Homocysteine and its relation to B-vitamins in Graves' disease before and after treatment: Effect modification by smoking

Journal of Internal Medicine

Volumn 254, Issue 5, 2003, Pages 504-512

  Nedrebo B G ^a,b,c   Hustad, S ^a   Schneede, J ^a   Ueland, P M ^a   Vollset, S E ^a   Holm, P I ^a,b   Aanderud, S ^b   Lien, E A ^a,b  

^a UNIVERSITY OF BERGEN   (Norway)

^b HAUKELAND UNIVERSITY HOSPITAL   (Norway)

^c HAUGESUND HOSPITAL   (Norway)

Author keywords

Folate; Homocysteine; Hyperthyroidism; Riboflavin; Smoking

Indexed keywords

ANTITHYROID AGENT; CARBIMAZOLE; COBALAMIN; CREATININE; FLAVINE ADENINE NUCLEOTIDE; FLAVINE MONONUCLEOTIDE; FOLIC ACID; HOMOCYSTEINE; LEVOTHYROXINE; PROPYLTHIOURACIL; RIBOFLAVIN; VITAMIN B GROUP;

ADOLESCENT; ADULT; AGE; AGED; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CREATININE BLOOD LEVEL; EUTHYROIDISM; FEMALE; FOLIC ACID BLOOD LEVEL; GRAVES DISEASE; HUMAN; HYPERTHYROIDISM; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; NORWAY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SMOKING;

ADOLESCENT; ADULT; AGED; ANTITHYROID AGENTS; CARBIMAZOLE; CREATININE; FEMALE; FOLIC ACID; GRAVES DISEASE; HOMOCYSTEINE; HUMANS; LONGITUDINAL STUDIES; MALE; MIDDLE AGED; REGRESSION ANALYSIS; RIBOFLAVIN; SMOKING; VITAMIN B 12; VITAMIN B COMPLEX;

EID: 0242288699     PISSN: 09546820     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2796.2003.01222.x     Document Type: Article

References (37)

