Protein degradation with photoactivated enediyne-amino acid conjugates

Bioorganic and Medicinal Chemistry Letters

Volumn 12, Issue 20, 2002, Pages 2985-2988

  Plourde, Ii, Gary ^a   El Shafey, Ahmed ^a   Fouad, Farid S ^a   Purohit, Ajay S ^a   Jones, Graham B ^a  

^a NORTHEASTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYNE DERIVATIVE; AMINO ACID DERIVATIVE;

ARTICLE; CONJUGATE; PHOTOACTIVATION; PROTEIN DEGRADATION; PROTEIN TARGETING;

DNA DAMAGE; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HISTONES; INDICATORS AND REAGENTS; OLIGOSACCHARIDES; PHOTOCHEMISTRY; PROTEINS; PYRIMIDINES; SERUM ALBUMIN, BOVINE;

EID: 0037152419     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(02)00618-2     Document Type: Article

References (24)

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22. -1) showed no detectable histone degradation after 12 h irradiation.
23. Compounds 19-21 produced no specific histone degradation products after 12 h irradiation (10 μM).
24. This work was supported by the National Institutes of Health (R01GM57123).