Modulation of host immune responses by overexpression of immunodominant antigens of Mycobacterium tuberculosis in bacille Calmette-Guérin

Scandinavian Journal of Immunology

Volumn 58, Issue 4, 2003, Pages 449-461

  Rao, V ^a   Dhar, N ^a   Tyagi, A K ^a  

^a UNIVERSITY OF DELHI   (India)

Author keywords

[No Author keywords available]

Indexed keywords

BCG VACCINE; GAMMA INTERFERON; LIPOPROTEIN; MYCOBACTERIUM ANTIGEN; RECOMBINANT VACCINE;

ANIMAL EXPERIMENT; ANTIGEN EXPRESSION; ARTICLE; BACTERIAL STRAIN; CELLULAR IMMUNITY; COMPARATIVE STUDY; CONTROLLED STUDY; HUMORAL IMMUNITY; IMMUNOMODULATION; MOLECULAR CLONING; MOLECULAR WEIGHT; MOUSE; MYCOBACTERIUM BOVIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; TH1 CELL; TH2 CELL; TRANSCRIPTION REGULATION; TUBERCULOSIS; ULTRASOUND;

ANIMALS; BCG VACCINE; CLONING, MOLECULAR; HOST-PARASITE RELATIONS; IMMUNODOMINANT EPITOPES; MICE; MYCOBACTERIUM TUBERCULOSIS; TUBERCULOSIS;

EID: 0141816758     PISSN: 03009475     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-3083.2003.01321.x     Document Type: Article

References (38)

