Fatty acid mobilization from adipose tissue during exercise

Trends in Endocrinology and Metabolism

Volumn 14, Issue 8, 2003, Pages 386-392

  Horowitz, Jeffrey F ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID; TRIACYLGLYCEROL;

ADIPOSE TISSUE; ENDURANCE; EXERCISE; FATTY ACID METABOLISM; FATTY ACID OXIDATION; FATTY ACID TRANSPORT; HUMAN; LIPID HYDROLYSIS; LIPOLYSIS; METABOLIC DISORDER; MUSCLE FUNCTION; OBESITY; PERFORMANCE; PRIORITY JOURNAL; REVIEW;

EID: 0141929524     PISSN: 10432760     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1043-2760(03)00143-7     Document Type: Review

References (89)

1. Horowitz, J.F. et al. (1997) Lipolytic suppression following carbohydrate ingestion limits fat oxidation during exercise. Am. J. Physiol. 273, E768-E775
2. Wolfe, R.R. et al. (1990) Role of triglyceride-fatty acid cycle in controlling fat metabolism in humans during and after exercise. Am. J. Physiol. 258, E382-E389
3. Klein, S. et al. (1994) Fat metabolism during low-intensity exercise in endurance trained and untrained men. Am. J. Physiol. 267, E934-E940
4. Romijn, J.A. et al. (1993) Regulation of endogenous fat and carbohydrate metabolism in relation to exercise intensity. Am. J. Physiol. 265, E380-E391
5. Romijn, J.A. et al. (1995) Fat oxidation is impaired somewhat during high-intensity exercise by limited plasma FFA mobilization. J. Appl. Physiol. 79, 1939-1945
6. Hodgetts, V. et al. (1991) Factors controlling fat mobilization from human subcutaneous adipose tissue during exercise. J. Appl. Physiol. 71, 445-451
7. Jensen, M.D. et al. (1989) Influence of body fat distribution on free fatty acid metabolism in obesity. J. Clin. Invest. 83, 1168-1173
8. Martin, M.L. and Jensen, M.D. (1991) Effects of body fat distribution on regional lipolysis in obesity. J. Clin. Invest. 88, 609-613
9. Mauriege, P. et al. (1987) Heterogeneous distribution of β and α-2 adrenoceptor binding sites in human fat cells from various fat deposits: functional consequences. Eur. J. Clin. Invest. 17, 156-165
10. Kissebah, A.H. et al. (1982) Relation of body fat distribution to metabolic complications of obesity. J. Clin. Endocrinol. Metab. 54, 254-260
11. Arner, P. et al. (1990) Adrenergic regulation of lipolysis in situ at rest and during exercise. J. Clin. Invest. 85, 893-898
12. Horowitz, J.F. and Klein, S. (2000) Oxidation ofnonplasma fatty acids during exercise is increased in women with abdominal obesity. J. Appl. Physiol. 89, 2276-2282
13. Bergman, B.C. et al. (1999) Evaluation of exercise and training on muscle lipid metabolism. Am. J. Physiol. 276, E106-E117
14. Kiens, B. and Richter, E.A. (1998) Utilization of skeletal muscle triacylglycerol during postexercise recovery in humans. Am. J. Physiol. 275, E332-E337
15. Kiens, B. et al. (1993) Skeletal muscle substrate utilization during submaximal exercise in man: effect ofendurance training. J. Physiol. 469, 459-478
16. Starling, R.D. et al. (1997) Effects of diet on muscle triglyceride and endurance performance. J. Appl. Physiol. 82, 1185-1189
17. Wendling, P.S. et al. (1996) Variability of triacylglycerol content in human skeletal muscle biopsy samples. J. Appl. Physiol. 81, 1150-1155
18. Roepstorff, C. et al. (2002) Gender differences in substrate utilization during submaximal exercise in endurance-trained subjects. Am. J. Physiol. 282, E435-E447
19. Krssak, M. et al. (2000) Intramuscular glycogen and intramuscular lipid utilization during prolonged exercise and recovery in man: a 13C and 1H nuclear magnetic resonance spectroscopy study. J. Clin. Endocrinol. Metab. 85, 748-754
20. Hurley, B.F. et al. (1986) Muscle triglyceride utilization during exercise: effect of training. J. Appl. Physiol. 60, 562-567
21. Cleroux, J. et al. (1989) Effects of β1-vs. β1 + β2-blockade on exercise endurance and muscle metabolism in humans. J. Appl. Physiol. 66, 548-554
