Histidine kinase, two-component signal transduction proteins of Candida albicans and the pathogenesis of candidosis

Mycoses, Supplement

Volumn 42, Issue 2, 1999, Pages 49-53

  Calera, J A ^a   Calderone, Richard ^a  

^a GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Candida albicans; Candidosis; Histidin kinases; Pathogenesis; Response regulator proteins; Signaling

Indexed keywords

PROTEIN HISTIDINE KINASE; REGULATOR PROTEIN;

CANDIDA ALBICANS; CANDIDIASIS; CONFERENCE PAPER; FUNGUS CULTURE; FUNGUS GROWTH; FUNGUS HYPHAE; GERMINATION; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

CANDIDA ALBICANS; FUNGI; MURINAE; NEUROSPORA CRASSA; SACCHAROMYCES CEREVISIAE; SCHIZOSACCHAROMYCES POMBE;

EID: 0033503638     PISSN: 09437312     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1439-0507.1999.tb00013.x     Document Type: Conference Paper

References (18)

1. Coleman, D. C., et al. (1993) Oral Candida in HIV infection and AIDS: new perspectives/new approaches. CRC Crit Rev. Microbiol 19, 61-82.
2. Barrett, J. F., & Hoch, J. A. (1998) Two-component signal transduction as a target for microbial anti-infective therapy. Antimicrob Ag Chemother 42, 1529-1536.
3. Barrett, J. F., et al. (1998) Antibacterial agents that inhibit two-component signal transduction systems. Proc Natl Acad Sci (USA) 95, 5317-5322.
4. Uhl, M. A., & Miller, J. F. (1996) Integration of multiple domains in a two-component sensor protein: the Bordetella pertussis BvgAS phosphorelay. EMBO J 15, 1028-1036.
5. Posas, F., & Saito, H. (1998) Activation of the yeast SSK2 MAP kinase kinase by the SSK1 two-component response regulator. EMBO J 17, 1385-1394.
6. Posas, F., et al. (1996) Yeast HOG1 MAP kinase cascade is regulated by a multistep phosphorelay mechanism in the SLN1-YPD1-SSK1 two-component osmosensor. Cell 86, 865-875.
7. Cottarel, G. (1997) Mcs4, a two-component system response regulator homologue, regulates the Schizosaccharomyces pombe cell cycle control. Genetics 147, 1043-1051.
8. Shieh, J. C., et al. (1997) The Mcs4 response regulator coordinately controls the stress-activated Wak1-Wis1-Sty1 MAP kinase pathway and fission yeast cell cycle. Genes Dev 11, 1008-1022.
9. Davie, J. R., et al. (1995) Expression and characterization of branched-chain alpha-ketoacid dehyrogenase kinase from the rat. Is it a histidine - protein kinase? J Biol Chem 270, 19861-19867.
10. Nagahashi, S. et al. (1998) Isolation of CaSLN1 and CaNIK1, the genes for osmosensing histidine kinase homologues, from the pathogenic fungus, Candida albicans. Microbiol 144, 425-432.
11. Alex, L. A., et al. (1998) COS1, a two-component histidine kinase that is involved in hyphal development in the opportunistic pathogen, Candida albicans. Proc Natl Acad Sci (USA) 95, 7069-7073.
12. Srikantha T., et al. (1998) The two-component hybrid kinase regulator CaNIK1 of Candida albicans. Microbiol 144, 2715-2729.
13. Calera, J. A., et al. (1998) Identification of a putative histidine kinase two-component phosphorelay gene (CaHK1) in Candida albicans. Yeast 14, 665-674.
14. Calera, J. A., & Calderone, R. A. (1999) Flocculation of hyphae is associated with a deletion in the putative CaHK1 two-component histidine kinase gene from Candida albicans. Microbiol 145, 1431-1442.
15. Calera, J. A., et al. (1999) Avirulence of Candida albicans CaHK1 mutants in a murine model of hematogenously disseminated candidiasis. Infect Immun 67, 4280-4281.
16. Calera, J. A. & Calderone, R. A. (1999) Identification of a putative response regulator, two-component phosphorelatory gene (CaSSK1) from Candida albicans. Yeast 15, 1243-1251.
17. Calera, J. A., et al. (2000) Defective hyphal formation and avirulence caused by a deletion of the CSSK1 response regulator gene in Candida albicans. Infect Immun 68, in press.
18. Perkins, D. D., et al. (1982) Chromosomal loci of Neurospora crassa. Microbiol Rev 46, 426-570.