Cardiotrophin-1 reduces stress-induced heat shock protein production in cardiac myocytes

Cytokine

Volumn 12, Issue 11, 2000, Pages 1741-1744

  Railson, Julia ^a   Lawrence, Kevin ^a   Stephanou, Anastasou ^a   Brar, Bhawanjit ^a   Pennica, Diane ^b   Latchman, David ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b GENENTECH INC   (United States)

Author keywords

Antagonism; Cardiac; Cardiocyte; Cardiotrophin 1; Heart; Heat shock protein; Hsp70; Hsp90; Post transcriptional

Indexed keywords

CARDIOTROPHIN 1; DACTINOMYCIN; HEAT SHOCK PROTEIN; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 90; MESSENGER RNA;

ARTICLE; CONTROLLED STUDY; HEART MUSCLE CELL; HEART PROTECTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; RNA SYNTHESIS; SIGNAL TRANSDUCTION; STRESS; TRANSCRIPTION REGULATION;

EID: 0033673337     PISSN: 10434666     EISSN: None     Source Type: Journal    
DOI: 10.1006/cyto.2000.0778     Document Type: Article

References (10)

1. Expression cloning of cardiotrophin 1, a cytokine that induces cardiac myocyte hypertrophy
2. Cardiotrophin-1, Biological activities and binding to the leukemia inhibitory factor receptor/gp130 signaling complex
3. Cardiotrophin-1 displays early expression in the murine heart tube and promotes cardiac myocyte survival
4. Cardiotrophin-1 induces heat shock protein accumulation in cultured cardiac cells and protects them from stressful stimuli
5. Cardiotrophin I (CT-1) inhibition of cardiac myocyte apoptosis via a mitogen-activated protein kinase-dependent pathway. Divergence from downstream CT-1 signals for myocardial cell hypertrophy
6. Heat shock proteins: Protective effect and potential therapeutic use
7. Differentiation of rat myocytes in single cell cultures with and without proliferating nonmyocardial cells. Cross-striations, ultrastructure, and chronotropic response to isoproterenol
8. A technique for radiolabelling DNA restriction endonuclease fragments to high specific activity
9. Distribution free methods
10. The nuclear factor interleukin-6 (NF-IL6) and signal transducer and activator of transcription-3 (STAT-3) signalling pathways co-operate to mediate the activation of the hsp90 beta gene by interleukin-6 but have opposite effects an its inducibility by heat shock