Impaired nitric oxide function in the basilar artery of the obese zucker rat

Journal of Cardiovascular Pharmacology

Volumn 42, Issue 4, 2003, Pages 497-505

  Karagiannis, J ^a   Reid, J J ^a   Darby, I ^a   Roche, P ^a   Rand, M J ^a   Li, C G ^a  

^a RMIT UNIVERSITY   (Australia)

Author keywords

Basilar artery; Endothelium; Nitric oxide; Obese Zucker rat

Indexed keywords

ACETYLCHOLINE; CALCIMYCIN; CHOLESTEROL; FREE RADICAL; HISTAMINE; INSULIN; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; NITROPRUSSIDE SODIUM; PAPAVERINE; SEROTONIN; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY CONSTRICTION; ARTERY DILATATION; ARTICLE; BASILAR ARTERY; BLOOD PRESSURE; BLOOD VESSEL FUNCTION; BODY WEIGHT; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; FEMALE; IMMUNOFLUORESCENCE; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; NONHUMAN; OBESITY; ORAL GLUCOSE TOLERANCE TEST; PRIORITY JOURNAL; PROTEINURIA; RAT; RAT STRAIN; TRIACYLGLYCEROL BLOOD LEVEL; WESTERN BLOTTING;

ACETYLCHOLINE; ANIMALS; BASILAR ARTERY; BIOGENIC AMINES; CALCIMYCIN; ENDOTHELIUM, VASCULAR; FEMALE; HEMODYNAMIC PROCESSES; INSULIN RESISTANCE; METABOLISM; MUSCLE RELAXATION; MUSCLE, SMOOTH; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITROPRUSSIDE; OBESITY; PAPAVERINE; RATS; RATS, ZUCKER;

EID: 0141642009     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-200310000-00007     Document Type: Article

References (53)

