Zinc and energy requirements in induction of oxidative stress to retinal pigmented epithelial cells

Neurochemical Research

Volumn 28, Issue 10, 2003, Pages 1525-1533

  Wood, John P M ^a   Osborne, Neville N ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Age related macular degeneration; Antioxidant; Apoptosis; Pyruvate; Retinal pigmented epithelium; Zinc

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; METIPRANOLOL; OXALOACETIC ACID; PYRUVIC ACID; TROLOX C; ZINC;

ARTICLE; CELL DEATH; CELL ENERGY; CELL PROTECTION; CONTROLLED STUDY; DRUG EFFICACY; DRUG SAFETY; HEALTH STATUS; HUMAN; HUMAN CELL; OXIDATIVE STRESS; PIGMENT EPITHELIUM; PRIORITY JOURNAL; RETINA MACULA AGE RELATED DEGENERATION;

ANTIOXIDANTS; CALCIUM; CATIONS; CELL SURVIVAL; CELLS, CULTURED; CHELATING AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENERGY METABOLISM; HUMANS; OXIDATIVE STRESS; PIGMENT EPITHELIUM OF EYE; ZINC;

EID: 0141593558     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1025622425501     Document Type: Article

References (45)

1. Weiss, J. H., Sensi, S. L., and Koh, J. Y. 2000. Zn(2+): A novel ionic mediator of neural injury in brain disease. Trends Pharmacol. Sci. 21:395-401.
2. Ugarte, M. and Osborne, N. N. 2001. Zinc in the retina. Prog. Neurobiol. 64:219-49.
3. Beyersmann, D. and Haase, H. 2001. Functions of zinc in signaling, proliferation and differentiation of mammalian cells. Biometals 14:331-341.
4. Kimura, E. and Kikuta, E. 2000. Why zinc in zinc enzymes? From biological roles to DNA base-selective recognition. J. Biol. Inorg. Chem. 5:139-155.
5. Mocchegiani, E., Muzzioli, M., and Giacconi, R. 2000. Zinc, metallothioneins, immune responses, survival and ageing. Biogerontology 1:133-143.
6. Evans, G. W. 1986. Zinc and its deficiency diseases. Clin. Physiol. Biochem. 4:94-98.
7. Menzano, E. and Carlen, P. L. 1994. Zinc deficiency and corticosteroids in the pathogenesis of alcoholic brain dysfunction: A review. Alcohol Clin. Exp. Res. 18:895-901.
8. Grahn, B. H., Paterson, P. G., Gottschall, Pass, K. T., and Zhang, Z. 2001. Zinc and the eye. J. Am. Coll. Nutr. 20:106-118.
9. Jampol, L. M. 2001. Antioxidants, zinc, and age-related macular degeneration: Results and recommendations. Arch Ophthalmol. 119:1533-1534.
10. Hyman, L. and Neborsky, R. 2002. Risk factors for age-related macular degeneration: An update. Curr. Opin. Ophthalmol. 13: 171-175.
11. Mares Perlman, J. A., Klein, R., Klein, B. E., Greger, J. L., Brady, W. E., Palta, M., and Ritter, L. L. 1996. Association of zinc and antioxidant nutrients with age-related maculopathy. Arch. Ophthalmol. 114:991-997.
12. Leure duPree, A. E. and McClain, C. J. 1982. The effect of severe zinc deficiency on the morphology of the rat retinal pigment epithelium. Invest. Ophthalmol. Vis. Sci. 23:425-434.
13. Cai, J., Nelson, K. C., Wu, M., Sternberg, P., Jr., and Jones, D. P. 2000. Oxidative damage and protection of the RPE. Prog. Retin. Eye Res. 19:205-221.
14. Seddon, J. M., Ajani, U. A., Sperduto, R. D., Hiller, R., Blair, N., Burton, T. C., Farber, M. D., Gragoudas, E. S., Haller, J., Miller, D. T., et al. 1994. Dietary carotenoids, vitamins A, C, and E, and advanced age-related macular degeneration. Eye Disease Case-Control Study Group. JAMA 272:1413-1420.
15. AREDS Study Group. 2001. A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8. Arch. Ophthalmol. 119: 1417-1436.
16. Davidson, P. C., Sternberg, P., Jr., Jones, D. P., and Reed, R. L. 1994. Synthesis and transport of glutathione by cultured human retinal pigment epithelial cells. Invest. Ophthalmol. Vis. Sci. 35: 2843-2849.
17. Sternberg, P., Jr., Davidson, P. C., Jones, D. P., Hagen, T. M., Reed, R. L., and Drews Botsch, C. 1993. Protection of retinal pigment epithelium from oxidative injury by glutathione and precursors. Invest. Ophthalmol. Vis. Sci. 34:3661-3668.
18. Tate, D. J., Jr., Miceli, M. V., and Newsome, D. A. 1999. Zinc protects against oxidative damage in cultured human retinal pigment epithelial cells. Free Radic. Biol. Med. 26:704-713.
19. Wood, J. and Osborne, N. 1997. Induction of apoptosis in cultured human retinal pigmented epithelial cells: The effect of protein kinase C activation and inhibition. Neurochem. Int. 31:261-274.