1. Fine PEM. The BCG story: lessons from the past and implications for the future. Rev Infect Dis 1989;11 (Suppl. 2):S353-9.
2. Andersen P. Effective vaccination of mice against Mycobacterium tuberculosis infection with a soluble mixture of secreted mycobacterial proteins. Infect Immun 1994;62:2536-44.
3. Vordermeier HM, Combes AGA, Jenkins P et al. Synthetic delivery system for TB vaccines: immunological evaluation of 38 kDa protein entrapped in biodegradable PLG microparticles. Vaccine 1995;13:1576-82.
4. Tascon RE, Colston MJ, Ragno S, Stavropoulos E, Gregory D, Lowrie DB. Vaccination against tuberculosis by DNA injection. Nat Med 1996;2:888-92.
5. Zhu X, Venkataprasad N, Thangaraj HS, Singh M, Ivanyi J, Vordermeier HM. Function and specificity of T cells following nucleic acid vaccination of mice against Mycobacterium tuberculosis infection. Infect Immun 1997;59:321-2.
6. Mustafa A, Amoudy H, Wiker H et al. Comparison of antigen specific T cell responses of tuberculosis patients using complex or single antigens of Mycobacterium tuberculosis. Scand J Immunol 1998;48:535-43.
7. Brandt L, Oettinger T, Holm A, Andersen A, Andersen P. Key epitopes on the Esat-6 antigen recognised in mice during the recall of protective immunity to Mycobacterium tuberculosis. J Immunol 1996;157:3527-33.
8. Morris S, Kelley C, Howard A, Li Z, Collins F. The immunogenicity of single and combination DNA vaccines against tuberculosis. Vaccine 2000;18:2155-63.
9. Olsen A, Hansen P, Holm A, Andersen P. Efficient protection against Mycobacterium tuberculosis vaccination with a single subdominant epitope from the ESAT6 antigen. Eur J Immunol 2000;30:1724-32.
10. Brandt L, Elhay M, Rosenkrands I, Lindblad EB, Andersen P. ESAT-6 subunit vaccination against Mycobacterium tuberculosis. Infect Immun 2000;68:91-795.
11. Weinrich Olsen A, van Pinxteren LA, Meng Okkels L, Birk Rasmussen P, Andersen P. Protection of mice with a tuberculosis subunit vaccine based on a fusion protein of antigen 85B and ESAT-6. Infect Immun 2001;69:2773-8.
12. Li Z, Howard A, Kelley C, Delogu G, Collins F, Morris S. Immunogenicity of DNA vaccines expressing tuberculosis proteins fused to tissue plasminogen activator signal sequences. Infect Immun 1999;67:4780-6.
13. Brightbill HD, Linraty DH, Krutzik SR et al. Host defense mechanisms triggered by microbial lipoproteins through Toll like receptors. Science 1999;285:732-6.
14. 37Rv, studied by crossed immunoelectrophoresis. Comparison with a reference system for Mycobacterium bovis, BCG. Scand J Immunol 1988;27:223-39.
15. Harris D, Vordermeier H, Roman E et al. Muirne T cell stimulatory peptides from the 19-kDa antigen of Mycobacterium tuberculosis: epitope restricted homology with the 28-kDa protein of Mycobacterium leprae. J Immunol 1991;147:2706-12.
16. Rees A, Faith A, Roman J, Ivanyi J, Wiesmullers K, Moreno C. The effect of lipoacylation on CD4 T cell recognition of the 19,000 MW Mycobacterium tuberculosis antigen. Immunology 1993;80:407-14.
17. Abou-Zeid C, Gates MP, Inwald J et al. Induction of a type 1 immune response to a recombinant antigen from Mycobacterium tuberculosis expressed in Mycobacterium vaccae. Infect Immun 1997;65:1856-62.
18. Yeremeev VV, Lyadova IV, Nikonenko BV et al. The 19-kDa antigen and protective immunity in a murine model of tuberculosis. Clin Exp Immunol 2000;120:274-9.
19. Orme IM. Induction of non specific resistance and delayed type hypersensitivity, but not specific acquired resistance, in mice inoculated with killed mycobacterial vaccines. Infect Immun 1988;56:3310-2.
20. Hanson MS, Lapcevich CV, Haun SL. Progress on the development of the live BCG recombinant (rBCG) vaccine vehicle for combined delivery. Ann N Y Acad Sci 1995;754:214-21.
21. Stover CK et al. New use of BCG for recombinant vaccines. Nature (Lon) 1991;351:456-9.
22. Horwitz MA, Harth G, Dillon BJ, Maslesa-Galic S. Recombinant bacillus Calmette Guerin (BCG) vaccines expressing the Mycobacterium tuberculosis 30-kDa major secretory protein induce greater protective immunity against tuberculosis than conventional BCG vaccines in a highly susceptible animal model. Proc Natl Acad Sci USA 2000;97:13853-8.
23. Ohara N, Matsuoka M, Nomaguchi H, Naito M, Yamada T. Inhibition of multiplication of Mycobaterium leprae in mouse foot pads by recombinant bacillus Calmette Guerin (BCG). Vaccine 2000;18:1294-7.
24. Dhar N, Rao V, Tyagi AK. Recombinant BCG approach for development of vaccines: cloning and expression of immunodominant antigens of M. tuberculosis. FEMS Microbiol Lett 2000;190:309-16.
25. DasGupta SK, Jain S, Kaushal D, Tyagi AK. Expression systems for study of mycobacterial gene regulation and development of recombinant BCG vaccines. Biochem Biophys Res Commun 1998;246:797-804.
26. DasGupta SK, Bashyam MD, Tyagi AK. Cloning and assesment of mycobacterial promoters by using a plasmid shuttle vector. J Bacteriol 1993;175:5186-92.
27. Andersen P, Askgaard D, Ljungqvist L, Bentzon MW, Heron I. T-cell proliferative response to antigens secreted by Mycobacterium tuberculosis. Infect Immun 1991;59:1558-63.
28. Young D, Garbe T, Lathigra R, Abou-Zeid C. Protein antigens: structure, function and regulation. In: Mcfadden J, ed. Molecular Biology of the Mycobacteria. London: Surrey University Press, 1990, 1-35.
29. Pal PG, Horwitz MA. Immunization with extracellular proteins of Mycobacterium tuberculosis induces cell-mediated immune responses and substantial protective immunity in a guinea pig model of pulmonary tuberculosis. Infect Immun 1992;60:4781-92.
30. Guleria I, Teitelbaum R, McAdam RA, Kalpana G, Jacobs WRJ, Bloom BR. Auxotrophic vaccines for tuberculosis. Nat Med 1996;2:334-7.
31. Aldovini A, Young RA. Humoral and cell mediated responses to recombinant BCG-HIV vaccines. Nature (Lon) 1991;351: 459-82.
32. Harboe M, Wiker HG. The 38 kDa protein of Mycobacterium tuberculosis: a review. J Infect Dis 1992;166:874-84.
33. Wiker HG, Harboe M, Nagai S. A localization index for distinction between extracellular and inttacellular antigens of Mycobacterium tuberculosis. J Gen Microbiol 1991;137:875-84.
34. Sorensen A, Nagai S, Houen G, Andersen P, Andersen AB. Purification and chracterisation of a low molecular mass T cell antigen secreted by Mycobaterium tuberculosis. Infect Immun 1995;63:1710-7.
35. Harboe M, Oettinger T, Wiker H, Rosenkrands I, Andersen P. Evidence of occurrence of the ESAT6 protein in Mycobacterium tuberculosis and virulent Mycobacterium bovis and for its absence in Mycobacterium bovis BCG. Infect Immun 1996;64:16-22.
36. Gordon SV, Brosch R, Billault A, Garnier T, Eiglmeier K, Cole ST. Identification of variable regions in the genomes of tubercle bacilli using bacterial artificial chromosome arrays. Mol Microbiol 1999;32:643-55.
37. Noss EH, Pai RK, Sellati TJ et al. Toll-like receptor 2-dependent inhibition of macrophage class II MHC expression and antigen processing by 19-kDa lipoprotein of Mycobacterium tuberculosis. J Immunol 2001;167:910-8.
38. Post FA, Manca C, Neyroles O, Ryfeel B, Young D, Kaplan G. Mycobacterium tuberculosis 19-Kildalton lipoprotein inhibits Mycobacterium smegmatis induced cytokine production by human macrophages in vitro. Infect Immun 2001;69:1433-9.