Cannabinoid CB1 receptor inhibition of mechanically evoked responses of spinal neurones in control rats, but not in rats with hindpaw inflammation

European Journal of Pharmacology

Volumn 474, Issue 2-3, 2003, Pages 209-216

  Kelly, Sara ^a   Chapman, Victoria ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

Cannabinoid CB1 receptor; Cannabinoid CB1 receptor agonist, selective; Carrageenan inflammation; Dorsal horn neurone; Spinal cord; Von Frey monofilament

Indexed keywords

AMIDE; ARACHIDONYL 2 CHLOROETHYLAMIDE; CANNABINOID 1 RECEPTOR; CANNABINOID RECEPTOR AGONIST; CANNABINOID RECEPTOR ANTAGONIST; CARRAGEENAN; PYRAZOLE DERIVATIVE; RIMONABANT; SRI 141716 A; UNCLASSIFIED DRUG; ARACHIDONIC ACID DERIVATIVE; ARACHIDONYL-2-CHLOROETHYLAMIDE;

ANALGESIC ACTIVITY; ANESTHESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; ELECTROPHYSIOLOGY; EVOKED SPINAL CORD RESPONSE; IN VIVO STUDY; INFLAMMATION; MALE; MECHANICAL STIMULATION; NOCICEPTIVE STIMULATION; NONHUMAN; PAIN; PRIORITY JOURNAL; RAT; RECEPTOR BLOCKING; SPINAL CORD DORSAL HORN; SPINAL CORD NERVE CELL; ANIMAL; CHEMICALLY INDUCED DISORDER; COMPARATIVE STUDY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG POTENTIATION; EVOKED RESPONSE; HINDLIMB; METABOLISM; METHODOLOGY; NERVE CELL INHIBITION; NONMYELINATED NERVE; PAIN ASSESSMENT; PHYSIOLOGY; POSTERIOR HORN CELL; SPRAGUE DAWLEY RAT; STIMULATION;

ANIMALS; ARACHIDONIC ACIDS; DOSE-RESPONSE RELATIONSHIP, DRUG; EVOKED POTENTIALS; HINDLIMB; INFLAMMATION; MALE; NERVE FIBERS, UNMYELINATED; NEURAL INHIBITION; PAIN MEASUREMENT; PHYSICAL STIMULATION; POSTERIOR HORN CELLS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, CANNABINOID, CB1;

EID: 0142102352     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(03)02085-5     Document Type: Article

References (46)

