Spinal cord injury: Promising interventions and realistic goals

American Journal of Physical Medicine and Rehabilitation

Volumn 82, Issue 10 SUPPL., 2003, Pages

  McDonald, John W ^a   Becker, Daniel ^b  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NONE

Author keywords

Activity Dependent Plasticity; Embryonic Stem Cells; Functional Electrical Stimulation; Patterned Neural Activity; Remyelination; Repair, Rehabilitation; Spinal Cord Injury; Spinal Cord Transplantation; Stem Cells

Indexed keywords

CELLS; PATIENT TREATMENT; TRANSPLANTATION (SURGICAL);

CLINICAL TRIALS;

PATIENT REHABILITATION;

CLINICAL STUDY; CLINICAL TRIAL; CONFERENCE PAPER; ELECTROSTIMULATION; HUMAN; INFORMATION PROCESSING; MACROPHAGE; MEDICAL RESEARCH; NERVE CELL PLASTICITY; NERVE STIMULATION; REMYELINIZATION; SAFETY; SPINAL CORD INJURY; STEM CELL TRANSPLANTATION; TREATMENT OUTCOME;

EID: 0141681057     PISSN: 08949115     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.phm.0000086994.53716.17     Document Type: Conference Paper

References (66)

1. Sadowsky C, Volshteyn O, Schultz L, et al: Spinal cord injury. Disabil Rehabil 2002;24:680-7
2. McDonald JW, Sadowsky C: Spinalcord injury. Lancet 2002;359:417-25
3. Bunge RP, Puckett WR, Becerra JL, et al: Observations on the pathology of human spinal cord injury: A review and classification of 22 new cases with details from a case of chronic cord compression with extensive focal demyelination. Adv Neurol 1993;59:75-89
4. Kakulas BA, Lorimer RL, Gubbay AD: White matter changes in human spinal cord injury, in Stalberg E, Sharma HS, Olsson Y (eds): Spinal Cord Monitoring. Wien, Springer-Verlag, 1998
5. Kakulas BA: The applied neuropathology of human spinal cord injury. Spinal Cord 1999;37:79-88
6. Hadi B, Zhang YP, Burke DA, et al: Lasting paraplegia caused by loss of lumbar spinal cord interneurons in rats: No direct correlation with motor neuron loss. J Neurosurg 2000;93(suppl 2):266-75
7. Reier PJ, Golder FJ, Bolser DC, et al: Gray matter repair in the cervical spinal cord. Prog Brain Res 2002;137:49-70
8. McDonald JW, Becker D, Sadowsky CL, et al: Late Recovery following spinal cord injury: Case report and review of the literature. J Neurosurg 2002;97(suppl 2):252-65
9. Blight AR: Cellular morphology of chronic spinal cord injury in the cat: Analysis of myelinated axons by line-sampling. Neuroscience 1983;10:521-43
10. Pepin A, Ladouceur M, Barbeau H: Treadmill walking in incomplete spinalcord-injured subjects: 2. Factors limiting the maximal speed. Spinal Cord 2003;41:271-9
11. Pepin A, Norman KE, Barbeau H: Treadmill walking in incomplete spinalcord-injured subjects: 1. Adaptation to changes in speed. Spinal Cord 2003;41:257-70
12. Barbeau H: Locomotor training in neurorehabilitation: Emerging rehabilitation concepts. Neurorehabil Neural Repair 2003;17:3-11
13. Maegele M, Muller S, Wernig A, et al: Recruitment of spinal motor pools during voluntary movements versus stepping after human spinal cord injury. J Neurotrauma 2002;19:1217-29
14. Horner PJ, Gage FH: Regenerating the damaged central nervous system. Nature 2000;407:963-70
15. McDonald JW, Howard MJ: Repairing the damaged spinal cord: A summary of our early success with embryonic stem cell transplantation and remyelination. Prog Brain Res 2002;137:299-309
16. McDonald JW: ES cells and neurogenesis, in Rao MS (ed): Stem Cells and CNS Development. Totowa, NJ, Humana Press, 2001, pp. 207-61
17. Suda Y, Suzuki M, Ikawa Y, et al: Mouse embryonic stem cells exhibit indefinite proliferative potential. J Cell Physiol 1987;133:197-201
18. Wobus AM: Potential of embryonic stem cells. Mol Aspects Med 2001;22:149-64
19. Gottlieb DI: Large-scale sources of neural stem cells. Annu Rev Neurosci 2002;25:381-407
20. Li M, Pevny L, Lovell-Badge R, et al: Generation of purified neural precursors from embryonic stem cells by lineage selection. Curr Biol 1998;8:971-4
