Predicting the kinetics of peptide-antibody interactions using a multivariate experimental design of sequence and chemical space

Journal of Molecular Recognition

Volumn 14, Issue 1, 2001, Pages 62-71

  Andersson, Karl ^a   Choulier, Laurence ^b   Hämäläinen, Markku D ^a   van Regenmortel, Marc H V ^b   Altschuh, Danièle ^b   Malmqvist, Magnus ^a  

^a BIACORE AB   (Sweden)

^b CNRS UPR9021   (France)

Author keywords

BIACORE; Experimental design; Informatics; Kinetics; Mathematical models; Multivariate analysis

Indexed keywords

AMINO ACID; BUFFER; CHEMICAL REACTION KINETICS; EPITOPE; PEPTIDE ANTIBODY INTERACTION; PEPTIDE ANTIBODY; SENSITIVITY; TOBACCO MOSAIC VIRUS; VIRUS PROTEIN;

AMINO ACID SEQUENCE; ANTIGENS, VIRAL; BUFFERS; EPITOPES, B-LYMPHOCYTE; IMMUNOGLOBULIN FAB FRAGMENTS; KINETICS; MOLECULAR SEQUENCE DATA; MULTIVARIATE ANALYSIS; PEPTIDES; TOBACCO MOSAIC VIRUS; VIRAL PROTEINS;

NICOTIANA TABACUM; TOBACCO MOSAIC VIRUS;

EID: 0035097167     PISSN: 09523499     EISSN: None     Source Type: Journal    
DOI: 10.1002/1099-1352(200101/02)14:1<62::AID-JMR520>3.0.CO;2-T     Document Type: Article

References (26)

1. Determination of kinetic constants for the interaction between a monoclonal antibody and peptides using surface plasmon resonance
2. Exploring buffer space for molecular interactions
3. Kinetic characterization of the interaction of the Z-fragment of protein A with mouse-IgG3 in a volume in chemical space
4. Affinity dependence of the B cell response to antigen: A threshold, a ceiling, and the importance of off-rate
5. Comparative interaction kinetics of two recombinant Fabs and of the corresponding antibodies directed to the coat protein of tobacco mosaic virus
6. Kinetic analysis of the effect on Fab binding of identical substitutions in a peptide and its parent protein
7. An algorithm for protein secondary structure prediction based on class prediction
8. Kinetics and affinity limits on antibodies produced during immune responses
9. p-s-p analysis. A method for the correlation of biological activity and chemical structure
10. Peptide quantitative structure-activity relationships, a multivariate approach
11. Real-time biospecific interaction analysis using surface plasmon resonance and a sensor chip technology
12. Experimental design for kinetic analysis of protein-protein interactions with surface plasmon resonance biosensors
13. Deciphering cryptic similarities in protein binding sites
14. Function and design
15. Sequences and topology. From sequence to structure to function
16. Kinetic analysis of macromolecular interactions using surface plasmon resonance biosensors
17. A multiway 3D QSAR analysis of a series of (S)-N-[1-ethyl-2-pyrrolidinyl)methyl]-6-methoxybenzamides
18. From protein structure to function
19. New chemical descriptors relevant for the design of biologically active peptides. A multivariate characterization of 87 amino acids
20. Multivariate quantitative structure-pharmacokinetic relationships (QSPKR) analysis of adenosine A1 receptor agonists in rat
21. Are there two distinct research strategies for developing biologically active molecules: Rational design and empirical selection
22. Novel variable selection quantitative structure-property relationship approach based on the k-nearest neighbor principle