Regioselective reduction of N-alkyl-3-sulfonyl glutarimides to δ-lactams. Formal synthesis of (±)-paroxetine and (±)-tacamonine

Tetrahedron

Volumn 59, Issue 47, 2003, Pages 9383-9387

  Chen, Chung Yi ^a   Chang, Bo Rui ^a   Tsai, Min Ruei ^a   Chang, Meng Yang ^b   Chang, Nein Chen ^a  

^a NATIONAL SUN YAT SEN UNIVERSITY   (Taiwan)

^b NATIONAL UNIVERSITY OF KAOHSIUNG   (Taiwan)

Author keywords

Glutarimide; Paroxetine; Regioselective reduction; Tacamonine; lactam

Indexed keywords

1 BENZYL 3 (TOLUENE 4 SULFONYL)PIPERIDIN 2 ONE; 1 BENZYL 4 (4 FLUOROPHENYL) 3 (TOLUENE 4 SULFONYL)PIPERIDIN 2 ONE; 1 BENZYL 4 DIMETHOXYMETHYL 3 (TOLUENE 4 SULFONYL)PIPERIDIN 2 ONE; 1 BENZYL 4 METHYL 3 (TOLUENE 4 SULFONYL)PIPERIDIN 2 ONE; 1 BENZYL 4 PHENYL 3 (TOLUENE 4 SULFONYL)PIPERIDIN 2 ONE; 1 [2 (1H INDOL 3 YL)ETHYL] 3 (TOLUENE 4 SULFONYL)PIPERIDIN 2 ONE; 5 ETHYL 1 [2 (1H INDOL 3 YL)ETHYL] 3 (TOLUENE 4 SULFONYL)PIPERIDIN 2 ONE; ALKALOID DERIVATIVE; GLUTARIMIDE DERIVATIVE; LACTAM DERIVATIVE; PAROXETINE; TACAMONINE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL ANALYSIS; CHEMICAL REACTION; DRUG SYNTHESIS; PRIORITY JOURNAL; REDUCTION; STEREOCHEMISTRY; TECHNIQUE;

EID: 0142246560     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tet.2003.09.076     Document Type: Article

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