21. Liu S, Qu Y, Stewart TJ, et al: Embryonic stem cells differentiate into oligodendrocytes and myelinate in culture and after spinal cord transplantation. Proc Natl Acad Sci U S A 2000;97:6126-31
22. Bain G, Kitchens D, Yao M, et al: Embryonic stem cells express neuronal properties in vitro. Dev Biol 1995;168:342-57
23. Gottlieb DI, Huettner JE: An in vitro pathway from embryonic stem cells to neurons and glia. Cells Tissues Organs 1999;165:165-72
24. McDonald JW, Liu XZ, Qu Y, et al: Transplanted embryonic stem cells survive, differentiate and promote recovery in injured rat spinal cord. Nat Med-1999;5:1410-2
25. Vadivelu S, Liu S, Howard MJ, et al: Embryonic stem cell transplantation: White matter is the preferred substrate for robust axonal regeneration in the injured adult rat spinal cord. Nat Neurosci (in press)
26. Bulte JW, Zhang S, van Gelderen P, et al: Neurotransplantation of magnetically labeled oligodendrocyte progenitors: Magnetic resonance tracking of cell migration and myelination. Proc Natl Acad Sci U S A 1999;96:15256-61
27. Bulte JW, Douglas T, Witwer B, et al: Magnetodendrimers allow endosomal magnetic labeling and in vivo tracking of stem cells. Nat Biotechnol 2001;19:1141-7
28. Thompson FJ, Uthman B, Mott S, et al: Neural tissue transplantation in syringomyelia patients: Neurophysiological assessments. Presented at the Fifth Annual Conference of the American Society for Neuronal Transplantation, 1998
29. Wirth DE III, Fessler RG, Reier PJ, et al: Neural tissue transplantation in patients with syringomyelia: Update on feasibility and safety, in Program and Abstracts of the American Society for Neural Transplantation and Repair, 1999
30. Reier PJ, Thompson FJ, Fessler RG, et al: Spinal cord injury and fetal CNS tissue transplantation: An initial "bench-to-bedside" translational research experience, in Ingogolia NA, Murray M (eds): Regeneration in the Central Nervous System. New York, Marcel-Dekker, 2001, pp. 603-47
31. Thompson FJ, Reier PJ, Uthman B, et al: Neurophysiological assessment of the feasibility and safety of neural tissue transplantation in patients with syringomyelia. J Neurotrauma 2001;18:931-45
32. Wirth ED III, Reier PJ, Fessler RG, et al: Feasibility and safety of neural tissue transplantation in patients with syringomyelia. J Neurotrauma 2001;18:911-29
33. Falci S, Holtz A, Akesson E, et al: Obliteration of a posttraumatic spinal cord cyst with solid human embryonic spinal cord grafts: First clinical attempt. J Neurotrauma 1997;14:875-84
34. Kocsis JD, Akiyama Y, Lankford KL, et al: Cell transplantation of peripheral-myelin-forming cells to repair the injured spinal cord. J Rehabil Res Dev 2002;39:287-98
35. Blakemore WF, Franklin RJ: Transplantation options for therapeutic central nervous system remyelination. Cell Transplant 2000;9:289-94
36. Bartolomei JC, Greer CA: Olfactory ensheathing cells: Bridging the gap in spinal cord injury. Neurosurgery 2000;47:1057-69
37. Ramon-Cueto A, Santos-Benito FF: Cell therapy to repair injured spinal cords: Olfactory ensheathing glia transplantation. Restor Neurol Neurosci 2001;19:149-56
38. Bunge MB: Bridging the transected or contused adult rat spinal cord with Schwann cell and olfactory ensheathing glia transplants. Prog Brain Res 2002;137:275-82
39. Teng YD, Lavik EB, Qu X, et al: Functional recovery following traumatic spinal cord injury mediated by a unique polymer scaffold seeded with neural stem cells. Proc Natl Acad Sci U S A 2002;99:3024-9
40. Huber AB, Schwab ME: Nogo-A, a potent inhibitor of neurite outgrowth and regeneration. Biol Chem 2000;381:407-19
41. Davies SJ, Silver J: Adult axon regeneration in adult CNS white matter. Trends Neurosci 1998;21:515
42. Blesch A, Grill RJ, Tuszynski MH: Neurotrophin gene therapy in CNS models of trauma and degeneration. Prog Brain Res 1998;117:473-84
43. Blesch A, Tuszynski MH: Spontaneous and neurotrophin-induced axonal plasticity after spinal cord injury. Prog Brain Res 2002;137:415-23
