Changeux J-P. 2001. Molecular and physiological diversity of nicotinic acetylcholine receptors in the midbrain dopaminergic nuclei. J Neurosci 21:1452-1463.
30. Lawand NB, Lu Y, Westlund KN. 1999. Nicotinic cholinergic receptors: potential targets for inflammatory pain relief. Pain 80:291-299.
31. Lena C, d'Exaerde AK, Cordero-Erausquin M, Nicolas N, Arroyo-Jimenez MM, Changeux JP. 1999. Diversity and distribution of nicotinic acetylcholine receptors in the locus ceruleus neurons. Proc Natl Acad Sci U S A 96:12126-12131.
32. Lindstrom J. 2000. The structure of neuronal nicotinic receptors. In: Clementi F, Fornasari D, Gotti C. editors. Neuronal nicotinic receptors. New York: Springer. p 101-162.
33. Lukas RJ, Changeux J-P, Le Novère N, Albuquerque EX, Balfour DJK, Berg DK, Bertrand D, Chiappinelli VA, Clarke PBS, Collins AC, Dani JA, Grady SR, Kellar KJ, Lindstrom JM, Marks MJ, Quik M, Taylor PW, Wonnacott S. 1999. International Union of Pharmacology. XX. Current status of the nomenclature for nicotinic acetylcholine receptors and their subunits. Pharmacol Rev 51:397-401.
34. MacDermott AB, Role LW, Siegelbaum SA. 1999. Presynaptic ionotropic receptors and the control of transmitter release. Annu Rev Neurosci 22:443-485.
35. Madhock TC, Bjercke RJ, Langone JJ, Sharp BM. 1992. Brain nicotinic receptors isolated by a monospecific antibody against a synthetic α3 subunit receptor peptide compared to a monoclonal anti-idiotypic (to nicotine) antibody. Biochem Biophys Res Commun 182:303-1308.
36. Martin-Ruiz CM, Court JA, Molnar E, Lee M, Gotti C, Mamalaki A, Tsouloufis T, Tzartos S, Ballard C, Perry RH, Perry EK. 1999. α4 but not α3 and α7 nicotinic acetylcholine receptor subunits are lost from the temporal cortex in Alzheimer's Disease. J Neurochem 73:1635-1640.
37. Marubio LM, Arroyo-Jimenez MM, Cordero-Erausquin M, Lena C, Novere NL, d'Exaerde AK, Huchet M, Damaj MI, Changeux J-P. 1999. Reduced antinociception in mice lacking neuronal nicotinic receptor subunits. Nature 398:805-810.
38. Mike A, Castro NG, Albuquerque EX. 2000. Choline and acetylcholine have similar kinetic properties of activation and desensitization on the alpha7 nicotinic receptors in rat hippocampal neurons. Brain Res 882:155-168.
39. Ohta M, Kitamoto T, Iwaki T, Ohgami T, Fukui M, Tateishi J. 1993. Immunohistochemical distribution of amyloid precursor protein during normal rat development. Dev Brain Res 75:151-161.
40. Perry DC, Xiao Y, Nguyen HN, Musachio JL, Davila-Garcia MI, Kellar KJ. 2002. Measuring nicotinic receptors with characteristics of α4β2, α3β2 and α3β4 subtypes in rat tissues by autoradiography. J Neurochem 82:68-481.
41. Redmond L, Xie H, Ziskind-Conhaim L, Hockfield S. 1997. Cues intrinsic to the spinal cord determine the pattern and timing of primary afferent growth. Dev Biol 182:205-218.
42. Reuss MH, Reuss S. 2001. Nitric oxide synthase neurons in the rodent spinal cord: distribution, relation to Substance P fibers, and effects of dorsal rhizotomy. J Chem Neuroanat 21:181-196.
43. Ribeiro-Da-Silva A, Cuello AC. 1990. Choline acetyltransferase-immunoreactive profiles are presynaptic to primary sensory fibers in the rat superficial dorsal horn. J Comp Neurol 295:370-384.
44. Rosenberg GA, Cunningham LA, Wallace J, Alexander S, Estrada EY, Grossetete M, Razhagi A, Mille RK, Gearing A. 2001. Immunohistochemistry of matrix metalloproteinases in reperfusion injury to rat brain: activation ofMMP-9 linked to stromelysin-1 and microglia in cell cultures. Brain Res 893:104-112.
45. Sann H, McCarthy PW, Mader M, Schemann M. 1995. Choline acetyltransferase-like immunoreactivity in small diameter neurons of the rat dorsal root ganglion. Neurosci Lett 198:17-20.
46. Schousboe A. 2003. Role of astrocytes in the maintenance and modulation of glutamatergic and GABAergic neurotransmission. Neurochem Res 28:347-352.
47. Sheffield EB, Quick MW, Lester RAJ. 2000. Nicotinic acetylcholine receptor subunit mRNA expression and channel function in medial habenula neurons. Neuropharmacology 39:2591-2603.
48. Stuesse SL, Crisp T, McBurney DL, Schechter JB, Lovell JA, Cruce WLR. 2001. Neuropathic pain in aged rats: behavioral responses and astrocytic activation. Exp Brain Res 137:219-227.
49. Svensson CI, Yaksh TL. 2002. The spinal phospholipase-cyclooxygenase-prostanoid cascade in nociceptive processing. Annu Rev Pharmacol Toxicol 42:553-583.
50. Viseshakul N, Figl A, Lytle C, Cohen BN. 1998. The α4 subunit of rat α4β2 nicotinic receptors is phosphorylated in vivo. Mol Brain Res 59:100-104.
51. Wada E, Wada K, Boulter J, Deneris E, Heinemann S, Patrick J, Swanson LW. 1989. Distribution of alpha2, alpha3, alpha4 and beta2 neuronal nAChR subunit mRNAs in the central nervous system: a hybridization histochemical study in the rat. J Comp Neurol 284:314-335.
52. Wada E, McKinnon D, Heinemann S, Patrick J, Swanson LW. 1990. The distribution of mRNA encoded by a new member of the neuronal nicotinic acetylcholine receptor gene family (α5) in the rat central nervous system. Brain Res 526:45-53.
53. Yaksh TL, Hua XY, Kalcheva I, Nozaki-Taguchi N, Marsala M. 1999. The spinal biology in humans and animals of pain states generated by persistent small afferent input. Proc Natl Acad Sci USA 96:7680-7686.
54. Yeh JJ, Yasuda P, Davila-Garcia MI, Xiao Y, Ebert S, Gupta T, Keller K, Wolfe BB. 2001a. Neuronal nicotinic acetylcholine α3 subunit protein in rat brain and sympathetic ganglion measured using a subunit-specific antibody: regional and ontogenic expression. J Neurochem 77:336-346.
55. Yeh JJ, Ferreira M, Ebert S, Yasuda RP, Kellar KJ, Wolfe BB. 2001b. Axotomy and nerve growth factor regulate levels of neuronal nicotinic acetylcholine receptor α3 subunit in the rat superior cervical ganglion. J Neurochem 79:258-265.