Identification of SNARE complex modulators that inhibit exocytosis from an α-helix-constrained combinatorial library

Biochemical Journal

Volumn 375, Issue 1, 2003, Pages 159-166

  Blanes Mira, Clara ^a   Pastor, Maria T ^b   Valera, Elvira ^c   Fernández Ballester, Gregorio ^a   Merino, Jaime M ^c   Gutierrez, Luis M ^d   Perez PAYÁ, Enrique ^b,e   Ferrer Montiel, Antonio ^a  

^a MIGUEL HERNÁNDEZ UNIVERSITY   (Spain)

^b UNIVERSITY OF VALENCIA   (Spain)

^c UNIVERSITY OF EXTREMADURA   (Spain)

^d INSTITUTO DE NEUROCIENCIAS   (Spain)

^e CSIC   (Spain)

Author keywords

Combinatorial chemistry; Drug discovery; Neurosecretion; Protein protein interaction; Synaptic transmission; Vesicle fusion

Indexed keywords

AMINO ACIDS; CELL CULTURE; DRUG PRODUCTS; NEUROLOGY; PROTEINS;

ANTI-SPASMODIC DRUGS;

POLYPEPTIDES;

ACETYLSERYLALANYLALANYLGLUTAMYLALANYLPHENYLALANYLALANYLLYSYLLEUCYLTYROSY LAL ANYLGLUTAMYLALANYLPHENYLALANYLALANYLLYSYLGLYCINAMIDE; CALCIUM ION; CATECHOLAMINE; DETERGENT; GLUTAMIC ACID; PEPTIDE; SNARE PROTEIN; UNCLASSIFIED DRUG; MEMBRANE PROTEIN; PEPTIDE LIBRARY; VESICULAR TRANSPORT PROTEIN;

ALPHA HELIX; AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CATECHOLAMINE RELEASE; CELL MEMBRANE PERMEABILITY; CHROMAFFIN CELL; COMBINATORIAL LIBRARY; COMPLEX FORMATION; CONTROLLED STUDY; DRUG POTENCY; DRUG RESEARCH; EXOCYTOSIS; HIPPOCAMPUS; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN ASSEMBLY; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN SYNTHESIS; ANIMAL; CATTLE; CELL CULTURE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECT; MACROMOLECULE; MOLECULAR GENETICS; PHYSIOLOGY; PROTEIN SECONDARY STRUCTURE; RAT;

ANIMALIA;

AMINO ACID SEQUENCE; ANIMALS; CATTLE; CELLS, CULTURED; CHROMAFFIN CELLS; EXOCYTOSIS; MACROMOLECULAR SUBSTANCES; MEMBRANE PROTEINS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NEURONS; PEPTIDE LIBRARY; PEPTIDES; PROTEIN STRUCTURE, SECONDARY; RATS; SNARE PROTEINS; VESICULAR TRANSPORT PROTEINS;

EID: 0141988381     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20030509     Document Type: Article

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