Nicotinic receptor gene cluster on rat chromosome 8 in nociceptive and blood pressure hyperresponsiveness

Physiological Genomics

Volumn 11, Issue , 2003, Pages 65-72

  Khan, Imran M ^a,c   Singletary, Erin ^a   Alemayehu, Adamu ^a   Stanislaus, Shanaka ^a   Printz, Morton P ^a   Yaksh, Tony L ^a,b   Taylor, Palmer ^a  

^a San Diego   (United States)

^b University of California   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Genetics of hypertension; Intrathecal cytisine; Sensory responses; Spinal nicotinic receptor; Spontaneously hypertensive rats

Indexed keywords

CYTISINE; NICOTINIC AGENT; NICOTINIC RECEPTOR; ALKALOID; AZOCINE DERIVATIVE; QUINOLIZINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE; CHROMOSOME 8; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; GENE CLUSTER; HEART RATE; HEMODYNAMICS; NERVOUS SYSTEM; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE TRAIT LOCUS; RAT; RAT STRAIN; STEM CELL; ANIMAL; BROWN NORWAY RAT; CHEMISTRY; CHROMOSOME; CONGENIC STRAIN; DRUG ADMINISTRATION; DRUG EFFECT; DRUG TOLERANCE; FEMALE; GENETICS; HYPERTENSION; INTRASPINAL DRUG ADMINISTRATION; MALE; METABOLISM; MULTIGENE FAMILY; PHYSIOLOGY; SPINAL NERVE; SPONTANEOUSLY HYPERTENSIVE RAT; TAIL; VASCULARIZATION;

ANIMALIA; RODENTIA;

ALKALOIDS; ANIMALS; ANIMALS, CONGENIC; AZOCINES; BLOOD PRESSURE; CHROMOSOMES; DRUG ADMINISTRATION SCHEDULE; DRUG TOLERANCE; FEMALE; HEART RATE; HYPERTENSION; INJECTIONS, SPINAL; MALE; MULTIGENE FAMILY; NICOTINIC AGONISTS; QUINOLIZINES; RATS; RATS, INBRED BN; RATS, INBRED SHR; RECEPTORS, NICOTINIC; SPINAL NERVES; TAIL;

EID: 0037195203     PISSN: 15312267     EISSN: None     Source Type: Journal    
DOI: 10.1152/physiolgenomics.00079.2002     Document Type: Article

References (40)