1. Reaven GM. Pathophysiology of insulin resistance in human disease. Physiol Rev. 1995;75:473-486.
2. Chisholm DJ, Campbell LV, Kraegen EW. Pathogenesis of the insulin resistance syndrome (syndrome X). Clin Exp Pharmacol Physiol. 1997;24:782-784.
3. van Zwieten, P.A. Diabetes and hypertension: experimental models for pharmacological studies. Clin Exp Hypertens. 1999;21:1-16.
4. Moncada S, Palmer RM, Higgs EA. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev. 1991;43:109-142.
5. De Vriese AS, Verbeuren TJ, Van de Voorde J, et al. Endothelial dysfunction in diabetes. Br J Pharmacol. 2000;130:963-974.
6. Bohlen HG, Nase GP. Obesity lowers hyperglycemic threshold for impaired in vivo endothelial nitric oxide function. Am J Physiol Heart Circ Physiol. 2002;283:H391-H397.
7. Zanchi A, Delacretaz E, Taleb V, et al. Endothelial function of the mesenteric arteriole and mechanical behaviour of the carotid artery in rats with insulin resistance and hypercholesterolaemia. J Hypertens. 1995;13:1463-1470.
8. Laight DW, Desai KM, Anggard EE, et al. Endothelial dysfunction accompanies a pro-oxidant, pro-diabetic challenge in the insulin resistant, obese Zucker rat in vivo. Eur J Pharmacol. 2000;402:95-99.
9. Andrews TJ, Laight DW, Anggard EE, et al. Investigation of endothelial hyperreactivity in the obese Zucker rat in-situ: reversal by vitamin E. J Pharm Pharmacol. 2000;52:83-86.
10. Stepp DW, Frisbee JC. Augmented adrenergic vasoconstriction in hypertensive diabetic obese Zucker rats. Am J Physiol Heart Circ Physiol. 2002;282:H816-H820.
11. Lukovits TG, Mazzone TM, Gorelick TM. Diabetes mellitus and cerebrovascular disease. Neuroepidemiology. 1999;18:1-14.
12. Yuan S, Liu Y, Zhu L. Vascular complications of diabetes mellitus. Clin Exp Pharmacol Physiol. 1999;26:977-978.
13. Spanheimer RG. Reducing cardiovascular risk in diabetes. Which factors to modify first? Postgrad Med J. 2001;109:26-30,33-36.
14. Laakso M, Lehto S. Epidemiology of risk factors for cardiovascular disease in diabetes and impaired glucose tolerance. Atherosclerosis. 1998;137(suppl):S65-S73.
15. Lowry OH, Rosenbrough NJ, Farr AL, et al. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951;193:265-275.
16. Mulvany MJ, Halpern W. Contractile properties of small arterial resistance vessels in spontaneously hypertensive and normotensive rats. Circ Res. 1977;41:19-26.
17. McPherson GA. Assessing vascular reactivity of arteries in the small vessel myograph. Clin Exp Pharmacol Physiol. 1992;19:815-825.
18. Garcia-Villalon AL, Krause DN, Ehlert FJ, et al. Heterogeneity of muscarinic receptor subtypes in cerebral blood vessels. J Pharmacol Exp Ther. 1991;258:304-310.
19. Estrada C, Hamel E, Krause DN. Biochemical evidence for cholinergic innervation of intracerebral blood vessels. Brain Res. 1983;266:261-270.
20. McNeill AM, Kim N, Duckles SP, et al. Chronic estrogen treatment increases levels of endothelial nitric oxide synthase protein in rat cerebral microvessels. Stroke. 1999;30:2186-2190.
21. Rajanayagam MA, Li CG, Rand MJ. Differential effects of hydroxocobalamin on NO-mediated relaxations in rat aorta and anococcygeus muscle. Br J Pharmacol. 1993;108:3-5.
22. Van Zwieten PA, Kam KL, Pijl AJ, et al. Hypertensive diabetic rats in pharmacological studies. Pharmacol Res. 1996;33:95-105.
23. Trezise DJ, Drew GM, Weston AH. Analysis of the depressant effect of the endothelium on contractions of rabbit isolated basilar artery to 5-hydroxytryptamine. Br J Pharmacol. 1992;106:587-592.
24. O'Brien SF, McKendrick JD, Radomski MW, et al. Vascular wall reactivity in conductance and resistance arteries: differential effects of insulin resistance. Can J Physiol Pharmacol. 1998;76:72-76.
25. Laight DW, Anggard EE, Carrier MJ. Investigation of basal endothelial function in the obese Zucker rat in vitro. Gen Pharmacol. 2002;35:303-309.
26. Frisbee JC, Stepp DW. Impaired NO-dependent dilation of skeletal muscle arterioles in hypertensive diabetic obese Zucker rats. Am J Physiol Heart Circ Physiol. 2001;281:H1304-H1311.
27. Duarte J, Martinez A, Bermejo A, et al. Cardiovascular effects of captopril and enalapril in obese Zucker rats. Eur J Pharmacol. 1999;365:225-232.
