Fat and carbohydrate metabolism during exercise in elderly and young subjects

American Journal of Physiology - Endocrinology and Metabolism

Volumn 271, Issue 6 34-6, 1996, Pages

  Sial, Shahid ^b   Coggan, Andrew R ^b   Carroll, Richard ^b   Goodwin, James ^b   Klein, Samuel ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NONE

Author keywords

fatty acids; glycerol; glycogen; lipolysis; palmitate; stable isotopes

Indexed keywords

AGE; AGED; AGING; ARTICLE; CARBOHYDRATE METABOLISM; CONTROLLED STUDY; EXERCISE; FEMALE; HUMAN; LIPID METABOLISM; LIPID OXIDATION; LIPOLYSIS; MALE; NORMAL HUMAN; PRIORITY JOURNAL;

EID: 0030465875     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.1996.271.6.e983     Document Type: Article

References (35)

1. Arner, P., E. Kreigholm, P. Engfeldt, and J. Bolinder. Adrenergic regulation of lipolysis in situ at rest and during exercise. J. Clin. Invest. 85: 893-898, 1990.
2. Benjamin, W., A. Gelhorn, M. Wagner, and H. Kundel. Effect of aging on lipid composition and metabolism in the adipose tissue of the rat. Am. J. Physiol 201: 540-546, 1961.
3. Buskirk, E. R., and J. L. Hodgson. Age and aerobic power: rate of change in men and women. Federation Proc. 46: 1824-1829, 1987.
4. Calles-Escandon, J., P. Arciero, A. Gardner, C. Bauman, and E. Poehlman. Basal fat oxidation decreases with aging in women. J. Appl. Physiol. 78: 266-271, 1995.
5. Carraro, F., C. A. Stuart, W. H. Hartl, J. I. Rosenblatt, and R. R. Wolfe. Effect of exercise and recovery on muscle protein synthesis in human subjects. Am. J. Physiol. 259 (Endocrinol. Metab. 22): E470-E476, 1990.
6. Cartee, G. D., and R. P. Farrar. Exercise training induces glycogen sparing during exercise by old rats. J. Appl. Physiol. 64: 259-265, 1988.
7. Coggan, A. R., A. M. Abduljalil, S. C. Swanson, M. S. Earle, J. W. Farris, L. A. Mendenhall, and P. M. Robitaille. Muscle metabolism during exercise in young and older untrained and endurance trained men. J. Appl. Physiol. 75: 2125-2133, 1993.
8. Coggan, A. R., R. J. Spina, D. S. King, M. A. Rogers, M. Brown, P. M. Nemeth, and J. O. Holloszy. Histochemical and enzymatic characteristics of the gastrocnemius muscle of young and elderly men and women. J. Gerontol. 47: B71-B76, 1992.
9. Davies, C. T. M., D. O. Thomas, and M. J. White. Mechanical properties of young and elderly muscle. Acta Med. Scand. Suppl. 711: 219-226, 1988.
10. Dax, E. M., J. S. Partilla, and R. I. Gregerman. Mechanism of the age-related decrease of epinephrine-stimulated lipolysis in isolated rate adipocytes. Beta-adrenergic receptor binding, adenylate cyclase activity, and cyclic AMP accumulation. J. Lipid Res. 22: 934-943, 1981.
11. Forbes, G. B., and J. C. Reina. Adult lean body mass declines with age: some longitudinal observations. Metab. Clin. Exp. 19: 653-663, 1970.
12. Frayn, K. Calculation of substrate oxidation rates in vivo from gaseous exchange. J. Appl. Physiol. 55: 628-634, 1983.
13. Hales, C. N., and P. J. Randle. Immunoassay of insulin with insulin antibody precipitate. Biochem. J. 88: 137-146, 1963.
14. Hall, P. E., S. R. Smith, D. B. Jack, and M. J. Kendall. The influence of beta-adrenoceptor blockade on the lipolytic response to exercise. J. Clin. Pharm. Ther. 12: 101-115, 1987.
15. Hargreaves, M., G. McConnell, and J. Proietto. Influence of muscle glycogen on glycogenolysis and glucose uptake during exercise in humans. J. Appl. Physiol. 78: 288-292, 1995.
16. Hoffman, B. B., H. Chang, Z. T. Farahbakhsh, and G. M. Reaven. Age-related decrement in hormone-stimulated lipolysis. Am. J. Physiol. 247 (Endocrinol. Metab. 10): E772-E777, 1984.
