Two Key Proteins of the Vitamin D Endocrine System Come Into Crystal Clear Focus: Comparison of the X-ray Structures of the Nuclear Receptor for 1α,25(OH)2 Vitamin D3, the Plasma Vitamin D Binding Protein, and Their Ligands

Journal of Bone and Mineral Research

Volumn 18, Issue 5, 2003, Pages 795-806

  Mizwicki, Mathew T ^a   Norman, Anthony W ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCITRIOL; CELL NUCLEUS RECEPTOR; COLECALCIFEROL; LIGAND; VITAMIN D; VITAMIN D BINDING PROTEIN; VITAMIN D RECEPTOR;

CALCIUM HOMEOSTASIS; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; DRUG PROTEIN BINDING; ENDOCRINE SYSTEM; HYDROGEN BOND; LIGAND BINDING; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN STRUCTURE; REVIEW; VITAMIN D METABOLISM; X RAY CRYSTALLOGRAPHY;

CALCITRIOL; CRYSTALLOGRAPHY, X-RAY; LIGANDS; MODELS, MOLECULAR; RECEPTORS, CALCITRIOL;

EID: 0142091160     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.2003.18.5.795     Document Type: Review

References (71)

1. Rochel N, Wurtz JM, Mitschler A, Klaholz B, Moras D 2000 The crystal structure of the nuclear receptor for vitamin D bound to its natural ligand. Mol Cell 5:173-179.
2. Tocchini-Valentini G, Rochel N, Wurtz JM, Mitschler A, Moras D 2001 Crystal structures of the vitamin D receptor complexed to superagonist 20-epi ligands. Proc Natl Acad Sci USA 98:5491-5496.
3. Verboven C, Rabijns A, De Maeyer M, Van Baelen H, Bouillon R, De Ranter C 2002 A structural basis for the unique binding features of the human vitamin D-binding protein. Nat Struct Biol 9:131-136.
4. Reichel H, Koeffler HP, Norman AW 1989 The role of the vitamin D endocrine system in health and disease. N Engl J Med 320:980-991.
5. Bouillon R, Okamura WH, Norman AW 1995 Structure-function relationships in the vitamin D endocrine system. Endocr Rev 16:200-257.
6. Henry HL 2000 Vitamin D In: Handbook of Physiology. Section 7: The Endocrine System. Oxford, New York, NY, USA, pp. 699-718.
7. 3 Steroids 67:457-466.
8. Okamura WH, Palenzuela JA, Plumet J, Midland MM 1992 Vitamin D: Structure-function analyses and the design of analogs. J Cell Biochem 49:10-18.
9. Midland MM, Plumet J, Okamura WH 1993 Effect of C20 stereochemistry on the conformational profile of the side chains of vitamin D analogs. Bioorg Med Chem Lett 3:1799-1804.
10. 3. Science 186:939-941.
11. Willson TM, Moore JT 2002 Genomics verus orphan nuclear receptors: A half-time report. Mol Endocrinol 16:1135-1144.
12. Evans RM 1988 The steroid and thyroid hormone receptor superfamily. Science 240:889-895.
13. Mangelsdorf DJ, Thummel C, Beato M, Herrlich P, Schütz G, Umesono K, Blumberg B, Kastner P, Mark M, Chambon P, Evans RM 1995 The nuclear receptor superfamily: The second decade. Cell 83:835-839.
14. Krust A, Green S, Argos P, Kumar V, Walter P, Bornert JM, Chambon P 1986 The chicken oestrogen receptor sequence: Homology with v-erbA and the human oestrogen and glucocorticoid receptors. EMBO J 5:891-897.
15. Beato M 1989 Gene regulation by steroid hormones. Cell 56:335-344.
16. McKenna NJ, O'Malley BW 2002 Combinatorial control of gene expression by nuclear receptors and coregulators. Cell 108:465-474.
17. Green S, Chambon P 1988 Nuclear receptors enhance our understanding of transcription regulation. Trends Genet 4:309-314.
18. Rastinejad F, Perlmann T, Evans RM, Sigler PB 1995 Structural determinants of nuclear receptor assembly on DNA direct repeats. Nature 375:203-211.
19. Bourguet W, Ruff M, Chambon P, Gronemeyer H, Moras D 1995 Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-α. Nature 375:377-382.
20. Tora L, White J, Brou C, Tasset D, Webster N, Scheer E, Chambon P 1989 The human estrogen receptor has two independent nonacidic transcriptional activation functions. Cell 59:477-487.
21. Weatherman RV, Fletterick RJ, Scanlon TS 1999 Nuclear receptor ligands and ligand-binding domains. Annu Rev Biochem 68:559-582.
