Clarification of the role of key active site residues of glutathione transferase Zeta/maleylacetoacetate isomerase by a new spectrophotometric technique

Biochemical Journal

Volumn 374, Issue 3, 2003, Pages 731-737

  Board, Philip G ^a   Taylor, Matthew C ^a   Coggan, Marjorie ^a   Parker, Michael W ^b   Lantum, Hoffman B ^c   Anders, M W ^c  

^a Biology and Environment   (Australia)

^b ST VINCENT'S INSTITUTE OF MEDICAL RESEARCH   (Australia)

^c UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

Catalysis; Glutathione transferase (GST); Maleylacetate isomerase (MAAI); Site directed mutagenesis; Spectrophotometry; Zeta class glutathione transferase

Indexed keywords

CARBOXYLIC ACIDS; CATALYSIS; METABOLISM; MUTAGENESIS; REACTION KINETICS; SPECTROPHOTOMETRY;

CATALYTIC CYCLE;

ENZYMES;

ALANINE; ARGININE; CARBOXYLIC ACID; CYSTEINE; GLUTATHIONE TRANSFERASE ZETA 1 1; ISOMERASE; LYSINE; MALEYLACETOACETATE ISOMERASE; SERINE; TRANSFERASE; TYROSINE; UNCLASSIFIED DRUG; AMINO ACID; CIS TRANS ISOMERASE; DRUG DERIVATIVE; GLUTATHIONE; GLUTATHIONE TRANSFERASE; GSTZ1 PROTEIN, HUMAN;

AMINO ACID SUBSTITUTION; ARTICLE; CATALYSIS; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ASSAY; ENZYME BINDING; ENZYME CONFORMATION; ENZYME LOCALIZATION; ENZYME SUBSTRATE; FUNCTIONAL ASSESSMENT; PRIORITY JOURNAL; PROTEIN VARIANT; SITE DIRECTED MUTAGENESIS; SPECTROPHOTOMETRY; BINDING SITE; CHEMISTRY; GENETICS; HUMAN; MASS FRAGMENTOGRAPHY; METABOLISM; METHODOLOGY; PHYSIOLOGY;

AMINO ACIDS; BINDING SITES; CIS-TRANS-ISOMERASES; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; GLUTATHIONE; GLUTATHIONE TRANSFERASE; HUMANS; MUTAGENESIS, SITE-DIRECTED; SPECTROPHOTOMETRY;

EID: 0141679076     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20030625     Document Type: Article

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