Evaluation of Aspergillus niger as host for virus-like particle production, using the hepatitis B surface antigen as a model

Current Genetics

Volumn 43, Issue 6, 2003, Pages 439-446

  Plüddemann, Annette ^a   van Zyl, Willem H ^a  

^a STELLENBOSCH UNIVERSITY   (South Africa)

Author keywords

Expression; Hepatitis B; Pseudoviral particles; Recombinant

Indexed keywords

DIMER; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; HEPATITIS B SURFACE ANTIGEN; RECOMBINANT PROTEIN; VIRUS ENVELOPE PROTEIN; VITRONECTIN;

ARTICLE; ASPERGILLUS NIDULANS; ASPERGILLUS NIGER; COST EFFECTIVENESS ANALYSIS; ELECTRON MICROSCOPY; FUNGAL STRAIN; FUNGUS CULTURE; GENE CASSETTE; GENE EXPRESSION; GENETIC TRANSCRIPTION; GENETIC TRANSFORMATION; GENOME; HEPATITIS B VIRUS; HOST; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PURIFICATION; PROTEIN SYNTHESIS; VACCINE PRODUCTION; VIRUS GENE; VIRUS PARTICLE; WESTERN BLOTTING;

ASPERGILLUS NIGER; BIOREACTORS; BIOTECHNOLOGY; GENE DOSAGE; GENETIC ENGINEERING; HEPATITIS B SURFACE ANTIGENS; HEPATITIS B VIRUS; HUMANS; MODELS, GENETIC; PROMOTER REGIONS (GENETICS); TRANSFORMATION, GENETIC; TRANSGENES; VIRAL PROTEINS; VIRION;

ASPERGILLUS; ASPERGILLUS NIGER; EMERICELLA NIDULANS; FUNGI; HEPATITIS B VIRUS;

EID: 0141855304     PISSN: 01728083     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00294-003-0409-0     Document Type: Article

References (58)