22. Brzozowski AM, Pike ACW, Dauter Z, Hubbard RE, Bonn T, Engstrom O, Ohman L, Greene GL, Gustafsson J-A, Carlquist M 1997 Molecular basis of agonism and antagonism of the oestrogen receptor. Nature 389:753-758.
23. Renaud J-P, Rochel N, Ruff M, Vivat V, Chambon P, Gronemeyer H, Moras D 1995 Crystal structure of the RAR-γ ligand-binding domain bound to all-trans retinoic acid. Nature 378:681-689.
24. Wagner RL, Apriletti JW, McGrath ME, West BL, Baxter JD, Fletterick RJ 1995 A structural role for hormone in the thyroid hormone receptor. Nature 378:690-697.
25. 3 are associated with enhanced activation of the vitamin D receptor. J Biol Chem 270:10551-10558.
26. 3 analogues and their 20-epi homologues with the vitamin D receptor. J Biol Chem 272:3336-3345.
27. Bourguet W, Germain P, Gronemeyer H 2000 Nuclear receptor ligand-binding domains: Three-dimensional structures, molecular interactions and pharmacological implications. Trends Pharmacol Sci 21:381-388.
28. Klaholz BP, Mitschler A, Belema M, Zusi C, Moras D 2000 Enantiomer discrimination illustrated by high-resolution crystal structures of the human nuclear receptor hRARγ. Proc Natl Acad Sci USA 97:6322-6327.
29. 3 with two side chains: Interaction with its nuclear receptor and cellular actions. J Med Chem 43:2719-2730.
30. Daiger SP, Schanfield MS, Cavalli-Sforza LL 1975 Group-specific component (Gc) proteins bind vitamin D and 25-hydroxyvitamin D. Proc Natl Acad Sci USA 72:2076-2080.
31. Delmez JA, Tindira C, Grooms P, Dusso A, Windus DW, Slatopolsky E 1989 Parathyroid hormone suppression by intravenous 1, 25-dihydroxyvitamin D. A role for increased sensitivity to calcium. J Clin Invest 83:1349-1355.
32. Bouillon R, Van Baelen H 1981 Transport of vitamin D: Significance of free and total concentrations of the vitamin D metabolites. Calcif Tissue Int 33:451-453.
33. Haddad JG 1995 Plasma vitamin D-binding protein (Gc-globulin): Multiple tasks. J Steroid Biochem Mol Biol 53:579-582.
34. Haddad JG Jr, Walgate J 1976 25-Hydroxyvitamin D transport in human plasma. Isolation and partial characterization of calcifidiol-binding protein. J Biol Chem 251:4803-4809.
35. Song YH, Naumova AK, Liebhaber SA, Cooke NE 1999 Physical and meiotic mapping of the region of human chromosome 4q11-q13 encompassing the vitamin D binding protein DBP/Gc-globulin and albumin multigene cluster. Genome Res 9:581-587.
36. Bouillon R, Van Baelen H, De Moor P 1977 The measurement of the vitamin D-binding protein in human serum. J Clin Endocrinol Metab 45:225-231.
37. Haddad JG, Harper KD, Guoth M, Pietra GG, Sanger JW 1990 Angiopathic consequences of saturating the plasma scavenger system for actin. Proc Natl Acad Sci USA 87:1381-1385.
38. Otterbein LR, Cosio C, Graceffa P, Dominguez R 2002 Crystal structures of the vitamin D-binding protein and its complex with actin: Structural basis of the actin-scavenger system. Proc Natl Acad Sci USA 99:8003-8008.
39. Swamy N, Head JF, Weitz D, Ray R 2002 Biochemical and preliminary crystallographic characterization of the vitamin D sterol- and actin-binding by human vitamin D-binding protein. Arch Biochem Biophys 402:14-23.
40. Bouillon R, Xiang D-Z, Convents R, Van Baelen H 1992 Polyunsaturated fatty acids decrease the apparent affinity of vitamin D metabolites for human vitamin D-binding protein. J Steroid Biochem Mol Biol 42:855-861.
41. DiMartino SJ, Shah AB, Trujillo G, Kew RR 2001 Elastase controls the binding of the vitamin D-binding protein (Gc-globulin) to neutrophils: A potential role in the regulation of C5a co-chemotactic activity. J Immunol 166:2688-2694.
42. DiMartino SJ, Kew RR 1999 Initial characterization of the vitamin D binding protein (Gc-globulin) binding site on the neutrophil plasma membrane: Evidence for a chondroitin sulfate proteoglycan. J Immunol 163:2135-2142.
43. Gibbs PEM, Dugaiczyk A 1987 Origin of structural domains of the serum albumin gene family and a predicted structure of the gene for vitamin D binding protein. Mol Biol Evol 4:364-379.