28. Bohlen HG, Lash JM. Endothelial-dependent vasodilation is preserved in non-insulin-dependent Zucker fatty diabetic rats. Am J Physiol. 1995;268: H2366-H2374.
29. Auguet M, Delaflotte S, Braquet P. Increased influence of endothelium in obese Zucker rat aorta. J Pharm Pharmacol. 1989;41:861-864.
30. Sexl V, Mancusi G, Raberger G, et al. Age-related changes in vascular reactivity in genetically diabetic rats. Pharmacology. 1995;50:238-246.
31. McNamee CJ, Kappagoda CT, Kunjara R, et al. Defective endothelium-dependent relaxation in the JCR:LA-corpulent rat. Circ Res. 1994;74:1126-1132.
32. Jin JS, Bohlen HG. Non-insulin-dependent diabetes and hyperglycemia impair rat intestinal flow-mediated regulation. Am J Physiol. 1997;272: H728-H734.
33. Pieper GM, Peltier BA. Amelioration by L-arginine of a dysfunctional arginine/nitric oxide pathway in diabetic endothelium. J Cardiovasc Pharmacol. 1995;25:397-403.
34. McNally PG, Watt PA, Rimmer T, et al. Impaired contraction and endothelium-dependent relaxation in isolated resistance vessels from patients with insulin-dependent diabetes mellitus. Clin Sci (Lond). 1994;87:31-36.
35. Gazis A, White DJ, Page SR, et al. Effect of oral vitamin E (alpha-tocopherol) supplementation on vascular endothelial function in type 2 diabetes mellitus. Diabet Med. 1999;16:304-311.
36. Lash JM, Bohlen HG. Structural and functional origins of suppressed acetylcholine vasodilation in diabetic rat intestinal arterioles. Circ Res. 1991;69:1259-1268.
37. Taylor PD, Graves JE, Poston L. Selective impairment of acetylcholine-mediated endothelium-dependent relaxation in isolated resistance arteries of the streptozotocin-induced diabetic rat. Clin Sci (Lond). 1995;88:519-524.
38. Marinos RS, Zhang W, Wu G, et al. Tetrahydrobiopterin levels regulate endothelial cell proliferation. Am J Physiol Heart Circ Physiol. 2001;281: H482-H489.
39. Prabhakar SS. Tetrahydrobiopterin reverses the inhibition of nitric oxide by high glucose in cultured murine mesangial cells. Am J Physiol Renal Physiol. 2001;281:F179-F188.
40. Guerci B, Bohme P, Kearney-Schwartz A, et al. Endothelial dysfunction and type 2 diabetes. Part 2: altered endothelial function and the effects of treatments in type 2 diabetes mellitus. Diabetes Metab. 2001;27:436-447.
41. Giugliano D, Ceriello A, Paolisso G. Oxidative stress and diabetic vascular complications. Diabetes Care. 1996;19(3):257-267.
42. Mayhan WG, Sun H, Irvine SD. Influence of gender on dilatation of the basilar artery during diabetes mellitus. Brain Res. 2002;930:182-190.
43. Kamata K, Kondoh H. Impairment of endothelium-dependent relaxation of the isolated basilar artery from streptozotocin-induced diabetic rats. Res Commun Mol Pathol Pharmacol. 1996;94:239-249.
44. Kowaluk EA, Seth P, Fung HL. Metabolic activation of sodium nitroprusside to nitric oxide in vascular smooth muscle. J Pharmacol Exp Ther. 1992;262:916-922.
45. Feelisch M. The use of nitric oxide donors in pharmacological studies. Naunyn Schmiedebergs Arch Pharmacol. 1998;358:113-122.
46. Friederich JA, Butterworth JFT. Sodium nitroprusside: twenty years and counting. Anesth Analg. 1995;81:152-162.
47. Russell JC, Graham SE, Richardson M. Cardiovascular disease in the JCR:LA-cp rat. Mol Cell Biochem. 1998;188:113-126.
48. Omar HA, Cherry PD, Mortelliti MP, et al. Inhibition of coronary artery superoxide dismutase attenuates endothelium-dependent and -independent nitrovasodilator relaxation. Circ Res. 1991;69:601-608.
49. Laight DW, Kengatharan KM, Gopaul NK, et al. Investigation of oxidant stress and vasodepression to glyceryl trinitrate in the obese Zucker rat in vivo. Br J Pharmacol. 1998;125(4):895-901.
50. Loesch A, Burnstock G. Ultrastructural study of perivascular nerve fibres and endothelial cells of the rat basilar artery immunolabelled with monoclonal antibodies to neuronal and endothelial nitric oxide synthase. J Neurocytol. 1996;25(9):525-534.
51. Samdani AF, Dawson TM, Dawson VL. Nitric oxide synthase in models of focal ischemia. Stroke. 1997;28(6):1283-1288.
52. Morley JE, Mattammal MB. Nitric oxide synthase levels in obese Zucker rats. Neurosci Lett. 1996;209:137-139.
53. Morley JE, Kumar VB, Mattammal M, et al. Measurement of nitric oxide synthase and its mRNA in genetically obese (ob/ob) mice. Life Sci. 1995;57:1327-1331.