Peptides that mimic the carboxy-terminal domain of SNAP-25 block acetylcholine release at an Aplysia synapse

Journal of Applied Toxicology

Volumn 19, Issue SUPPL. 1, 1999, Pages

  Apland, J P ^a   Biser, J A ^a   Adler, M ^a   Ferrer Montiel, A V ^b   Montal, M ^b   Filbert, M G ^a  

^a US ARMY MEDICAL RESEARCH INSTITUTE OF CHEMICAL DEFENSE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Botulinum; Neurotransmitter release; Synaptic protein; Toxin

Indexed keywords

ACETYLCHOLINE; BOTULINUM TOXIN; HYBRID PROTEIN; NERVE PROTEIN;

ACETYLCHOLINE RELEASE; APLYSIA; CARBOXY TERMINAL SEQUENCE; CONFERENCE PAPER; CONTROLLED STUDY; GANGLION; INHIBITORY POSTSYNAPTIC POTENTIAL; NONHUMAN; PRESYNAPTIC NERVE; PRIORITY JOURNAL; SEROTYPE; SYNAPTIC INHIBITION;

ACETYLCHOLINE; ACTION POTENTIALS; ANIMALS; APLYSIA; BOTULINUM TOXINS; MEMBRANE PROTEINS; NERVE TISSUE PROTEINS; PEPTIDE FRAGMENTS; SYNAPSES; SYNAPTOSOMAL-ASSOCIATED PROTEIN 25;

APLYSIA; APLYSIA CALIFORNICA; BOVINAE;

EID: 0033382114     PISSN: 0260437X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1099-1263(199912)19:1+3.0.CO;2-X     Document Type: Conference Paper

References (16)

1. G. Sakaguchi, Clostridium botulinum toxins. Pharmacol. Ther. 19, 165-194 (1983).
2. L. L. Simpson, Molecular pharmacology of botulinum toxin and tetanus toxin. Annu. Rev. Pharmacol. Toxicol. 26, 427-453 (1986).
3. G. Schiavo, O. Rossetto, A, Santucci, B. R. DasGupta and C. Montecucco, Botulinum neurotoxins are zinc proteins. J. Biol. Chem. 267, 23479-23483 (1992).
4. H. Niemann, J. Blasi and R. Jahn, Clostridial neurotoxins: new tools for dissecting exocytosis. Trends Cell Biol. 4, 179-185 (1994).
5. T. Binz, J. Blasi, S. Yamasaki, A. Baumeister, E. Link, T. Sudhof, R. Jahn and H. Niemann, Proteolysis of SNAP-25 by types E and A botulinal neurotoxins. J. Biol. Chem. 269, 1617-1620 (1994).
6. G. Schiavo, A. Santucci, B. R. DasGupta, P. P. Metha, J. Jontes, F. Benfenati, M. C. Wilson and C. Montecucco, Botulinum neurotoxin serotypes A and E cleave SNAP-25 at distinct COOH-terminal peptide bonds. FEBS Lett. 335, 99-103 (1993).
7. 2+-dependent exocytosis in chromaffin cells. FEBS Lett. 372, 39-43 (1995).
8. L. M. Gutierrez, S. Viniegra, J. Rueda, A. V. Ferrer-Montiel, J. M. Canaves and M. Montal, A peptide that mimics the C-terminal sequence of SNAP-25 inhibits secretory vesicle docking in chromaffin cells. J. Biol. Chem. 272, 2634-2639 (1997).
9. A. V. Ferrer-Montiel, L. M. Gutiérrez, J. P. Apland, J. M. Canaves, A. Gil, S. Viniegra, J. A. Biser, M. Adler and M. Montal, The 26-mer peptide released from SNAP-25 cleavage by botulinum neurotoxin E inhibits vesicle docking. FEBS Lett. 435, 84-88 (1998).
10. D. Gardner and E. R. Kandel, Physiological and kinetic properties of cholinergic receptors activated by multiaction interneurons in buccal ganglia of Aplysia. J. Neurophysiol. 40, 333-348 (1977).
11. B. Poulain, L. Tauc, E. A. Maisey, J. D. F. Wadsworth, P. M. Mohan and J. O. Dolly, Neurotransmitter release is blocked intracellularly by botulinum neurotoxin, and this requires uptake of both toxin polypeptides by a process mediated by the larger chain. Proc. Natl. Acad. Sci. USA 85, 4090-4094 (1988).
12. S. Mochida, B. Poulain, U. Eisel, T. Binz, H. Kurazono, H. Niemann and L. Tauc, Exogenous mRNA encoding tetanus or botulinum neurotoxins expressed in Aplysia neurons. Proc. Natl. Acad. Sci. USA 87, 7844-7848 (1990).
13. C. Geourjon and G. Deleage, SOPMA: significant improvements in protein secondary structure prediction by consensus prediction from multiple alignments. Comput. Appl. Biosci. 11, 681-684 (1995).
14. D. M. Evans, R. S. Williams, C. C. Shone, P. Hambleton, J. Melling and J. O. Dolly, Botulinum neurotoxin type B. Its purification, radioiodination and interaction with ratbrain synaptosomal membranes. Eur. J. Biochem. 154, 409-416 (1986).
15. M. Wictome, O. Rosetto, C. Montecucco and C. C. Shone, Substrate residues N-terminal to the cleavage site of botulinum type B neurotoxin play a role in determining the specificity of its endopeptidase activity. FEBS Lett. 386, 133-136 (1996).
16. R. B. Sutton, D. Fasshauer, R. Jahn and A. T. Brunger, Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 Å resolution. Nature (London) 395, 347-353 (1998).