44. Cooke NE, Haddad JG 1997 Vitamin D binding protein. In: Feldman D, Glorieux FH, Pike VW (eds.) Vitamin D. Academic Press, San Diego, CA, USA, pp. 87-101.
45. Petitpas I, Bhattacharya AA, Twine S, East M, Curry S 2001 Crystal structure analysis of warfarin binding to human serum albumin: Anatomy of drug site I. J Biol Chem 276:22804-22809.
46. Nakhla AM, Khan MS, Romas NP, Rosner W 1994 Estradiol causes the rapid accumulation of cAMP in human prostate. Proc Natl Acad Sci USA 91:5402-5405.
47. Porto CS, Lazari MF, Abreu LC, Bardin CW, Gunsalus GL 1995 Receptors for androgen-binding proteins: Internalization and intracellular signalling. J Steroid Biochem Mol Biol 53:561-565.
48. Grishkovskaya I, Avvakumov GV, Sklenar G, Dales D, Hammond GL, Muller YA 2000 Crystal structure of human sex hormone-binding globulin: Steroid transport by a laminin G-like domain. EMBO J 19:504-512.
49. Beato M 1976 Binding of steroids to uteroglobin. J Steroid Biochem 7:327-334.
50. He XM, Carter DC 1992 Atomic structure and chemistry of human serum albumin. Nature 358:209-215.
51. Sugio S, Kashima A, Mochizuki S, Noda M, Kobayashi K 1999 Crystal structure of human serum albumin at 2.5 A resolution. Protein Eng 12:439-446.
52. Cooke NE, David EV 1985 Serum vitamin D-binding protein is a third member of the albumin and α-fetoprotein gene family. J Clin Invest 76:2420-2424.
53. Janssen OE, Lahner H, Grasberger H, Spring SA, Saller B, Mann K, Refetoff S, Einspanier R 2002 Characterization and primary structures of bovine and porcine thyroxine-binding globulin. Mol Cell Endocrinol 186:27-35.
54. Head JF, Swamy N, Ray R 2002 Crystal structure of the complex between actin and human vitamin D- binding protein at 2.5. A resolution. Biochemistry 41:9015-9020.
55. Bhattacharya AA, Grune T, Curry S 2000 Crystallographic analysis reveals common modes of binding of medium and long-chain fatty acids to human serum albumin. J Mol Biol 303:721-732.
56. Zanotti G, Calderone V, Beda M, Malpeli G, Folli C, Berni R 2001 Structure of chicken plasma retinol-binding protein. Biochim Biophys Acta 1550:64-69.
57. 3 and its analogs. J Bone Miner Res 9:1277-1288.
58. 3. In: Norman AW, Bouillon R, Thomasset M (eds.) Vitamin D: Gene Regulation, Structure-Function Analysis and Clinical Application. Walter de Gruyter, Berlin, Germany, pp. 165-166.
59. 3. In: Norman AW, Schaefer K, von Herraoh D, Coburn JW, Deluca HF, Mower EB, Suda T (eds.) Vitamin D: Biochemical, Chemical and Clinical Aspects Related to Calcium Metabolism. Walter de Gruyter, Berlin, Germany, pp. 587-589.
60. 3 analogs to mice. J Endocrinol 165:163-172.
61. 3 and its synthetic analogue decrease tumor load in the Apc(min) Mouse. Cancer Res 62:741-746.
62. 3. J Med Chem 34:2452-2463.
63. 3 analog with potent ability to induce HL-60 cell differentiation without modulating calcium metabolism. Blood 78:75-82.
64. 3 prolongs survival time of leukemic mice. Proc Natl Acad Sci USA 87:3929-3932.
65. Hamdy NAT, Kanis JA, Beneton MNC, Brown CB, Juttmann JR, Jordans JGM, Josse S, Meyrier A, Lins RL, Fairey IT 1995 Effect of alfacalcidol on natural course of renal bone disease in mild to moderate renal failure. BMJ 310:358-363.
66. Shiraishi A, Higashi S, Ohkawa H, Kubodera N, Hirasawa T, Ezawa I, Ikeda K, Ogata E 1999 The advantage of alfacalcidol over vitamin D in the treatment of osteoporosis. Calcif Tissue Int 65:311-316.
67. Binderup L, Kragballe K 1992 Origin of the use of calcipotriol in psoriasis treatment. Rev Contemp Pharmacother 3:357-365.
68. 3 (tacalcitol) for steroid-resistant prurigo. Br J Dermatol 135:237-240.
69. 3 derivative tacalcitol increases the responsiveness to 311-nm ultraviolet B: Results of a controlled, right/left study. Br J Dermatol 144:628-629.
70. 3 analogues: A novel class of potent regulators of cell growth and immune responses. Biochem Pharmacol 42:1569-1575.
71. Bertolini DL, Araujo PR, Silva RN, Duarte AJ, Tzanno-Martins CB 1999 Immunomodulatory effects of vitamin D analog KH1060 on an experimental skin transplantation model. Transplant Proc 31:2998-2999.