Identification of peptides that neutralize bacterial endotoxins using β-hairpin conformationally restricted libraries

Molecular Diversity

Volumn 5, Issue 3, 2000, Pages 117-126

  González Navarro, Herminia ^a,c   Mora, Puig ^a,c   Pastor, Mayte ^a,c   Serrano, Luis ^b,c   Mingarro, Ismael ^a,c   Pérez Payá, Enrique ^a,c  

^a UNIVERSITY OF VALENCIA   (Spain)

^b EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^c NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

Author keywords

Combinatorial libraries; Endotoxin; Molecular recognition; Peptide conformation; Septic shock

Indexed keywords

1,6 DIPHENYL 1,3,5 HEXATRIENE; BACTERICIDAL PERMEABILITY INCREASING PROTEIN; BINDING PROTEIN; ENDOTOXIN; LIPOPOLYSACCHARIDE; LIPOPOLYSACCHARIDE BINDING PROTEIN; PEPTIDE DERIVATIVE; PEPTIDE LIBRARY;

ARTICLE; BIOMEDICINE; COMBINATORIAL LIBRARY; CONFORMATIONAL TRANSITION; DRUG ACTIVITY; MOLECULAR RECOGNITION; NONHUMAN; PEPTIDE ANALYSIS; PRIORITY JOURNAL; PROCESS DESIGN; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN SECONDARY STRUCTURE; SEPTIC SHOCK; SEQUENCE ANALYSIS; STRUCTURE ANALYSIS;

AMINO ACID SEQUENCE; BACTERIAL PROTEINS; CIRCULAR DICHROISM; COMBINATORIAL CHEMISTRY TECHNIQUES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; ENDOTOXINS; LIPOPOLYSACCHARIDES; PEPTIDE LIBRARY; PEPTIDES; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN STRUCTURE, SECONDARY; SPECTROMETRY, FLUORESCENCE;

EID: 0034583686     PISSN: 13811991     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1016207717213     Document Type: Article

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