Betaxolol, a β1-adrenoceptor antagonist, has an affinity for L-type Ca2+ channels

European Journal of Pharmacology

Volumn 378, Issue 3, 1999, Pages 317-322

  Melena, José ^a   Wood, John P M ^a   N Osborne, Neville ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Adrenoceptor antagonist; 3H Diltiazem; 3H Nitrendipine; Betaxolol; Ca2+ channel, L type

Indexed keywords

BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BETAXOLOL; CALCIUM CHANNEL; CARTEOLOL; DILTIAZEM; NITRENDIPINE; PROPRANOLOL; TIMOLOL; DIAGNOSTIC AGENT; TRITIUM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; DISSOCIATION CONSTANT; GLAUCOMA; HYPERTENSION; NONHUMAN; PRIORITY JOURNAL; RAT; ANIMAL; BINDING COMPETITION; CHEMISTRY; DOSE RESPONSE; DRUG EFFECT; FEMALE; MALE; MEMBRANE; METABOLISM; RADIOASSAY; STEREOISOMERISM; WISTAR RAT;

ADRENERGIC BETA-ANTAGONISTS; ANIMALS; BETAXOLOL; BINDING, COMPETITIVE; CALCIUM CHANNELS; CARTEOLOL; CEREBRAL CORTEX; DILTIAZEM; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; MALE; MEMBRANES; NITRENDIPINE; PROPRANOLOL; RADIOLIGAND ASSAY; RATS; RATS, WISTAR; STEREOISOMERISM; TIMOLOL; TRITIUM;

EID: 0032588879     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(99)00459-8     Document Type: Article

References (29)

1. Alward W.L. Drug therapy: medical management of glaucoma. New Engl. J. Med. 339:1998;1298-1307.
2. Araie M., Muta K. Effect of long-term topical betaxolol on tissue circulation in the iris and optic nerve head. Exp. Eye Res. 64:1997;167-172.
3. Beresford R., Heel R.C. Betaxolol: a review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in hypertension. Drugs. 31:1986;6-28.
4. Bessho H., Suzuki J., Narimatsu A., Tobe A. Antihypertensive effect of betaxolol, a cardioselective β-adrenoceptor antagonist, in experimental hypertensive rats. Jpn. J. Pharmacol. 52(Suppl. 1):1990;315P.
5. Bessho H., Suzuki J., Tobe A. Vascular effects of betaxolol, a cardioselective β-adrenoceptor antagonist, in isolated rat arteries. Jpn. J. Pharmacol. 55:1991;351-358.
6. Collignon-Brach J. Longterm effect of topical beta-blockers on intraocular pressure and visual field sensitivity in ocular hypertension and chronic open-angle glaucoma. Surv. Ophthalmol. 38:1994;S149-155. suppl.
7. Drance S.M. A comparison of the effects of betaxolol, timolol and pilocarpine on visual function in patients with open-angle glaucoma. J. Glaucoma. 7:1998;247-252.
8. Ehlert F.J. Estimation of the affinities of allosteric ligands using radioligand binding and pharmacological null methods. Mol. Pharmacol. 33:1988;187-194.
9. Hennekens C.H. Lessons from hypertension trials. Am. J. Med. 104:1998;50S-53S.
10. Hester R.K., Chen Z., Becker E.J., McLaughlin M., DeSantis L. The direct vascular relaxing action of betaxolol, carteolol and timolol in porcine long posterior ciliary artery. Surv. Ophthalmol. 38:1994;S125-134. suppl.
11. Hoste A.M., Sys S.U. The relaxant action of betaxolol on isolated bovine retinal microarteries. Curr. Eye Res. 13:1994;483-487.
12. 2+ channel-blocking activity of propranolol and betaxolol in isolated bovine retinal microartery. J. Cardiovasc. Pharmacol. 32:1998;390-396.
13. Hoste A.M., Boels P.J., Andries L.J., Brutsaert D.L., De Laey J.J. Effects of beta-antagonists on contraction of bovine retinal microarteries in vitro. Invest. Ophthalmol. Vis. Sci. 31:1990;1231-1237.
14. 3H ]PN200-110 to rabbit T-tubule calcium channels Eur. J. Pharmacol. 208:1991;199-205.
15. Kaiser H.J., Flammer J., Messmer C., Stümpfig D., Hendrickson P. Thirty-month visual field follow-up of glaucoma patients treated with beta-blockers. J. Glaucoma. 1:1992;153-155.
16. Kaiser H.J., Flammer J., Stümpfig D., Hendrickson P. Longterm visual field follow-up of glaucoma patients treated with beta-blockers. Surv. Ophthalmol. 38:1994;S156-159. suppl.
17. Mason R.C., Rhodes D.G., Herbette L.G. Reevaluating equilibrium and kinetic binding parameters for lipophilic drugs based on a structural model for drug interaction with biological membranes. J. Med. Chem. 34:1991;869-877.
18. Messmer C., Flammer J., Stümpfig D. Influence of betaxolol and timolol on the visual fields of patients with glaucoma. Am. J. Ophthalmol. 112:1991;678-681.
19. Mir K.A., Spedding M. Calcium antagonist properties of diclofurime isomers: II. Molecular aspects: allosteric interactions with dihydropyridine recognition sites. J. Cardiovasc. Pharmacol. 9:1987;469-477.
20. Nathanson J.A. Stereospecificiy of beta adrenergic antagonists: R-enantiomers show increased selectivity for beta-2 receptors in ciliary process. J. Pharmacol. Exp. Ther. 245:1988;94-101.
21. Osborne N.N., Cazevieille C., Carvalho A.L., Larsen A.K., DeSantis L. In vivo and in vitro experiments show that betaxolol is a retinal neuroprotective agent. Brain Res. 751:1997;113-123.
22. Osborne, N.N., DeSantis, L., Bae, J.H., Ugarte, M., Wood, J.P.M., Chidlow, G., 1999. Topically applied betaxolol attenuates NMDA-induced toxicity to ganglion cells and the effects of ischaemia to the rat retina. Exp. Eye Res., in press.
23. Satoh N., Suzuki J., Bessho H., Kitada Y., Narimatsu A., Tobe A. Effects of betaxolol on cardiohemodynamics and coronary circulation in anesthetized dogs: comparison with atenolol and propranolol. Jpn. J. Pharmacol. 54:1990;113-119.
24. Schaeffer P., Lugnier C., Stoclet J.-C. Interactions of calmodulin antagonists with calcium antagonists binding sites. Eur. J. Pharmacol. 206:1991;325-332.
25. 3H ]diltiazem binding to calcium channel antagonists recognition sites in rat cerebral cortex Eur. J. Pharmacol. 111:1985;273-277.
26. 1-selective adrenoceptor antagonist, on voltage-dependent calcium channels in guinea-pig artery and vein. Br. J. Pharmacol. 115:1995;198-202.
27. Walle T., Byington R.P., Furberg C.D., McIntyre K.M., Vokonas P.S. Biologic determinants of propranolol disposition: results from 1308 patients in the beta-blocker heart attack trial. Clin. Pharmacol. Ther. 38:1985;509-518.
28. 2+ channels. Circ. Res. 81:1997;526-532.
29. Yu D.-Y., Su E.-N., Cringle S.J., Alder V.A., Yu P.K., DeSantis L. Effect of betaxolol, timolol and nimodipine in pig retinal arterioles. Exp. Eye Res. 67:1998;73-81.