1. Arneric SP and Holladay MW. Agonists and antagonists of nicotinic acetylcholine receptors. In: Neuronal Nicotinic Receptors, edited by Clementi F, Fornasari D, and Gotti C. New York: Springer-Verlag, 2000, p. 419-453.
2. Boulter J, O'Shea-Greenfield A, Duvoisin RM, Connolly JG, Wada E, Jensen A, Gardner PD, Ballivet M, Deneris ES, and McKinnon D. α3, α5 and β4: three members of the rat neuronal nicotinic receptor form a cluster. J Biol Chem 265: 4472-4482, 1990.
3. Boyd RT, Jacob MH, McEachern AE, Caron S, and Berg DK. Nicotinic acetylcholine receptor mRNA in dorsal root ganglion neurons. J Neurobiol 22: 1-14, 1991.
4. Buccafusco JJ. The role of central cholinergic neurons in the regulation of blood pressure and in experimental hypertension. Pharmacol Rev 48: 179-211, 1996.
5. Carretero OA and Scicli AG. Local hormonal factors (intracrine, autocrine, and paracrine) in hypertension. Hypertension 18, Suppl 3: 158-169, 1991.
6. Flores CM, DeCamp RM, Kilo S, Rogers SW, and Hargreaves M. Neuronal nAChR expression in sensory neurons of the rat trigeminal ganglion: demonstration of α3β4, a novel subtype in the mammalian nervous system. J Neurosci 16: 7892-7901, 1996.
7. Fyodorov D, Nelson T, and Deneris E. Pet-1, a novel ETS domain factor that can activate neuronal nAchR transcription. J Neurobiol 34: 151-163, 1998.
8. Gattu M, Pauly JR, Boss KL, Summers JB, and Buccafusco JJ. Cognitive impairment in spontaneously hypertensive rats: role of central nicotinic receptors. I. Brain Res 771: 89-103, 1997.
9. Hamet P, Pausova Z, Dumas P, Sun YL, Tremblay J, Pravenec M, Kunes J, Krenova D, and Kren V. Newborn and adult recombinant inbred strains: a tool to search for genetic determinants of target organ damage in hypertension. Kidney Int 53: 1488-1492, 1998.
10. Higaki J, Katsuya T, Morishita R, and Ogihara T. Symposium on the etiology of hypertension-summarizing studies in 20th century. 1. Hypertension and genes. Intern Med 40: 144-147, 2001.
11. Keiger CJH and Alker JC. Individual variation in the expression profiles of nicotinic receptors in the olfactory bulb and trigeminal ganglion and identification of α2, α6, α9, and β3 transcripts. Biochem Pharmacol 59: 233-240, 2000.
12. Khan IM, Printz MP, Yaksh TL, and Taylor P. Augmented responses to intrathecal nicotinic agonists in spontaneous hypertension. Hypertension 24: 611-619, 1994.
13. Khan IM, Stanislaus S, Zhang Vaughn L, D, Printz MP, and Taylor P. Spinal nicotinic receptor activity in a genetic model of hypertension. Clin Exp Hypertens 23: 555-568, 2001.
14. Khan IM, Marsala M, Printz MP, Taylor P, and Yaksh TL. Intrathecal nicotinic agonist-elicited release of excitatory amino acids as measured by in vivo spinal microdialysis in rats. J Pharmacol Exp Ther 278: 97-106, 1996.
15. Khan IM, Taylor P, and Yaksh TL. Stimulatory pathways and sites of actions of intrathecally administered nicotinic agonists. J Pharmacol Exp Ther 271: 1550-1557, 1994.
16. Khan IM, Taylor P, and Yaksh TL. Cardiovascular and behavioral responses to nicotinic agonists administered intrathecally. J Pharmacol Exp Ther 270: 150-158, 1994.
17. Khan IM, Yaksh TL, and Taylor P. Epibatidine binding sites and activity in the spinal cord. Brain Res 753: 269-282, 1997.
18. Khan IM, Youngblood KL, Yaksh TL, Printz MP, and Taylor P. Spinal nicotinic receptor expression in spontaneously hypertensive rats, Hypertension 28: 1093-1098, 1996.
19. Kiyosawa A, Katsurabayashi S, Akaike N, Pang ZP, and Akaike N. Nicotine facilitates glycine release in the rat spinal dorsal horn. J Physiol 536: 101-110, 2001.
20. Klink R, de Kerchove d'Exaerde A, Zoli M, and Changeux JP. Molecular and physiological diversity of nicotinic acetylcholine receptors in the midbrain dopaminergic nuclei. J Neurosci 21: 1452-1463, 2001.
