Probing the kinetic landscape of transient peptide-protein interactions by use of peptide 15N NMR relaxation dispersion spectroscopy: Binding of an antithrombin peptide to human prothrombin

Journal of the American Chemical Society

Volumn 125, Issue 41, 2003, Pages 12432-12442

  Tolkatchev, Dmitri ^a   Xu, Ping ^a   Ni, Feng ^a  

^a NATIONAL RESEARCH COUNCIL CANADA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

LIGANDS;

BIOCHEMISTRY; CONFORMATIONS; MAGNETIC RELAXATION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; REACTION KINETICS; TITRATION;

PROTEINS;

ANTITHROMBIN; N ACETYLASPARTYLPHENYLALANYLGLUTAMYLGLUTAMYLISOLEUCYLPROLYLGLUTAMYLGLUTAMYLTYROSYL LEUCYLGLYCINAMIDE; NITROGEN 15; PROTHROMBIN; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING KINETICS; COMPLEX FORMATION; DISSOCIATION CONSTANT; EQUILIBRIUM CONSTANT; MOLECULAR DYNAMICS; MOLECULAR MECHANICS; NUCLEAR MAGNETIC RESONANCE; PROTEIN CONFORMATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; QUANTITATIVE ANALYSIS; THERMODYNAMICS;

ANTITHROMBINS; HUMANS; KINETICS; NITROGEN ISOTOPES; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PEPTIDE FRAGMENTS; PROTEIN BINDING; PROTHROMBIN;

EID: 0141988954     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja021238l     Document Type: Article

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