17. Holloszy, J. O., and E. F. Coyle. Adaptations of skeletal muscle to endurance exercise and their metabolic consequences. J. Appl. Physiol 56: 831-838, 1984.
18. Hussain, M. N., and C. R. Benedict. Radioenzymatic microassay for simultaneous estimations of dopamine, norepinephrine, and epinephrine in plasma, urine, and tissues. Clin. Chem. 31: 1861-1864, 1985.
19. Klein, S., Y. Sakurai, J. A. Romijn, and R. M. Carroll. Progressive alterations in lipid and glucose metabolism during short-term fasting in humans. Am. J. Physiol. 265 (Endocrinol. Metab. 28): E801-E806, 1993.
20. Kohrt, W. M., M. T. Malley, G. P. Dalsky, and J. O. Holloszy. Body composition of healthy sedentary and trained, young and older men and women. Med. Sci. Sports Exercise 24: 832-837, 1992.
21. Kohrt, W. M., K. A. Obert, and J. O. Holloszy. Exercise training improves fat distribution patterns in 60- to 70-year old men and women. J. Gerontol. 47: M99-M105, 1992.
22. Kohrt, W. M., R. J. Spina, A. A. Ehsani, P. E. Cryer, and J. O. Holloszy. Effects of age, adiposity, and fitness level on plasma catecholamine responses to standing and exercise. J. Appl. Physiol. 75: 1828-1835, 1993.
23. Lonnqvist, F., B. Nyberg, H. Wahrenberg, and P. Arner. Catecholamine-induced lipolysis in adipose tissue of the elderly. J. Clin. Invest. 85: 1614-1621, 1990.
24. McDonald-Gibson, R. G., and M. Young. The use of an automatic solids injection system for quantitative determination of plasma long chain non-esterified fatty acids by gas-lipid chromatography. Clin. Chim. Acta 53: 117-126, 1974.
25. McGuire, E. A. H., J. H. Helderman, J. D. Tobin, R. Andres, and M. Herman. Effects of arterial versus venous sampling on analysis of glucose kinetics in man. J. Appl. Physiol. 41: 565-573, 1976.
26. Meredith, C. N., W. R. Frontera, E. C. Fisher, V. A. Hughes, J. C. Herland, J. Edwards, and W. J. Evans. Peripheral effects of endurance training in young and old subjects. J. Appl. Physiol. 66: 2844-2849, 1989.
27. Munro, H. M. Aging. In: Nutrition and Metabolism in Patient Care, edited by J. Kinney, K. Jeejeebhoy, G. Hill, and O. Owen. Philadelphia, PA: Saunders, 1988, p. 145-166.
28. Poehlman, E., A. Gardner, P. Arciero, M. Goran, and J. Calles-Escandon. Effects of endurance training on total fat oxidation in elderly persons. J. Appl. Physiol. 76: 2281-2287, 1994.
29. Ren, J. M., E. A. Gulve, G. D. Cartee, and J. O. Holloszy. Hypoxia causes glycogenolysis without an increase in percent phosphorylase alpha in rat skeletal muscle. Am. J. Physiol. 263 (Endocrinol. Physiol. 26): E1086-E1091, 1993.
30. Schwartz, R. S., W. P. Shuman, V. Larson, K. C. Cain, G. W. Fellingham, J. C. Beard, S. E. Kahn, J. R. Stratton, M. D. Cerqueira, and I. B. Abrass. The effect of intensive endurance exercise training on body fat distribution in young and older men. Metab. Clin. Exp. 40: 545-551, 1991.
31. Seals, D. R., B. F. Hurley, J. Schultz, and J. M. Hagberg. Endurance training in older men and women. II. Blood lactate response to submaximal exercise. J. Appl. Physiol. 57: 1030-1033, 1984.
32. Steele, R. Influences of glucose loading and of injected insulin on hepatic glucose output. Ann. NY Acad. Sci. 82: 420-430, 1959.
33. Terjung, R. L. V. H. Lipid metabolism during exercise. Diabetes Metab. Rev. 2: 33-51, 1986.
34. Trappe, S. W., D. L. Costill, M. D. Vikovich, J. Jones, and T. Melham. Aging among elite distance runners: a 22-yr longitudinal study J. Appl. Physiol. 80: 285-290, 1996.
35. Winder, W. W., J. Arogyasami, R. J. Barton, I. M. Elayan, and P. R. Vehrs. Muscle malonyl CoA decreases during exercise. J. Appl. Physiol. 67: 2230-2233, 1989.