22. Gorski, J. (1992) Muscle triglyceride metabolism during exercise. Can. J. Physiol. Pharmacol. 70, 123-131
23. Larson-Meyer, D.E. et al. (2002) Influence of endurance running and recovery diet on intramyocellular lipid content in women: a 1H NMR study. Am. J. Physiol. 282, E95-E106
24. Carlson, L.A. et al. (1971) Concentration of triglycerides, phospholipids, and glycogen in skeletal muscle and of free fatty acids and β-hydroxybutyric acid in blood in man in response to exercise. Eur. J. Clin. Invest. 1, 248-254
25. Frayn, K.N. et al. (1995) Coordinated regulation of hormone-sensitive lipase and lipoprotein lipase in human adipose tissue in vivo: implications for the control of fat storage and fat mobilization. Adv. Enzyme Regul. 35, 163-178
26. Teusink, B. et al. (2003) Contribution of fatty acids released from lipolysis of plasma triglycerides to total plasma fatty acid flux and tissue-specific fatty acid uptake. Diabetes 52, 614-620
27. Olsson, A.G. et al. (1975) Extraction of exogenous plasma triglycerides by the working human forearm muscle in the fasting state. Scand. J. Clin. Lab. Invest. Suppl. 35, 231-236
28. Helge, J.W. et al. (2001) Fat utilization during exercise: adaptation to a fat-rich diet increases utilization of plasma fatty acids and very low density lipoprotein-tracylglycerol in humans. J. Physiol. 537, 1009-1020
29. Egan, J.J. et al. (1992) Mechanism of hormone-stimulated lipolysis in adipocytes: translocation of hormone-sensitive lipase to the lipid storage droplet. Proc. Natl. Acad. Sci. U. S. A. 89, 8537-8541
30. Londos, C. et al. (1995) Perilipin: unique proteins associated with intracellular muetral lipid droplets in adipocytes and steroidogenic cells. Biochem. Soc. Trans. 23, 611-615
31. Tansey, J.T. et al. (2003) Functional studies on native and mutated forms of perilipins: a role in protein kinase A-mediated lipolysis of triacylglycerols in CHO cells. J. Biol. Chem. 278, 8401-8406
32. Garcia, A. et al. (2003) The central domain is required to target and anchor perilipin A to lipid droplets. J. Biol. Chem. 278, 625-635
33. Souza, S.C. et al. (1998) Overexpression of perilipin A and B blocks the ability of tumor necrosis factor α to increase lipolysis in 3T3-L1 adipocytes. J. Biol. Chem. 273, 24665-24669
34. Galitzky, J. et al. (1993) Coexistence of β1-, β2-, and β 3-adrenoceptors in dog fat cells and their differential activation by catecholamines. Am. J. Physiol. 264, E402-E412
35. Lafontan, M. et al. (1995) Adrenergic receptors and fat cells: differential recruitment by physiological amines and homologous regulation. Obes. Res. 3, 507S-514S
36. Granneman, J.G. (1995) Why do adipocytes make the β 3 adrenergic receptor? Cell Signal 7, 9-15
37. Lonnqvist, F. et al. (1995) A pathogenic role of visceral adenosine concentration in subcutaneous tissue in humans. J. Clin. Invest. 95, 1109-1116
38. Campbell, P.J. et al. (1992) Regulation of free fatty acid metabolism by insulin in humans: role of lipolysis and reesterification. Am. J. Physiol. 26, E1063-E1069
39. Wasserman, D.H. et al. (1989) Exercise-induced fall in insulin and increase in fat metabolism during prolonged muscular work. Diabetes 38, 484-490
40. Lonnroth, P. and Smith, U. (1986) The antilipolytic effect of insulin in human adipocytes requires activation of the phosphodiesterase. Biochem. Biophys. Res. Commun. 141, 1157-1161
41. Makino, H. et al. (1992) The role of insulin-sensitive phosphodiesterase in insulin action. Adv. Second Messenger Phosphoprotein Res. 25, 185-199
42. Rahn, T. et al. (1994) Essential role of phosphatidylinositol 3-kinase in insulin-induced activation and phosphorylation of the cGMP-inhibited cAMP phosphodiesterase in rat adipocytes. Studies using the selective inhibitor wortmannin. FEBS Lett. 350, 314-318
