Enzymatic resolution of secondary alcohols coupled with ruthenium- catalyzed racemization without hydrogen mediator

Tetrahedron Letters

Volumn 40, Issue 34, 1999, Pages 6281-6284

  Koh, Jeong Hwan ^a   Jung, Hyun Min ^a   Kim, Mahn Joo ^a   Park, Jaiwook ^a  

^a Pohang University of Science and Technology (POSTECH)   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; HYDROGEN; KETONE; OXYGEN; RUBIDIUM; RUTHENIUM; TRIETHYLAMINE;

ACETYLATION; ARTICLE; CHEMICAL REACTION; ENZYME ANALYSIS; HYDROGENATION; ISOMERISM; KINETICS; NONHUMAN;

EID: 0033588195     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(99)01237-X     Document Type: Article

References (16)

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10. In Ref. 3d, DKR was carried out without adding ketones. However, substrate alcohols were oxidized to ketones through unidentified hydrogen-consuming processes.
11. Koh, J. H.; Jeong, H. M.; Park, J. Tetrahedron Lett. 1998, 39, 5545-5548.
12. When the reaction mixture was exposed to excess oxygen, the reaction mixture turned into a dark brown solution, losing the catalytic activity for racemization.
13. PCL immobilized on ceramic particles (trade name: Lipase PS-C (type II), Amano, Japan) was used.
14. 1H NMR).
15. The absolute configuration of the acetates was determined by comparing their optical rotations with known data. See: (a) Naemura, K.; Murata, M.; Tanaka, R.; Yano, M.; Hirose, K.; Tobe, Y. Tetrahedron: Asymmetry 1996, 7, 3285-3294.
16. (b) Laumen, K.; Schneider, M. P. J. Chem. Soc., Chem. Commun. 1988, 598-600.