1. Ayoola EA (1988) Viral hepatitis in Africa. In: Zuckerman AJ (ed) Viral hepatitis and liver disease. Liss, New York, pp 161-169
2. Barr PJ, Gibson HL, Bathurst IC, Sabin EA, Medina-Selby A, Coit D, Valenzuela P (1989) Recombinant subunit vaccines from yeast. In: Barr PJ, Brake AJ, Valenzuela P (eds) Yeast genetic engineering. Butterworths, Boston, pp 319-335
3. Bennett JW, Lasure LL (1991) Growth media. In: Bennett JW, Lasure LL (eds) More gene manipulations in fungi. Academic Press, San Diego, pp 441-458
4. Blum H, Beier H, Gross HJ (1987) Improved silver staining of plant proteins, RNA and DNA in polyacrylamide gets. Electrophoresis 8:93-99
5. Bodie EA, Bower B, Berka RM, Dunn-Coleman NS (1994) Economically important organic acid and enzyme products. In: Martinelli SD, Kinghorn JR (eds) Aspergillus: 50 years on. Elsevier, Amsterdam, pp 561-602
6. Christensen T, Tschopp JF, Stillman C, Siegel R, Akong M, Craig WS, Buckholz RG, Madden KR, Kellaris PA, Davis GR, Smiley BL, Cruze J, Torregrossa R, Velicelebi G, Thill GP (1988) High level expression of recombinant genes in Aspergillus oryzae. Bio/Technology 6:1419-1422
7. Collins ML, Salton MR (1979) Solubility characteristics of Micrococcus lysodeikticus membrane components in detergents and chaotropic salts analyzed by immunoelectrophoresis. Biochim Biophys Acta 553:40-53
8. Cregg JM, Tschopp JF, Stillman C, Siegel R, Akong M, Craig WS, Buckholz RG, Madden KR, Kellaris PA, Davis GR, Smiley BL, Cruze J, Torregrossa R, Velicelebi G, Thill GP (1987) High-level expression and efficient assembly of hepatitis B surface antigen in the methylotrophic yeast, Pichia pastoris. Bio/Technology 5:479-485
9. Davies RW (1991) Molecular biology of a high-level recombinant protein production system in Aspergillus. In: Leong SA, Berka RM (eds) Molecular industrial mycology: systems and applications for filamentous fungi. Dekker, New York, pp 45-81
10. Davies RW (1994) Heterologous gene expression and protein secretion in Aspergillus. In: Martinelli SD, Kinghorn JR (eds) Aspergillus: 50 years on. Elsevier, Amsterdam, pp 527-559
11. Dehoux P, Ribes V, Sobczak E, Streeck RE (1986) Expression of the hepatitis B large envelope protein in Saccharomyces cerevisiae. Gene 48:155-163
12. Domansky N, Ehsani P, Salmanian A-H, Medvedeva T (1995) Organ-specific expression of hepatitis B surface antigen in potato. Biotechnol Lett 17:863-866
13. Ganem D, Varmus HE (1987) The molecular biology of the hepatitis B viruses. Annu Rev Biochem 56:651-693
14. Gerlich W (1991) Hepatitis B surface proteins. J Hepatol 13[Suppl 4]:S90-S92
15. Gordon CL, Khalaj V, Ram AFJ, Archer DB, Brockman JL, Trinci APJ, Jeenes DJ, Doonan JH, Wells B, Punt PJ, Van den Hondel CAMJJ, Robson GD (2000) Glucoamylase:green fluorescent protein fusions to monitor protein secretion in Aspergillus niger. Microbiology 146:415-426
16. Gouka RJ, Punt PJ, Hessing JGM, Van den Hondel CAMJJ (1996) Analysis of heterologous protein production in defined recombinant Aspergillus awamori strains. Appl Environ Microbiol 62:1951-1957
17. Gouka RJ, Punt PJ, Van den Hondel CAMJJ (1997a) Glucoamylase gene fusions alleviate limitations for protein production in Aspergillus awamori at the transcriptional and (post) translational levels. Appl Environ Microbiol 63:488-497
18. Gouka RJ, Punt PJ, Van den Hondel CAMJJ (1997b) Efficient production of secreted proteins by Aspergillus: progress, limitations and prospects. Appl Microbiol Biotechnol 47:1-11
19. Gwynne DI, Buxton FP, Williams SA, Garven S, Davies RW (1987) Genetically engineered secretion of active human interferon and a bacterial endoglucanase from Aspergillus nidulans. Bio/Technology 5:713-719
20. Hadfield C, Raina KK, Shashi-Menon K, Mount RC (1993) The expression and performance of cloned genes in yeasts. Mycol Res 97:897-944
21. Hardy E, Martinez E, Diago D, Diaz R, Gonzalez D, Herrera L (2000) Large-scale production of recombinant hepatitis B surface antigen from Pichia pastoris. J Biotechnol 77:157-167
22. Hilleman MR (1987) Yeast recombinant hepatitis B vaccine. Infection 15:3-7
23. Hitzeman RA, Chen CY, Hagie FE, Patzer FJ, Liu C-C, Estell DA, Miller JV, Yaffe A, Kleid DG, Levinson AD, Oppermann H (1983) Expression of hepatitis B virus surface antigen in yeast. Nucleic Acids Res 11:2745-2763
24. Howard CR, Young PR, Lee S, Dixon J, Zuckerman AJ, McAleer WJ, Lehman ED (1986) Hepatitis B surface antigen polypeptide micelles from antigen expressed in Saccharomyces cerevisiae. J Virol Methods 14:25-35
25. Huovila A-PJ, Eder AM, Fuller SD (1992) Hepatitis B surface antigen assembles in a post-ER, pre-Golgi compartment. J Cell Biol 118:1305-1320
26. Janowicz ZA, Melber K, Merckelbach A, Jacobs E, Harford N, Comberbach M, Hollenberg CP (1991) Simultaneous expression of the S and L surface antigens of hepatitis B, and formation of mixed particles in the methylotrophic yeast, Hansenula polymorpha. Yeast 7:431-443
27. Jeenes DJ, MacKenzie DA, Roberts IN, Archer DB (1991) Heterologous protein production by filamentous fungi. Biotechnol Genet Eng Rev 9:327-367
28. Kassianides C, Di Bisceglie AM, Hoofnagle JH, Mullen K, Peters M, Rustgi V, Jones B, Lisker-Melman M, Park Y, Waggoner JG, Jones EA (1988) Alpha-interferon therapy in patients with decompensated chronic type B hepatitis. In: Zuckerman AJ (ed) Viral hepatitis and liver disease. Liss, New York, pp 840-843
