The Cardioprotective Agent Urocortin Induces Expression of CT-1

Cardiovascular Toxicology

Volumn 3, Issue 3, 2003, Pages 255-261

  Janjua, Sadia ^a   Lawrence, Kevin M ^a   Ng, Leong L ^b   Latchman, David S ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

Cardioprotection; Cardiotrophin 1; Gene regulation; Interleukin 6 family cytokines; Urocortin

Indexed keywords

CARDIOTROPHIN 1; CARDIOVASCULAR AGENT; CCAAT ENHANCER BINDING PROTEIN; CORTICOTROPIN RELEASING FACTOR; INTERLEUKIN 6; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; UROCORTIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; GENE ACTIVATION; GENE EXPRESSION; HEART MUSCLE ISCHEMIA; HEART PROTECTION; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN SYNTHESIS; RAT;

ANIMALS; ANOXIA; CELLS, CULTURED; CORTICOTROPIN-RELEASING HORMONE; CYTOKINES; LUCIFERASES; LUMINESCENT MEASUREMENTS; MUTATION; RATS; RATS, SPRAGUE-DAWLEY; RNA;

ANIMALIA;

EID: 0142117326     PISSN: 15307905     EISSN: None     Source Type: Journal    
DOI: 10.1385/CT:3:3:255     Document Type: Article

References (24)

