Preparation of 2-hydroxybenzamidines from 3-aminobenzisoxazoles

Tetrahedron Letters

Volumn 43, Issue 48, 2002, Pages 8777-8779

  Lepore, Salvatore D ^a   Schacht, Aaron L ^a   Wiley, Michael R ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKENE DERIVATIVE; BENZAMIDINE DERIVATIVE; BROMINE DERIVATIVE; CARBAMIC ACID DERIVATIVE; FUNCTIONAL GROUP; ISOXAZOLE DERIVATIVE; NICKEL CHLORIDE; NITROGEN; OXYGEN; SODIUM DERIVATIVE; ZINC DERIVATIVE;

ARTICLE; CHEMICAL BOND; DEGRADATION; HYDROGENATION; REDUCTION; RING OPENING; STEREOCHEMISTRY;

EID: 0037175480     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(02)02095-6     Document Type: Article

References (23)

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10. We recently reported on a solid phase method for the synthesis of this heterocycle: (a) Lepore, S. D.; Wiley, M. R. J. Org. Chem. 1999, 64, 4547; (b) Lepore, S. D.; Wiley, M. R. J. Org. Chem. 2000, 65, 2924.
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21. 6) δ 167.64, 163.82, 158.78, 142.72, 133.53, 129.72, 124.79, 117.63, 117.13, 115.56. X-ray crystallography also confirms the structure of synthetic material 12. An ORTEP of the X-ray structure is shown below. In the unit cell is also contained 1 molecule of ethanol and the chloride counterion.
22. 6) δ 167.64, 163.82, 158.78, 142.72, 133.53, 129.72, 124.79, 117.63, 117.13, 115.56. X-ray crystallography also confirms the structure of synthetic material 12. An ORTEP of the X-ray structure is shown below. In the unit cell is also contained 1 molecule of ethanol and the chloride counterion.
23. The physical chemical and biological properties of representative 2-hydroxybenzamidienes will be reported separately.