29. Kinghorn JR, Unkles SE (1994) Molecular genetics and expression of foreign proteins in the genus Aspergillus. In: Smith JE (ed) Aspergillus. Plenum, New York, pp 65-100
30. La Grange DC, Pretorius IS, Van Zyl WH (1996) Expression of a Trichoderma reesei β-xylanase gene (XYN2) in Saccharomyces cerevisiae. Appl Environ Microbiol 62:1036-1044
31. Manyike PT, Aspinall S, Summers RS (1992) Immunogenicity of recombinant hepatitis B vaccine in urban black children from Ga-Rankuwa, Bophuthatswana, South Africa. Pediatr Infect Dis J 11:726-730
32. Martinez E, Morales J, Aguiar J, Pineda Y, Izquierdo M, Ferbeyre G (1992) Cloning and expression of hepatitis B surface antigen in the yeast Kluyveromyces lactis. Biotechnol Lett 14:83-86
33. Mason HS, Lam DMK, Arntzen J (1992) Expression of hepatitis B surface antigen in transgenic plants. Proc Natl Acad Sci USA 89:11745-11749
34. McAleer WJ, Buynak EB, Maigetter RZ, Wampler DE, Miller WJ, Hilleman MR (1984) Human hepatitis B vaccine from recombinant yeast. Nature 307:178-180
35. Michel M-L, Pontisso P, Sobczak E, Malpièce Y, Streeck RE, Tiollais P (1984) Synthesis in animal cells of hepatitis B surface antigen particles carrying a receptor for polymerized human serum albumin. Proc Natl Acad Sci USA 81:7708-7712
36. Miyanohara A, Toh-e A, Nozaki C, Hamada F, Ohtomo N, Matsubara K (1983) Expression of hepatitis B surface antigen gene in yeast. Proc Natl Acad Sci USA 80:1-5
37. O'Keefe DO, Paiva AM (1995) Assay for recombinant hepatitis B surface antigen using reversed-phase high-performance liquid chromatography. Anal Biochem 230:48-54
38. Peterson DL (1987) The structure of the hepatitis B surface antigen and its antigenic sites. BioEssays 6:258-262
39. Punt PJ, Van den Hondel CAMJJ (1992) Transformation of filamentous fungi based on hygromycin B and phleomycin resistance markers. Methods Enzymol 216:447-457
40. Punt PJ, Zegers ND, Busscher M, Pouwels PH, Van den Hondel CAMJJ (1991) Intracellular and extracellular production of proteins in Aspergillus under the control of expression signals of the highly expressed Aspergillus nidulans gpdA gene. J Biotechnol 17:19-34
41. Sambrook J, Fritsch EF, Maniatis T (1989) Molecular cloning: a laboratory manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
42. Sato M, Sato-Miyamoto Y, Kameyama K, Ishikawa N, Imai M, Ito Y, Takagi T (1995) Peripherally biased distribution of antigen proteins on the recombinant yeast-derived human hepatitis B virus surface antigen vaccine particle: structural characteristics revealed by small-angle neutron scattering using the contrast variation method. J Biochem 118:1297-1302
43. Seeger C, Mason WS (2000) Hepatitis B virology. Microbiol Mol Biol Rev 64:51-68
44. Tautz D, Renz N (1983) An optimized freeze squeeze method for the recovery of DNA fragments from agarose gels. Anal Biochem 132:503-517
45. Thanavala Y, Yang Y-F, Lyons P, Mason HS, Arntzen C (1995) Immunogenicity of transgenic plant-derived hepatitis B surface antigen. Proc Natl Acad Sci USA 92:3358-3361
46. Tiollais P, Pourcel C, Dejean A (1985) The hepatitis B virus. Nature 317:489-495
47. Tleugabulova D (1998) Size-exclusion chromatograhic study of the reduction of recombinant hepatitis B surface antigen. J Chromatogr B 713:401-407
48. Upshall A, Kumar AA, Bailey MC, Parker MD, Favreau MA, Lewison KP, Joseph ML, Maraganore JM, McKnight GL (1987) Secretion of active human tissue plasminogen activator from the filamentous fungus Aspergillus nidulans. Bio/Technology 5:1301-1304
49. Valenzuela P, Gray P, Quiroga M, Zaldivar J, Goodman HM, Rutter WJ (1979) Nucleotide sequence of the gene coding for the major protein of hepatitis B virus surface antigen. Nature 280:815-819
50. Valenzuela P, Medina A, Rutter WJ, Ammerer G, Hall BD (1982) Synthesis and assembly of hepatitis B virus surface antigen particles in yeast. Nature 298:347-350
51. Van den Hondel CAMJJ, Punt PJ (1991) Gene transfer systems and vector development for filamentous fungi. In: Peberdy JF, Caten CE, Ogden JE, Bennett JW (eds) Applied molecular genetics of fungi. Cambridge University Press, Cambridge, pp 1-28
52. Van den Hondel CAMJJ, Punt PJ, Van Gorcom RFM (1991) Heterologous gene expression in filamentous fungi. In: Bennett JW, Lasure LL (eds) More gene manipulations in fungi. Academic Press, San Diego, pp 397-428
53. Verdoes JC, Punt PJ, Schrickx JM, Van Verseveld HW, Stouthamer AH, Van den Hondel CAMJJ (1993) Glucoamylase overexpression in Aspergillus niger: molecular genetic analysis of strains containing multiple copies of the glaA gene. Transgenic Res 2:84-92
54. Vryheid RE, Kane MA, Muller N, Schatz GC, Bezabeh S (2001) Infant and adolescent hepatitis B immunization up to 1999: a global overview. Vaccine 19:1026-1037
55. Ward M, Wilson LJ, Kodama KH, Rey MW, Berka RM (1990) Improved production of chymosin in Aspergillus by expression as a glucoamylase-chymosin fusion. Bio/Technology 8:435-440
56. Wiebe MG, Karandikar A, Robson GD, Trinci APJ, Flores Candia J-L, Trappe S, Wallis GLF, Rinas U, Derkx PMF, Madrid SM, Sisniega H, Faus I, Montijn R, Van den Hondel CAMJJ, Punt PJ (2001) Production of tissue plasminogen activator (t-PA) in Aspergillus niger. Biotechnol Bioeng 76:164-174
57. WHO (1996) Hepatitis B vaccine - making global progress. (EPI update 31) World Health Organisation, Geneva
58. Yamaguchi M, Sugahara K, Shiosaki K, Mizokami H, Takeo K (1998) Fine structure of hepatitis B virus surface antigen produced by recombinant yeast: comparison with HBsAg of human origin. FEMS Microbiol Lett 165:363-367