Molecular determinants of exocytosis

Pflugers Archiv European Journal of Physiology

Volumn 443, Issue 3, 2002, Pages 333-338

  Bruns, Dieter ^a   Jahn, Reinhard ^a  

^a MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

Author keywords

Exocytosis; Membrane fusion; SNARE proteins

Indexed keywords

SNARE PROTEIN;

CELL ADHESION; CELL ORGANELLE; EXOCYTOSIS; MEMBRANE FUSION; MEMBRANE MODEL; PRIORITY JOURNAL; REVIEW;

ANIMALS; EXOCYTOSIS; HUMANS; MEMBRANE FUSION; MEMBRANE PROTEINS; SNARE PROTEINS; VESICULAR TRANSPORT PROTEINS;

EID: 0036151862     PISSN: 00316768     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00424-001-0742-4     Document Type: Review

References (60)

1. Stepping rotation of Fl-ATPase visualized through angle-resolved single-fluorophore imaging
2. Fusion needs more than SNAREs
3. Transmitter release from synapses: Does a preassembled fusion pore initiate exocytosis?
4. Calmodulin is the divalent cation receptor for rapid endocytosis, but not exocytosis, in adrenal chromaffin cells
5. Calcium-induced desensitization of acetylcholine release from synaptosomes or proteoliposomes equipped with mediatophore, a presynaptic membrane protein
6. A 15 kDa proteolipid found in mediatophore preparations from Torpedo electric organ presents high sequence homology with the bovine chromaffin granule protonophore
7. Botulinum neurotoxin A selectively cleaves the synaptic protein SNAP-25
8. Syntaxin and synaptobrevin function downstream of vesicle docking in Drosophila
9. Inhibition of transmitter release correlates with the proteolytic activity of tetanus toxin and botulinus toxin A in individual cultured synapses of Hirudo medicinalis
10. SNARE-mediated membrane fusion
11. Sequential SNARE assembly underlies priming and triggering of exocytosis
12. Distinct requirements for evoked and spontaneous release of neurotransmitter are revealed by mutations in the Drosophila gene neuronal-synaptobrevin
13. A structural change occurs upon binding of syntaxin to SNAP-25
14. Cytosolic calcium facilitates release of secretory products after exocytotic vesicle fusion
15. Folding intermediates of SNARE complex assembly
16. +)-ATPases
17. The VO sector of the V-ATPase, synaptobrevin, and synaptophysin are associated on synaptic vesicles in a Triton X-100-resistant, freeze-thawing sensitive, complex
18. CaM kinase II-dependent mobilization of secretory granules underlies acetylcholine-induced stimulation of exocytosis in mouse pancreatic B-cells
19. G-protein ligands inhibit in vitro reactions of vacuole inheritance
20. Structure and conformational changes in NSF and its membrane receptor complexes visualized by quick-freeze/deepetch electron microscopy
21. Activity-dependent changes in partial VAMP complexes during neurotransmitter release
22. A post-docking role for synaptobrevin in synaptic vesicle fusion
23. Membrane fusion and exocytosis
24. Lipid-anchored influenza hemagglutinin promotes hemifusion, not complete fusion
25. Protein machines and lipid assemblies: Current views of cell membrane fusion
26. Structural organization of the synaptic exocytosis core complex
27. Structure and function of fusion pores in exocytosis and ectoplasmic membrane fusion
28. Temperature-sensitive paralytic mutations demonstrate that synaptic exocytosis requires SNARE complex assembly and disassembly
29. Relationship between presynaptic calcium current and postsynaptic potential in squid giant synapse
30. Assembly of SNARE core complexes prior to neurotransmitter release sets the readily releasable pool of synaptic vesicles
31. Homo- and heterooligomeric SNARE complexes studied by site-directed spin labeling
32. The length of the flexible SNAREpin juxtamembrane region is a critical determinant of SNARE-dependent fusion
33. Close is not enough: SNARE-dependent membrane fusion requires an active mechanism that transduces force to membrane anchors
34. In vivo biosynthesis of the vacuolar proteinases A and B in the yeast Saccharomyces cerevisiae
35. A point mutation in the transmembrane domain of the hemagglutinin of influenza virus stabilizes a hemifusion intermediate that can transit to fusion
36. The fusion pore and mechanisms of biological membrane fusion
37. 2+/calmodulin signals the completion of docking and triggers a late step of vacuole fusion
38. Trans-complex formation by proteolipid channels in the terminal phase of membrane fusion
39. Transport-vesicle targeting: Tethers before SNAREs
40. The synaptic SNARE complex is a parallel four-stranded helical bundle
41. Hemifusion between cells expressing hemagglutinin of influenza virus and planar membranes can precede the formation of fusion pores that subsequently fully enlarge
42. Timing of synaptic transmission
43. Absence of junctional glutamate receptor clusters in Drosophila mutants lacking spontaneous transmitter release
44. SNAREs contribute to the specificity of membrane fusion
45. 2+ and protein kinase C via distinct mechanisms
46. Tetanus and botulinum-B neurotoxins block neurotransmitter release by proteolytic cleavage of synaptobrevin
47. Genetic and electrophysiological studies of Drosophila syntaxin-1A demonstrate its role in nonneuronal secretion and neurotransmission
48. Receptor binding and membrane fusion in virus entry: The influenza hemagglutinin
49. +)-ATPase
50. Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 Å resolution
51. Defining the functions of trans-SNARE pairs
52. 2+-dependent steps leading to secretion in chromaffin cells from mouse adrenal slices
53. SNAREpins: Minimal machinery for membrane fusion
54. Exocytotic mechanism studied by truncated and zero layer mutants of the C-terminus of SNAP-25
55. Yeast homotypic vacuole fusion: A window on organelle trafficking mechanisms
56. Multiple kinetic components of exocytosis distinguished by neurotoxin sensitivity
57. Inhibition of SNARE complex assembly differentially affects kinetic components of exocytosis
58. 2+ increases and by cAMP
59. How can proteolipids be central players in membrane fusion?
60. Membrane fusion