1. Latchman, D.S. (1999). Cardiotrophin-1 (CT-1): A novel hypertrophic and cardioprotective agent. Int. J. Exp. Pathol. 80:189-196.
2. Latchman, D.S. (2000). Cardiotrophin-1 (CT-1): A novel cytokine and its effects in the heart and other tissues. Pharmacol. Ther. 85:29-37.
3. Latchman, D.S. (2001). Urocortin protects against ischemic injury via a MAPK-dependent pathway. Trends Cardiovasc. Med. 11:167-169.
4. Latchman, D.S. (2002). Urocortin. Int. J. Biochem. Cell Biol. 34:907-910.
5. Brar, B.K., Stephanou, A.S., Liao, Z., O'Leary, R.M., Pennica, D., Yellon, D.M., and Latchman, D.S. (2001). Cardiotrophin-1 can protect cardiac myocytes from injury when added both prior to simulated ischaemia and at reoxygenation. Cardiovasc. Res. 51:265-274.
6. Liao, Z., Brar, B.K., Cai, Q., Stephanou, A., O'Leary, R.M., Pennica, D., Yellon, D.M., and Latchman, D.S. (2002). Cardiotrophin-1 can protect the adult heart from injury when added both prior to ischaemia and at reperfusion. Cardiovasc. Res. 53:902-910.
7. Brar, B.K., Jonassen, A.K., Stephanou, A.S., Santilli, G., Railson, J.E., Knight, R.A., Yellon, D.M., and Latchman, D.S. (2000). Urocortin protects against ischemic and reperfusion injury via a MAP-kinase dependent pathway. J. Biol. Chem. 275:8508-8514.
8. Pennica, D., Wood, W.I., and Chien, K.R. (1996). Cardiotrophin-1: A multifunctional cytokine that signals via LIF receptor gp130 Dependent pathways. Cytokine Growth Factor Rev. 7:81-91.
9. Pennica, D., Shaw, K.J., Swanson, T.A., Moore, M.W., Shelton, D.L., Zioncheck, K.A., Rosenthal, A., Taga, T., Paoni, N.F., and Wood, W.I. (1995). Cardiotrophin-1: Biological activities and binding to the leukemia inhibitory factor receptor/gp130 signalling complex. J. Biol. Chem. 270:10915-10922.
10. Vaughan, J., Donaldson, C., Bittencourt, J., Perrin, M. H., Lewis, K., Sutton, S., Chan, R., Turnbull, A. V., Lovejoy, D., and Rivier, C. (1995). Urocortin, a mammalian neuropeptide related to fish urotensin I and to corticotropin-releasing factor. Nature 378:287-292.
11. Kishimoto, T., Pearse, R.V., Lin, C.R., and Rosenfeld, M.G. (1995). A sauvagine/corticotropin-releasing factor receptor expressed in heart and skeletal muscle. Proc. Natl. Acad. Sci. USA 92:1108-1112.
12. Sheng, Z., Knowlton, K., Chen, J., Hoshijima, M., Brown, H., and Chien, K.R. (1997). Cardiotrophin 1 (CT-1) inhibition of cardiac myocyte apoptosis via a mitogen activated protein kinase dependent pathway. J. Biol. Chem. 272:5783-5791.
13. Brar, B.K., Stephanou, A., Pennica, D., and Latchman, D.S. (2001). CT-1 mediated cardioprotection against ischemic reoxygenation injury is mediated by PI3-kinase, Akt and MEK1/2 pathways. Cytokine 16:93-96.
14. Brar, B.K., Stephanou, A., Knight, R., and Latchman, D.S. (2002). Activation of protein kinase B/Akt by urocortin is essential for its ability to protect cardiac cells against hypoxia/reoxygenation-induced cell death. J. Mol. Cell. Cardiol. 34:483-492.
15. Brar, B.K., Railson, J., Stephanou, A., Knight, R.A., and Latchman, D.S. (2002). Urocortin increases the expression of heat shock protein 90 in rat cardiac myocytes in a MEK 1/2-dependent manner. J. Endocrinol. 172:283-293.
16. Railson, J.E., Lawrence, K., Stephanou, A.S., Brar, B.K., Pennica, D., and Latchman, D.S. (2000). Cardiotrophin-1 reduces stress induced heat shock protein production in cardiac myocytes. Cvtokine 12:1741-1744.
17. Ng, L.L., O'Brien, R.J., Demme, B. and Jennings, S. (2002). Non-competitive immunochemiluminometric assay for cardiotrophin-1 detects elevated plasma levels in human heart failure. Clin. Sci. 102:411-416.
18. Field, A. (1998). Discovery Statistics Using SPSS for Windows. Chicago, IL: Sage Publications Ltd.
19. Okosi, A., Brar, B.K., Chan, M., De Souza, L., Smith, E., Stephanou, A.S., Latchman, D.S., Chowdry, H.S., and Knight, R. A. (1998). Expression and protective effects of urocortin in cardiac myocytes. Neuropeptides 32:167-171.
20. Brar, B.K., Stephanou, A.S., Okosi, A., Lawrence, K.M., Knight, R.A., Marber, M.S., and Latchman, D.S. (1999). CRH-like peptides protect cardiac myocytes from lethal ischaemic injury: Mol. Cell. Endocrinol. 158:55-63.
21. Funamoto, M., Hishinuma, S., Fujio, Y., Matsuda, Y., Kunisada, K, Oh, H., Negoro, S., Tone, E., Kishimoto, T., and Yamauchi-Takihara, K. (2000). Isolation and characterisation of the murine cardiotrophin-1 gene: expression and norepinephrine-induced transcriptional activation. J. Mol. Cell. Cardiol. 32:1275-1284.
22. Erdmann, J., Hassfeld, S., Kallisch, H., Fleck, E., and Regitz-Zagrosek, V. (1998). Cloning and characterisation of the 5′-flanking region of the human cardiotrophin-1 gene. Biochem. Biophys. Res. Commun. 244:494-497.
23. Nakajima, T., Kinoshita, S., Sasagawa, T., Sasaki, K., Naruto, M., Kishimoto, T., and Akira, S. (1993). Phosphorylation at threonine-235 by a ras-dependent mitogen activated protein kinase cascade is essential for transcription factor NF-IL6. Proc. Natl. Acad. Sci. USA 90:2207-2211.
24. Lawrence, K.M., Chanalaris, A., Scarabelli, T., Hubank, M., Comini, L., Ferrari, R., Tinker, A., Stephanou, A., Knight, R.A. and Latchman, D.S. (2002). KATP channel gene expression is induced by urocortin and mediates its cardioprotective effect. Circulation 106:1556-1562.