1. Ackley M.A., Asghar A.U.R., Worsley M.A., King A.E. Peripheral inflammation reduces the response of spinal dorsal horn neurones to an NK3 receptor agonist. Neurosci. Lett. 308:2001;13-16.
2. Ahluwalia J., Urban L., Capogna M., Bevan S., Nagy I. Cannabinoid 1 receptors are expressed in nociceptive primary sensory neurones. Neuroscience. 100:2000;685-688.
3. Ahluwalia J., Urban L., Capogna M., Bevan S., Capogna M., Nagy I. Cannabinoid 1 receptors are expressed by nerve growth factor- and glial cell derived neurotrophic factor-responsive primary sensory neurones. Neuroscience. 110:2002;747-753.
4. Breivogel C.S., Griffin G., Di Marzo V., Martin B.R. Evidence for a new G-protein coupled cannabinoid receptor in mouse brain. Mol. Pharmacol. 60:2001;155-163.
5. Carpenter K.J., Vithlani M., Dickenson A.H. Unaltered peripheral excitatory actions of nociceptin contrast with enhanced spinal inhibitory effects of carrageenan inflammation: an electrophysiological study in the rat. Pain. 85:2000;433-441.
6. Chaplan S.R., Bach F.W., Pogrel J.W., Chung J.M., Yaksh T.L. Quantitative assessment of tactile allodynia in the rat paw. J. Neurosci. Methods. 53:1994;55-63.
7. 1 receptor antagonist, SR141716A, selectively facilitates nociceptive responses of dorsal horn neurones in the rat. Br. J. Pharmacol. 127:1999;1765-1767.
8. De Petrocellis L., Bisogno T., Maccarrone M., Davis J.B., Finazzi-Agro A., Di Marzo V. The activity of anandamide at vanilloid VR1 receptors requires facilitated transport across the cell membrane and is limited by intracellular metabolism. J. Biol. Chem. 276:2001;12856-12863.
9. 2 receptor-mediated actions of anandmide in mouse brain. J. Neurochem. 75:2000;2434-2444.
10. γS binding in the dorsal horn of the spinal cord of non-inflamed and inflamed rats. Eur. J. Neurosci. 12:2000;2079-2086.
11. 1 receptor expression in rat spinal cord. Mol. Cell. Neurosci. 15:2000;510-521.
12. 1 cannabinoid receptor. J. Neurosci. 18:1998;2834-2841.
13. Hajos N., Freund T.F. Pharmacological separation of cannabinoid sensitive receptors on hippocampal excitatory and inhibitory fibres. Neuropharmacology. 43:2002;503-510.
14. Hargreaves K., Dubner R., Brown F., Flores C., Joris J. A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia. Pain. 32:1988;77-88.
15. Harris J., Drew L.J., Chapman V. Spinal anandamide inhibits nociceptive transmission via cannabinoid receptor activation in vivo. NeuroReport. 11:2000;2817-2819.
16. 1). J. Pharmacol. Exp. Ther. 289:1999;1427-1433.
17. Hohmann A.G., Herkenham M. Regulation of cannabinoid and mu opioid receptors in the rat lumbar spinal cord. Brain Res. 822:1998;17-25.
18. Hohmann A.G., Herkenham M. Localization of central cannabinoid CB1 receptor messenger RNA in neuronal subpopulations of rat dorsal root ganglia: a double-label in situ hybridization study. Neuroscience. 90:1999;923-931.
19. Hohmann A.G., Tsou K., Walker J.M. Cannabinoid modulation of wide dynamic range neurons in the lumbar dorsal horn of the rat by spinally administered WIN55, 212-2. Neurosci. Lett. 257:1998;119-122.
20. Hohmann A.G., Briley E.M., Herkenham M. Pre- and postsynaptic distribution of cannabinoid and mu opioid receptors in rat spinal cord. Brain Res. 822:1999;17-25.
21. Howlett A.C., Barth F., Bonner T.I., Cabral G., Casellas P., Devane W.A., Felder C.C., Herkenham M., Mackie K., Martin B.R., Mechoulam R., Pertwee R.G. International Union of Pharmacology: XXVII. Classification of cannabinoid receptors. Pharmacol. Rev. 54:2002;161-202.
22. Huang C.-C., Chen Y.-L., Lo S.-W., Hsu K.-S. Activation of cAMP-dependent protein kinase suppresses the presynaptic cannabinoid inhibiton of glutamatergic transmission at corticostriatal synapses. Mol. Pharmacol. 61:2002;578-585.
23. 1 agonist inhibits spinal nociceptive transmission in vivo. J. Neurophysiol. 86:2001;3061-3064.
24. Kelly S., Chapman V. Spinal administration of capsazepine inhibits noxious evoked responses of dorsal horn neurons in non-inflamed rats and carrageenan inflamed rats. Brain Res. 935:2002;103-108.