21. Kren V, Drenova D, Sedova L, Soda O, Kostka V, Pravenec N, Qui N, St-Lezin E, and Kurtz TW. Detailed mapping of blood pressure QTL on rat chromosome 8 (Abstract). Am J Hypertens 14: 83, 2001.
22. Kren V, Pravenec M, Lu S, Krenova D, Wang JM, Wang N, Merriouns T, Wong A, St Lezin E, Lau D, Szpirer C, Szpirer J, and Kurtz TW. Genetic isolation of a region of chromosome 8 that exerts major effects on blood pressure and cardiac mass in the spontaneously hypertensive rat. J Clin Invest 99: 577-581, 1997.
23. Krushkal J, Ferrell R, Mockrin SC, Turner ST, Sing CF, and Boerwinkle E. Genome-wide linkage analyses of systolic blood pressure using highly discordant siblings. Circulation 99: 1407-1410, 1999.
24. Kubo T, Fukumori R, Kobayashi M, and Yamaguchi H. Enhanced cholinergic activity in the medulla oblongata of DOCA-salt hypertensive and renal hypertensive rats. Hypertens Res 19: 213-219, 1996.
25. Lazartigues E, Brefel-Courbon C, Tran MA, Montastruc JL, and Rascol O. Spontaneously hypertensive rats cholinergic hyper-responsiveness: central and peripheral pharmacological mechanisms. Br J Pharmacol 127: 1657-1665, 1999.
26. Lena C, de Kerchove D'Exaerde A, Cordero-Erausquin M, Le Novere N, del Mar Arroyo-Jimenez M, and Changeux JP. Diversity and distribution of nicotinic acetylcholine receptors in the locus ceruleus neurons. Proc Natl Acad Sci USA 96: 12126-12131, 1999.
27. Lindstrom J. The structure of neuronal nicotinic receptors. In: Neuronal Nicotinic Receptors, edited by Clementi F, Fornasari D, and Gotti C. New York: Springer-Verlag, 2000, p. 101-162.
28. MacDermott AB, Role LW, and Siegelbaum SA. Presynaptic ionotropic receptors and the control of transmitter release. Annu Rev Neurosci 22: 443-485, 1999.
29. McDonough J and Deneris E. β43′: an enhancer displaying neural-restricted activity is located in the 3′-untranslated exon of the rat nicotinic receptor β4 gene. J Neurosci 17: 2273-2283, 1997.
30. McDonough J, Francis N, Miller T, and Deneris ES. Regulation of transcription in the neuronal nicotinic receptor subunit gene cluster by a neuron-selective enhancer and ETS domain factors. J Biol Chem 275: 28962-28970, 2000.
31. McGehee DS, Heath MJS, Gelber S, Devay P, and Role LW. Nicotine enhancement of fast excitatory synaptic transmission in CNS by presynaptic receptors. Science 269: 1692-1696, 1995.
32. McGehee DS. Molecular plasticity of neuronal nicotinic acetylcholine receptors. Ann NY Acad Sci 868: 565-577, 1999.
33. Okamoto K and Aoki K. Development of a strain of spontaneously hypertensive rats. Jpn Circ J 27: 282-293, 1963.
34. Papke RL and Heinemann SF. Partial agonist properties of cytisine on neuronal nicotinic receptors containing the β2 subunit. Mol Pharmacol 45: 142-149, 1994.
35. Rapp JP. Genetic analysis of inherited hypertension in the rat, Physiol Rev 80: 135-172, 2000.
36. Roberts RGD, Stevenson JE, Westerman RA, and Pennefather J. Nicotinic acetylcholine receptors on capsaicin-sensitive nerves. Neuroreport 6: 1578-1582, 1995.
37. Stoll M, Kwitek-Black AE, Cowley AW, Harris EL, Harrap SB, Krieger JE, Printz MP, Provoost AP, Sassard J, and Jacob HJ. New target regions for human hypertension via comparative genomics. Genome Res 10: 473-482, 2000.
38. Wada E, Wada K, Boulter J, Deneris E, Heinemann S, Patrick J, and Swanson LW. Distribution of α2, α3, α4 and β2 neuronal nAChR subunit mRNAs in the central nervous system: A hybridization histochemical study in the rat. J Comp Neurol 284: 314-335, 1989.
39. Wada E, McKinnon D, Heinemann S, Patrick J, and Swanson LW. The distribution of mRNA encoded by a new member of the neuronal nicotinic acetylcholine receptor gene family (α5) in the rat central nervous system. Brain Res 526: 45-53, 1990.
40. Winzer-Serhan UH and Leslie FM. Codistribution of nicotinic acetylcholine receptor subunit α3 and β4 mRNAs during rat brain development. J Comp Neurol 386: 540-554, 1997.