Environmentally friendly and efficient: Iron-mediated reduction of 3-methyl-5-aryl-1,2,4-oxadiazoles to benzamidines

Tetrahedron Letters

Volumn 44, Issue 48, 2003, Pages 8697-8700

  Sendzik, Martin ^a   Hui, Hon C ^a  

^a CELERA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDINE; BENZAMIDINE DERIVATIVE; IRON; OXADIAZOLE DERIVATIVE; PLASMINOGEN ACTIVATOR INHIBITOR;

AQUEOUS SOLUTION; ARTICLE; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; REDUCTION;

EID: 0142153447     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2003.09.139     Document Type: Article

References (24)

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12. Unpublished results.
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16. 2 using iron: (a) Desai, D. G.; Swami, S. S.; Hapase, S. B. Synth. Comm. 1999, 29, 1033-1036; (b) Koch, V.; Schnatterer, S. Synthesis 1990, 499-501.
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22. Iron, powder, -325 mesh, 97%; commercially available from Acros Organics.
23. Heating the reaction mixture for 3 days at 50-55°C does not initiate the formation of byproducts.
24. 2-HCl), C, H, N, Cl. Fe detection (Robertson Microlit Laboratories, Inc.)=33 ppm.