25. 2+ influx in intermediate-size primary afferent neurons of adult rats. Neuroscience. 115:2002;613-625.
26. Kumar R.N., Chambers W.A., Pertwee R.G. Pharmacological actions and therapeutic uses of cannabis and cannabinoids. Anaesthesia. 56:2001;1059-1068.
27. Ma Y.-T., Sluka K.A. Reduction in inflammation-induced sensitization of dorsal horn neurons by transcutaneous electrical nerve stimulation in anesthetised rats. Exp. Brain Res. 137:2001;94-102.
28. 2 receptors. Br. J. Pharmacol. 124:1998;619-622.
29. Malmberg A.B., Brandon E.P., Idzerda R.L., Liu H., McKnight G.S., Basbaum A.I. Diminished inflammation and nociceptive pain with preservation of neuropathic pain in mice with a targeted mutation of the type I regulatory subunit of cAMP-dependent protein kinase. J. Neurosci. 17:1997;7462-7470.
30. Martin W.J., Liu H., Wang H., Malmberg A.B., Basbaum A.I. Inflammation-induced up-regulation of protein kinase Cγ immunoreactivity in rat spinal cord correlates with enhanced nociceptive processing. Neuroscience. 88:1999;1267-1274.
31. Martin W.J., Loo C.M., Basbaum A.I. Spinal cannabinoids are anti-allodynic in rats with persistent inflammation. Pain. 82:1999;199-205.
32. Merrill E.G., Ainsworth A. Glass-coated platinum-plated tungsten microelectrodes. Med. Biol. Eng. 10:1972;662-671.
33. Morisset V., Urban L. Cannabinoid induced presynaptic inhibition of glutamatergic EPSCs in substantia gelatinosa neurons of the rat spinal cord. J. Neurophysiol. 86:2001;40-48.
34. Pertwee R.G. Cannabinoid receptors and pain. Prog. Neurobiol. 63:2001;569-611.
35. Richardson J.D., Aanonsen L., Hargreaves K.M. SR141716A, a cannabinoid receptor antagonist, produces hyperalgesia in untreated mice. Eur. J. Pharmacol. 319:1997;R3-R4.
36. Richardson J.D., Aanonsen L., Hargreaves K.M. Antihyperalgesic effects of spinal cannabinoids. Eur. J. Pharmacol. 345:1998;145-153.
37. Rinaldi-Carmona M., Barth F., Heaulme M., Shire D., Calandra B., Congy C., Martinex S., Maruani J., Neliat G., Caput D., Ferrara P., Soubrie P., Breliere J.C., Lefur G. SR141716A a potent and selective antagonist of the brain cannabinoid receptor. FEBS Lett. 350:1994;240-244.
38. Ross R.A., Coutts A.A., McFarlane S.M., Anavi-Goffer S., Irving A.J., Pertwee R.G., MacEwan D.J., Scott R.H. Actions of cannabinoid receptor ligands on rat cultured sensory neurones: implications for antinociception. Neuropharmacology. 40:2001;221-232.
39. 1 cannabinoid receptor in the dorsal horn of the rat spinal cord. Neuroscience. 110:2002;755-764.
40. Sluka K.A., Chandran P. Enhanced reduction in hyperalgesia by combined administration of clonidine and TENS. Pain. 100:2002;183-190.
41. Smith P.B., Martin B.R. Spinal mechanisms of delta 9- tetrahydrocannabinoid-induced analgesia. Brain Res. 578:1992;8-12.
42. Stanfa L.C., Dickenson A.H. Cholecystokinin as a factor in the enhanced potency of spinal morphine following carrageenan inflammation. Br. J. Pharmacol. 108:1993;967-973.
43. Stanfa L.C., Sullivan A.F., Dickenson A.H. Alterations in neuronal excitability and the potency of spinal mu, delta and kappa, opioids after carrageenan-induced inflammation. Pain. 50:1992;345-354.
44. Welch S.P., Stevens D.L. Anti-nociceptive activity of intrathecally administered cannabinoids alone, and in combination with morphine, in mice. J. Pharmacol. Exp. Ther. 262:1992;10-18.
45. Xu G.-Y., Huang L.-Y.M., Zhao Z.-Q. Activation of silent mechanoreceptive cat C and Aδ sensory neurons and their substance P expression following peripheral inflammation. J. Physiol. 528.2:2000;339-348.
46. Yashpal K., Pitcher G.M., Parent A., Quirion R., Coderre T.J. Noxious thermal and chemical stimulation induce increases in 3H-phorbol 12, 13-dibutyrate binding in spinal cord dorsal horn as well as persistent pain and hyperalgeisa, which is reduced by inhibition of protein kinase C. J. Neurosci. 15:1995;3263-3272.