43. Slavin, B.G. et al. (1994) Hormonal regulation of hormone-sensitive lipase activity and mRNA levels in isolated rat adipocytes. J. Lipid Res. 35, 1535-1541
44. Samra, J.S. et al. (1996) Effects of morning rise in cortisol concentration on regulation of lipolysis in subcutaneous adipose tissue. Am. J. Physiol. 271, E996-E1002
45. Ottosson, M. et al. (2000) Effects of cortisol and growth hormone on lipolysis in human adipose tissue. J. Clin. Endocrinol. Metab. 85, 799-803
46. Mittendorfer, B. et al. (2002) Effect of gender on lipid kinetics during moderate intensity endurance exercise in untrained subjects. Am. J. Physiol. 283, E58-E65
47. Sial, S. et al. (1996) Fat and carbohydrate metabolism during exercise in elderly and young subjects. Am. J. Physiol. 271, E983-E989
48. Podolin, D.A. et al. (1999) Effects ofa high-fat diet and voluntary wheel running on gluconeogenesis and lipolysis in rats. J. Appl. Physiol. 86, 1374-1380
49. Kanaley, J.A. et al. (1993) Fatty acid kinetic responses to exercise. Effects of obesity, body fat distribution, and energy-restricted diet. J. Clin. Invest. 92, 255-261
50. Berman, D. et al. (1998) Regional differences in adrenoceptor binding and fat cell lipolysis in obese, postmenopausal women. Metab. Clin. Exp. 47, 467-473
51. Richelsen, B. et al. (1991) Regional differences in triglyceride breakdown in human adipose tissue: effects of catecholamines, insulin, and prostaglandin E2. Metabolism 40, 990-996
52. Rosenbaum, M. et al. (1991) Regional differences in adrenoreceptor status of adipose tissue in adults and prepubertal children. J. Clin. Endocrinol. Metab. 73, 341-347
53. Wahrenberg, H. et al. (1989) Mechanisms underlying regional differences in lipolysis in human adipose tissue. J. Clin. Invest. 84, 458-467
54. Lafontan, M. et al. (1979) α-Adrenergic antilipolytic effect of adrenaline in human fat cells of the thigh: comparison with adrenaline responsiveness of different fat deposits. Eur. J. Clin. Invest. 9, 261-266
55. Horowitz, J.F. and Klein, S. (2000) Whole body and abdominal lipolytic sensitivity to epinephrine is suppressed in upper body obese women. Am. J. Physiol. 278, E1144-E1152
56. Langfort, J. et al. (1999) Expression of hormone-sensitive lipase and its regulation by adrenaline in skeletal muscle. Biochem. J. 340, 459-465
57. Kjaer, M. et al. (2000) Adrenaline and glycogenolysis in skeletal muscle during exercise: a study in adrenalectomised humans. J. Physiol. 528, 371-378
58. Watt, M.J. et al. (2003) Effects of dynamic exercise intensity on the activation of hormone-sensitive lipase in human skeletal muscle. J. Physiol. 547, 301-308
59. Langfort, J. et al. (2000) Stimulation of hormone-sensitive lipase activity by contractions in rat skeletal muscle. Biochem. J. 351, 207-214
60. Holloszy, J.O. and Coyle, E.F. (1984) Adaptations of skeletal muscle to endurance exercise and their metabolic consequences. J. Appl. Physiol. 56, 831-838
61. Horowitz, J.F. et al. (2000) Effect of endurance training on lipid metabolism in women: a potential role for PPARa in the metabolic response to training. Am. J. Physiol. 279, E348-E355
62. Martin, W.H.I. et al. (1993) Effect of endurance training on plasma free fatty acid turnover and oxidation during exercise. Am. J. Physiol. 265, E708-E714
63. Horowitz, J.F. et al. (1999) Endurance exercise training does not alter lipolytic or adipose tissue blood flow sensitivity to epinephrine. Am. J. Physiol. 277, E325-E331
64. Crampes, F. et al. (1989) Lipolytic response of adipocytes to epinephrine in sedentary and exercise-trained subjects: sex related differences. Eur. J. Appl. Physiol. 59, 249-255
65. Riviere, D. et al. (1989) Lipolytic response of fat cells to catecholamines in sedentary and exercise-trained women. J. Appl. Physiol. 66, 330-335