20. Wood, J. P. and Osborne, N. N. 2001. The influence of zinc on caspase-3 and DNA breakdown in cultured human retinal pigment epithelial cells. Arch. Ophthalmol. 119:81-88.
21. Mosmann T. 1983. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J. Immunol. Methods 65:55-63.
22. Melena, J. and Osborne, N. N. 2003. Metipranolol attenuates lipid peroxidation in rat brain: A comparative study with other anti-glaucoma drugs. Craepés Arch. Clin. Exp. Ophthamol. in press.
23. Wood, J. P. M., Schmidt, K.-G., Melena, J., Chidlow, G., Allmeier, H., and Osborne, N. N. 2003. The β-adrenoceptor antagonists metipranolol and timolol are retinal neuroprotectants: Comparison with betaxolol. Exp. Eye Res. 36:505-516.
24. + channels: Comparison with other beta-adrenoceptor antagonists. Br. J. Pharmacol. 130:759-766.
25. 2+ channel-blocking activity of propranolol and betaxolol in isolated bovine retinal microartery. J. Cardiovasc. Pharmacol. 32:390-396.
26. 1-adrenoceptor antagonist, has an affinity for L-type calcium channels. Eur. J. Pharmacol. 378:317-332.
27. Philp, N. J., Yoon, H., Grollman, E. F. 1998. Monocarboxylate transporter MCT1 is located in the apical membrane and MCT3 in the basal membrane of rat RPE. Am. J. Physiol. 274: R1824-R1828.
28. To, C. H. and Hodson, S. A. 1998. The glucose transport in retinal pigment epithelium is via passive facilitated diffusion. Comp. Biochem. Physiol. A Mol. Integr. Physiol. 121:441-444.
29. Halestrap, A. P. and Price, N. T. 1999. The proton-linked monocarboxylate transporter (MCT) family: Structure, function and regulation. Biochem. J. 2:281-299.
30. 2+ ions with glyceraldehyde-3-phosphate dehydrogenase from bovine heart and rabbit muscle. Int. J. Biochem. 24: 1501-1505.
31. Sheline, C. T., Behrens, M. M., Choi, D. W. 2000. Zinc-induced cortical neuronal death: Contribution of energy failure attributable to loss of NAD(+) and inhibition of glycolysis. J. Neurosci. 20:3139-3146.
32. Foo, S. Y. and Nolan, G. P. 1999. NF-kappaB to the rescue: RELs, apoptosis and cellular transformation. Trends Genet. 15:229-235.
33. Lovell, M. A., Xie, C., and Markesbery, W. R. 1999. Protection against amyloid beta peptide toxicity by zinc. Brain Res. 823:88-95.
34. Lobner, D., Canzoniero, L. M., Manzerra, P., Gottron, F., Ying, H., Knudson, M., Tian, M., Dugan, L. L., Kerchner, G. A., Sheline, C. T., Korsmeyer, S. J., Choi, D. W. 2000. Zinc-induced neuronal death in cortical neurons. Cell Mol. Biol. 46:797-806.
35. Ugarte, M. and Osborne, N. N. 1998. The localization of endogenous zinc and the in vitro effect of exogenous zinc on the GABA immunoreactivity and formation of reactive oxygen species in the retina. Gen. Pharmacol. 30:297-303.
36. Boland, M. P. 2001. DNA damage signalling and NF-kappaB: Implications for survival and death in mammalian cells. Biochem. Soc. Trans. 29:674-678.
37. Koh, J. Y. 2001. Zinc and disease of the brain. Mol. Neurobiol. 24:99-106.
38. Nakano, M., Saito, S., Nakano, Y., Yamasu, H., Matsuura, M., and Shinomiya, H. 1993. Intracellular protein phosphorylation in murine peritoneal macrophages in response to bacterial lipopolysaccharide (LPS): Effects of kinase-inhibitors and LPS-induced tolerance. Immunobiology 187:272-282.
39. Gopalakrishna, R. and Jaken S. 2000. Protein kinase C signalling and oxidative stress. Free Rad. Biol. Med. 28:1349-1361.
40. Nicotera, P. and Orrenius S. 1998. The role of calcium in apoptosis. Cell Calcium 23:173-180.
41. Choi, D. W. and Koh, J. Y. 1998. Zinc and brain injury. Ann. Rev. Neurosci. 21:347-375.
42. Lopez Colome, A. M., Fragoso, G., Wright, C. E., Sturman, J. A. 1994. Excitatory amino acid receptors in membranes from cultured human retinal pigment epithelium. Curr. Eye Res. 13: 553-560.
43. A-receptor subunits in cultured human and rat retinal pigment epithelium. Exp. Eye Res. 63:113-116.
44. Raha, S. and Robinson, B. H. 2001. Mitochondria, oxygen free radicals, and apoptosis. Am. J. Med. Genet. 106:62-70.
45. Algvere, P. V. and Seregard, S. 2002. Age-related maculopathy: Pathogenetic features and new treatment modalities. Acta Ophthalmol. Scand. 80:136-143.