1. Finkelstein JD. Methionine metabolism in mammals. J Nutr Biochem 1990; 1: 228-37.
2. Nygård O, Vollset SE, Refsum H, Brattström L, Ueland PM. Total homocysteine and cardiovascular disease. J Intern Med 1999; 246: 425-54.
3. Miller JW. Homocysteine. Alzheimer's disease, and cognitive function. Nutrition 2000; 16: 675-7.
4. Vollset SE, Refsum H, Irgens LM et el. Plasma total homocysteine, pregnancy complications, and adverse pregnancy outcomes: the Hordaland Homocysteine study. Am J Clin Nutr 2000; 71: 962-8.
5. Vollset SE, Refsum H, Nygård O, Ueland MP. Lifestyle factors associated with hyperhomocysteinemia. In: Carmel R, Jacobsen DW. eds. Homocysteine in Health and Disease. New York: Cambridge University Press. 2001: 341-55.
6. Nygård O, Refsum H, Ueland PM, Vollset SE. Major lifestyle determinants of plasma total homocysteine distribution: the Hordaland Homocysteine Study. Am J Clin Nutr 1998; 67: 263-70.
7. Hustad S, Ueland PM, Vollset SE, Zhang Y, Bjoørke-Monsen AL, Schneede J. Riboflavin as a determinant of plasma total homocysteine: effect modification by the methylenetetra-hydrofolate reductase C677T polymorphism. Clin Chem 2000; 46: 1065-71.
8. Jacques PF, Kalmbach R, Bagley PJ et al. The relationship between riboflavin and plasma total homocysteine in the Framingham Offspring cohort is influenced by folate status and the C677T transition in the methylenetetrahydrofolate reductase gene. J Nutr 2002; 132: 283-8.
9. McNulty H, McKinley MC, Wilson B et al. Impaired functioning of thermolabile methylenetetrahydrofolate reductase is dependent on riboflavin status: implications for riboflavin requirements. Am J Clin Nutr 2002; 76: 436-41.
10. Nygård O, Vollset SE, Refsum H et al. Total plasma homocysteine and cardiovascular risk profile. The Hordaland Homocysteine Study. JAMA 1995; 274: 1526-33.
11. Mansoor MA, Kristensen O, Hervig T et al. Low concentrations of folate in serum and erythrocytes of smokers: methionine loading decreases folate concentrations in serum of smokers and nonsmokers. Clin Chem 1997; 43: 2192-4.
12. Dastur DK, Quadros EV, Wadia NH, Desai MM, Bharucha EP. Effect of vegetarianism and smoking on vitamin B12, thiocyanate, and folate levels in the blood of normal subjects. Br Med J 1972; 3: 260-3.
13. Linnell JC, Smith AD, Smith CL, Wilson J, Matthews DM. Effects of smoking on metabolism and excretion of vitamin B12. Br Med J 1968; 2: 215-6.
14. Margetts BM, Jackson AA. Interactions between people's diet and their smoking habits: the dietary and nutritional survey of British adults. Br Med J 1993; 307: 1381-4.
15. Friedman AN, Bostom AG, Selhub J, Levey AS, Rosenberg IH. The kidney and homocysteine metabolism. J Am Soc Nephrol 2001; 12: 2181-9.
16. Nedrebø BG, Ericsson UB, Nygård O et al. Plasma total homocysteine levels in hyperthyroid and hypothyroid patients. Metabolism 1998; 47: 89-93.
17. Catargi B, Parrot-Roulaud F, Cochet C, Ducassou D, Roger P, Tabarin A. Homocysteine, hypothyroidism, and effect of thyroid hormone replacement. Thyroid 1999; 9: 1163-6.
18. Hussein WI, Green R, Jacobsen DW, Faiman C. Normalization of hyperhomocysteinemia with L-thyroxine in hypothyroidism. Ann Intern Med 1999; 131: 348-51.
19. Lien EA, Nedrebø BG, Varhaug JE, Nygård O, Aakvaag A, Ueland PM. Plasma total homocysteine levels during short-term iatrogenic hypothyroidism. J Clin Endocrinol Metab 2000; 85: 1049-53.
20. Diekman MJ, der Put NM, Blom HJ, Tijssen JG, Wiersinga WM. Determinants of changes in plasma homocysteine in hyperthyroidism and hypothyroidism. Clin Endocrinol (Oxf) 2001; 54: 197-204.
21. Nedrebø BG, Nygård O, Ueland PM, Lien EA. Plasma total homocysteine in hyper-and hypothyroid patients before and during 12 months of treatment. Clin Chem 2001; 47: 1738-11.
22. Barbé F, Klein M, Chango A et al. Homocysteine, folate, vitamin B12, and transcobalamins in patients undergoing successive hypo-and hyperthyroid states. J Clin Endocrinol Metab 2001; 86: 1845-6.
23. Lien EA, Hustad S, Nedrebø BG, Nygård O, Ueland PM. Total plasma homocysteine in hypo-and hyperthyroidism: covariations and causality. J Clin Endocrinol Metab 2001; 86: 1846.
24. Vestergaard P. Smoking and thyroid disorders - a meta-analysis. Eur J Endocrinol 2002; 146: 153-61.
25. Nedrebø BG, Holm PI, Uhlving S et al. Predictors of outcome and comparison of different drug regimens for the prevention of relapse in patients with Graves disease. Eur J Endocrinol 2002; 147: 583-9.
26. Fiskerstrand T, Refsum H, Kvalheim G, Ueland PM. Homocysteine and other thiols in plasma and urine: automated determination and sample stability. Clin Chem 1993; 39: 263-71.
27. Hustad S, Ueland PM, Schneede J. Quantification of riboflavin, flavin mononucleotide, and flavin adenine dinucleotide in human plasma by capillary electrophoresis and laser-induced fluorescence detection. Clin Chem 1999; 45: 862-8.
28. Molloy AM, Scott JM. Microbiological assay for serum, plasma, and red cell folate using cryopreserved, microtiter plate method. Methods Enzymol 1997; 281: 43-53.
29. Kelleher BP, Broin SD. Microbiological assay for vitamin B12 performed in 96-well microtitre plates. J Clin Pathol 1991; 44: 592-5.
30. Schneede J, Refsum H, Ueland PM. Biological and environmental determinants of plasma homocysteine. Semin Thromb Hemost 2000; 26: 263-79.
31. Rivlin RS. Hormones, drugs and riboflavin. Nutr Rev 1979; 37: 241-5.
32. Lee SS, McCormick DB. Thyroid hormone regulation of flavocoenzyme biosynthesis. Arch Biochem Biophys 1985; 237: 197-201.
33. Selhub J. Homocysteine metabolism. Annu Rev Nutr 1999; 19: 217-46.
34. Ford HC, Carter JM, Rendle MA. Serum and red cell folate and serum vitamin B12 levels in hyperthyroidism. Am J Hematol 1989; 31: 233-6.
35. Nair CP, Viswanathan G, Noronha JM. Folate-mediated incorporation of ring-2-carbon of histidine into nucleic acids: influence of thyroid hormone. Metabolism 1994; 43: 1575-8.
36. Piyathilake CJ, Hine RJ, Dasanayake AP et al. Effect of smoking on folate levels in buccal mucosal cells. Int J Cancer 1992; 52: 566-9.
37. Petridou E, Zavras AI, Lefatzis D et al. The role of diet and specific micronutrients in the etiology of oral carcinoma. Cancer 2002; 94: 2981-8.