66. Stallknecht, B. et al. (1995) Effect of training on epinephrine-stimulated lipolysis determined by microdialysis in human adipose tissue. Am. J. Physiol. 269, E1059-E1066
67. van Aggel-Leijssen, D.P. et al. (2001) The effect of exercise training on β-adrenergic stimulation of fat metabolism in obese men. Int. J. Obes. Relat. Metab. Disord. 25, 16-23
68. Turcotte, L.P. et al. (1992) Increased plasma FFA uptake and oxidation during prolonged exercise in trained vs. untrained humans. Am. J. Physiol. 262, E791-E799
69. Phillips, S.M. et al. (1996) Effects of training duration on substrate turnover and oxidation during exercise. J. Appl. Physiol. 81, 2182-2191
70. Watt, M.J. et al. (2002) Intramuscular triacylglycerol utilization in human skeletal muscle during exercise: is there a controversy? J. Appl. Physiol. 93, 1185-1195
71. Coggan, A.R. et al. (2000) Fat metabolism during high-intensity exercise in endurance-trained and untrained men. Metabolism 49, 122-128
72. De Glisezinski, I. et al. (2001) Lack of a2-adrenergic antilipolytic effect during exercise in subcutaneous adipose tissue of trained men. J. Appl. Physiol. 91, 1760-1765
73. Bonen, A. et al. (2000) Acute regulation of fatty acid uptake involves the cellular redistribution of fatty acid translocase. J. Biol. Chem. 275, 14501-14508
74. McGarry, J.D. (1995) The mitochondrial carnitine palmitoyltransferase system: its broadening role in fuel homeostasis and new insights into its molecular features. Biochem. Soc. Trans. 23, 321-324
75. Bonen, A. et al. (1998) Palmitate transport and fatty acid transporters in red and white muscles. Am. J. Physiol. 275, E471-E478
76. Spriet, L.L. (2002) Regulation of skeletal muscle fat oxidation during exercise in humans. Med. Sci. Sports Exerc. 34, 1477-1484
77. Shulman, G.I. (2000) Cellular mechanisms of insulin resistance. J. Clin. Invest. 106, 171-176
78. Asada, N. et al. (2000) Effects of 22K or 20K human growth hormone on lipolysis; leptin production in adipocytes in presence and absence of human growth hormone binding protein. Horm. Res. 54, 203-207
79. Asada, N. et al. (2000) GH induced lipolysis stimulation in 3T3-L1 adipocytes stably expressing hGHR: analysis on signaling pathway and activity of 20K hGH. Mol. Cell. Endocrinol. 162, 121-129
80. Viguerie, N. et al. (2002) Regulation of human adipocyte gene expression by thyroid hormone. J. Clin. Endocrinol. Metab. 87, 630-634
81. Botion, L.M. et al. (2001) Inhibition of proteasome activity blocks the ability of TNFa to down-regulate Gi proteins and stimulate lipolysis. Endocrinology 142, 5069-5075
82. Fruhbeck, G. and Gomez-Ambrosi, J. (2001) Modulation of the leptin-induced white adipose tissue lipolysis by nitric oxide. Cell. Signal. 13, 827-833
83. Wang, M.Y. et al. (1999) Novel form of lipolysis induced by leptin. J. Biol. Chem. 274, 17541-17544
84. Yang, S. et al. (1995) Additive effects of growth homone and testosterone on lipolysis in adipocytes of hypophysectomized rats. J. Endocrinol. 147, 147-152
85. Xu, X. et al. (1993) Postreceptor events involved in the up-regulation of (-adrenergic receptor mediated lipolysis by testosterone in rat white adipocytes. Endocrinology 132, 1651-1657
86. Pascual, M. et al. (1995) Insulin-like growth factor-I (IGF-I) affects plasma lipid profile and inhibits the lipolytic action ofgrowth hormone (GH) in isolated adipocytes. Life Sci. 57, 1213-1218
87. Lonnroth, P. et al. (1989) Microdialysis of intracellular adenosine concentration in subcutaneous tissue in humans. Am. J. Physiol. 256, E250-E255
88. Green, A. et al. (1989) Characterization of human adipocyte adenosine receptors. Biochem. Biophys. Res. Commun. 163, 137-142
89. Labelle, M. et al. (1997) Tissue-specific regulation offat cell lipolysis by NPY in 6-OHDA-treated rats. Peptides 18, 801-808