Downregulation of PPARγ expression in peripheral blood monocytes correlated with adhesion molecules in acute coronary syndrome

Clinica Chimica Acta

Volumn 336, Issue 1-2, 2003, Pages 19-25

  Zhao, Shui Ping ^a   Li, Yi Fu ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

Acute coronary syndrome; Gene expression; Monocytes; Peroxisome proliferator activated receptor gamma (PPAR )

Indexed keywords

CELL ADHESION MOLECULE; INTERCELLULAR ADHESION MOLECULE 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; CELL RECEPTOR; LIPID; MESSENGER RNA; TRANSCRIPTION FACTOR; VASCULAR CELL ADHESION MOLECULE 1;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE ASSOCIATION; DOWN REGULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HEART MUSCLE ISCHEMIA; HUMAN; HUMAN CELL; LIPID METABOLISM; MALE; MONOCYTE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; ACUTE DISEASE; BIOSYNTHESIS; BLOOD; BODY MASS; CASE CONTROL STUDY; CORONARY ARTERY DISEASE; GENETICS; METABOLISM; MIDDLE AGED; SOLUBILITY; SYNDROME;

ACUTE DISEASE; ADULT; AGED; AGED, 80 AND OVER; BODY MASS INDEX; CASE-CONTROL STUDIES; CORONARY DISEASE; DOWN-REGULATION; FEMALE; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; LIPIDS; MALE; MIDDLE AGED; MONOCYTES; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RNA, MESSENGER; SOLUBILITY; SYNDROME; TRANSCRIPTION FACTORS; VASCULAR CELL ADHESION MOLECULE-1;

EID: 0142247159     PISSN: 00098981     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-8981(03)00290-0     Document Type: Article

References (22)

1. Braissant O., Foufelle F., Scotto C., Dauca M., Wahli W. Differential expression of peroxisome proliferator-activated receptors: tissue distribution of PPARα, β, and γ in the adult rat. Endocrinology. 137:1995;354-366.
2. Mansen A., Guardiola-Diaz H., Rafter J., Branting C., Gustafsson J.A. Expression of the peroxisome proliferator-activated receptor in the mouse colonic mucosa. Biochem. Biophys. Res. Commun. 222:1996;844-851.
3. Nagy L., Tontonoz P., Alvarez J.G., Chen H., Evans R.M. Oxidized LDL regulated macrophage gene expression through ligand activation of PPAR-γ Cell. 93:1998;229-240.
4. Staels B., Koenig W., Habib A., Merval R.et al. Activation of human aortic smooth-muscle cells is inhibited by PPAR-a but not by PPAR-γ activators. Nature. 393:1998;790-793.
5. Marx N., Sukhova G.M., Murphy C., Libby P., Plutzky J. Macrophages in human atheroma contain PPARgamma: differentiation-dependent PPARgamma expression and reduction of MMP-9 activity through PPARgamma activation in mononuclear phagocytes in vitro. Am. J. Pathol. 153:1998;17-23.
6. Ricote M., Huang J., Fajas L.et al. Expression of the peroxisome proliferator-activated receptor γ (PPARgamma) in human atherosclerosis and regulation in macrophages by colony stimulating factors and oxidized low density lipoprotein. Proc. Natl. Acad. Sci. U. S. A. 95:1998;7614-7619.
7. Vamecq J., Latruffe N. PPAR's - their implications in diseases. Cur. Opin. Endocrinol. Diabetes. 7:2000;8-18.
8. Fogelman A.M., Elahi F., Sykes K., Van Lenten B.J., Territo M.C., Berliner J.A. Modification of the Recalde method for the isolation of human monocytes. J. Lipid Res. 29:1988;1243-1247.
9. Dufour V., Arnauld C., Lantz O.et al. Quantification of porcine cytokine gene expression using RT-PCR: a homologous internal control and chemiluminescence for microplate detection. J. Immunol. Methods. 229:1999;49-60.
10. 2+ precipitation procedure for quantification of high-density- lipoprotein cholesterol. Clin. Chem. 28:1982;1379-1388.
11. Gaubatz J.W., Heideman C., Gotto A.M. Jr., Morrisett J.D., Dahlen G.H. Human plasma lipoprotein[a]: structural properties. J Biol Chem. 258:1983;4582-4589.
12. Vamecq J., Latruffe N. Medical significance of peroxisome proliferator-activated receptors. Lancet. 354:1999;141-148.
13. Tontonoz P., Nagy L., Alvarez J.G., Thomazy V.A., Evans R.M. PPARγ promotes monocyte/macrophage differentiation and uptake of oxidized LDL. Cell. 93:1998;241-252.
14. Tontonoz P., Nagy L. Regulation of macrophage gene expression by peroxisome-proliferator- activated receptor gamma: implications for cardiovascular disease. Curr. Opin. Lipidol. 10:1999;485-490.
15. Jiang C., Ting A.T., Seed B. PPARγ agonists inhibit production of monocyte inflammatory cytokines. Nature. 391:1998;82-86.
16. Pasceri V., Wu H.D., Willerson J.T., Yeh E.T. ET modulation of vascular inflammation in vitro and in vivo by peroxisome proliferator-activated receptor-gamma activators. Circulation. 101:2000;235-238.
17. Kamijikkoku S., Murohara T., Tayama S.et al. Acute myocardial infarction and increased soluble intercellular adhesion molecule-1: a marker of vascular inflammation and a risk of early restenosis? Am. Heart J. 136:1998;231-236.
18. Gervois P., Torra I.P., Fruchart J.C., Staels B. Regulation of lipid and lipoprotein metabolism by PPARγ activators. Clin. Chem. Lab. Med. 38:2000;3-11.
19. Itoh H., Doi K., Tanaka T.et al. Hypertension and insulin resistance: role of peroxisome proliferator-activated receptor gamma. Clin. Exp. Pharmacol. Physiol. 26:1999;558-560.
20. Krempler F., Breban D., Oberkofler H.et al. Leptin, peroxisome proliferator-activated receptor-gamma, and CCAAT/enhancer binding protein-alpha mRNA expression in adipose tissue of humans and their relation to cardiovascular risk factors. Arterioscler. Thromb. Vasc. Biol. 20:2000;443-449.
21. Gorla-Bajszczak A., Siegrist-Kaiser C., Boss O., Burger A.G., Meier C.A. Expression of peroxisome proliferator-activated receptors in lean and obese Zucker rats. Eur. J. Endocrin. 142:2000;71-78.
22. Vidal-Puig A.J., Considine R.V., Jimenez-Linan M.et al. Peroxisome proliferator-activated receptor gene expression in human tissues: effects of obesity, weight loss, and regulation by insulin and glucocorticoids. J. Clin. Invest. 99:1997;2416-2422.