44. Tuszynski MH, Grill R, Jones LL, et al: Spontaneous and augmented growth of axons in the primate spinal cord: Effects of local injury and nerve growth factor-secreting cell grafts. J Comp Neurol 2002;449:88-101
45. Dimitrijevic MR, Faganel J, Lehmkuhl D, et al: Motor control in man after partial or complete spinal cord injury. Adv Neurol 1983;39:915-26
46. Dimitrijevic MR: Residual motor functions in spinal cord injury. Adv Neurol 1988;47:138-55
47. Corbetta M, Burton H, Sinclair RJ, et al: Functional reorganization and stability of somatosensory-motor cortical topography in a tetraplegic subject with late recovery. Proc Natl Acad Sci U S A 2002;99:17066-71
48. Taub E, Miller NE, Novack TA, et al: Technique to improve chronic motor deficit after stroke. Arch Phys Med Rehabil 1993;74:347-54
49. Taub E, Crago JE, Burgio LD, et al: An operant approach to rehabilitation medicine: Overcoming learned nonuse by shaping. J Exp Anal Behav 1994;61:281-93
50. van der Lee JH, Wagenaar RC, Lankhorst GJ, et al: Forced use of the upper extremity in chronic stroke patients: Results from a single-blind randomized clinical trial. Stroke 1999;30:2369-75
51. van der Lee JH, Snels IA, Beckerman H, et al: Exercise therapy for arm function in stroke patients: A systematic review of randomized controlled trials. Clin Rehabil 2001;15:20-31
52. Taub E, Uswatte G, Pidikiti R: Constraint-induced movement therapy: A new family of techniques with broad application to physical rehabilitation. A clinical review. J Rehabil Res Dev 1999;36:237-51
53. Bregman BS, Coumans JV, Dai HN, et al: Transplants and neurotrophic factors increase regeneration and recovery of function after spinal cord injury. Prog Brain Res 2002;137:257-73
54. Becker D, Grill WM, McDonald JW: Functional electrical stimulation helps replenish neural cells in the adult CNS after spinal cord injury. Presented at the 55th Annual Meeting of the American Academy of Neurology, 2003
55. Li Q, McDonald JW: Effect of baclofen on overall cellular vs. oligodendrocyto progenitor proliferation in SCI: A quantitative analysis. Presented at the 33nd Annual Meeting of the Society for Neuroscience, 2003
56. Li Q, Farhangrazi ZS, McDonald JW: Baclofen reduces proliferation/survival of neural stem cells after spinal cord injury (SCI). Presented at the 32nd Annual Meeting of the Society for Neuroscience, 2002
57. Sherrington CS: Flexion-reflex of the limb, crossed extension-reflex and reflex stepping and standing. J Physiol 1910;40:28-121
58. Barbeau H, McCrea DA, O'Donovan MJ, et al: Tapping into spinal circuits to restore motor function. Brain Res Rev 1999;30:27-51
59. Wernig A, Muller S: Laufband locomotion with body weight support improved walking in persons with severe spinal cord injuries. Paraplegia 1992;30:229-38
60. Kozlowski DA, James DC, Schallert T: Use-dependent exaggeration of neuronal injury after unilateral sensorimotor cortex lesions. J Neurosci 1996;16:4776-86
61. Humm JL, Kozlowski DA, James DC, et al: Use-dependent exacerbation of brain damage occurs during an early post- lesion vulnerable period. Brain Res 1998;783:286-92
62. Humm JL, Kozlowski DA, Bland ST, et al: Use-dependent exaggeration of brain injury: Is glutamate involved? Exp Neurol 1999;157:349-58
63. Barbeau H, Ladouceur M, Mirbagheri MM, et al: The effect of locomotor training combined with functional electrical stimulation in chronic spinal cord injured subjects: Walking and reflex studies. Brain Res Rev 2002;40:274-91
64. Wilder RP, Jones EV, Wind TC, et al: Functional electrical stimulation cycle ergometer exercise for spinal cord injured patients. J Long Term Eff Med Implants 2002;12:161-74
65. Faghri PD, Yount J: Electrically induced and voluntary activation of physiologic muscle pump: A comparison between spinal cord-injured and able-bodied individuals. Clin Rehabil 2002;16:878-85
66. Mirbagheri MM, Ladouceur M, Barbeau H, et al: The effects of long-term FES-assisted walking on intrinsic and reflex dynamic stiffness in spastic spinalcord-injured subjects. IEEE Trans Neural Syst Rehabil Eng 2002;10:280-9